YLR358C_p

Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR358C / YLR358C

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:4.26|P-value:1.03E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.16|P-value:7.17E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.80|P-value:6.94E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.35|P-value:3.79E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.68|P-value:1.10E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:5.98|P-value:1.51E-9 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.69|P-value:8.36E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.16|P-value:7.18E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.40|P-value:4.01E-8 ID:SGTC_377|Compound:3970-0964|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.30|P-value:4.37E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.49|P-value:2.22E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.72|P-value:9.64E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.98|P-value:3.62E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.50|P-value:5.18E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.45|P-value:2.62E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.33|P-value:4.06E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.07|P-value:9.57E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.41|P-value:5.24E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.49|P-value:3.69E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.50|P-value:5.18E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.94|P-value:4.29E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:-5.03|P-value:9.07E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:3.20|P-value:6.22E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.64|P-value:1.28E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.39|P-value:3.24E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.61|P-value:1.29E-8 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.34|P-value:3.90E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.33|P-value:4.04E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.06|P-value:2.38E-5 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.27|P-value:5.00E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.27|P-value:4.95E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.43|P-value:9.54E-11 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.46|P-value:4.22E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.49|P-value:5.25E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.15|P-value:7.36E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.05|P-value:2.58E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.96|P-value:3.68E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.18|P-value:6.59E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.88|P-value:5.02E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.53|P-value:1.91E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.49|P-value:2.55E-8 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.37|P-value:6.36E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.47|P-value:1.18E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.54|P-value:2.90E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.56|P-value:4.21E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.41|P-value:5.31E-6 ID:SGTC_2193|Compound:5925765|FD-Score:5.05|P-value:2.53E-7 ID:SGTC_2195|Compound:6536160|FD-Score:3.28|P-value:4.68E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.14|P-value:7.54E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.35|P-value:1.62E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.48|P-value:1.15E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.07|P-value:9.78E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.24|P-value:5.52E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.33|P-value:7.79E-6 ID:SGTC_2952|Compound:9073731|FD-Score:4.03|P-value:2.80E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.54|P-value:2.96E-6 ID:SGTC_3013|Compound:9080133|FD-Score:3.21|P-value:5.96E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.28|P-value:2.61E-5 ID:SGTC_3120|Compound:9124077|FD-Score:3.97|P-value:3.48E-5 ID:SGTC_3159|Compound:9100096|FD-Score:5.88|P-value:2.71E-9 ID:SGTC_3209|Compound:9113616|FD-Score:3.63|P-value:1.32E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:4.26|P-value:1.03E-5 ID:SGTC_29|Compound:0299-0004|FD-Score:3.19|P-value:6.38E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.16|P-value:7.17E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.80|P-value:6.94E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:3.35|P-value:3.79E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.68|P-value:1.10E-4 ID:SGTC_203|Compound:k066-0004|FD-Score:5.98|P-value:1.51E-9 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:5.69|P-value:8.36E-9 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.16|P-value:7.18E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.40|P-value:4.01E-8 ID:SGTC_377|Compound:3970-0964|FD-Score:3.51|P-value:2.10E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.30|P-value:4.37E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.49|P-value:2.22E-4 ID:SGTC_493|Compound:zm226600|FD-Score:3.72|P-value:9.64E-5 ID:SGTC_537|Compound:1334-0398|FD-Score:3.70|P-value:1.03E-4 ID:SGTC_556|Compound:4058-0063|FD-Score:4.98|P-value:3.62E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.50|P-value:5.18E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.45|P-value:2.62E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.33|P-value:4.06E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.07|P-value:9.57E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.41|P-value:5.24E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:4.49|P-value:3.69E-6 ID:SGTC_845|Compound:0330-0138|FD-Score:-3.50|P-value:5.18E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.94|P-value:4.29E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:-5.03|P-value:9.07E-7 ID:SGTC_960|Compound:1222-0186|FD-Score:3.20|P-value:6.22E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.64|P-value:1.28E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.39|P-value:3.24E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:5.61|P-value:1.29E-8 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.34|P-value:3.90E-4 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.33|P-value:4.04E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.06|P-value:2.38E-5 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.65|P-value:1.23E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:3.27|P-value:5.00E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.27|P-value:4.95E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:6.43|P-value:9.54E-11 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.46|P-value:4.22E-6 ID:SGTC_1217|Compound:1183-1422|FD-Score:-3.49|P-value:5.25E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.59|P-value:1.57E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.15|P-value:7.36E-4 ID:SGTC_1306|Compound:1185-0270|FD-Score:5.05|P-value:2.58E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.96|P-value:3.68E-5 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.18|P-value:6.59E-4 ID:SGTC_1417|Compound:3966-0327|FD-Score:3.88|P-value:5.02E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.53|P-value:1.91E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.42|P-value:2.93E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:5.49|P-value:2.55E-8 ID:SGTC_1645|Compound:Cervolide|FD-Score:4.37|P-value:6.36E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-4.47|P-value:1.18E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.56|P-value:1.74E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.54|P-value:2.90E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-3.56|P-value:4.21E-4 ID:SGTC_1944|Compound:st076371|FD-Score:4.41|P-value:5.31E-6 ID:SGTC_2193|Compound:5925765|FD-Score:5.05|P-value:2.53E-7 ID:SGTC_2195|Compound:6536160|FD-Score:3.28|P-value:4.68E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.14|P-value:7.54E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.35|P-value:1.62E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.48|P-value:1.15E-5 ID:SGTC_2455|Compound:5377712|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.07|P-value:9.78E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.24|P-value:5.52E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.33|P-value:7.79E-6 ID:SGTC_2952|Compound:9073731|FD-Score:4.03|P-value:2.80E-5 ID:SGTC_3000|Compound:9075062|FD-Score:4.54|P-value:2.96E-6 ID:SGTC_3013|Compound:9080133|FD-Score:3.21|P-value:5.96E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-4.28|P-value:2.61E-5 ID:SGTC_3120|Compound:9124077|FD-Score:3.97|P-value:3.48E-5 ID:SGTC_3159|Compound:9100096|FD-Score:5.88|P-value:2.71E-9 ID:SGTC_3209|Compound:9113616|FD-Score:3.63|P-value:1.32E-4

Top fitness defect scores for YLR358C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1144 3486-0183 6.43 12.5 µM 9.54E-11 3 6.24E-11
2 SGTC_2405 ticlatone 6.35 3.5 µM 1.62E-10 27 1.08E-10
3 SGTC_203 k066-0004 5.98 30.9 µM 1.51E-9 RSC & ERG11 2 1.10E-9
4 SGTC_3159 9100096 5.88 49.5 µM 2.71E-9 3 2.02E-9
5 SGTC_241 5hr heat shock (37°C) + cantharidin 5.69 155.4 µM 8.36E-9 cell wall signaling 36 6.49E-9
6 SGTC_1009 4106-0057 5.61 9.9 µM 1.29E-8 2 1.02E-8
7 SGTC_1529 apigenin 5.49 74.0 µM 2.55E-8 9 2.06E-8
8 SGTC_351 caspofungin 5.40 25.0 nM 4.01E-8 cell wall 48 3.29E-8
9 SGTC_2193 5925765 5.05 200.0 µM 2.53E-7 4 2.21E-7
10 SGTC_1306 1185-0270 5.05 9.0 µM 2.58E-7 Golgi 38 2.26E-7
11 SGTC_556 4058-0063 4.98 51.5 µM 3.62E-7 14 3.21E-7
12 SGTC_939 1165-0479 4.94 45.3 µM 4.29E-7 11 3.82E-7
13 SGTC_1873 rapamycin 4.54 2.0 nM 2.90E-6 57 2.75E-6
14 SGTC_3000 9075062 4.54 71.4 µM 2.96E-6 8 2.81E-6
15 SGTC_831 k061-1017 4.49 217.0 µM 3.69E-6 translation 37 3.52E-6
16 SGTC_1153 4055-0057 4.46 267.0 µM 4.22E-6 14 4.05E-6
17 SGTC_723 4182-0001 4.41 115.0 µM 5.24E-6 21 5.06E-6
18 SGTC_1944 st076371 4.41 56.9 µM 5.31E-6 14 5.13E-6
19 SGTC_1645 Cervolide 4.37 78.0 µM 6.36E-6 2 6.18E-6
20 SGTC_2943 9068529 4.33 45.3 µM 7.79E-6 11 7.61E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.01E-19 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.140 4.16E-16 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.134 6.61E-15 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.104 1.86E-9 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.103 2.47E-9 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.102 3.77E-9 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.100 6.28E-9 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.100 6.60E-9 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.098 1.13E-8 YGR163W GTR2 hom Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
0.094 4.69E-8 YPL051W ARL3 hom GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor
0.094 5.65E-8 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.093 6.63E-8 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.091 1.22E-7 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.088 3.04E-7 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.088 3.28E-7 YBR164C ARL1 hom Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor