YLR375W / STP3

Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR375W / STP3

Click on Significant Values for Screen Details ID:SGTC_173|Compound:1273-0061|FD-Score:-3.94|P-value:1.02E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.47|P-value:5.28E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.42|P-value:1.74E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.78|P-value:3.28E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.55|P-value:4.03E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-3.70|P-value:2.38E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.60|P-value:3.45E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.31|P-value:9.50E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.04|P-value:7.33E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.07|P-value:6.61E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.53|P-value:4.55E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.12|P-value:5.09E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.49|P-value:1.24E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.49|P-value:4.95E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.54|P-value:9.90E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.37|P-value:7.39E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.43|P-value:6.38E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.30|P-value:9.36E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.46|P-value:5.75E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.90|P-value:1.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.20|P-value:3.67E-5 ID:SGTC_1612|Compound:st002233|FD-Score:3.50|P-value:5.00E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.39|P-value:1.82E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.29|P-value:9.43E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.12|P-value:7.28E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.94|P-value:1.67E-6 ID:SGTC_1847|Compound:st056231|FD-Score:4.89|P-value:2.15E-6 ID:SGTC_1950|Compound:st077106|FD-Score:3.81|P-value:1.69E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.47|P-value:5.38E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.84|P-value:1.52E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.78|P-value:1.88E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.90|P-value:1.19E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.82|P-value:2.88E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.02|P-value:8.02E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.46|P-value:5.57E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.44|P-value:5.94E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.96|P-value:1.02E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.57|P-value:3.99E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.29|P-value:9.65E-4 ID:SGTC_2881|Compound:9058953|FD-Score:7.70|P-value:2.21E-13 ID:SGTC_2887|Compound:9044784|FD-Score:3.50|P-value:4.98E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.81|P-value:1.70E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.57|P-value:3.80E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.87|P-value:1.39E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.67|P-value:2.82E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-3.99|P-value:8.36E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.94|P-value:1.02E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.47|P-value:5.28E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:5.42|P-value:1.74E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.78|P-value:3.28E-6 ID:SGTC_464|Compound:bw-b 70c|FD-Score:-3.55|P-value:4.03E-4 ID:SGTC_470|Compound:aa-861|FD-Score:-3.70|P-value:2.38E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.60|P-value:3.45E-4 ID:SGTC_480|Compound:am 92016|FD-Score:3.31|P-value:9.50E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.04|P-value:7.33E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.07|P-value:6.61E-5 ID:SGTC_662|Compound:k832-1615|FD-Score:3.53|P-value:4.55E-4 ID:SGTC_683|Compound:panaxydol|FD-Score:-4.12|P-value:5.09E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:5.49|P-value:1.24E-7 ID:SGTC_860|Compound:0443-0016|FD-Score:-3.49|P-value:4.95E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:3.87|P-value:1.37E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:4.54|P-value:9.90E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.37|P-value:7.39E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:5.05|P-value:1.03E-6 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.43|P-value:6.38E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:-3.30|P-value:9.36E-4 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.46|P-value:5.75E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.90|P-value:1.23E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.20|P-value:3.67E-5 ID:SGTC_1612|Compound:st002233|FD-Score:3.50|P-value:5.00E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.39|P-value:1.82E-5 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:-3.29|P-value:9.43E-4 ID:SGTC_1773|Compound:st048542|FD-Score:5.12|P-value:7.28E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.94|P-value:1.67E-6 ID:SGTC_1847|Compound:st056231|FD-Score:4.89|P-value:2.15E-6 ID:SGTC_1950|Compound:st077106|FD-Score:3.81|P-value:1.69E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-3.47|P-value:5.38E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.84|P-value:1.52E-4 ID:SGTC_2253|Compound:7938677|FD-Score:3.78|P-value:1.88E-4 ID:SGTC_2292|Compound:7671323|FD-Score:-3.90|P-value:1.19E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.82|P-value:2.88E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.02|P-value:8.02E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.46|P-value:5.57E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.44|P-value:5.94E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:5.96|P-value:1.02E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.57|P-value:3.99E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.29|P-value:9.65E-4 ID:SGTC_2881|Compound:9058953|FD-Score:7.70|P-value:2.21E-13 ID:SGTC_2887|Compound:9044784|FD-Score:3.50|P-value:4.98E-4 ID:SGTC_2952|Compound:9073731|FD-Score:3.81|P-value:1.70E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.57|P-value:3.80E-4 ID:SGTC_3057|Compound:9095946|FD-Score:3.87|P-value:1.39E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.67|P-value:2.82E-4 ID:SGTC_3340|Compound:9146634|FD-Score:-3.99|P-value:8.36E-5

Top fitness defect scores for YLR375W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2881 9058953 7.70 52.0 µM 2.21E-13 2 6.83E-15
2 SGTC_2607 solasodine 5.96 47.4 µM 1.02E-8 28 1.23E-9
3 SGTC_841 0251-0215 5.49 91.2 µM 1.24E-7 45 2.03E-8
4 SGTC_351 caspofungin 5.42 25.0 nM 1.74E-7 cell wall 47 2.99E-8
5 SGTC_1773 st048542 5.12 73.6 µM 7.28E-7 25 1.49E-7
6 SGTC_1286 0929-0070 5.05 131.0 µM 1.03E-6 9 2.22E-7
7 SGTC_1788 fluconazole 4.94 20.0 µM 1.67E-6 azole & statin 42 3.82E-7
8 SGTC_1847 st056231 4.89 15.0 µM 2.15E-6 16 5.06E-7
9 SGTC_2488 5268135 4.82 45.7 µM 2.88E-6 29 7.02E-7
10 SGTC_1124 fisetin 4.54 1.2 µM 9.90E-6 21 2.81E-6
11 SGTC_1687 st020778 4.39 55.4 µM 1.82E-5 156 5.59E-6
12 SGTC_582 0987-0078 4.07 156.0 µM 6.61E-5 calcium & mitochondrial duress 64 2.38E-5
13 SGTC_528 3492-0019 4.04 172.0 µM 7.33E-5 calcium & mitochondrial duress 215 2.67E-5
14 SGTC_2565 isoliquiritigenin 4.02 100.0 µM 8.02E-5 35 2.96E-5
15 SGTC_1453 4237-0541 3.90 195.0 µM 1.23E-4 heme biosynthesis & mitochondrial translocase 30 4.78E-5
16 SGTC_922 1866-0035 3.87 480.0 µM 1.37E-4 excess fatty acid 62 5.41E-5
17 SGTC_3057 9095946 3.87 49.5 µM 1.39E-4 Golgi 17 5.49E-5
18 SGTC_2165 5727197 3.84 32.1 µM 1.52E-4 34 6.04E-5
19 SGTC_1950 st077106 3.81 7.2 µM 1.69E-4 RNA processing & uracil transport 33 6.84E-5
20 SGTC_2952 9073731 3.81 13.8 µM 1.70E-4 tubulin folding & SWR complex 49 6.86E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 1.09E-30 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.157 6.31E-20 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.135 4.95E-15 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.134 7.86E-15 YDR095C_d YDR095C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.127 1.44E-13 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.122 1.68E-12 YMR063W RIM9 hom Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
0.121 2.23E-12 YGL212W VAM7 hom Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress
0.120 2.85E-12 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.119 5.51E-12 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.118 6.94E-12 YLR374C_d YLR374C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
0.118 7.48E-12 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.117 8.59E-12 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.117 9.26E-12 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.112 7.67E-11 YDR203W_d YDR203W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.111 1.07E-10 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p