YLR361C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR361C-A / YLR361C-A

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:3.03|P-value:3.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:2.82|P-value:8.21E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.19|P-value:1.18E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.99|P-value:8.78E-20 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.00|P-value:4.00E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:4.05|P-value:2.77E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:3.52|P-value:4.01E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:2.83|P-value:7.99E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.66|P-value:2.05E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:4.09|P-value:2.15E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:3.63|P-value:2.29E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.32|P-value:1.02E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.34|P-value:9.16E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:2.80|P-value:8.76E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.24|P-value:1.45E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.14|P-value:2.20E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.99|P-value:4.18E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.27|P-value:8.03E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.71|P-value:1.54E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.14|P-value:1.66E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:6.45|P-value:1.76E-13 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.05|P-value:3.20E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.32|P-value:6.52E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.39|P-value:4.64E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-2.83|P-value:5.31E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.90|P-value:6.04E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.12|P-value:2.36E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.44|P-value:1.64E-7 ID:SGTC_1850|Compound:st056238|FD-Score:-3.66|P-value:1.27E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.79|P-value:1.03E-5 ID:SGTC_1898|Compound:st060199|FD-Score:4.49|P-value:2.22E-7 ID:SGTC_1904|Compound:st060225|FD-Score:-2.97|P-value:3.02E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.77|P-value:1.15E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-2.99|P-value:2.79E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.16|P-value:2.01E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.05|P-value:3.17E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.94|P-value:3.34E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-2.73|P-value:7.96E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.63|P-value:9.31E-8 ID:SGTC_2377|Compound:9073351|FD-Score:-2.69|P-value:9.09E-4 ID:SGTC_2394|Compound:5221648|FD-Score:2.82|P-value:8.18E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.60|P-value:2.69E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.23|P-value:1.02E-6 ID:SGTC_2426|Compound:5582046|FD-Score:5.93|P-value:1.14E-11 ID:SGTC_2427|Compound:5545055|FD-Score:3.76|P-value:1.25E-5 ID:SGTC_2430|Compound:5571206|FD-Score:5.55|P-value:2.07E-10 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.18|P-value:1.89E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.25|P-value:1.38E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:2.89|P-value:6.20E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.06|P-value:6.27E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.78|P-value:9.67E-4 ID:SGTC_3270|Compound:9137563|FD-Score:2.83|P-value:7.80E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.46|P-value:3.29E-5 ID:SGTC_3305|Compound:9127027|FD-Score:2.89|P-value:6.29E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:3.03|P-value:3.51E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:2.82|P-value:8.21E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.28|P-value:1.19E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.19|P-value:1.18E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.99|P-value:8.78E-20 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.00|P-value:4.00E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:4.05|P-value:2.77E-6 ID:SGTC_307|Compound:1501-1223|FD-Score:3.52|P-value:4.01E-5 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.11|P-value:2.52E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:2.83|P-value:7.99E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.66|P-value:2.05E-5 ID:SGTC_623|Compound:k072-0108|FD-Score:4.09|P-value:2.15E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:3.63|P-value:2.29E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.32|P-value:1.02E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.34|P-value:9.16E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:2.80|P-value:8.76E-4 ID:SGTC_932|Compound:2857-0803|FD-Score:3.24|P-value:1.45E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.14|P-value:2.20E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:2.99|P-value:4.18E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.27|P-value:8.03E-5 ID:SGTC_1184|Compound:1269-1718|FD-Score:3.71|P-value:1.54E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.14|P-value:1.66E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:6.45|P-value:1.76E-13 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.05|P-value:3.20E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.32|P-value:6.52E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.39|P-value:4.64E-5 ID:SGTC_1513|Compound:0337-0559|FD-Score:-2.83|P-value:5.31E-4 ID:SGTC_1716|Compound:st033144|FD-Score:2.90|P-value:6.04E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.12|P-value:2.36E-4 ID:SGTC_1722|Compound:st034304|FD-Score:-4.44|P-value:1.64E-7 ID:SGTC_1850|Compound:st056238|FD-Score:-3.66|P-value:1.27E-5 ID:SGTC_1851|Compound:st056236|FD-Score:3.79|P-value:1.03E-5 ID:SGTC_1898|Compound:st060199|FD-Score:4.49|P-value:2.22E-7 ID:SGTC_1904|Compound:st060225|FD-Score:-2.97|P-value:3.02E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.77|P-value:1.15E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-2.99|P-value:2.79E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.16|P-value:2.01E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.05|P-value:3.17E-4 ID:SGTC_2293|Compound:7624732|FD-Score:-2.94|P-value:3.34E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-2.73|P-value:7.96E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.63|P-value:9.31E-8 ID:SGTC_2377|Compound:9073351|FD-Score:-2.69|P-value:9.09E-4 ID:SGTC_2394|Compound:5221648|FD-Score:2.82|P-value:8.18E-4 ID:SGTC_2398|Compound:5228213|FD-Score:3.60|P-value:2.69E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.23|P-value:1.02E-6 ID:SGTC_2426|Compound:5582046|FD-Score:5.93|P-value:1.14E-11 ID:SGTC_2427|Compound:5545055|FD-Score:3.76|P-value:1.25E-5 ID:SGTC_2430|Compound:5571206|FD-Score:5.55|P-value:2.07E-10 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.18|P-value:1.89E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:3.25|P-value:1.38E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:2.89|P-value:6.20E-4 ID:SGTC_2713|Compound:st079149|FD-Score:5.06|P-value:6.27E-9 ID:SGTC_2959|Compound:9079155|FD-Score:3.00|P-value:4.05E-4 ID:SGTC_3065|Compound:9113888|FD-Score:2.78|P-value:9.67E-4 ID:SGTC_3270|Compound:9137563|FD-Score:2.83|P-value:7.80E-4 ID:SGTC_3290|Compound:9121031|FD-Score:-3.46|P-value:3.29E-5 ID:SGTC_3305|Compound:9127027|FD-Score:2.89|P-value:6.29E-4

Top fitness defect scores for YLR361C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 7.99 5.3 µM 8.78E-20 251 6.75E-16
2 SGTC_1276 0871-0068 6.45 94.2 µM 1.76E-13 3 5.72E-11
3 SGTC_2426 5582046 5.93 32.2 µM 1.14E-11 5 1.50E-9
4 SGTC_2430 5571206 5.55 200.0 µM 2.07E-10 28 1.47E-8
5 SGTC_2713 st079149 5.06 53.4 µM 6.27E-9 9 2.14E-7
6 SGTC_2309 7664088 4.63 163.9 µM 9.31E-8 14 1.79E-6
7 SGTC_1898 st060199 4.49 18.6 µM 2.22E-7 6 3.56E-6
8 SGTC_2408 sulbentine 4.23 18.4 µM 1.02E-6 41 1.19E-5
9 SGTC_1212 0520-0165 4.14 585.0 µM 1.66E-6 22 1.74E-5
10 SGTC_623 k072-0108 4.09 16.9 µM 2.15E-6 heme biosynthesis & mitochondrial translocase 15 2.14E-5
11 SGTC_280 3448-3607 4.05 3.0 µM 2.77E-6 60S ribosome export 7 2.61E-5
12 SGTC_1851 st056236 3.79 18.9 µM 1.03E-5 18 7.40E-5
13 SGTC_1950 st077106 3.77 7.2 µM 1.15E-5 RNA processing & uracil transport 35 8.06E-5
14 SGTC_2427 5545055 3.76 42.8 µM 1.25E-5 18 8.61E-5
15 SGTC_1184 1269-1718 3.71 139.0 µM 1.54E-5 37 1.02E-4
16 SGTC_611 3453-1652 3.66 23.7 µM 2.05E-5 31 1.28E-4
17 SGTC_740 k014-0057 3.63 261.0 µM 2.29E-5 36 1.39E-4
18 SGTC_2398 5228213 3.60 48.8 µM 2.69E-5 iron homeostasis 50 1.58E-4
19 SGTC_307 1501-1223 3.52 22.3 µM 4.01E-5 19 2.17E-4
20 SGTC_810 3825-7150 3.34 143.0 µM 9.16E-5 60S ribosome export 21 4.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.260 9.76E-53 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.244 1.07E-46 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.239 6.75E-45 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.235 2.09E-43 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.230 1.74E-41 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.228 1.02E-40 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.220 4.80E-38 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.220 6.62E-38 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.215 1.67E-36 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.213 7.92E-36 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.209 2.50E-34 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.207 1.14E-33 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.206 1.87E-33 YDL069C CBS1 hom Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.204 6.03E-33 YJR077C MIR1 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
0.204 1.11E-32 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex