YLR388W / RPS29A

Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR388W / RPS29A

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.85|P-value:6.61E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.54|P-value:1.87E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.51|P-value:2.11E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.84|P-value:6.84E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:5.73|P-value:8.44E-7 ID:SGTC_533|Compound:1222-0222|FD-Score:-4.59|P-value:5.66E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:-4.98|P-value:1.42E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.16|P-value:2.64E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.56|P-value:7.12E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.89|P-value:2.27E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.71|P-value:9.84E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.95|P-value:5.01E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.43|P-value:1.11E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.72|P-value:9.69E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.30|P-value:1.66E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.84|P-value:6.14E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.25|P-value:5.97E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.90|P-value:5.67E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.01|P-value:4.21E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.79|P-value:7.91E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-4.46|P-value:8.83E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.96|P-value:4.76E-4 ID:SGTC_1637|Compound:st007924|FD-Score:5.46|P-value:2.59E-6 ID:SGTC_1769|Compound:st044406|FD-Score:3.94|P-value:5.15E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.07|P-value:2.03E-7 ID:SGTC_1813|Compound:st051246|FD-Score:-5.50|P-value:1.91E-6 ID:SGTC_1855|Compound:st056195|FD-Score:-6.19|P-value:1.00E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:-5.10|P-value:8.92E-6 ID:SGTC_1953|Compound:st076800|FD-Score:4.47|P-value:9.71E-5 ID:SGTC_2013|Compound:4024628|FD-Score:6.72|P-value:1.01E-8 ID:SGTC_2041|Compound:5107442|FD-Score:-3.76|P-value:7.66E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.72|P-value:9.80E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.07|P-value:3.10E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.87|P-value:6.20E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.99|P-value:4.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.93|P-value:5.21E-4 ID:SGTC_2699|Compound:st077704|FD-Score:5.46|P-value:2.64E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:5.46|P-value:2.56E-6 ID:SGTC_2785|Compound:7756463|FD-Score:4.31|P-value:1.64E-4 ID:SGTC_2802|Compound:7925815|FD-Score:6.59|P-value:1.86E-8 ID:SGTC_2821|Compound:7996764|FD-Score:4.00|P-value:4.31E-4 ID:SGTC_2922|Compound:7999257|FD-Score:4.50|P-value:8.69E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-6.61|P-value:1.43E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.73|P-value:9.28E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.59|P-value:5.68E-5 ID:SGTC_3318|Compound:9139014|FD-Score:3.81|P-value:7.57E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.85|P-value:6.61E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.54|P-value:1.87E-6 ID:SGTC_129|Compound:0088-0017|FD-Score:5.51|P-value:2.11E-6 ID:SGTC_176|Compound:1486-1328|FD-Score:3.84|P-value:6.84E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:5.73|P-value:8.44E-7 ID:SGTC_533|Compound:1222-0222|FD-Score:-4.59|P-value:5.66E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:-4.98|P-value:1.42E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:4.16|P-value:2.64E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.56|P-value:7.12E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.89|P-value:2.27E-5 ID:SGTC_754|Compound:3474-0146|FD-Score:3.71|P-value:9.84E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.95|P-value:5.01E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:4.43|P-value:1.11E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.72|P-value:9.69E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.30|P-value:1.66E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:-3.84|P-value:6.14E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:5.25|P-value:5.97E-6 ID:SGTC_1508|Compound:1080-0625|FD-Score:3.90|P-value:5.67E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.01|P-value:4.21E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.79|P-value:7.91E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-4.46|P-value:8.83E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.96|P-value:4.76E-4 ID:SGTC_1637|Compound:st007924|FD-Score:5.46|P-value:2.59E-6 ID:SGTC_1769|Compound:st044406|FD-Score:3.94|P-value:5.15E-4 ID:SGTC_1781|Compound:st038725|FD-Score:6.07|P-value:2.03E-7 ID:SGTC_1813|Compound:st051246|FD-Score:-5.50|P-value:1.91E-6 ID:SGTC_1855|Compound:st056195|FD-Score:-6.19|P-value:1.00E-7 ID:SGTC_1875|Compound:nocodazole|FD-Score:-5.10|P-value:8.92E-6 ID:SGTC_1953|Compound:st076800|FD-Score:4.47|P-value:9.71E-5 ID:SGTC_2013|Compound:4024628|FD-Score:6.72|P-value:1.01E-8 ID:SGTC_2041|Compound:5107442|FD-Score:-3.76|P-value:7.66E-4 ID:SGTC_2150|Compound:5556613|FD-Score:3.72|P-value:9.80E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.07|P-value:3.10E-4 ID:SGTC_2414|Compound:st077232|FD-Score:3.87|P-value:6.20E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.99|P-value:4.45E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.93|P-value:5.21E-4 ID:SGTC_2699|Compound:st077704|FD-Score:5.46|P-value:2.64E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:5.46|P-value:2.56E-6 ID:SGTC_2785|Compound:7756463|FD-Score:4.31|P-value:1.64E-4 ID:SGTC_2802|Compound:7925815|FD-Score:6.59|P-value:1.86E-8 ID:SGTC_2821|Compound:7996764|FD-Score:4.00|P-value:4.31E-4 ID:SGTC_2922|Compound:7999257|FD-Score:4.50|P-value:8.69E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-6.61|P-value:1.43E-8 ID:SGTC_2936|Compound:9038235|FD-Score:3.73|P-value:9.28E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.59|P-value:5.68E-5 ID:SGTC_3318|Compound:9139014|FD-Score:3.81|P-value:7.57E-4

Top fitness defect scores for YLR388W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2013 4024628 6.72 200.0 µM 1.01E-8 11 9.26E-12
2 SGTC_2802 7925815 6.59 54.5 µM 1.86E-8 4 2.20E-11
3 SGTC_1781 st038725 6.07 66.3 µM 2.03E-7 NEO1 56 6.51E-10
4 SGTC_380 3970-0968 5.73 6.0 µM 8.44E-7 3 4.89E-9
5 SGTC_118 0083-0097 5.54 135.3 µM 1.87E-6 translation 36 1.51E-8
6 SGTC_129 0088-0017 5.51 176.6 µM 2.11E-6 35 1.78E-8
7 SGTC_2754 granisetron 5.46 64.0 µM 2.56E-6 13 2.34E-8
8 SGTC_1637 st007924 5.46 17.4 µM 2.59E-6 6 2.38E-8
9 SGTC_2699 st077704 5.46 54.6 µM 2.64E-6 endomembrane recycling 24 2.44E-8
10 SGTC_1394 3474-0001 5.25 65.7 µM 5.97E-6 endomembrane recycling 18 7.75E-8
11 SGTC_704 1310-0270 4.89 142.0 µM 2.27E-5 17 5.09E-7
12 SGTC_648 0375-0473 4.56 33.3 µM 7.12E-5 10 2.55E-6
13 SGTC_2922 7999257 4.50 32.5 µM 8.69E-5 7 3.38E-6
14 SGTC_1953 st076800 4.47 12.1 µM 9.71E-5 36 3.95E-6
15 SGTC_967 1306-0166 4.43 352.0 µM 1.11E-4 17 4.76E-6
16 SGTC_2785 7756463 4.31 72.7 µM 1.64E-4 20 8.24E-6
17 SGTC_1238 0333-0287 4.30 48.8 µM 1.66E-4 Golgi 17 8.41E-6
18 SGTC_610 4215-0184 4.16 155.0 µM 2.64E-4 exosome 8 1.61E-5
19 SGTC_1571 st070080 4.01 73.4 µM 4.21E-4 15 3.10E-5
20 SGTC_2821 7996764 4.00 71.4 µM 4.31E-4 35 3.20E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.24E-15 YMR230W RPS10B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication
0.128 1.11E-13 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.126 2.48E-13 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.104 1.58E-9 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.103 2.30E-9 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.099 9.31E-9 YDR174W HMO1 hom Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
0.099 1.01E-8 YGR118W RPS23A hom Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal
0.097 1.75E-8 YGR081C SLX9 hom Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
0.094 4.27E-8 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.094 5.84E-8 YMR302C YME2 hom Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases
0.091 1.15E-7 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.091 1.32E-7 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.091 1.40E-7 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.090 1.65E-7 YLR184W_d YLR184W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.087 4.55E-7 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching