YLR382C / NAM2

Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR382C / NAM2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.15|P-value:6.50E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.82|P-value:1.72E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.42|P-value:6.87E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.56|P-value:9.30E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.44|P-value:1.55E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:3.77|P-value:2.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.45|P-value:8.52E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.89|P-value:1.60E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:5.30|P-value:3.18E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:7.83|P-value:8.72E-14 ID:SGTC_393|Compound:acivicin|FD-Score:-3.65|P-value:2.47E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.36|P-value:6.66E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-12.80|P-value:5.74E-34 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.44|P-value:5.08E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.36|P-value:6.67E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.38|P-value:1.96E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.22|P-value:3.80E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.16|P-value:4.72E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:2.92E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-6.17|P-value:2.32E-9 ID:SGTC_712|Compound:r015-0009|FD-Score:6.00|P-value:8.49E-9 ID:SGTC_748|Compound:0136-0228|FD-Score:3.57|P-value:4.15E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.16|P-value:6.36E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:3.63|P-value:3.36E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.53|P-value:4.75E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.32|P-value:2.51E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.49|P-value:5.43E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.04|P-value:7.62E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.45|P-value:1.14E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.88|P-value:1.69E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-5.32|P-value:2.11E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.72|P-value:4.71E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.27|P-value:3.09E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:6.82|P-value:7.01E-11 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.57|P-value:4.18E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.13|P-value:5.39E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.47|P-value:5.82E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.40|P-value:7.25E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.90|P-value:1.01E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.89|P-value:2.23E-6 ID:SGTC_1774|Compound:st048371|FD-Score:-3.28|P-value:8.64E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.15|P-value:2.50E-9 ID:SGTC_1796|Compound:st049173|FD-Score:4.42|P-value:1.68E-5 ID:SGTC_1850|Compound:st056238|FD-Score:3.57|P-value:4.15E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-4.86|P-value:1.90E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-4.49|P-value:9.41E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.75|P-value:2.20E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.46|P-value:5.99E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.07|P-value:9.75E-7 ID:SGTC_2271|Compound:7849410|FD-Score:-4.11|P-value:4.51E-5 ID:SGTC_2317|Compound:5986382|FD-Score:-4.28|P-value:2.26E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.43|P-value:6.52E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.54|P-value:4.53E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.48|P-value:4.52E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.26|P-value:3.27E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.45|P-value:4.95E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.09|P-value:4.89E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.51|P-value:1.14E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.75|P-value:4.05E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.90|P-value:1.26E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.73|P-value:3.62E-8 ID:SGTC_2849|Compound:9019321|FD-Score:8.43|P-value:1.03E-15 ID:SGTC_2854|Compound:9024559|FD-Score:4.76|P-value:3.91E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-4.94|P-value:1.32E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.56|P-value:3.37E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.43|P-value:6.69E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.15|P-value:6.50E-7 ID:SGTC_41|Compound:0478-0632|FD-Score:3.82|P-value:1.72E-4 ID:SGTC_56|Compound:0957-0365|FD-Score:3.42|P-value:6.87E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.56|P-value:9.30E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.44|P-value:1.55E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:3.77|P-value:2.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:8.45|P-value:8.52E-16 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.89|P-value:1.60E-6 ID:SGTC_365|Compound:0121-0052|FD-Score:5.30|P-value:3.18E-7 ID:SGTC_386|Compound:1509-0011|FD-Score:7.83|P-value:8.72E-14 ID:SGTC_393|Compound:acivicin|FD-Score:-3.65|P-value:2.47E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.36|P-value:6.66E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-12.80|P-value:5.74E-34 ID:SGTC_455|Compound:paf C-16|FD-Score:-3.44|P-value:5.08E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-3.36|P-value:6.67E-4 ID:SGTC_462|Compound:ag-879|FD-Score:4.38|P-value:1.96E-5 ID:SGTC_576|Compound:1073-0113|FD-Score:4.22|P-value:3.80E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.16|P-value:4.72E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.67|P-value:2.92E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-6.17|P-value:2.32E-9 ID:SGTC_712|Compound:r015-0009|FD-Score:6.00|P-value:8.49E-9 ID:SGTC_748|Compound:0136-0228|FD-Score:3.57|P-value:4.15E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:5.16|P-value:6.36E-7 ID:SGTC_824|Compound:1304-0008|FD-Score:3.63|P-value:3.36E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.53|P-value:4.75E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:4.32|P-value:2.51E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.49|P-value:5.43E-4 ID:SGTC_992|Compound:3909-8734|FD-Score:4.04|P-value:7.62E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:-4.45|P-value:1.14E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.88|P-value:1.69E-6 ID:SGTC_1136|Compound:pergolide|FD-Score:-5.32|P-value:2.11E-7 ID:SGTC_1182|Compound:1222-0449|FD-Score:4.72|P-value:4.71E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.27|P-value:3.09E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:6.82|P-value:7.01E-11 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.57|P-value:4.18E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:4.13|P-value:5.39E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.47|P-value:5.82E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.40|P-value:7.25E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.90|P-value:1.01E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.89|P-value:2.23E-6 ID:SGTC_1774|Compound:st048371|FD-Score:-3.28|P-value:8.64E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.15|P-value:2.50E-9 ID:SGTC_1796|Compound:st049173|FD-Score:4.42|P-value:1.68E-5 ID:SGTC_1850|Compound:st056238|FD-Score:3.57|P-value:4.15E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-4.86|P-value:1.90E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-4.49|P-value:9.41E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.75|P-value:2.20E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.46|P-value:5.99E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.07|P-value:9.75E-7 ID:SGTC_2271|Compound:7849410|FD-Score:-4.11|P-value:4.51E-5 ID:SGTC_2317|Compound:5986382|FD-Score:-4.28|P-value:2.26E-5 ID:SGTC_2327|Compound:6189656|FD-Score:3.43|P-value:6.52E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.54|P-value:4.53E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.48|P-value:4.52E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:4.26|P-value:3.27E-5 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.45|P-value:4.95E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:-4.09|P-value:4.89E-5 ID:SGTC_2783|Compound:7738165|FD-Score:4.51|P-value:1.14E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.75|P-value:4.05E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.90|P-value:1.26E-4 ID:SGTC_2802|Compound:7925815|FD-Score:5.73|P-value:3.62E-8 ID:SGTC_2849|Compound:9019321|FD-Score:8.43|P-value:1.03E-15 ID:SGTC_2854|Compound:9024559|FD-Score:4.76|P-value:3.91E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-4.94|P-value:1.32E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.56|P-value:3.37E-4 ID:SGTC_2943|Compound:9068529|FD-Score:3.43|P-value:6.69E-4

Top fitness defect scores for YLR382C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 8.45 5.3 µM 8.52E-16 236 1.41E-17
2 SGTC_2849 9019321 8.43 13.0 µM 1.03E-15 4 1.75E-17
3 SGTC_386 1509-0011 7.83 3.1 µM 8.72E-14 66 2.53E-15
4 SGTC_1249 0481-0015 6.82 10.2 µM 7.01E-11 6 4.59E-12
5 SGTC_712 r015-0009 6.00 80.6 µM 8.49E-9 8 9.95E-10
6 SGTC_2802 7925815 5.73 54.5 µM 3.62E-8 9 5.06E-9
7 SGTC_365 0121-0052 5.30 13.6 µM 3.18E-7 mitochondrial response to ROS 23 5.79E-8
8 SGTC_800 3448-7362 5.16 155.0 µM 6.36E-7 translation 82 1.26E-7
9 SGTC_10 0279-0212 5.15 42.6 µM 6.50E-7 TRP & mitochondrial translation 55 1.29E-7
10 SGTC_2266 7929956 5.07 200.0 µM 9.75E-7 13 2.03E-7
11 SGTC_1742 st038235 4.89 28.9 µM 2.23E-6 mitochondrial stress 82 5.13E-7
12 SGTC_2854 9024559 4.76 71.4 µM 3.91E-6 10 9.66E-7
13 SGTC_2785 7756463 4.75 72.7 µM 4.05E-6 13 1.00E-6
14 SGTC_1182 1222-0449 4.72 220.0 µM 4.71E-6 6 1.19E-6
15 SGTC_70 0141-0289 4.56 43.3 µM 9.30E-6 mitochondrial stress 133 2.55E-6
16 SGTC_2783 7738165 4.51 71.4 µM 1.14E-5 19 3.19E-6
17 SGTC_157 1348-1695 4.44 65.8 µM 1.55E-5 iron homeostasis 46 4.50E-6
18 SGTC_1796 st049173 4.42 110.4 µM 1.68E-5 9 4.95E-6
19 SGTC_462 ag-879 4.38 158.0 µM 1.96E-5 18 5.86E-6
20 SGTC_882 0843-0131 4.32 351.0 µM 2.51E-5 11 7.76E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.303 4.75E-72 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.300 2.93E-70 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.296 1.07E-68 YDR237W MRPL7 hom Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.294 1.43E-67 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.293 2.72E-67 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.293 3.31E-67 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.281 6.11E-62 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.278 1.78E-60 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.277 5.00E-60 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport
0.275 3.04E-59 YMR138W CIN4 hom GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog
0.268 5.31E-56 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.263 6.28E-54 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.263 6.36E-54 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.260 1.40E-52 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.258 6.68E-52 YJR144W MGM101 hom Protein with a role in mitochondrial DNA recombinational repair;also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage