Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR369W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.453 | 6.01E-169 | YDL198C | GGC1 | hom | Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family |
0.437 | 2.87E-156 | YOR158W | PET123 | hom | Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator |
0.433 | 7.38E-154 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.433 | 3.01E-153 | YGR257C | MTM1 | hom | Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor |
0.424 | 6.39E-147 | YDR518W | EUG1 | hom | Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER |
0.420 | 9.51E-144 | YGL064C | MRH4 | hom | Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function |
0.417 | 3.28E-141 | YJL023C | PET130 | hom | Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
0.413 | 1.21E-138 | YLR304C | ACO1 | hom | Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy |
0.413 | 1.84E-138 | YBR179C | FZO1 | hom | Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system |
0.410 | 1.47E-136 | YNL252C | MRPL17 | hom | Mitochondrial ribosomal protein of the large subunit |
0.410 | 5.54E-136 | YGR220C | MRPL9 | hom | Mitochondrial ribosomal protein of the large subunit |
0.407 | 8.91E-134 | YPR166C | MRP2 | hom | Mitochondrial ribosomal protein of the small subunit |
0.401 | 2.52E-129 | YMR098C | ATP25 | hom | Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene |
0.397 | 2.41E-127 | YDR237W | MRPL7 | hom | Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein |
0.394 | 4.85E-125 | YDR533C | HSP31 | hom | Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress |