YLR354C / TAL1

Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR354C / TAL1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:-4.09|P-value:7.95E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.76|P-value:2.54E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.75|P-value:8.23E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:3.79|P-value:3.03E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.56|P-value:6.53E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.74|P-value:3.61E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.81|P-value:2.82E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.75|P-value:3.45E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.92|P-value:1.94E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.40|P-value:8.24E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:7.21|P-value:2.80E-11 ID:SGTC_1046|Compound:2001-0062|FD-Score:6.51|P-value:1.72E-9 ID:SGTC_1056|Compound:3448-1962|FD-Score:6.04|P-value:2.14E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.25|P-value:6.03E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.55|P-value:5.21E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.25|P-value:7.01E-9 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.94|P-value:3.57E-8 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.41|P-value:4.54E-7 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.45|P-value:3.91E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.21|P-value:7.03E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.01|P-value:1.44E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.64|P-value:5.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.67|P-value:3.46E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.95|P-value:1.33E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.42|P-value:9.93E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-4.41|P-value:2.35E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.71|P-value:3.99E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.64|P-value:3.83E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.52|P-value:7.32E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.66|P-value:4.78E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.42|P-value:7.85E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.69|P-value:3.25E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.34|P-value:4.19E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.75|P-value:3.53E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.90|P-value:3.10E-6 ID:SGTC_2967|Compound:9089538|FD-Score:-3.42|P-value:7.89E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:-4.09|P-value:7.95E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.76|P-value:2.54E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:4.75|P-value:8.23E-6 ID:SGTC_126|Compound:0417-1624|FD-Score:3.79|P-value:3.03E-4 ID:SGTC_231|Compound:b-estradiol|FD-Score:3.56|P-value:6.53E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.74|P-value:3.61E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.81|P-value:2.82E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.75|P-value:3.45E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:3.92|P-value:1.94E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:-3.40|P-value:8.24E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:7.21|P-value:2.80E-11 ID:SGTC_1046|Compound:2001-0062|FD-Score:6.51|P-value:1.72E-9 ID:SGTC_1056|Compound:3448-1962|FD-Score:6.04|P-value:2.14E-8 ID:SGTC_1057|Compound:3448-5381|FD-Score:4.25|P-value:6.03E-5 ID:SGTC_1138|Compound:3761-0006|FD-Score:-3.55|P-value:5.21E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.25|P-value:7.01E-9 ID:SGTC_1159|Compound:4092-0538|FD-Score:5.94|P-value:3.57E-8 ID:SGTC_1160|Compound:4092-0570|FD-Score:5.41|P-value:4.54E-7 ID:SGTC_1163|Compound:k060-0048|FD-Score:5.45|P-value:3.91E-7 ID:SGTC_1253|Compound:0550-0034|FD-Score:4.21|P-value:7.03E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:4.01|P-value:1.44E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.64|P-value:5.08E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.67|P-value:3.46E-4 ID:SGTC_2143|Compound:5623677|FD-Score:-3.95|P-value:1.33E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.42|P-value:9.93E-4 ID:SGTC_2309|Compound:7664088|FD-Score:-4.41|P-value:2.35E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.71|P-value:3.99E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-3.64|P-value:3.83E-4 ID:SGTC_2486|Compound:5283202|FD-Score:3.52|P-value:7.32E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.66|P-value:4.78E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.42|P-value:7.85E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.69|P-value:3.25E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.34|P-value:4.19E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.75|P-value:3.53E-4 ID:SGTC_2946|Compound:9065502|FD-Score:-4.90|P-value:3.10E-6 ID:SGTC_2967|Compound:9089538|FD-Score:-3.42|P-value:7.89E-4

Top fitness defect scores for YLR354C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_632 0781-2353 7.21 4.7 µM 2.80E-11 Golgi 6 2.77E-13
2 SGTC_1046 2001-0062 6.51 216.0 µM 1.72E-9 1 3.86E-11
3 SGTC_1144 3486-0183 6.25 12.5 µM 7.01E-9 6 2.08E-10
4 SGTC_1056 3448-1962 6.04 115.0 µM 2.14E-8 amide catabolism 4 7.92E-10
5 SGTC_1159 4092-0538 5.94 61.2 µM 3.57E-8 5 1.46E-9
6 SGTC_1163 k060-0048 5.45 49.9 µM 3.91E-7 7 2.58E-8
7 SGTC_1160 4092-0570 5.41 10.5 µM 4.54E-7 plasma membrane duress 18 3.09E-8
8 SGTC_122 0236-0016 4.75 402.4 µM 8.23E-6 RNA processing & uracil transport 20 9.95E-7
9 SGTC_2607 solasodine 4.34 47.4 µM 4.19E-5 47 6.99E-6
10 SGTC_1057 3448-5381 4.25 134.0 µM 6.03E-5 calcium & mitochondrial duress 21 1.08E-5
11 SGTC_1253 0550-0034 4.21 176.0 µM 7.03E-5 17 1.30E-5
12 SGTC_1256 0570-0116 4.01 285.0 µM 1.44E-4 17 3.07E-5
13 SGTC_596 1155-0152 3.92 116.0 µM 1.94E-4 TRP & mitochondrial translation 40 4.38E-5
14 SGTC_255 tunicamycin 3.81 200.5 nM 2.82E-4 unfolded protein response 81 6.83E-5
15 SGTC_126 0417-1624 3.79 672.5 µM 3.03E-4 DNA intercalators 39 7.46E-5
16 SGTC_538 2922-0838 3.75 53.3 µM 3.45E-4 Golgi 34 8.72E-5
17 SGTC_2857 9024691 3.75 58.4 µM 3.53E-4 28 8.96E-5
18 SGTC_248 streptozotocin 3.74 5.2 mM 3.61E-4 DNA damage response 27 9.19E-5
19 SGTC_2314 7727897 3.71 200.0 µM 3.99E-4 30 1.04E-4
20 SGTC_2582 agaric acid 3.66 100.0 µM 4.78E-4 redox potentiating 350 1.29E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.19E-18 YDR452W PPN1 hom Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress
0.148 6.75E-18 YDL048C STP4 hom Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p; predicted to be a transcription factor; relative distribution to the nucleus increases upon DNA replication stress
0.136 2.91E-15 YMR080C NAM7 hom ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance; forms cytoplasmic foci upon DNA replication stress
0.127 1.42E-13 YML091C RPM2 het Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
0.125 3.59E-13 YPL274W SAM3 hom High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
0.119 3.75E-12 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.108 4.18E-10 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.106 6.56E-10 YKL102C_d YKL102C_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
0.104 1.68E-9 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.102 3.65E-9 YDL043C PRP11 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.101 6.02E-9 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.099 8.51E-9 YEL040W UTR2 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck
0.099 9.83E-9 YPR177C_d YPR177C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex
0.097 1.77E-8 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.096 2.22E-8 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin