YLR370C / ARC18

Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR370C / ARC18

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:4.70|P-value:2.38E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.93|P-value:4.97E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.32|P-value:5.31E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.64|P-value:1.33E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:5.37|P-value:3.23E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.41|P-value:4.10E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.10|P-value:7.30E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.88|P-value:4.41E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:-5.00|P-value:7.55E-5 ID:SGTC_264|Compound:promethazine|FD-Score:4.30|P-value:7.07E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.72|P-value:2.27E-4 ID:SGTC_469|Compound:w7|FD-Score:4.66|P-value:2.66E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-4.22|P-value:6.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.86|P-value:1.48E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:6.16E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:6.49|P-value:6.51E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:5.08|P-value:7.91E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:6.68|P-value:3.11E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:4.61|P-value:3.02E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.63|P-value:2.92E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.58|P-value:3.31E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.20|P-value:9.16E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.41|P-value:5.18E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.29|P-value:7.22E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:7.33|P-value:2.29E-8 ID:SGTC_1352|Compound:1496-0991|FD-Score:6.71|P-value:2.82E-7 ID:SGTC_1407|Compound:3909-7909|FD-Score:5.78|P-value:8.45E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.60|P-value:3.11E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.33|P-value:2.27E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.46|P-value:4.63E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.17|P-value:3.71E-12 ID:SGTC_1687|Compound:st020778|FD-Score:10.80|P-value:4.17E-16 ID:SGTC_1705|Compound:st027868|FD-Score:4.34|P-value:6.34E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.85|P-value:1.18E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.27|P-value:7.57E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.32|P-value:6.67E-4 ID:SGTC_1824|Compound:st053723|FD-Score:6.79|P-value:2.08E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.13|P-value:6.79E-5 ID:SGTC_1884|Compound:5633444|FD-Score:4.24|P-value:8.09E-4 ID:SGTC_1904|Compound:st060225|FD-Score:4.16|P-value:9.91E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.51|P-value:6.05E-7 ID:SGTC_2054|Compound:5233173|FD-Score:4.26|P-value:7.77E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.27|P-value:7.62E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-5.17|P-value:4.57E-5 ID:SGTC_2189|Compound:6047310|FD-Score:4.48|P-value:4.40E-4 ID:SGTC_2197|Compound:6588183|FD-Score:6.06|P-value:3.19E-6 ID:SGTC_2200|Compound:6600604|FD-Score:9.77|P-value:1.46E-13 ID:SGTC_2218|Compound:6965428|FD-Score:4.39|P-value:5.51E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-4.10|P-value:9.42E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:5.04|P-value:8.89E-5 ID:SGTC_2241|Compound:6772625|FD-Score:5.14|P-value:6.53E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.91|P-value:1.31E-4 ID:SGTC_2318|Compound:6029776|FD-Score:6.10|P-value:2.74E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.81|P-value:1.75E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.35|P-value:2.05E-8 ID:SGTC_2399|Compound:5884133|FD-Score:5.14|P-value:6.48E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.46|P-value:2.38E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.77|P-value:1.97E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.83|P-value:1.62E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:7.10|P-value:5.99E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:4.39|P-value:5.56E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.41|P-value:5.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.78|P-value:8.30E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.98|P-value:1.04E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.98|P-value:1.05E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.02|P-value:9.49E-5 ID:SGTC_2900|Compound:5328528|FD-Score:8.12|P-value:6.58E-10 ID:SGTC_2925|Compound:9010536|FD-Score:7.03|P-value:8.00E-8 ID:SGTC_2926|Compound:9010726|FD-Score:8.27|P-value:3.35E-10 ID:SGTC_2953|Compound:9074162|FD-Score:4.63|P-value:2.87E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.80|P-value:1.77E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.50|P-value:6.42E-7 ID:SGTC_2998|Compound:9066762|FD-Score:5.35|P-value:3.39E-5 ID:SGTC_3034|Compound:9090421|FD-Score:4.89|P-value:1.36E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.61|P-value:2.41E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.78|P-value:1.87E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-4.59|P-value:2.53E-4 ID:SGTC_3274|Compound:9138298|FD-Score:6.11|P-value:2.60E-6 ID:SGTC_21|Compound:0849-0113|FD-Score:4.70|P-value:2.38E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.93|P-value:4.97E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.32|P-value:5.31E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:5.64|P-value:1.33E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:5.37|P-value:3.23E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.41|P-value:4.10E-4 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.10|P-value:7.30E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.88|P-value:4.41E-6 ID:SGTC_156|Compound:3474-0145|FD-Score:-5.00|P-value:7.55E-5 ID:SGTC_264|Compound:promethazine|FD-Score:4.30|P-value:7.07E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:4.72|P-value:2.27E-4 ID:SGTC_469|Compound:w7|FD-Score:4.66|P-value:2.66E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:-4.22|P-value:6.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.86|P-value:1.48E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.35|P-value:6.16E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:6.49|P-value:6.51E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:5.08|P-value:7.91E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:6.68|P-value:3.11E-7 ID:SGTC_878|Compound:0828-0289|FD-Score:4.61|P-value:3.02E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:4.63|P-value:2.92E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.58|P-value:3.31E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.20|P-value:9.16E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.41|P-value:5.18E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:4.29|P-value:7.22E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:7.33|P-value:2.29E-8 ID:SGTC_1352|Compound:1496-0991|FD-Score:6.71|P-value:2.82E-7 ID:SGTC_1407|Compound:3909-7909|FD-Score:5.78|P-value:8.45E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.60|P-value:3.11E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:7.33|P-value:2.27E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.46|P-value:4.63E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.17|P-value:3.71E-12 ID:SGTC_1687|Compound:st020778|FD-Score:10.80|P-value:4.17E-16 ID:SGTC_1705|Compound:st027868|FD-Score:4.34|P-value:6.34E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.85|P-value:1.18E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.27|P-value:7.57E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.32|P-value:6.67E-4 ID:SGTC_1824|Compound:st053723|FD-Score:6.79|P-value:2.08E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.13|P-value:6.79E-5 ID:SGTC_1884|Compound:5633444|FD-Score:4.24|P-value:8.09E-4 ID:SGTC_1904|Compound:st060225|FD-Score:4.16|P-value:9.91E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.51|P-value:6.05E-7 ID:SGTC_2054|Compound:5233173|FD-Score:4.26|P-value:7.77E-4 ID:SGTC_2057|Compound:5236571|FD-Score:4.27|P-value:7.62E-4 ID:SGTC_2120|Compound:5538279|FD-Score:-5.17|P-value:4.57E-5 ID:SGTC_2189|Compound:6047310|FD-Score:4.48|P-value:4.40E-4 ID:SGTC_2197|Compound:6588183|FD-Score:6.06|P-value:3.19E-6 ID:SGTC_2200|Compound:6600604|FD-Score:9.77|P-value:1.46E-13 ID:SGTC_2218|Compound:6965428|FD-Score:4.39|P-value:5.51E-4 ID:SGTC_2223|Compound:6903751|FD-Score:-4.10|P-value:9.42E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:5.04|P-value:8.89E-5 ID:SGTC_2241|Compound:6772625|FD-Score:5.14|P-value:6.53E-5 ID:SGTC_2293|Compound:7624732|FD-Score:4.91|P-value:1.31E-4 ID:SGTC_2318|Compound:6029776|FD-Score:6.10|P-value:2.74E-6 ID:SGTC_2358|Compound:9037157|FD-Score:4.81|P-value:1.75E-4 ID:SGTC_2396|Compound:5342950|FD-Score:7.35|P-value:2.05E-8 ID:SGTC_2399|Compound:5884133|FD-Score:5.14|P-value:6.48E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.46|P-value:2.38E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.77|P-value:1.97E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.83|P-value:1.62E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:7.10|P-value:5.99E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:4.39|P-value:5.56E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:4.41|P-value:5.28E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:5.78|P-value:8.30E-6 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.98|P-value:1.04E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.98|P-value:1.05E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.02|P-value:9.49E-5 ID:SGTC_2900|Compound:5328528|FD-Score:8.12|P-value:6.58E-10 ID:SGTC_2925|Compound:9010536|FD-Score:7.03|P-value:8.00E-8 ID:SGTC_2926|Compound:9010726|FD-Score:8.27|P-value:3.35E-10 ID:SGTC_2953|Compound:9074162|FD-Score:4.63|P-value:2.87E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.80|P-value:1.77E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.50|P-value:6.42E-7 ID:SGTC_2998|Compound:9066762|FD-Score:5.35|P-value:3.39E-5 ID:SGTC_3034|Compound:9090421|FD-Score:4.89|P-value:1.36E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.61|P-value:2.41E-4 ID:SGTC_3091|Compound:9116372|FD-Score:4.78|P-value:1.87E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-4.59|P-value:2.53E-4 ID:SGTC_3274|Compound:9138298|FD-Score:6.11|P-value:2.60E-6

Top fitness defect scores for YLR370C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 10.80 55.4 µM 4.17E-16 44 2.43E-27
2 SGTC_2200 6600604 9.77 21.9 µM 1.46E-13 tubulin folding & SWR complex 11 7.76E-23
3 SGTC_1635 st007035 9.17 42.4 µM 3.71E-12 87 2.38E-20
4 SGTC_2926 9010726 8.27 65.2 µM 3.35E-10 3 6.79E-17
5 SGTC_2900 5328528 8.12 85.3 µM 6.58E-10 Golgi 4 2.24E-16
6 SGTC_2396 5342950 7.35 42.8 µM 2.05E-8 RSC complex & mRNA processing 7 9.67E-14
7 SGTC_1495 4469-0029 7.33 237.0 µM 2.27E-8 31 1.15E-13
8 SGTC_1268 0828-0275 7.33 2.5 µM 2.29E-8 1 1.17E-13
9 SGTC_2600 tangeritin 7.10 88.0 µM 5.99E-8 6 6.38E-13
10 SGTC_2925 9010536 7.03 32.5 µM 8.00E-8 azole & statin 10 1.06E-12
11 SGTC_1824 st053723 6.79 68.6 µM 2.08E-7 8 5.70E-12
12 SGTC_1352 1496-0991 6.71 99.0 µM 2.82E-7 tubulin folding & SWR complex 4 9.74E-12
13 SGTC_841 0251-0215 6.68 91.2 µM 3.11E-7 31 1.16E-11
14 SGTC_1959 st077091 6.51 55.8 µM 6.05E-7 RPP1 & pyrimidine depletion 4 3.73E-11
15 SGTC_2997 9067075 6.50 71.4 µM 6.42E-7 unfolded protein response 12 4.14E-11
16 SGTC_776 4476-4378 6.49 112.0 µM 6.51E-7 ERG2 6 4.24E-11
17 SGTC_3274 9138298 6.11 49.5 µM 2.60E-6 2 4.84E-10
18 SGTC_2318 6029776 6.10 164.0 µM 2.74E-6 6 5.30E-10
19 SGTC_2197 6588183 6.06 93.1 µM 3.19E-6 12 6.93E-10
20 SGTC_22 0964-0034 5.93 14.5 µM 4.97E-6 unfolded protein response 18 1.51E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.320 4.18E-80 YOR035C SHE4 hom Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization
0.311 1.03E-75 YDR129C SAC6 hom Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.240 5.06E-45 YLR338W_d OPI9_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
0.191 9.26E-29 YGL012W ERG4 hom C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
0.191 1.06E-28 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.185 4.70E-27 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.181 5.25E-26 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.178 2.79E-25 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.176 1.42E-24 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.174 4.12E-24 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.169 9.74E-23 YDR276C PMP3 hom Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
0.157 7.97E-20 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
0.155 2.00E-19 YGR167W CLC1 hom Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W
0.149 4.95E-18 YGL095C VPS45 hom Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment
0.147 1.44E-17 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport