HIPHOP chemogenomics database

YLR388W / RPS29A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR388W / RPS29A

Click on Significant Values for Screen Details

Top fitness defect scores for YLR388W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2013	4024628	6.72	200.0 µM	1.01E-8		11	9.26E-12
2	SGTC_2802	7925815	6.59	54.5 µM	1.86E-8		4	2.20E-11
3	SGTC_1781	st038725	6.07	66.3 µM	2.03E-7	NEO1	56	6.51E-10
4	SGTC_380	3970-0968	5.73	6.0 µM	8.44E-7		3	4.89E-9
5	SGTC_118	0083-0097	5.54	135.3 µM	1.87E-6	translation	36	1.51E-8
6	SGTC_129	0088-0017	5.51	176.6 µM	2.11E-6		35	1.78E-8
7	SGTC_2754	granisetron	5.46	64.0 µM	2.56E-6		13	2.34E-8
8	SGTC_1637	st007924	5.46	17.4 µM	2.59E-6		6	2.38E-8
9	SGTC_2699	st077704	5.46	54.6 µM	2.64E-6	endomembrane recycling	24	2.44E-8
10	SGTC_1394	3474-0001	5.25	65.7 µM	5.97E-6	endomembrane recycling	18	7.75E-8
11	SGTC_704	1310-0270	4.89	142.0 µM	2.27E-5		17	5.09E-7
12	SGTC_648	0375-0473	4.56	33.3 µM	7.12E-5		10	2.55E-6
13	SGTC_2922	7999257	4.50	32.5 µM	8.69E-5		7	3.38E-6
14	SGTC_1953	st076800	4.47	12.1 µM	9.71E-5		36	3.95E-6
15	SGTC_967	1306-0166	4.43	352.0 µM	1.11E-4		17	4.76E-6
16	SGTC_2785	7756463	4.31	72.7 µM	1.64E-4		20	8.24E-6
17	SGTC_1238	0333-0287	4.30	48.8 µM	1.66E-4	Golgi	17	8.41E-6
18	SGTC_610	4215-0184	4.16	155.0 µM	2.64E-4	exosome	8	1.61E-5
19	SGTC_1571	st070080	4.01	73.4 µM	4.21E-4		15	3.10E-5
20	SGTC_2821	7996764	4.00	71.4 µM	4.31E-4		35	3.20E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.138	1.24E-15	YMR230W	RPS10B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.128	1.11E-13	YDL082W	RPL13A	hom	Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.126	2.48E-13	YJL136C	RPS21B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.104	1.58E-9	YOR293W	RPS10A	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.103	2.30E-9	YBL071C-B_p	YBL071C-B_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.099	9.31E-9	YDR174W	HMO1	hom	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
0.099	1.01E-8	YGR118W	RPS23A	hom	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.097	1.75E-8	YGR081C	SLX9	hom	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
0.094	4.27E-8	YGR162W	TIF4631	hom	Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.094	5.84E-8	YMR302C	YME2	hom	Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
0.091	1.15E-7	YDR101C	ARX1	hom	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.091	1.32E-7	YKL110C	KTI12	hom	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.091	1.40E-7	YBR189W	RPS9B	hom	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.090	1.65E-7	YLR184W_d	YLR184W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087	4.55E-7	YFR032C-B_p	YFR032C-B_p	hom	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching