YLR373C / VID22

Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR373C / VID22

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:-3.99|P-value:9.55E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.55|P-value:1.12E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:9.42|P-value:7.82E-19 ID:SGTC_68|Compound:0986-0284|FD-Score:6.02|P-value:1.01E-8 ID:SGTC_75|Compound:0159-0059|FD-Score:7.41|P-value:2.37E-12 ID:SGTC_266|Compound:formosanin C|FD-Score:4.87|P-value:2.79E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.10|P-value:6.54E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.22|P-value:3.99E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.72|P-value:2.66E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.45|P-value:1.70E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:5.62|P-value:8.23E-8 ID:SGTC_783|Compound:0848-0141|FD-Score:4.37|P-value:2.36E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.16|P-value:7.13E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:6.06|P-value:7.90E-9 ID:SGTC_831|Compound:k061-1017|FD-Score:3.98|P-value:1.03E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.50|P-value:5.57E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.42|P-value:6.90E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.80|P-value:3.18E-8 ID:SGTC_953|Compound:1188-0045|FD-Score:3.32|P-value:9.78E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.49|P-value:5.76E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.83|P-value:3.32E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.36|P-value:2.39E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.97|P-value:1.83E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.39|P-value:7.86E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.64|P-value:3.48E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.98|P-value:1.05E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.96|P-value:1.10E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.11|P-value:6.40E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.65|P-value:3.32E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-4.23|P-value:3.92E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-4.22|P-value:4.10E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.71|P-value:2.75E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.85|P-value:1.61E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-6.01|P-value:9.95E-9 ID:SGTC_1990|Compound:st072050|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.31|P-value:9.87E-4 ID:SGTC_2105|Compound:5350118|FD-Score:7.35|P-value:3.54E-12 ID:SGTC_2122|Compound:5258151|FD-Score:4.55|P-value:1.10E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-3.57|P-value:4.25E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.54|P-value:4.85E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.39|P-value:2.18E-5 ID:SGTC_2361|Compound:9034121|FD-Score:4.16|P-value:5.28E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.20|P-value:4.50E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.48|P-value:5.84E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.82|P-value:1.88E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.34|P-value:9.40E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.21|P-value:4.27E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.33|P-value:9.35E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:5.56|P-value:1.07E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:4.78|P-value:4.20E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.37|P-value:8.35E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.66|P-value:3.12E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-6.34|P-value:1.59E-9 ID:SGTC_2877|Compound:9040724|FD-Score:-4.74|P-value:4.71E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.69|P-value:6.05E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.86|P-value:1.58E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.81|P-value:1.89E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.00|P-value:9.52E-5 ID:SGTC_3015|Compound:9080845|FD-Score:-3.77|P-value:2.17E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.52|P-value:1.24E-5 ID:SGTC_3124|Compound:9127567|FD-Score:5.06|P-value:1.22E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.78|P-value:2.11E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_3298|Compound:9116858|FD-Score:-3.55|P-value:4.54E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.57|P-value:1.03E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.99|P-value:1.02E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.99|P-value:9.55E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:5.55|P-value:1.12E-7 ID:SGTC_65|Compound:0798-0905|FD-Score:9.42|P-value:7.82E-19 ID:SGTC_68|Compound:0986-0284|FD-Score:6.02|P-value:1.01E-8 ID:SGTC_75|Compound:0159-0059|FD-Score:7.41|P-value:2.37E-12 ID:SGTC_266|Compound:formosanin C|FD-Score:4.87|P-value:2.79E-6 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.10|P-value:6.54E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.22|P-value:3.99E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.72|P-value:2.66E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:4.45|P-value:1.70E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:5.62|P-value:8.23E-8 ID:SGTC_783|Compound:0848-0141|FD-Score:4.37|P-value:2.36E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:-5.16|P-value:7.13E-7 ID:SGTC_829|Compound:1635-0120|FD-Score:6.06|P-value:7.90E-9 ID:SGTC_831|Compound:k061-1017|FD-Score:3.98|P-value:1.03E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.50|P-value:5.57E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.42|P-value:6.90E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.80|P-value:3.18E-8 ID:SGTC_953|Compound:1188-0045|FD-Score:3.32|P-value:9.78E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.49|P-value:5.76E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.83|P-value:3.32E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.36|P-value:2.39E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:4.97|P-value:1.83E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.39|P-value:7.86E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:3.64|P-value:3.48E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.98|P-value:1.05E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.96|P-value:1.10E-4 ID:SGTC_1621|Compound:st003705|FD-Score:4.11|P-value:6.40E-5 ID:SGTC_1622|Compound:st003707|FD-Score:3.65|P-value:3.32E-4 ID:SGTC_1845|Compound:st056753|FD-Score:-4.23|P-value:3.92E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-4.22|P-value:4.10E-5 ID:SGTC_1854|Compound:st056233|FD-Score:3.71|P-value:2.75E-4 ID:SGTC_1861|Compound:st057647|FD-Score:-3.85|P-value:1.61E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-6.01|P-value:9.95E-9 ID:SGTC_1990|Compound:st072050|FD-Score:3.60|P-value:3.97E-4 ID:SGTC_2068|Compound:5226020|FD-Score:-3.31|P-value:9.87E-4 ID:SGTC_2105|Compound:5350118|FD-Score:7.35|P-value:3.54E-12 ID:SGTC_2122|Compound:5258151|FD-Score:4.55|P-value:1.10E-5 ID:SGTC_2139|Compound:5578692|FD-Score:-3.57|P-value:4.25E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.54|P-value:4.85E-4 ID:SGTC_2358|Compound:9037157|FD-Score:4.39|P-value:2.18E-5 ID:SGTC_2361|Compound:9034121|FD-Score:4.16|P-value:5.28E-5 ID:SGTC_2399|Compound:5884133|FD-Score:4.20|P-value:4.50E-5 ID:SGTC_2443|Compound:5493264|FD-Score:3.48|P-value:5.84E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.82|P-value:1.88E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.34|P-value:9.40E-4 ID:SGTC_2632|Compound:3-hydroxy-4-(succin-2-yl)-caryolane delta-lactone|FD-Score:4.21|P-value:4.27E-5 ID:SGTC_2639|Compound:lactacystin|FD-Score:-3.33|P-value:9.35E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:5.56|P-value:1.07E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:4.78|P-value:4.20E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.37|P-value:8.35E-4 ID:SGTC_2812|Compound:7970281|FD-Score:-3.66|P-value:3.12E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-6.34|P-value:1.59E-9 ID:SGTC_2877|Compound:9040724|FD-Score:-4.74|P-value:4.71E-6 ID:SGTC_2912|Compound:7964298|FD-Score:4.69|P-value:6.05E-6 ID:SGTC_2925|Compound:9010536|FD-Score:3.86|P-value:1.58E-4 ID:SGTC_2934|Compound:9036370|FD-Score:3.81|P-value:1.89E-4 ID:SGTC_2965|Compound:9082772|FD-Score:4.00|P-value:9.52E-5 ID:SGTC_3015|Compound:9080845|FD-Score:-3.77|P-value:2.17E-4 ID:SGTC_3016|Compound:9080866|FD-Score:4.52|P-value:1.24E-5 ID:SGTC_3124|Compound:9127567|FD-Score:5.06|P-value:1.22E-6 ID:SGTC_3129|Compound:9127257|FD-Score:3.78|P-value:2.11E-4 ID:SGTC_3285|Compound:9112818|FD-Score:4.41|P-value:2.01E-5 ID:SGTC_3298|Compound:9116858|FD-Score:-3.55|P-value:4.54E-4 ID:SGTC_3305|Compound:9127027|FD-Score:4.57|P-value:1.03E-5 ID:SGTC_3311|Compound:9131146|FD-Score:3.99|P-value:1.02E-4

Top fitness defect scores for YLR373C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_65 0798-0905 9.42 35.0 µM 7.82E-19 calcium & mitochondrial duress 11 2.26E-21
2 SGTC_75 0159-0059 7.41 199.0 µM 2.37E-12 fatty acid desaturase (OLE1) 3 6.13E-14
3 SGTC_2105 5350118 7.35 200.0 µM 3.54E-12 3 9.72E-14
4 SGTC_829 1635-0120 6.06 117.0 µM 7.90E-9 DNA damage response 10 6.69E-10
5 SGTC_68 0986-0284 6.02 82.8 µM 1.01E-8 20 8.88E-10
6 SGTC_915 methyl methanesulfonate (MMS) 5.80 110.0 mM 3.18E-8 DNA damage response 12 3.29E-9
7 SGTC_779 1360-0071 5.62 233.0 µM 8.23E-8 fatty acid desaturase (OLE1) 10 9.79E-9
8 SGTC_2664 lyso-paf C-16 5.56 73.5 µM 1.07E-7 1 1.33E-8
9 SGTC_58 0957-0393 5.55 9.0 µM 1.12E-7 cell wall 240 1.39E-8
10 SGTC_3124 9127567 5.06 49.5 µM 1.22E-6 DNA damage response 8 2.15E-7
11 SGTC_1137 ixabepilone 4.97 100.0 µM 1.83E-6 13 3.40E-7
12 SGTC_266 formosanin C 4.87 406.0 nM 2.79E-6 sphingolipid biosynthesis & PDR1 48 5.52E-7
13 SGTC_1106 tegaserod maleate 4.83 11.7 µM 3.32E-6 5 6.74E-7
14 SGTC_2756 carbadox 4.78 75.1 µM 4.20E-6 40 8.81E-7
15 SGTC_2912 7964298 4.69 10.9 µM 6.05E-6 cell wall 74 1.34E-6
16 SGTC_3305 9127027 4.57 53.8 µM 1.03E-5 9 2.45E-6
17 SGTC_2122 5258151 4.55 111.7 µM 1.10E-5 17 2.65E-6
18 SGTC_3016 9080866 4.52 49.5 µM 1.24E-5 16 3.03E-6
19 SGTC_774 k060-0086 4.45 136.0 µM 1.70E-5 11 4.35E-6
20 SGTC_3285 9112818 4.41 20.9 µM 2.01E-5 cell wall 23 5.26E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.181 4.04E-26 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.141 2.20E-16 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.126 2.80E-13 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.119 5.20E-12 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.118 8.66E-12 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.116 1.38E-11 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.112 7.43E-11 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.112 7.97E-11 YBR169C SSE2 hom Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
0.112 8.42E-11 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.110 1.96E-10 YJL150W_d YJL150W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.68E-10 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.108 3.74E-10 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.108 3.86E-10 YGR106C VOA1 hom Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
0.108 4.09E-10 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.106 8.47E-10 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event