YLR369W / SSQ1

Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR369W / SSQ1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.96|P-value:3.69E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.11|P-value:9.20E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.18|P-value:1.12E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:5.60|P-value:1.11E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:5.49|P-value:2.04E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:10.80|P-value:3.84E-27 ID:SGTC_94|Compound:0334-0113|FD-Score:-4.35|P-value:7.72E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.50|P-value:2.29E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.79|P-value:6.10E-12 ID:SGTC_156|Compound:3474-0145|FD-Score:11.80|P-value:4.12E-32 ID:SGTC_158|Compound:k038-0087|FD-Score:3.20|P-value:6.83E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.95|P-value:3.81E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:3.12|P-value:8.83E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.00|P-value:3.21E-33 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:1.43E-27 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.40|P-value:1.72E-30 ID:SGTC_310|Compound:1273-0058|FD-Score:8.40|P-value:2.59E-17 ID:SGTC_314|Compound:1671-0008|FD-Score:3.79|P-value:7.43E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.26|P-value:1.00E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.41|P-value:3.91E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.54|P-value:3.23E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:4.21|P-value:1.30E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.88|P-value:2.63E-9 ID:SGTC_444|Compound:curcumin|FD-Score:-3.80|P-value:8.23E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.12|P-value:8.95E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.75|P-value:8.79E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.08|P-value:2.53E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.56|P-value:2.10E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.88|P-value:5.25E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.50|P-value:3.48E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:3.60|P-value:1.55E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.70|P-value:1.21E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.17|P-value:7.53E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.49|P-value:3.51E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.42|P-value:3.41E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.09|P-value:9.97E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.56|P-value:1.38E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_1521|Compound:st012942|FD-Score:6.12|P-value:5.02E-10 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.00|P-value:3.16E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.84|P-value:7.04E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-3.77|P-value:9.13E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.27|P-value:5.85E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.02|P-value:2.90E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.68|P-value:1.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.98|P-value:1.54E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.70|P-value:6.29E-9 ID:SGTC_1814|Compound:st052110|FD-Score:-3.44|P-value:3.17E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.59|P-value:1.85E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.28|P-value:5.64E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.39|P-value:3.82E-4 ID:SGTC_1834|Compound:st055981|FD-Score:8.05|P-value:4.67E-16 ID:SGTC_1835|Compound:st008666|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.92|P-value:4.48E-5 ID:SGTC_1840|Compound:st055363|FD-Score:4.53|P-value:3.01E-6 ID:SGTC_1842|Compound:st055362|FD-Score:-3.68|P-value:1.33E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.23|P-value:6.22E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.06|P-value:2.47E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.94|P-value:4.00E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:7.52E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.52|P-value:2.12E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.13|P-value:8.55E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.48|P-value:2.45E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.45|P-value:2.81E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.83|P-value:6.79E-7 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.79|P-value:5.86E-12 ID:SGTC_2513|Compound:baicalein|FD-Score:8.83|P-value:6.06E-19 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:5.31|P-value:5.56E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.27|P-value:5.84E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.24|P-value:1.11E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.67|P-value:1.20E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.60|P-value:2.16E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:3.96|P-value:3.74E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-3.94|P-value:4.52E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.15|P-value:8.98E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.93|P-value:4.17E-5 ID:SGTC_2711|Compound:st079103|FD-Score:4.93|P-value:4.21E-7 ID:SGTC_2717|Compound:st081029|FD-Score:5.72|P-value:5.58E-9 ID:SGTC_2835|Compound:9006588|FD-Score:3.48|P-value:2.44E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.09|P-value:9.79E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.93|P-value:4.23E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.84|P-value:6.16E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.96|P-value:3.69E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:3.11|P-value:9.20E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.18|P-value:1.12E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:5.60|P-value:1.11E-8 ID:SGTC_81|Compound:0411-0046|FD-Score:5.49|P-value:2.04E-8 ID:SGTC_86|Compound:0417-1630|FD-Score:10.80|P-value:3.84E-27 ID:SGTC_94|Compound:0334-0113|FD-Score:-4.35|P-value:7.72E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:3.50|P-value:2.29E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:6.79|P-value:6.10E-12 ID:SGTC_156|Compound:3474-0145|FD-Score:11.80|P-value:4.12E-32 ID:SGTC_158|Compound:k038-0087|FD-Score:3.20|P-value:6.83E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.95|P-value:3.81E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:3.12|P-value:8.83E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.00|P-value:3.21E-33 ID:SGTC_236|Compound:1509-0011|FD-Score:10.80|P-value:1.43E-27 ID:SGTC_275|Compound:trichlorophene|FD-Score:11.40|P-value:1.72E-30 ID:SGTC_310|Compound:1273-0058|FD-Score:8.40|P-value:2.59E-17 ID:SGTC_314|Compound:1671-0008|FD-Score:3.79|P-value:7.43E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:4.26|P-value:1.00E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.41|P-value:3.91E-8 ID:SGTC_374|Compound:0880-0231|FD-Score:-4.54|P-value:3.23E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:4.21|P-value:1.30E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.88|P-value:2.63E-9 ID:SGTC_444|Compound:curcumin|FD-Score:-3.80|P-value:8.23E-5 ID:SGTC_446|Compound:go6976|FD-Score:3.12|P-value:8.95E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.75|P-value:8.79E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.08|P-value:2.53E-5 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.56|P-value:2.10E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.13|P-value:8.70E-4 ID:SGTC_611|Compound:3453-1652|FD-Score:3.88|P-value:5.25E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.50|P-value:3.48E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:3.60|P-value:1.55E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:-3.70|P-value:1.21E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.17|P-value:7.53E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.49|P-value:3.51E-6 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-3.42|P-value:3.41E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.09|P-value:9.97E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:5.56|P-value:1.38E-8 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.39|P-value:3.41E-4 ID:SGTC_1521|Compound:st012942|FD-Score:6.12|P-value:5.02E-10 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.00|P-value:3.16E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.84|P-value:7.04E-5 ID:SGTC_1594|Compound:piperine|FD-Score:-3.77|P-value:9.13E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:-3.27|P-value:5.85E-4 ID:SGTC_1622|Compound:st003707|FD-Score:4.02|P-value:2.90E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.68|P-value:1.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.98|P-value:1.54E-12 ID:SGTC_1724|Compound:st037281|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.70|P-value:6.29E-9 ID:SGTC_1814|Compound:st052110|FD-Score:-3.44|P-value:3.17E-4 ID:SGTC_1815|Compound:st051655|FD-Score:-3.59|P-value:1.85E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.28|P-value:5.64E-4 ID:SGTC_1826|Compound:st055655|FD-Score:-3.39|P-value:3.82E-4 ID:SGTC_1834|Compound:st055981|FD-Score:8.05|P-value:4.67E-16 ID:SGTC_1835|Compound:st008666|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_1839|Compound:st053978|FD-Score:3.92|P-value:4.48E-5 ID:SGTC_1840|Compound:st055363|FD-Score:4.53|P-value:3.01E-6 ID:SGTC_1842|Compound:st055362|FD-Score:-3.68|P-value:1.33E-4 ID:SGTC_2077|Compound:5212015|FD-Score:3.23|P-value:6.22E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.06|P-value:2.47E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.94|P-value:4.00E-5 ID:SGTC_2375|Compound:9072683|FD-Score:3.17|P-value:7.52E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.52|P-value:2.12E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.13|P-value:8.55E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.48|P-value:2.45E-4 ID:SGTC_2488|Compound:5268135|FD-Score:3.45|P-value:2.81E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:4.83|P-value:6.79E-7 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:6.79|P-value:5.86E-12 ID:SGTC_2513|Compound:baicalein|FD-Score:8.83|P-value:6.06E-19 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:5.31|P-value:5.56E-8 ID:SGTC_2586|Compound:curcumin|FD-Score:-3.27|P-value:5.84E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.24|P-value:1.11E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.67|P-value:1.20E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.60|P-value:2.16E-6 ID:SGTC_2686|Compound:alizarin|FD-Score:3.96|P-value:3.74E-5 ID:SGTC_2698|Compound:st077697|FD-Score:-3.94|P-value:4.52E-5 ID:SGTC_2699|Compound:st077704|FD-Score:-3.15|P-value:8.98E-4 ID:SGTC_2708|Compound:st078559|FD-Score:3.93|P-value:4.17E-5 ID:SGTC_2711|Compound:st079103|FD-Score:4.93|P-value:4.21E-7 ID:SGTC_2717|Compound:st081029|FD-Score:5.72|P-value:5.58E-9 ID:SGTC_2835|Compound:9006588|FD-Score:3.48|P-value:2.44E-4 ID:SGTC_2910|Compound:7948405|FD-Score:3.09|P-value:9.79E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.93|P-value:4.23E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.84|P-value:6.16E-5

Top fitness defect scores for YLR369W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_173 1273-0061 12.00 2.7 µM 3.21E-33 mitochondrial stress 26 2.27E-33
2 SGTC_156 3474-0145 11.80 5.6 µM 4.12E-32 endomembrane recycling 5 2.96E-32
3 SGTC_275 trichlorophene 11.40 5.7 µM 1.72E-30 mitochondrial stress 29 1.26E-30
4 SGTC_236 1509-0011 10.80 5.3 µM 1.43E-27 174 1.10E-27
5 SGTC_86 0417-1630 10.80 471.9 µM 3.84E-27 ubiquinone biosynthesis & proteasome 33 2.95E-27
6 SGTC_2513 baicalein 8.83 25.6 µM 6.06E-19 calcium & mitochondrial duress 3 5.19E-19
7 SGTC_310 1273-0058 8.40 1.1 µM 2.59E-17 mitochondrial stress 77 2.26E-17
8 SGTC_1834 st055981 8.05 52.8 µM 4.67E-16 RPP1 & pyrimidine depletion 2 4.15E-16
9 SGTC_1635 st007035 6.98 42.4 µM 1.54E-12 115 1.43E-12
10 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 6.79 54.6 µM 5.86E-12 RPP1 & pyrimidine depletion 3 5.47E-12
11 SGTC_149 3970-0822 6.79 46.1 µM 6.10E-12 tubulin folding & SWR complex 24 5.70E-12
12 SGTC_1521 st012942 6.12 49.4 µM 5.02E-10 7 4.80E-10
13 SGTC_2717 st081029 5.72 62.3 µM 5.58E-9 2 5.38E-9
14 SGTC_1742 st038235 5.70 28.9 µM 6.29E-9 mitochondrial stress 54 6.07E-9
15 SGTC_70 0141-0289 5.60 43.3 µM 1.11E-8 mitochondrial stress 95 1.08E-8
16 SGTC_1369 1866-0067 5.56 208.0 µM 1.38E-8 RPP1 & pyrimidine depletion 13 1.34E-8
17 SGTC_81 0411-0046 5.49 10.0 µM 2.04E-8 11 1.98E-8
18 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 5.31 19.9 µM 5.56E-8 redox potentiating 3 5.42E-8
19 SGTC_63 0099-0242 5.18 26.7 µM 1.12E-7 mitochondrial stress 50 1.09E-7
20 SGTC_159 3970-0959 4.95 50.0 µM 3.81E-7 45 3.75E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.453 6.01E-169 YDL198C GGC1 hom Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
0.437 2.87E-156 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.433 7.38E-154 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.433 3.01E-153 YGR257C MTM1 hom Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.424 6.39E-147 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.420 9.51E-144 YGL064C MRH4 hom Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.417 3.28E-141 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.413 1.21E-138 YLR304C ACO1 hom Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
0.413 1.84E-138 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.410 1.47E-136 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.410 5.54E-136 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.407 8.91E-134 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.401 2.52E-129 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.397 2.41E-127 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.394 4.85E-125 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress