YLR374C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR374C / YLR374C

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:-5.61|P-value:4.87E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:4.34|P-value:1.24E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.76|P-value:1.54E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:10.50|P-value:1.52E-19 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.77|P-value:2.43E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:3.94|P-value:4.49E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.94|P-value:4.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.57|P-value:1.18E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:7.01|P-value:1.25E-9 ID:SGTC_252|Compound:miconazole|FD-Score:8.61|P-value:1.09E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.59|P-value:7.95E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.70|P-value:3.54E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.06|P-value:9.00E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.81|P-value:6.76E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.96|P-value:4.25E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.76|P-value:7.78E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:9.31|P-value:1.01E-15 ID:SGTC_598|Compound:3937-0236|FD-Score:4.19|P-value:2.04E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.53|P-value:1.35E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.25|P-value:1.55E-15 ID:SGTC_730|Compound:1436-0052|FD-Score:4.78|P-value:2.63E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:7.91|P-value:8.35E-12 ID:SGTC_883|Compound:0850-0245|FD-Score:5.45|P-value:1.95E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.60|P-value:7.65E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.58|P-value:5.47E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.81|P-value:6.61E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.93|P-value:4.64E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.47|P-value:1.94E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.12|P-value:2.53E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.72|P-value:8.60E-4 ID:SGTC_1641|Compound:st009299|FD-Score:6.03|P-value:1.55E-7 ID:SGTC_1687|Compound:st020778|FD-Score:7.65|P-value:3.68E-11 ID:SGTC_1961|Compound:st076550|FD-Score:5.26|P-value:4.25E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.74|P-value:5.04E-4 ID:SGTC_2084|Compound:5306078|FD-Score:5.65|P-value:8.10E-7 ID:SGTC_2241|Compound:6772625|FD-Score:9.33|P-value:8.53E-16 ID:SGTC_2868|Compound:9035608|FD-Score:3.70|P-value:9.16E-4 ID:SGTC_2975|Compound:9084847|FD-Score:6.42|P-value:2.44E-8 ID:SGTC_3019|Compound:9081971|FD-Score:4.41|P-value:9.89E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.87|P-value:5.58E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.72|P-value:8.63E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.98|P-value:2.36E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-5.61|P-value:4.87E-7 ID:SGTC_114|Compound:0364-0001|FD-Score:4.34|P-value:1.24E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-4.76|P-value:1.54E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:10.50|P-value:1.52E-19 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.77|P-value:2.43E-7 ID:SGTC_166|Compound:k072-0058|FD-Score:3.94|P-value:4.49E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.94|P-value:4.51E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.57|P-value:1.18E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:7.01|P-value:1.25E-9 ID:SGTC_252|Compound:miconazole|FD-Score:8.61|P-value:1.09E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.59|P-value:7.95E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.70|P-value:3.54E-5 ID:SGTC_354|Compound:2783-3500|FD-Score:5.06|P-value:9.00E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.81|P-value:6.76E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.96|P-value:4.25E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.76|P-value:7.78E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:9.31|P-value:1.01E-15 ID:SGTC_598|Compound:3937-0236|FD-Score:4.19|P-value:2.04E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:5.53|P-value:1.35E-6 ID:SGTC_682|Compound:0kpi-0099|FD-Score:9.25|P-value:1.55E-15 ID:SGTC_730|Compound:1436-0052|FD-Score:4.78|P-value:2.63E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:7.91|P-value:8.35E-12 ID:SGTC_883|Compound:0850-0245|FD-Score:5.45|P-value:1.95E-6 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.60|P-value:7.65E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.58|P-value:5.47E-5 ID:SGTC_1296|Compound:1068-0102|FD-Score:3.81|P-value:6.61E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.93|P-value:4.64E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:6.47|P-value:1.94E-8 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:4.12|P-value:2.53E-4 ID:SGTC_1612|Compound:st002233|FD-Score:3.72|P-value:8.60E-4 ID:SGTC_1641|Compound:st009299|FD-Score:6.03|P-value:1.55E-7 ID:SGTC_1687|Compound:st020778|FD-Score:7.65|P-value:3.68E-11 ID:SGTC_1961|Compound:st076550|FD-Score:5.26|P-value:4.25E-6 ID:SGTC_2016|Compound:5121758|FD-Score:-3.74|P-value:5.04E-4 ID:SGTC_2084|Compound:5306078|FD-Score:5.65|P-value:8.10E-7 ID:SGTC_2241|Compound:6772625|FD-Score:9.33|P-value:8.53E-16 ID:SGTC_2868|Compound:9035608|FD-Score:3.70|P-value:9.16E-4 ID:SGTC_2975|Compound:9084847|FD-Score:6.42|P-value:2.44E-8 ID:SGTC_3019|Compound:9081971|FD-Score:4.41|P-value:9.89E-5 ID:SGTC_3031|Compound:9088762|FD-Score:3.87|P-value:5.58E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.72|P-value:8.63E-4 ID:SGTC_3234|Compound:9132280|FD-Score:-3.98|P-value:2.36E-4

Top fitness defect scores for YLR374C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 10.50 40.9 µM 1.52E-19 cell wall 40 4.18E-26
2 SGTC_2241 6772625 9.33 37.8 µM 8.53E-16 2 5.11E-21
3 SGTC_528 3492-0019 9.31 172.0 µM 1.01E-15 calcium & mitochondrial duress 47 6.41E-21
4 SGTC_682 0kpi-0099 9.25 17.0 µM 1.55E-15 10 1.15E-20
5 SGTC_252 miconazole 8.61 1.3 nM 1.09E-13 ergosterol depletion effects on membrane 6 3.71E-18
6 SGTC_841 0251-0215 7.91 91.2 µM 8.35E-12 22 1.33E-15
7 SGTC_1687 st020778 7.65 55.4 µM 3.68E-11 74 1.00E-14
8 SGTC_227 fluconazole 7.01 33.5 µM 1.25E-9 azole & statin 32 1.20E-12
9 SGTC_178 4092-0806 6.57 87.5 µM 1.18E-8 ergosterol depletion effects on membrane 32 2.52E-11
10 SGTC_1495 4469-0029 6.47 237.0 µM 1.94E-8 44 4.94E-11
11 SGTC_2975 9084847 6.42 53.7 µM 2.44E-8 3 6.74E-11
12 SGTC_1641 st009299 6.03 47.1 µM 1.55E-7 mitochondrial processes 1 8.27E-10
13 SGTC_2084 5306078 5.65 60.6 µM 8.10E-7 4 7.80E-9
14 SGTC_666 0272-0154 5.53 136.0 µM 1.35E-6 cell wall 23 1.56E-8
15 SGTC_883 0850-0245 5.45 24.6 µM 1.95E-6 cell wall 9 2.57E-8
16 SGTC_1961 st076550 5.26 68.7 µM 4.25E-6 6 7.38E-8
17 SGTC_354 2783-3500 5.06 4.9 µM 9.00E-6 cell wall 29 2.04E-7
18 SGTC_730 1436-0052 4.78 41.2 µM 2.63E-5 mitochondrial processes 4 8.74E-7
19 SGTC_351 caspofungin 4.70 25.0 nM 3.54E-5 cell wall 64 1.31E-6
20 SGTC_1133 3473-0247 4.58 50.0 µM 5.47E-5 RSC complex & mRNA processing 31 2.36E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.236 1.69E-43 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.230 2.25E-41 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.201 7.29E-32 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.191 8.56E-29 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.184 5.00E-27 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.181 4.26E-26 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.181 4.60E-26 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.175 1.77E-24 YPR070W MED1 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.164 1.61E-21 YML126C ERG13 het 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
0.164 1.74E-21 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.162 3.19E-21 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.159 2.39E-20 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.158 4.42E-20 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.155 1.46E-19 YJL195C_d YJL195C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
0.153 4.70E-19 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions