YLR357W / RSC2

Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR357W / RSC2

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:5.34|P-value:4.82E-8 ID:SGTC_38|Compound:0929-0051|FD-Score:-4.30|P-value:6.97E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.64|P-value:6.57E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:4.31|P-value:8.73E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:4.74|P-value:1.13E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:3.16|P-value:8.42E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.12|P-value:9.47E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.49|P-value:2.54E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.03|P-value:2.52E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.18|P-value:7.67E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.13|P-value:1.91E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.92|P-value:3.69E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:3.43|P-value:3.19E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.19|P-value:1.48E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.44|P-value:3.05E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.39|P-value:8.36E-11 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.77|P-value:4.16E-9 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.17|P-value:1.62E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.25|P-value:6.14E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.11|P-value:8.11E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.97|P-value:3.84E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.83|P-value:6.86E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.54|P-value:2.94E-6 ID:SGTC_1672|Compound:st016598|FD-Score:3.79|P-value:7.82E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.21|P-value:9.83E-8 ID:SGTC_1938|Compound:st074717|FD-Score:3.98|P-value:3.65E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.86|P-value:5.92E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.21|P-value:6.97E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.01|P-value:3.21E-5 ID:SGTC_2154|Compound:5570129|FD-Score:4.35|P-value:7.07E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.13|P-value:1.94E-5 ID:SGTC_2278|Compound:7948257|FD-Score:-3.69|P-value:9.64E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.33|P-value:4.64E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-3.09|P-value:8.93E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.32|P-value:8.27E-6 ID:SGTC_2387|Compound:9077560|FD-Score:3.53|P-value:2.20E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.69|P-value:1.17E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.52|P-value:2.26E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.55|P-value:2.02E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.94|P-value:4.21E-5 ID:SGTC_2849|Compound:9019321|FD-Score:4.33|P-value:7.87E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.55|P-value:2.07E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.27|P-value:8.15E-6 ID:SGTC_3031|Compound:9088762|FD-Score:4.97|P-value:3.51E-7 ID:SGTC_37|Compound:0566-0070|FD-Score:5.34|P-value:4.82E-8 ID:SGTC_38|Compound:0929-0051|FD-Score:-4.30|P-value:6.97E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-5.64|P-value:6.57E-9 ID:SGTC_149|Compound:3970-0822|FD-Score:4.31|P-value:8.73E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:4.74|P-value:1.13E-6 ID:SGTC_212|Compound:3807-4682|FD-Score:3.16|P-value:8.42E-4 ID:SGTC_306|Compound:1672-3436|FD-Score:3.12|P-value:9.47E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.49|P-value:2.54E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.03|P-value:2.52E-7 ID:SGTC_574|Compound:1315-0397|FD-Score:3.18|P-value:7.67E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.13|P-value:1.91E-5 ID:SGTC_930|Compound:2810-3379|FD-Score:-3.92|P-value:3.69E-5 ID:SGTC_954|Compound:1189-0853|FD-Score:3.43|P-value:3.19E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:4.19|P-value:1.48E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.44|P-value:3.05E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.39|P-value:8.36E-11 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.77|P-value:4.16E-9 ID:SGTC_1142|Compound:3253-1408|FD-Score:4.17|P-value:1.62E-5 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.25|P-value:6.14E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.11|P-value:8.11E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.97|P-value:3.84E-5 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.83|P-value:6.86E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.00|P-value:3.40E-5 ID:SGTC_1627|Compound:st003713|FD-Score:4.54|P-value:2.94E-6 ID:SGTC_1672|Compound:st016598|FD-Score:3.79|P-value:7.82E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.21|P-value:9.83E-8 ID:SGTC_1938|Compound:st074717|FD-Score:3.98|P-value:3.65E-5 ID:SGTC_2085|Compound:5307070|FD-Score:3.86|P-value:5.92E-5 ID:SGTC_2120|Compound:5538279|FD-Score:3.21|P-value:6.97E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.01|P-value:3.21E-5 ID:SGTC_2154|Compound:5570129|FD-Score:4.35|P-value:7.07E-6 ID:SGTC_2266|Compound:7929956|FD-Score:4.13|P-value:1.94E-5 ID:SGTC_2278|Compound:7948257|FD-Score:-3.69|P-value:9.64E-5 ID:SGTC_2346|Compound:9031566|FD-Score:3.67|P-value:1.28E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.33|P-value:4.64E-4 ID:SGTC_2374|Compound:9071832|FD-Score:-3.09|P-value:8.93E-4 ID:SGTC_2378|Compound:9074213|FD-Score:4.32|P-value:8.27E-6 ID:SGTC_2387|Compound:9077560|FD-Score:3.53|P-value:2.20E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.69|P-value:1.17E-4 ID:SGTC_2702|Compound:st077768|FD-Score:3.52|P-value:2.26E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.55|P-value:2.02E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.41|P-value:2.79E-4 ID:SGTC_2827|Compound:7993847|FD-Score:3.94|P-value:4.21E-5 ID:SGTC_2849|Compound:9019321|FD-Score:4.33|P-value:7.87E-6 ID:SGTC_2927|Compound:9011802|FD-Score:3.55|P-value:2.07E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-4.27|P-value:8.15E-6 ID:SGTC_3031|Compound:9088762|FD-Score:4.97|P-value:3.51E-7

Top fitness defect scores for YLR357W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1130 3454-2858 6.39 15.9 µM 8.36E-11 NEO1 35 8.17E-11
2 SGTC_1133 3473-0247 5.77 50.0 µM 4.16E-9 RSC complex & mRNA processing 9 4.02E-9
3 SGTC_37 0566-0070 5.34 1.6 µM 4.82E-8 9 4.63E-8
4 SGTC_1844 rapamycin 5.21 4.0 nM 9.83E-8 109 9.43E-8
5 SGTC_351 caspofungin 5.03 25.0 nM 2.52E-7 cell wall 55 2.42E-7
6 SGTC_3031 9088762 4.97 49.5 µM 3.51E-7 5 3.36E-7
7 SGTC_168 3970-0862 4.74 530.5 µM 1.13E-6 80 1.08E-6
8 SGTC_1627 st003713 4.54 25.6 µM 2.94E-6 calcium & mitochondrial duress 53 2.80E-6
9 SGTC_2154 5570129 4.35 200.0 µM 7.07E-6 7 6.73E-6
10 SGTC_2849 9019321 4.33 13.0 µM 7.87E-6 23 7.49E-6
11 SGTC_2378 9074213 4.32 121.4 µM 8.27E-6 RSC complex & mRNA processing 10 7.87E-6
12 SGTC_149 3970-0822 4.31 46.1 µM 8.73E-6 tubulin folding & SWR complex 77 8.31E-6
13 SGTC_962 1254-0300 4.19 21.5 µM 1.48E-5 18 1.41E-5
14 SGTC_1142 3253-1408 4.17 9.8 µM 1.62E-5 4 1.54E-5
15 SGTC_710 3448-4187 4.13 58.0 µM 1.91E-5 fatty acid desaturase (OLE1) 55 1.81E-5
16 SGTC_2266 7929956 4.13 200.0 µM 1.94E-5 27 1.85E-5
17 SGTC_2145 5634607 4.01 200.0 µM 3.21E-5 5 3.05E-5
18 SGTC_1574 spiramycin 4.00 23.7 µM 3.40E-5 27 3.23E-5
19 SGTC_1938 st074717 3.98 56.4 µM 3.65E-5 11 3.47E-5
20 SGTC_1362 1611-0397 3.97 101.0 µM 3.84E-5 20 3.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.41E-17 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.138 1.02E-15 YNR006W VPS27 hom Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)
0.134 7.95E-15 YLR384C IKI3 hom Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
0.128 1.19E-13 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.119 4.32E-12 YGL060W YBP2 hom Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication
0.118 8.22E-12 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.113 5.60E-11 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.110 2.03E-10 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.108 3.13E-10 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
0.107 4.25E-10 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.107 4.81E-10 YMR032W HOF1 hom Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
0.106 8.49E-10 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.101 4.85E-9 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.101 5.03E-9 YGL211W NCS6 hom Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae
0.099 8.59E-9 YHR205W SCH9 hom AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan