YLR379W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR379W / YLR379W

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:3.22|P-value:7.99E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.27|P-value:1.38E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.69|P-value:1.14E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.82|P-value:8.92E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:-5.05|P-value:2.40E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:6.79|P-value:1.14E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:3.17|P-value:9.58E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.27|P-value:1.06E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.59|P-value:1.89E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:5.40|P-value:5.33E-8 ID:SGTC_340|Compound:k038-0059|FD-Score:3.66|P-value:1.63E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:8.10|P-value:6.76E-16 ID:SGTC_635|Compound:k038-0028|FD-Score:4.64|P-value:2.57E-6 ID:SGTC_719|Compound:2810-4230|FD-Score:4.05|P-value:3.53E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.40|P-value:9.95E-11 ID:SGTC_779|Compound:1360-0071|FD-Score:-5.66|P-value:8.78E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.24|P-value:7.60E-4 ID:SGTC_1684|Compound:st024538|FD-Score:4.52|P-value:4.50E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.47|P-value:3.34E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.80|P-value:9.40E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.82|P-value:9.00E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.54|P-value:4.12E-6 ID:SGTC_2052|Compound:5265182|FD-Score:-3.36|P-value:3.90E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.08|P-value:2.99E-7 ID:SGTC_2708|Compound:st078559|FD-Score:-3.41|P-value:3.30E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.19|P-value:8.78E-4 ID:SGTC_3230|Compound:9131665|FD-Score:-3.31|P-value:4.65E-4 ID:SGTC_3302|Compound:9125395|FD-Score:7.51|P-value:6.81E-14 ID:SGTC_3308|Compound:9128332|FD-Score:4.51|P-value:4.76E-6 ID:SGTC_16|Compound:erodoxin|FD-Score:3.22|P-value:7.99E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.27|P-value:1.38E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.69|P-value:1.14E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:3.82|P-value:8.92E-5 ID:SGTC_84|Compound:0443-0269|FD-Score:-5.05|P-value:2.40E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:6.79|P-value:1.14E-11 ID:SGTC_90|Compound:0870-0863|FD-Score:3.17|P-value:9.58E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:5.27|P-value:1.06E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:5.59|P-value:1.89E-8 ID:SGTC_294|Compound:k038-0071|FD-Score:5.40|P-value:5.33E-8 ID:SGTC_340|Compound:k038-0059|FD-Score:3.66|P-value:1.63E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:8.10|P-value:6.76E-16 ID:SGTC_635|Compound:k038-0028|FD-Score:4.64|P-value:2.57E-6 ID:SGTC_719|Compound:2810-4230|FD-Score:4.05|P-value:3.53E-5 ID:SGTC_758|Compound:0868-0029|FD-Score:-6.40|P-value:9.95E-11 ID:SGTC_779|Compound:1360-0071|FD-Score:-5.66|P-value:8.78E-9 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.24|P-value:7.60E-4 ID:SGTC_1684|Compound:st024538|FD-Score:4.52|P-value:4.50E-6 ID:SGTC_1696|Compound:st025591|FD-Score:3.47|P-value:3.34E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.80|P-value:9.40E-5 ID:SGTC_1884|Compound:5633444|FD-Score:3.82|P-value:9.00E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.54|P-value:4.12E-6 ID:SGTC_2052|Compound:5265182|FD-Score:-3.36|P-value:3.90E-4 ID:SGTC_2086|Compound:5274770|FD-Score:3.48|P-value:3.19E-4 ID:SGTC_2301|Compound:7769476|FD-Score:5.08|P-value:2.99E-7 ID:SGTC_2708|Compound:st078559|FD-Score:-3.41|P-value:3.30E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.19|P-value:8.78E-4 ID:SGTC_3230|Compound:9131665|FD-Score:-3.31|P-value:4.65E-4 ID:SGTC_3302|Compound:9125395|FD-Score:7.51|P-value:6.81E-14 ID:SGTC_3308|Compound:9128332|FD-Score:4.51|P-value:4.76E-6

Top fitness defect scores for YLR379W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_367 0335-0881 8.10 7.1 µM 6.76E-16 ubiquinone biosynthesis & proteasome 5 2.65E-16 0.04
2 SGTC_3302 9125395 7.51 16.4 µM 6.81E-14 2 2.99E-14 2.52
3 SGTC_86 0417-1630 6.79 471.9 µM 1.14E-11 ubiquinone biosynthesis & proteasome 8 5.71E-12 0.06
4 SGTC_142 0335-0849 5.59 62.7 µM 1.89E-8 ubiquinone biosynthesis & proteasome 10 1.14E-8 0.01
5 SGTC_294 k038-0071 5.40 157.0 µM 5.33E-8 ubiquinone biosynthesis & proteasome 9 3.30E-8 0.31
6 SGTC_137 0438-0332 5.27 85.4 µM 1.06E-7 ubiquinone biosynthesis & proteasome 24 6.70E-8 0.12
7 SGTC_2301 7769476 5.08 200.0 µM 2.99E-7 6 1.93E-7 0.29
8 SGTC_635 k038-0028 4.64 24.7 µM 2.57E-6 ubiquinone biosynthesis & proteasome 9 1.76E-6 0.01
9 SGTC_2017 5132927 4.54 60.6 µM 4.12E-6 2 2.85E-6 0.02
10 SGTC_1684 st024538 4.52 14.6 µM 4.50E-6 2 3.13E-6 1.07
11 SGTC_3308 9128332 4.51 17.6 µM 4.76E-6 plasma membrane duress 6 3.31E-6 0.03
12 SGTC_36 0335-0881 4.27 14.2 µM 1.38E-5 ubiquinone biosynthesis & proteasome 30 9.89E-6 0.33
13 SGTC_719 2810-4230 4.05 27.3 µM 3.53E-5 1 2.59E-5 0.58
14 SGTC_79 0052-0007 3.82 94.1 µM 8.92E-5 2 6.72E-5 0.34
15 SGTC_1884 5633444 3.82 25.0 µM 9.00E-5 redox potentiating 17 6.78E-5 0.13
16 SGTC_1724 st037281 3.80 8.3 µM 9.40E-5 15 7.09E-5 0.01
17 SGTC_340 k038-0059 3.66 454.0 µM 1.63E-4 ubiquinone biosynthesis & proteasome 10 1.25E-4 0.12
18 SGTC_2086 5274770 3.48 176.6 µM 3.19E-4 15 2.49E-4 0.06
19 SGTC_1696 st025591 3.47 34.8 µM 3.34E-4 SWF1 & branched chain AA biosynthesis 7 2.61E-4 0.16
20 SGTC_1239 0337-0584 3.24 35.4 µM 7.60E-4 unfolded protein response 43 6.08E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.363 4.92E-105 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.360 1.63E-103 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.347 9.43E-96 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.335 4.86E-89 YLR378C SEC61 het Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
0.328 1.03E-84 YDR086C SSS1 het Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
0.275 2.61E-59 YBR275C RIF1 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.275 3.06E-59 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.271 1.11E-57 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.266 1.27E-55 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.254 1.30E-50 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.252 8.75E-50 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.251 1.93E-49 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.250 4.17E-49 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.246 2.93E-47 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.245 3.41E-47 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene