YLR348C / DIC1

Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR348C / DIC1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.47|P-value:1.50E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.18|P-value:6.85E-6 ID:SGTC_500|Compound:h-89|FD-Score:3.10|P-value:6.16E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.27|P-value:3.25E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.99|P-value:1.64E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.38|P-value:2.15E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:5.37|P-value:1.09E-8 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.33|P-value:2.58E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.32|P-value:2.74E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.16|P-value:4.99E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.26|P-value:3.49E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.25|P-value:3.58E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.68|P-value:6.18E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.14|P-value:7.96E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.25|P-value:3.58E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.29|P-value:3.09E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.99|P-value:1.62E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.17|P-value:4.71E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-2.97|P-value:9.91E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.14|P-value:5.34E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.38|P-value:2.10E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.07|P-value:6.85E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_2237|Compound:6667747|FD-Score:5.77|P-value:9.04E-10 ID:SGTC_2238|Compound:6671620|FD-Score:3.24|P-value:3.64E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.40|P-value:1.98E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.32|P-value:2.77E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.42|P-value:1.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.20|P-value:4.19E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.37|P-value:2.20E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.74|P-value:4.90E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.43|P-value:1.96E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.21|P-value:2.90E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.30|P-value:3.69E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.35|P-value:2.37E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.59|P-value:9.06E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.21|P-value:4.18E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.86|P-value:2.08E-7 ID:SGTC_3056|Compound:9094900|FD-Score:-3.14|P-value:5.42E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.00|P-value:1.55E-5 ID:SGTC_3237|Compound:9133362|FD-Score:5.59|P-value:2.86E-9 ID:SGTC_3338|Compound:9144300|FD-Score:-3.11|P-value:6.07E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.47|P-value:1.50E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:-4.18|P-value:6.85E-6 ID:SGTC_500|Compound:h-89|FD-Score:3.10|P-value:6.16E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:3.27|P-value:3.25E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-3.99|P-value:1.64E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:3.38|P-value:2.15E-4 ID:SGTC_717|Compound:1532-0246|FD-Score:3.47|P-value:1.48E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:5.37|P-value:1.09E-8 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.33|P-value:2.58E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:-3.32|P-value:2.74E-4 ID:SGTC_1376|Compound:2910-0861|FD-Score:-3.16|P-value:4.99E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.26|P-value:3.49E-4 ID:SGTC_1400|Compound:3771-8998|FD-Score:-3.25|P-value:3.58E-4 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.68|P-value:6.18E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.14|P-value:7.96E-6 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.30|P-value:2.99E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.25|P-value:3.58E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.29|P-value:3.09E-4 ID:SGTC_1729|Compound:st035615|FD-Score:3.99|P-value:1.62E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.17|P-value:4.71E-4 ID:SGTC_1846|Compound:st056244|FD-Score:-2.97|P-value:9.91E-4 ID:SGTC_1855|Compound:st056195|FD-Score:3.14|P-value:5.34E-4 ID:SGTC_2095|Compound:5432005|FD-Score:3.38|P-value:2.10E-4 ID:SGTC_2171|Compound:5739187|FD-Score:-3.07|P-value:6.85E-4 ID:SGTC_2174|Compound:5790901|FD-Score:3.20|P-value:4.29E-4 ID:SGTC_2237|Compound:6667747|FD-Score:5.77|P-value:9.04E-10 ID:SGTC_2238|Compound:6671620|FD-Score:3.24|P-value:3.64E-4 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.40|P-value:1.98E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.32|P-value:2.77E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.42|P-value:1.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.20|P-value:4.19E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.37|P-value:2.20E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.74|P-value:4.90E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.43|P-value:1.96E-6 ID:SGTC_2752|Compound:diclazuril|FD-Score:5.21|P-value:2.90E-8 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-4.30|P-value:3.69E-6 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.35|P-value:2.37E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:3.59|P-value:9.06E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.21|P-value:4.18E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.86|P-value:2.08E-7 ID:SGTC_3056|Compound:9094900|FD-Score:-3.14|P-value:5.42E-4 ID:SGTC_3135|Compound:9127742|FD-Score:4.00|P-value:1.55E-5 ID:SGTC_3237|Compound:9133362|FD-Score:5.59|P-value:2.86E-9 ID:SGTC_3338|Compound:9144300|FD-Score:-3.11|P-value:6.07E-4

Top fitness defect scores for YLR348C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2237 6667747 5.77 47.2 µM 9.04E-10 6 3.92E-9
2 SGTC_3237 9133362 5.59 49.5 µM 2.86E-9 9 1.13E-8
3 SGTC_789 1309-1135 5.37 70.6 µM 1.09E-8 ERG2 9 3.91E-8
4 SGTC_2752 diclazuril 5.21 33.1 µM 2.90E-8 71 9.62E-8
5 SGTC_3029 9088683 4.86 49.5 µM 2.08E-7 11 5.94E-7
6 SGTC_1453 4237-0541 4.14 195.0 µM 7.96E-6 heme biosynthesis & mitochondrial translocase 21 1.73E-5
7 SGTC_3135 9127742 4.00 49.5 µM 1.55E-5 18 3.19E-5
8 SGTC_1729 st035615 3.99 46.0 µM 1.62E-5 36 3.33E-5
9 SGTC_2657 nystatin 3.74 74.4 µM 4.90E-5 17 9.26E-5
10 SGTC_1421 4029-0249 3.68 71.4 µM 6.18E-5 23 1.15E-4
11 SGTC_2766 oltipraz 3.59 83.9 µM 9.06E-5 heme requiring 41 1.64E-4
12 SGTC_717 1532-0246 3.47 73.2 µM 1.48E-4 Golgi 50 2.58E-4
13 SGTC_2342 7990637 3.42 118.9 µM 1.80E-4 RNA processing & uracil transport 61 3.09E-4
14 SGTC_2095 5432005 3.38 200.0 µM 2.10E-4 31 3.56E-4
15 SGTC_704 1310-0270 3.38 142.0 µM 2.15E-4 56 3.64E-4
16 SGTC_2421 5690543 3.37 90.7 µM 2.20E-4 36 3.72E-4
17 SGTC_2759 disulfiram 3.35 3.4 µM 2.37E-4 59 3.99E-4
18 SGTC_745 0469-0705 3.31 296.0 µM 2.86E-4 mitochondrial processes 39 4.75E-4
19 SGTC_1564 D-Arginine 3.29 115.0 µM 3.09E-4 53 5.10E-4
20 SGTC_558 k064-0027 3.27 21.3 µM 3.25E-4 DNA damage response 55 5.34E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 8.08E-13 YDL015C TSC13 het Enoyl reductase; catalyzes the last step in each cycle of very long chain fatty acid elongation; localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Fen1p and Sur4p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress
0.103 2.68E-9 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.100 5.85E-9 YFR018C_p YFR018C_p hom Putative protein of unknown function
0.094 4.61E-8 YJL031C BET4 het Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
0.094 4.54E-8 YKR013W PRY2 hom Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
0.094 4.81E-8 YBR236C ABD1 het Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA
0.092 8.75E-8 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene
0.092 9.95E-8 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.091 1.47E-7 YGL248W PDE1 hom Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation
0.085 8.78E-7 YGR028W MSP1 hom Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
0.082 2.17E-6 YDR365C ESF1 het Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
0.081 2.67E-6 YDR219C MFB1 hom Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
0.079 4.57E-6 YJL211C_d YJL211C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
0.078 5.42E-6 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.078 7.04E-6 YBR094W PBY1 hom Putative tubulin tyrosine ligase associated with P-bodies; forms cytoplasmic foci upon DNA replication stress