YLR356W / ATG33

Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR356W / ATG33

Click on Significant Values for Screen Details ID:SGTC_148|Compound:3253-0744|FD-Score:-3.27|P-value:3.59E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.86|P-value:3.31E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.48|P-value:1.60E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.02|P-value:8.93E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.70|P-value:6.31E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.08|P-value:7.26E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.72|P-value:6.08E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.09|P-value:7.00E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.60|P-value:1.02E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.05|P-value:1.38E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.28|P-value:3.58E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.01|P-value:9.49E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.05|P-value:7.84E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.71|P-value:6.26E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.37|P-value:2.38E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.55|P-value:1.23E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.28|P-value:3.52E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.85|P-value:2.49E-16 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.74|P-value:4.86E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.00|P-value:9.35E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.80|P-value:4.26E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.87|P-value:3.08E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.49|P-value:1.52E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.53|P-value:1.34E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.86|P-value:3.28E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.27|P-value:3.54E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.38|P-value:2.37E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.44|P-value:1.82E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-4.45|P-value:2.16E-6 ID:SGTC_2081|Compound:5214970|FD-Score:4.48|P-value:1.77E-6 ID:SGTC_2150|Compound:5556613|FD-Score:-3.04|P-value:8.36E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.29|P-value:3.41E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.54|P-value:1.30E-4 ID:SGTC_2253|Compound:7938677|FD-Score:6.18|P-value:8.04E-11 ID:SGTC_2319|Compound:6033012|FD-Score:-3.14|P-value:5.97E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.59|P-value:1.03E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.18|P-value:7.54E-6 ID:SGTC_2696|Compound:st077691|FD-Score:5.00|P-value:1.12E-7 ID:SGTC_2790|Compound:5423970|FD-Score:3.64|P-value:8.30E-5 ID:SGTC_2797|Compound:7859098|FD-Score:6.54|P-value:6.72E-12 ID:SGTC_2799|Compound:7812892|FD-Score:8.45|P-value:1.13E-18 ID:SGTC_2856|Compound:9022925|FD-Score:-3.12|P-value:6.33E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.33|P-value:3.64E-6 ID:SGTC_2969|Compound:9091408|FD-Score:5.60|P-value:3.48E-9 ID:SGTC_3141|Compound:9094609|FD-Score:5.00|P-value:1.17E-7 ID:SGTC_3143|Compound:9086658|FD-Score:3.55|P-value:1.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.08|P-value:7.22E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.43|P-value:1.92E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.27|P-value:3.59E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:-3.86|P-value:3.31E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:-3.48|P-value:1.60E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.02|P-value:8.93E-4 ID:SGTC_406|Compound:estrone|FD-Score:3.70|P-value:6.31E-5 ID:SGTC_422|Compound:cantharidin|FD-Score:3.08|P-value:7.26E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:-3.72|P-value:6.08E-5 ID:SGTC_424|Compound:splitomicin|FD-Score:3.09|P-value:7.00E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-3.60|P-value:1.02E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.05|P-value:1.38E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.28|P-value:3.58E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.01|P-value:9.49E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.05|P-value:7.84E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.71|P-value:6.26E-5 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.37|P-value:2.38E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:-3.55|P-value:1.23E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:-3.28|P-value:3.52E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-7.85|P-value:2.49E-16 ID:SGTC_1463|Compound:k081-0032|FD-Score:-4.74|P-value:4.86E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.00|P-value:9.35E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.80|P-value:4.26E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.87|P-value:3.08E-5 ID:SGTC_1588|Compound:farnesol|FD-Score:3.49|P-value:1.52E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:-3.53|P-value:1.34E-4 ID:SGTC_1733|Compound:st037357|FD-Score:-3.35|P-value:2.67E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.86|P-value:3.28E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.27|P-value:3.54E-4 ID:SGTC_1911|Compound:st060208|FD-Score:3.38|P-value:2.37E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.44|P-value:1.82E-4 ID:SGTC_1942|Compound:st076330|FD-Score:-4.45|P-value:2.16E-6 ID:SGTC_2081|Compound:5214970|FD-Score:4.48|P-value:1.77E-6 ID:SGTC_2150|Compound:5556613|FD-Score:-3.04|P-value:8.36E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.29|P-value:3.41E-4 ID:SGTC_2252|Compound:omeprazole|FD-Score:-3.54|P-value:1.30E-4 ID:SGTC_2253|Compound:7938677|FD-Score:6.18|P-value:8.04E-11 ID:SGTC_2319|Compound:6033012|FD-Score:-3.14|P-value:5.97E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.59|P-value:1.03E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.18|P-value:7.54E-6 ID:SGTC_2696|Compound:st077691|FD-Score:5.00|P-value:1.12E-7 ID:SGTC_2790|Compound:5423970|FD-Score:3.64|P-value:8.30E-5 ID:SGTC_2797|Compound:7859098|FD-Score:6.54|P-value:6.72E-12 ID:SGTC_2799|Compound:7812892|FD-Score:8.45|P-value:1.13E-18 ID:SGTC_2856|Compound:9022925|FD-Score:-3.12|P-value:6.33E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.33|P-value:3.64E-6 ID:SGTC_2969|Compound:9091408|FD-Score:5.60|P-value:3.48E-9 ID:SGTC_3141|Compound:9094609|FD-Score:5.00|P-value:1.17E-7 ID:SGTC_3143|Compound:9086658|FD-Score:3.55|P-value:1.17E-4 ID:SGTC_3304|Compound:9125678|FD-Score:3.08|P-value:7.22E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.43|P-value:1.92E-4

Top fitness defect scores for YLR356W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2799 7812892 8.45 81.8 µM 1.13E-18 superoxide 2 1.43E-17
2 SGTC_2797 7859098 6.54 81.8 µM 6.72E-12 3 3.14E-11
3 SGTC_2253 7938677 6.18 135.8 µM 8.04E-11 3 3.20E-10
4 SGTC_2969 9091408 5.60 28.7 µM 3.48E-9 5 1.09E-8
5 SGTC_2696 st077691 5.00 74.3 µM 1.12E-7 13 2.82E-7
6 SGTC_3141 9094609 5.00 49.5 µM 1.17E-7 iron homeostasis 19 2.92E-7
7 SGTC_2081 5214970 4.48 32.3 µM 1.77E-6 14 3.73E-6
8 SGTC_2952 9073731 4.33 13.8 µM 3.64E-6 tubulin folding & SWR complex 30 7.34E-6
9 SGTC_2450 5739737 4.18 12.9 µM 7.54E-6 21 1.45E-5
10 SGTC_710 3448-4187 4.05 58.0 µM 1.38E-5 fatty acid desaturase (OLE1) 57 2.56E-5
11 SGTC_1575 cyproterone acetate 3.87 48.0 µM 3.08E-5 23 5.43E-5
12 SGTC_1741 st038134 3.86 10.2 µM 3.28E-5 34 5.75E-5
13 SGTC_1569 carminic acid 3.80 40.6 µM 4.26E-5 18 7.35E-5
14 SGTC_1247 0448-0043 3.71 5.8 µM 6.26E-5 ERG2 58 1.06E-4
15 SGTC_406 estrone 3.70 100.0 µM 6.31E-5 13 1.06E-4
16 SGTC_2790 5423970 3.64 71.4 µM 8.30E-5 endomembrane recycling 82 1.37E-4
17 SGTC_2442 5158906 3.59 48.5 µM 1.03E-4 30 1.68E-4
18 SGTC_3143 9086658 3.55 49.5 µM 1.17E-4 70 1.90E-4
19 SGTC_1588 farnesol 3.49 29.9 µM 1.52E-4 19 2.42E-4
20 SGTC_1915 st067105 3.44 30.6 µM 1.82E-4 RNA pol III & RNase P/MRP 67 2.87E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.266 2.47E-55 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.249 1.23E-48 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.245 4.53E-47 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension
0.225 1.24E-39 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.224 3.25E-39 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.212 2.83E-35 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.205 8.08E-33 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.204 9.61E-33 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.204 1.13E-32 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.203 1.37E-32 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.201 6.33E-32 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.196 2.15E-30 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.195 7.64E-30 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.187 1.25E-27 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
0.186 1.41E-27 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies