YLR387C / REH1

Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR387C / REH1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.59|P-value:7.45E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:3.40|P-value:7.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.79|P-value:8.87E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.34|P-value:4.55E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.53|P-value:4.62E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.34|P-value:2.12E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.50|P-value:2.65E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.79|P-value:1.80E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.37|P-value:1.91E-5 ID:SGTC_1519|Compound:esterone|FD-Score:4.20|P-value:3.70E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.77|P-value:1.95E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.78|P-value:3.15E-6 ID:SGTC_1674|Compound:st016616|FD-Score:3.31|P-value:9.76E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.32|P-value:9.36E-4 ID:SGTC_1828|Compound:st055811|FD-Score:-3.12|P-value:9.61E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.29|P-value:2.57E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.49|P-value:5.35E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.53|P-value:2.32E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.34|P-value:8.67E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.46|P-value:5.92E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.45|P-value:1.36E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.44|P-value:3.22E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.42|P-value:1.51E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.64|P-value:3.12E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.47|P-value:2.87E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.36|P-value:8.78E-6 ID:SGTC_2891|Compound:9063876|FD-Score:-3.13|P-value:9.22E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-4.40|P-value:7.31E-6 ID:SGTC_3339|Compound:9145883|FD-Score:7.66|P-value:1.45E-13 ID:SGTC_3343|Compound:9148379|FD-Score:3.68|P-value:2.70E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-4.18|P-value:1.88E-5 ID:SGTC_3352|Compound:9151559|FD-Score:-3.98|P-value:4.17E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:4.59|P-value:7.45E-6 ID:SGTC_341|Compound:1486-1430|FD-Score:3.40|P-value:7.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-3.79|P-value:8.87E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:-3.34|P-value:4.55E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:3.53|P-value:4.62E-4 ID:SGTC_645|Compound:0845-0943|FD-Score:4.34|P-value:2.12E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:-3.50|P-value:2.65E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:3.79|P-value:1.80E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.37|P-value:1.91E-5 ID:SGTC_1519|Compound:esterone|FD-Score:4.20|P-value:3.70E-5 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.77|P-value:1.95E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:4.78|P-value:3.15E-6 ID:SGTC_1674|Compound:st016616|FD-Score:3.31|P-value:9.76E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.32|P-value:9.36E-4 ID:SGTC_1828|Compound:st055811|FD-Score:-3.12|P-value:9.61E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.29|P-value:2.57E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.49|P-value:5.35E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.53|P-value:2.32E-4 ID:SGTC_2364|Compound:9055074|FD-Score:3.34|P-value:8.67E-4 ID:SGTC_2393|Compound:9031399|FD-Score:3.46|P-value:5.92E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.45|P-value:1.36E-5 ID:SGTC_2404|Compound:5161160|FD-Score:3.91|P-value:1.16E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.44|P-value:3.22E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.42|P-value:1.51E-5 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.64|P-value:3.12E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-3.47|P-value:2.87E-4 ID:SGTC_2693|Compound:st077581|FD-Score:-4.36|P-value:8.78E-6 ID:SGTC_2891|Compound:9063876|FD-Score:-3.13|P-value:9.22E-4 ID:SGTC_3297|Compound:9117502|FD-Score:-3.19|P-value:7.66E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-4.40|P-value:7.31E-6 ID:SGTC_3339|Compound:9145883|FD-Score:7.66|P-value:1.45E-13 ID:SGTC_3343|Compound:9148379|FD-Score:3.68|P-value:2.70E-4 ID:SGTC_3346|Compound:9158254|FD-Score:-4.18|P-value:1.88E-5 ID:SGTC_3352|Compound:9151559|FD-Score:-3.98|P-value:4.17E-5

Top fitness defect scores for YLR387C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3339 9145883 7.66 14.9 µM 1.45E-13 1 9.03E-15
2 SGTC_1557 sumaresinolic acid 4.78 42.3 µM 3.15E-6 6 8.86E-7
3 SGTC_10 0279-0212 4.59 42.6 µM 7.45E-6 TRP & mitochondrial translation 87 2.27E-6
4 SGTC_2394 5221648 4.45 200.0 µM 1.36E-5 14 4.37E-6
5 SGTC_2409 alverine citrate 4.42 64.0 µM 1.51E-5 41 4.89E-6
6 SGTC_1128 3448-9350 4.37 235.0 µM 1.91E-5 17 6.35E-6
7 SGTC_645 0845-0943 4.34 5.4 µM 2.12E-5 60S ribosome export 4 7.10E-6
8 SGTC_1833 st055984 4.29 71.0 µM 2.57E-5 13 8.79E-6
9 SGTC_1519 esterone 4.20 74.0 µM 3.70E-5 DNA intercalators 15 1.31E-5
10 SGTC_2404 5161160 3.91 200.0 µM 1.16E-4 20 4.58E-5
11 SGTC_924 2046-0044 3.79 21.3 µM 1.80E-4 17 7.40E-5
12 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 3.77 61.9 µM 1.95E-4 21 8.07E-5
13 SGTC_3343 9148379 3.68 19.0 µM 2.70E-4 8 1.15E-4
14 SGTC_2562 3',7'-dimethoxyflavone 3.64 64.9 µM 3.12E-4 44 1.35E-4
15 SGTC_620 0109-0052 3.53 432.0 µM 4.62E-4 30 2.08E-4
16 SGTC_2056 5235370 3.49 200.0 µM 5.35E-4 61 2.44E-4
17 SGTC_2393 9031399 3.46 185.9 µM 5.92E-4 RNA processing & uracil transport 51 2.72E-4
18 SGTC_341 1486-1430 3.40 230.0 µM 7.13E-4 38 3.34E-4
19 SGTC_2364 9055074 3.34 200.0 µM 8.67E-4 35 4.14E-4
20 SGTC_1745 st081495 3.32 74.0 µM 9.36E-4 RNA processing & uracil transport 109 4.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.74E-12 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.106 6.30E-10 YGR066C_p YGR066C_p hom Putative protein of unknown function
0.104 1.45E-9 YNL085W MKT1 hom Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress
0.103 2.24E-9 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.099 9.39E-9 YGL136C MRM2 hom Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ
0.099 1.05E-8 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.097 1.76E-8 YMR040W YET2 hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
0.094 5.32E-8 YPR086W SUA7 het Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II
0.094 5.60E-8 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.093 8.00E-8 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.089 2.41E-7 YLR453C RIF2 hom Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
0.085 7.90E-7 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
0.083 1.53E-6 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.083 1.58E-6 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.082 1.85E-6 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex