Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR387C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.120 | 3.74E-12 | YGL098W | USE1 | het | Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p |
0.106 | 6.30E-10 | YGR066C_p | YGR066C_p | hom | Putative protein of unknown function |
0.104 | 1.45E-9 | YNL085W | MKT1 | hom | Protein that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress |
0.103 | 2.24E-9 | YKR102W | FLO10 | hom | Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth |
0.099 | 9.39E-9 | YGL136C | MRM2 | hom | Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ |
0.099 | 1.05E-8 | YGL097W | SRM1 | het | Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p |
0.097 | 1.76E-8 | YMR040W | YET2 | hom | Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein |
0.094 | 5.32E-8 | YPR086W | SUA7 | het | Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II |
0.094 | 5.60E-8 | YGR110W | CLD1 | hom | Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 |
0.093 | 8.00E-8 | YER121W_p | YER121W_p | hom | Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy |
0.089 | 2.41E-7 | YLR453C | RIF2 | hom | Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation |
0.085 | 7.90E-7 | YPR140W | TAZ1 | hom | Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome |
0.083 | 1.53E-6 | YKR058W | GLG1 | hom | Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication |
0.083 | 1.58E-6 | YGR096W | TPC1 | hom | Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family |
0.082 | 1.85E-6 | YDR101C | ARX1 | hom | Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex |