HIPHOP chemogenomics database

YLR369W / SSQ1

Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR369W / SSQ1

Click on Significant Values for Screen Details

Top fitness defect scores for YLR369W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_173	1273-0061	12.00	2.7 µM	3.21E-33	mitochondrial stress	26	2.27E-33
2	SGTC_156	3474-0145	11.80	5.6 µM	4.12E-32	endomembrane recycling	5	2.96E-32
3	SGTC_275	trichlorophene	11.40	5.7 µM	1.72E-30	mitochondrial stress	29	1.26E-30
4	SGTC_236	1509-0011	10.80	5.3 µM	1.43E-27		174	1.10E-27
5	SGTC_86	0417-1630	10.80	471.9 µM	3.84E-27	ubiquinone biosynthesis & proteasome	33	2.95E-27
6	SGTC_2513	baicalein	8.83	25.6 µM	6.06E-19	calcium & mitochondrial duress	3	5.19E-19
7	SGTC_310	1273-0058	8.40	1.1 µM	2.59E-17	mitochondrial stress	77	2.26E-17
8	SGTC_1834	st055981	8.05	52.8 µM	4.67E-16	RPP1 & pyrimidine depletion	2	4.15E-16
9	SGTC_1635	st007035	6.98	42.4 µM	1.54E-12		115	1.43E-12
10	SGTC_2509	methyl 7-deshydroxypyrogallin-4-carboxylate	6.79	54.6 µM	5.86E-12	RPP1 & pyrimidine depletion	3	5.47E-12
11	SGTC_149	3970-0822	6.79	46.1 µM	6.10E-12	tubulin folding & SWR complex	24	5.70E-12
12	SGTC_1521	st012942	6.12	49.4 µM	5.02E-10		7	4.80E-10
13	SGTC_2717	st081029	5.72	62.3 µM	5.58E-9		2	5.38E-9
14	SGTC_1742	st038235	5.70	28.9 µM	6.29E-9	mitochondrial stress	54	6.07E-9
15	SGTC_70	0141-0289	5.60	43.3 µM	1.11E-8	mitochondrial stress	95	1.08E-8
16	SGTC_1369	1866-0067	5.56	208.0 µM	1.38E-8	RPP1 & pyrimidine depletion	13	1.34E-8
17	SGTC_81	0411-0046	5.49	10.0 µM	2.04E-8		11	1.98E-8
18	SGTC_2548	3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin	5.31	19.9 µM	5.56E-8	redox potentiating	3	5.42E-8
19	SGTC_63	0099-0242	5.18	26.7 µM	1.12E-7	mitochondrial stress	50	1.09E-7
20	SGTC_159	3970-0959	4.95	50.0 µM	3.81E-7		45	3.75E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.453	6.01E-169	YDL198C	GGC1	hom	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
0.437	2.87E-156	YOR158W	PET123	hom	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.433	7.38E-154	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.433	3.01E-153	YGR257C	MTM1	hom	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
0.424	6.39E-147	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.420	9.51E-144	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.417	3.28E-141	YJL023C	PET130	hom	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.413	1.21E-138	YLR304C	ACO1	hom	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
0.413	1.84E-138	YBR179C	FZO1	hom	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.410	1.47E-136	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.410	5.54E-136	YGR220C	MRPL9	hom	Mitochondrial ribosomal protein of the large subunit
0.407	8.91E-134	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.401	2.52E-129	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.397	2.41E-127	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.394	4.85E-125	YDR533C	HSP31	hom	Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress