YLR372W / SUR4

Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR372W / SUR4

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:5.51|P-value:5.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.39|P-value:2.10E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.94|P-value:2.01E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.97|P-value:1.86E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.14|P-value:1.25E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.53|P-value:5.15E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.90|P-value:6.33E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-4.79|P-value:8.05E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.35|P-value:7.66E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:7.05|P-value:1.16E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.65|P-value:3.92E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:6.51|P-value:4.90E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:8.50|P-value:1.43E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:6.56|P-value:4.36E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:6.98|P-value:1.40E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:10.50|P-value:1.01E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.71|P-value:1.09E-8 ID:SGTC_459|Compound:nigericin|FD-Score:7.81|P-value:1.26E-6 ID:SGTC_470|Compound:aa-861|FD-Score:6.06|P-value:1.53E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:7.77|P-value:1.45E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:6.03|P-value:1.62E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:5.83|P-value:2.63E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:5.52|P-value:5.32E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:7.00|P-value:1.36E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:7.76|P-value:1.51E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:5.84|P-value:2.53E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:6.37|P-value:7.14E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.55|P-value:4.52E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:7.92|P-value:9.12E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:7.34|P-value:5.09E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:5.91|P-value:2.15E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:6.80|P-value:2.32E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:8.55|P-value:1.20E-7 ID:SGTC_1100|Compound:amiodarone|FD-Score:5.48|P-value:5.72E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:7.18|P-value:8.15E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.30|P-value:8.50E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.64|P-value:3.54E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:6.98|P-value:1.42E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:8.21|P-value:3.61E-7 ID:SGTC_1325|Compound:1431-0015|FD-Score:7.85|P-value:1.12E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:6.76|P-value:2.55E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:6.64|P-value:3.57E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:9.85|P-value:1.15E-9 ID:SGTC_1410|Compound:3909-8106|FD-Score:8.61|P-value:9.86E-8 ID:SGTC_1464|Compound:k208-0027|FD-Score:8.96|P-value:2.94E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.81|P-value:2.26E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:7.48|P-value:3.43E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:11.80|P-value:3.37E-13 ID:SGTC_1573|Compound:oleylamine|FD-Score:7.31|P-value:5.64E-6 ID:SGTC_1602|Compound:st001878|FD-Score:6.41|P-value:6.41E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-5.86|P-value:6.65E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.40|P-value:6.82E-4 ID:SGTC_1726|Compound:st035556|FD-Score:6.00|P-value:1.75E-4 ID:SGTC_1736|Compound:st036774|FD-Score:9.26|P-value:1.02E-8 ID:SGTC_1737|Compound:st035557|FD-Score:6.01|P-value:1.71E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.92|P-value:2.10E-4 ID:SGTC_1909|Compound:st060837|FD-Score:8.62|P-value:9.63E-8 ID:SGTC_1917|Compound:st066507|FD-Score:8.89|P-value:3.78E-8 ID:SGTC_1941|Compound:st076221|FD-Score:12.60|P-value:7.23E-15 ID:SGTC_1982|Compound:st072467|FD-Score:11.40|P-value:1.60E-12 ID:SGTC_2077|Compound:5212015|FD-Score:7.66|P-value:2.00E-6 ID:SGTC_2119|Compound:5528445|FD-Score:5.82|P-value:2.68E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-4.94|P-value:5.89E-4 ID:SGTC_2157|Compound:5649910|FD-Score:5.71|P-value:3.45E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.49|P-value:5.28E-5 ID:SGTC_2242|Compound:6630449|FD-Score:6.28|P-value:8.83E-5 ID:SGTC_2248|Compound:tofa|FD-Score:5.59|P-value:4.53E-4 ID:SGTC_2292|Compound:7671323|FD-Score:7.22|P-value:7.24E-6 ID:SGTC_2334|Compound:9017922|FD-Score:7.56|P-value:2.73E-6 ID:SGTC_2363|Compound:9053361|FD-Score:5.86|P-value:2.46E-4 ID:SGTC_2416|Compound:tofa|FD-Score:10.40|P-value:1.41E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:11.60|P-value:8.90E-13 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-5.08|P-value:4.30E-4 ID:SGTC_2472|Compound:5377652|FD-Score:10.40|P-value:1.35E-10 ID:SGTC_2482|Compound:5981709|FD-Score:5.39|P-value:6.99E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:8.31|P-value:2.69E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:6.87|P-value:1.93E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.40|P-value:4.38E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:6.50|P-value:5.07E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.40|P-value:1.32E-10 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.67|P-value:3.29E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.90|P-value:2.23E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.48|P-value:5.81E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:8.66|P-value:8.23E-8 ID:SGTC_2740|Compound:felodipine|FD-Score:15.40|P-value:1.58E-21 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.60|P-value:6.46E-13 ID:SGTC_2755|Compound:lomerizine|FD-Score:11.70|P-value:4.19E-13 ID:SGTC_2814|Compound:7977482|FD-Score:7.33|P-value:5.30E-6 ID:SGTC_2820|Compound:7989630|FD-Score:5.25|P-value:9.38E-4 ID:SGTC_2828|Compound:7998861|FD-Score:6.77|P-value:2.50E-5 ID:SGTC_2830|Compound:7992007|FD-Score:5.50|P-value:5.54E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.56|P-value:5.24E-7 ID:SGTC_2906|Compound:7926292|FD-Score:5.56|P-value:4.78E-4 ID:SGTC_2918|Compound:7977171|FD-Score:8.21|P-value:3.66E-7 ID:SGTC_2923|Compound:7992654|FD-Score:8.44|P-value:1.72E-7 ID:SGTC_2934|Compound:9036370|FD-Score:9.13|P-value:1.63E-8 ID:SGTC_2953|Compound:9074162|FD-Score:6.99|P-value:1.39E-5 ID:SGTC_3143|Compound:9086658|FD-Score:6.44|P-value:5.94E-5 ID:SGTC_3199|Compound:9111318|FD-Score:7.78|P-value:1.39E-6 ID:SGTC_3212|Compound:9128307|FD-Score:5.63|P-value:4.15E-4 ID:SGTC_3219|Compound:9131112|FD-Score:6.76|P-value:2.58E-5 ID:SGTC_3237|Compound:9133362|FD-Score:8.35|P-value:2.31E-7 ID:SGTC_3331|Compound:9141060|FD-Score:6.61|P-value:3.80E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:5.51|P-value:5.35E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.39|P-value:2.10E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.94|P-value:2.01E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.97|P-value:1.86E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.14|P-value:1.25E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:5.53|P-value:5.15E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-4.90|P-value:6.33E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:-4.79|P-value:8.05E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:5.35|P-value:7.66E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:7.05|P-value:1.16E-5 ID:SGTC_391|Compound:gliotoxin|FD-Score:5.65|P-value:3.92E-4 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:6.51|P-value:4.90E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:8.50|P-value:1.43E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:6.56|P-value:4.36E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:6.98|P-value:1.40E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:10.50|P-value:1.01E-10 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-8.71|P-value:1.09E-8 ID:SGTC_459|Compound:nigericin|FD-Score:7.81|P-value:1.26E-6 ID:SGTC_470|Compound:aa-861|FD-Score:6.06|P-value:1.53E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:7.77|P-value:1.45E-6 ID:SGTC_528|Compound:3492-0019|FD-Score:6.03|P-value:1.62E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:5.83|P-value:2.63E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:5.52|P-value:5.32E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:7.00|P-value:1.36E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:7.76|P-value:1.51E-6 ID:SGTC_800|Compound:3448-7362|FD-Score:5.84|P-value:2.53E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:6.37|P-value:7.14E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:6.55|P-value:4.52E-5 ID:SGTC_935|Compound:2996-0153|FD-Score:7.92|P-value:9.12E-7 ID:SGTC_955|Compound:1216-0110|FD-Score:7.34|P-value:5.09E-6 ID:SGTC_958|Compound:1222-0007|FD-Score:5.91|P-value:2.15E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:6.80|P-value:2.32E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:8.55|P-value:1.20E-7 ID:SGTC_1100|Compound:amiodarone|FD-Score:5.48|P-value:5.72E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:7.18|P-value:8.15E-6 ID:SGTC_1263|Compound:0774-1208|FD-Score:5.30|P-value:8.50E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:6.64|P-value:3.54E-5 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:6.98|P-value:1.42E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:8.21|P-value:3.61E-7 ID:SGTC_1325|Compound:1431-0015|FD-Score:7.85|P-value:1.12E-6 ID:SGTC_1333|Compound:1482-0047|FD-Score:6.76|P-value:2.55E-5 ID:SGTC_1334|Compound:1486-0610|FD-Score:6.64|P-value:3.57E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:9.85|P-value:1.15E-9 ID:SGTC_1410|Compound:3909-8106|FD-Score:8.61|P-value:9.86E-8 ID:SGTC_1464|Compound:k208-0027|FD-Score:8.96|P-value:2.94E-8 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.81|P-value:2.26E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:7.48|P-value:3.43E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:11.80|P-value:3.37E-13 ID:SGTC_1573|Compound:oleylamine|FD-Score:7.31|P-value:5.64E-6 ID:SGTC_1602|Compound:st001878|FD-Score:6.41|P-value:6.41E-5 ID:SGTC_1632|Compound:st005650|FD-Score:-5.86|P-value:6.65E-5 ID:SGTC_1687|Compound:st020778|FD-Score:5.40|P-value:6.82E-4 ID:SGTC_1726|Compound:st035556|FD-Score:6.00|P-value:1.75E-4 ID:SGTC_1736|Compound:st036774|FD-Score:9.26|P-value:1.02E-8 ID:SGTC_1737|Compound:st035557|FD-Score:6.01|P-value:1.71E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.92|P-value:2.10E-4 ID:SGTC_1909|Compound:st060837|FD-Score:8.62|P-value:9.63E-8 ID:SGTC_1917|Compound:st066507|FD-Score:8.89|P-value:3.78E-8 ID:SGTC_1941|Compound:st076221|FD-Score:12.60|P-value:7.23E-15 ID:SGTC_1982|Compound:st072467|FD-Score:11.40|P-value:1.60E-12 ID:SGTC_2077|Compound:5212015|FD-Score:7.66|P-value:2.00E-6 ID:SGTC_2119|Compound:5528445|FD-Score:5.82|P-value:2.68E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-4.94|P-value:5.89E-4 ID:SGTC_2157|Compound:5649910|FD-Score:5.71|P-value:3.45E-4 ID:SGTC_2200|Compound:6600604|FD-Score:6.49|P-value:5.28E-5 ID:SGTC_2242|Compound:6630449|FD-Score:6.28|P-value:8.83E-5 ID:SGTC_2248|Compound:tofa|FD-Score:5.59|P-value:4.53E-4 ID:SGTC_2292|Compound:7671323|FD-Score:7.22|P-value:7.24E-6 ID:SGTC_2334|Compound:9017922|FD-Score:7.56|P-value:2.73E-6 ID:SGTC_2363|Compound:9053361|FD-Score:5.86|P-value:2.46E-4 ID:SGTC_2416|Compound:tofa|FD-Score:10.40|P-value:1.41E-10 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:11.60|P-value:8.90E-13 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-5.08|P-value:4.30E-4 ID:SGTC_2472|Compound:5377652|FD-Score:10.40|P-value:1.35E-10 ID:SGTC_2482|Compound:5981709|FD-Score:5.39|P-value:6.99E-4 ID:SGTC_2514|Compound:salinomycin|FD-Score:8.31|P-value:2.69E-7 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:6.87|P-value:1.93E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:7.40|P-value:4.38E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:6.50|P-value:5.07E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:10.40|P-value:1.32E-10 ID:SGTC_2616|Compound:abietic acid|FD-Score:6.67|P-value:3.29E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.90|P-value:2.23E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.48|P-value:5.81E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:8.66|P-value:8.23E-8 ID:SGTC_2740|Compound:felodipine|FD-Score:15.40|P-value:1.58E-21 ID:SGTC_2752|Compound:diclazuril|FD-Score:11.60|P-value:6.46E-13 ID:SGTC_2755|Compound:lomerizine|FD-Score:11.70|P-value:4.19E-13 ID:SGTC_2814|Compound:7977482|FD-Score:7.33|P-value:5.30E-6 ID:SGTC_2820|Compound:7989630|FD-Score:5.25|P-value:9.38E-4 ID:SGTC_2828|Compound:7998861|FD-Score:6.77|P-value:2.50E-5 ID:SGTC_2830|Compound:7992007|FD-Score:5.50|P-value:5.54E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-7.56|P-value:5.24E-7 ID:SGTC_2906|Compound:7926292|FD-Score:5.56|P-value:4.78E-4 ID:SGTC_2918|Compound:7977171|FD-Score:8.21|P-value:3.66E-7 ID:SGTC_2923|Compound:7992654|FD-Score:8.44|P-value:1.72E-7 ID:SGTC_2934|Compound:9036370|FD-Score:9.13|P-value:1.63E-8 ID:SGTC_2953|Compound:9074162|FD-Score:6.99|P-value:1.39E-5 ID:SGTC_3143|Compound:9086658|FD-Score:6.44|P-value:5.94E-5 ID:SGTC_3199|Compound:9111318|FD-Score:7.78|P-value:1.39E-6 ID:SGTC_3212|Compound:9128307|FD-Score:5.63|P-value:4.15E-4 ID:SGTC_3219|Compound:9131112|FD-Score:6.76|P-value:2.58E-5 ID:SGTC_3237|Compound:9133362|FD-Score:8.35|P-value:2.31E-7 ID:SGTC_3331|Compound:9141060|FD-Score:6.61|P-value:3.80E-5

Top fitness defect scores for YLR372W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2740 felodipine 15.40 17.1 µM 1.58E-21 2 4.85E-54
2 SGTC_1941 st076221 12.60 61.8 µM 7.23E-15 sphingolipid biosynthesis & PDR1 7 1.01E-36
3 SGTC_1568 digitonin 11.80 820.0 nM 3.37E-13 sphingolipid biosynthesis & PDR1 7 2.22E-32
4 SGTC_2755 lomerizine 11.70 42.7 µM 4.19E-13 1 3.92E-32
5 SGTC_2752 diclazuril 11.60 33.1 µM 6.46E-13 16 1.21E-31
6 SGTC_2420 aureobasidin a 11.60 50.0 nM 8.90E-13 1 2.77E-31
7 SGTC_1982 st072467 11.40 71.9 µM 1.60E-12 2 1.27E-30
8 SGTC_439 amiodarone 10.50 34.4 µM 1.01E-10 NEO1-PIK1 13 6.17E-26
9 SGTC_2567 aureobasidin a 10.40 60.0 nM 1.32E-10 12 1.24E-25
10 SGTC_2472 5377652 10.40 49.4 µM 1.35E-10 TRP & mitochondrial translation 9 1.31E-25
11 SGTC_2416 tofa 10.40 880.0 nM 1.41E-10 sphingolipid biosynthesis & PDR1 9 1.48E-25
12 SGTC_1408 3909-7976 9.85 48.8 µM 1.15E-9 Golgi 1 3.46E-23
13 SGTC_1736 st036774 9.26 51.0 µM 1.02E-8 1 1.02E-20
14 SGTC_2934 9036370 9.13 36.9 µM 1.63E-8 1 3.42E-20
15 SGTC_1464 k208-0027 8.96 110.0 µM 2.94E-8 6 1.58E-19
16 SGTC_1917 st066507 8.89 28.5 µM 3.78E-8 Golgi 5 3.04E-19
17 SGTC_2645 abamectin 8.66 100.0 µM 8.23E-8 heme requiring 2 2.29E-18
18 SGTC_1909 st060837 8.62 51.5 µM 9.63E-8 7 3.45E-18
19 SGTC_1410 3909-8106 8.61 77.9 µM 9.86E-8 2 3.67E-18
20 SGTC_1078 idebenone 8.55 36.1 µM 1.20E-7 Golgi 6 6.14E-18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.308 1.43E-74 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.245 4.65E-47 YGL013C PDR1 hom Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
0.214 6.35E-36 YKL126W YPK1 hom Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
0.203 1.21E-32 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.198 3.99E-31 YMR102C_p YMR102C_p hom Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
0.198 4.71E-31 YIL036W CST6 hom Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; CST6 has a paralog, ACA1, that arose from the whole genome duplication
0.195 7.18E-30 YNL323W LEM3 hom Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
0.190 1.12E-28 YBR058C-A TSC3 hom Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
0.175 2.05E-24 YGR037C ACB1 hom Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress
0.171 2.30E-23 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.167 2.65E-22 YML122C_d YML122C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.167 2.47E-22 YCR034W FEN1 hom Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; FEN1 has a paralog, ELO1, that arose from the whole genome duplication
0.165 1.14E-21 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.163 2.30E-21 YDR072C IPT1 hom Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin
0.162 4.74E-21 YOL001W PHO80 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling