YLR366W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR366W / YLR366W

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:5.69|P-value:9.23E-9 ID:SGTC_251|Compound:melphalan|FD-Score:3.26|P-value:6.13E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.10|P-value:2.87E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:5.07|P-value:2.64E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.40|P-value:4.30E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.19|P-value:7.79E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.24|P-value:6.59E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.20|P-value:7.46E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.59|P-value:1.92E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.15|P-value:8.87E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.54|P-value:2.31E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.18|P-value:9.31E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.22|P-value:7.14E-4 ID:SGTC_1709|Compound:st033179|FD-Score:5.29|P-value:8.60E-8 ID:SGTC_1786|Compound:berberine|FD-Score:-3.53|P-value:2.69E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.15|P-value:9.00E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.54|P-value:2.27E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.14|P-value:9.19E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.30|P-value:5.47E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.17|P-value:8.27E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.44|P-value:3.75E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.35|P-value:4.59E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.55|P-value:2.17E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-3.37|P-value:4.78E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.20|P-value:7.50E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.60|P-value:1.82E-4 ID:SGTC_2904|Compound:7225135|FD-Score:5.14|P-value:1.83E-7 ID:SGTC_2967|Compound:9089538|FD-Score:-3.28|P-value:6.54E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.47|P-value:3.40E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.76|P-value:1.52E-6 ID:SGTC_3258|Compound:9138477|FD-Score:3.30|P-value:5.34E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:5.69|P-value:9.23E-9 ID:SGTC_251|Compound:melphalan|FD-Score:3.26|P-value:6.13E-4 ID:SGTC_348|Compound:k064-0012|FD-Score:-4.10|P-value:2.87E-5 ID:SGTC_382|Compound:3229-0966|FD-Score:5.07|P-value:2.64E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.40|P-value:4.30E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.68|P-value:1.35E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.19|P-value:7.79E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.24|P-value:6.59E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.52|P-value:2.48E-4 ID:SGTC_901|Compound:1112-0062|FD-Score:3.20|P-value:7.46E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.59|P-value:1.92E-4 ID:SGTC_1323|Compound:1348-1351|FD-Score:3.15|P-value:8.87E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:3.54|P-value:2.31E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.66|P-value:1.46E-4 ID:SGTC_1650|Compound:st011916|FD-Score:-3.18|P-value:9.31E-4 ID:SGTC_1696|Compound:st025591|FD-Score:3.22|P-value:7.14E-4 ID:SGTC_1709|Compound:st033179|FD-Score:5.29|P-value:8.60E-8 ID:SGTC_1786|Compound:berberine|FD-Score:-3.53|P-value:2.69E-4 ID:SGTC_1937|Compound:st074714|FD-Score:3.15|P-value:9.00E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.54|P-value:2.27E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.14|P-value:9.19E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.30|P-value:5.47E-4 ID:SGTC_2202|Compound:7226349|FD-Score:3.17|P-value:8.27E-4 ID:SGTC_2327|Compound:6189656|FD-Score:-3.44|P-value:3.75E-4 ID:SGTC_2352|Compound:9027995|FD-Score:3.35|P-value:4.59E-4 ID:SGTC_2432|Compound:5630864|FD-Score:3.55|P-value:2.17E-4 ID:SGTC_2678|Compound:equilin|FD-Score:-3.37|P-value:4.78E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.20|P-value:7.50E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.60|P-value:1.82E-4 ID:SGTC_2904|Compound:7225135|FD-Score:5.14|P-value:1.83E-7 ID:SGTC_2967|Compound:9089538|FD-Score:-3.28|P-value:6.54E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.40|P-value:3.84E-4 ID:SGTC_3117|Compound:9124945|FD-Score:-3.47|P-value:3.40E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-4.76|P-value:1.52E-6 ID:SGTC_3258|Compound:9138477|FD-Score:3.30|P-value:5.34E-4

Top fitness defect scores for YLR366W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_6 0844-0013 5.69 19.8 µM 9.23E-9 19 6.28E-9
2 SGTC_1709 st033179 5.29 39.1 µM 8.60E-8 2 6.21E-8
3 SGTC_2904 7225135 5.14 42.0 µM 1.83E-7 3 1.35E-7
4 SGTC_382 3229-0966 5.07 23.2 µM 2.64E-7 3 1.96E-7
5 SGTC_536 3852-0578 3.68 10.6 µM 1.35E-4 35 1.17E-4
6 SGTC_1642 st009582 3.66 77.7 µM 1.46E-4 RPP1 & pyrimidine depletion 22 1.27E-4
7 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 3.60 39.7 µM 1.82E-4 5 1.60E-4
8 SGTC_1006 4099-6547 3.59 255.0 µM 1.92E-4 34 1.68E-4
9 SGTC_2432 5630864 3.55 12.2 µM 2.17E-4 39 1.91E-4
10 SGTC_2020 4017018 3.54 200.0 µM 2.27E-4 33 2.00E-4
11 SGTC_1416 3966-0321 3.54 25.3 µM 2.31E-4 32 2.04E-4
12 SGTC_897 1000-0139 3.52 31.4 µM 2.48E-4 34 2.19E-4
13 SGTC_3013 9080133 3.40 71.4 µM 3.84E-4 45 3.43E-4
14 SGTC_2352 9027995 3.35 87.8 µM 4.59E-4 tubulin folding & SWR complex 47 4.11E-4
15 SGTC_3258 9138477 3.30 49.5 µM 5.34E-4 15 4.80E-4
16 SGTC_2150 5556613 3.30 200.0 µM 5.47E-4 36 4.92E-4
17 SGTC_251 melphalan 3.26 456.5 µM 6.13E-4 DNA damage response 54 5.52E-4
18 SGTC_760 0568-0725 3.24 82.9 µM 6.59E-4 30 5.95E-4
19 SGTC_1696 st025591 3.22 34.8 µM 7.14E-4 SWF1 & branched chain AA biosynthesis 52 6.46E-4
20 SGTC_901 1112-0062 3.20 60.1 µM 7.46E-4 26 6.76E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.164 1.45E-21 YNL176C_p TDA7_p hom Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele
0.126 2.39E-13 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.121 2.44E-12 YML003W_p YML003W_p hom Putative protein of unknown function
0.119 4.40E-12 YEL023C_p YEL023C_p hom Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene
0.115 2.34E-11 YLR345W_p YLR345W_p hom Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene
0.110 1.83E-10 YLR316C TAD3 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
0.108 4.18E-10 YKL161C KDX1 hom Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p
0.102 3.39E-9 YGR237C_p YGR237C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.099 8.85E-9 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.099 9.93E-9 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.098 1.52E-8 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.097 2.04E-8 YNL039W BDP1 het Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs
0.096 2.74E-8 YDR085C AFR1 hom Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication
0.094 5.69E-8 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
0.093 6.98E-8 YPL228W CET1 het Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide