YLR389C / STE23

Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR389C / STE23

Click on Significant Values for Screen Details ID:SGTC_68|Compound:0986-0284|FD-Score:3.36|P-value:1.06E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.19|P-value:2.19E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.77|P-value:1.64E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.50|P-value:5.78E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:-5.44|P-value:9.84E-10 ID:SGTC_523|Compound:1934-0222|FD-Score:3.01|P-value:4.52E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.35|P-value:1.12E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.17|P-value:2.13E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.27|P-value:1.54E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.54|P-value:4.76E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.09|P-value:3.22E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.95|P-value:5.58E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.64|P-value:3.02E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.24|P-value:1.74E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.23|P-value:1.60E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.78|P-value:1.59E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:6.86|P-value:1.96E-14 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:2.86|P-value:8.30E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.43|P-value:7.62E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.26|P-value:1.64E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.36|P-value:1.08E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.82|P-value:9.53E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.29|P-value:1.13E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:5.29|P-value:2.86E-9 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.18|P-value:2.29E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.24|P-value:1.77E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:2.81|P-value:9.93E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.61|P-value:3.44E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.19|P-value:2.12E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-2.84|P-value:8.58E-4 ID:SGTC_1908|Compound:st060353|FD-Score:2.84|P-value:8.76E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.07|P-value:3.54E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.24|P-value:1.41E-6 ID:SGTC_2160|Compound:5660466|FD-Score:3.95|P-value:6.59E-6 ID:SGTC_2189|Compound:6047310|FD-Score:-3.06|P-value:3.61E-4 ID:SGTC_2255|Compound:7941087|FD-Score:4.16|P-value:2.34E-6 ID:SGTC_2261|Compound:9010538|FD-Score:-4.37|P-value:7.10E-7 ID:SGTC_2456|Compound:5770359|FD-Score:2.92|P-value:6.62E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.07|P-value:3.66E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-6.27|P-value:2.34E-12 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.06|P-value:3.89E-6 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.60|P-value:3.59E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-3.62|P-value:3.26E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-3.29|P-value:1.38E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.97|P-value:6.17E-6 ID:SGTC_2786|Compound:7743617|FD-Score:3.51|P-value:5.57E-5 ID:SGTC_2797|Compound:7859098|FD-Score:4.21|P-value:1.72E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.19|P-value:2.23E-4 ID:SGTC_3163|Compound:9099914|FD-Score:-2.96|P-value:5.37E-4 ID:SGTC_3184|Compound:9108758|FD-Score:-3.19|P-value:2.16E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-4.14|P-value:2.44E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:3.36|P-value:1.06E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.19|P-value:2.19E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.77|P-value:1.64E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.50|P-value:5.78E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:-5.44|P-value:9.84E-10 ID:SGTC_523|Compound:1934-0222|FD-Score:3.01|P-value:4.52E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.35|P-value:1.12E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.17|P-value:2.13E-6 ID:SGTC_545|Compound:4218-0007|FD-Score:-3.27|P-value:1.54E-4 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.54|P-value:4.76E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.09|P-value:3.22E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:-2.95|P-value:5.58E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:3.64|P-value:3.02E-5 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.24|P-value:1.74E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.23|P-value:1.60E-6 ID:SGTC_939|Compound:1165-0479|FD-Score:3.78|P-value:1.59E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:6.86|P-value:1.96E-14 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:2.86|P-value:8.30E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.30|P-value:1.37E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:-3.43|P-value:7.62E-5 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.26|P-value:1.64E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.36|P-value:1.08E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:2.82|P-value:9.53E-4 ID:SGTC_1475|Compound:4092-1048|FD-Score:4.29|P-value:1.13E-6 ID:SGTC_1489|Compound:4065-0444|FD-Score:5.29|P-value:2.86E-9 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.18|P-value:2.29E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.24|P-value:1.77E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:2.81|P-value:9.93E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.61|P-value:3.44E-5 ID:SGTC_1761|Compound:st044296|FD-Score:-3.19|P-value:2.12E-4 ID:SGTC_1770|Compound:st043884|FD-Score:-2.84|P-value:8.58E-4 ID:SGTC_1908|Compound:st060353|FD-Score:2.84|P-value:8.76E-4 ID:SGTC_2005|Compound:4024620|FD-Score:-3.07|P-value:3.54E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-4.24|P-value:1.41E-6 ID:SGTC_2160|Compound:5660466|FD-Score:3.95|P-value:6.59E-6 ID:SGTC_2189|Compound:6047310|FD-Score:-3.06|P-value:3.61E-4 ID:SGTC_2255|Compound:7941087|FD-Score:4.16|P-value:2.34E-6 ID:SGTC_2261|Compound:9010538|FD-Score:-4.37|P-value:7.10E-7 ID:SGTC_2456|Compound:5770359|FD-Score:2.92|P-value:6.62E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.07|P-value:3.66E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-6.27|P-value:2.34E-12 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:4.06|P-value:3.89E-6 ID:SGTC_2524|Compound:avocatin b|FD-Score:3.60|P-value:3.59E-5 ID:SGTC_2701|Compound:st077767|FD-Score:-3.62|P-value:3.26E-5 ID:SGTC_2712|Compound:st079126|FD-Score:-3.29|P-value:1.38E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.97|P-value:6.17E-6 ID:SGTC_2786|Compound:7743617|FD-Score:3.51|P-value:5.57E-5 ID:SGTC_2797|Compound:7859098|FD-Score:4.21|P-value:1.72E-6 ID:SGTC_2809|Compound:7964133|FD-Score:3.19|P-value:2.23E-4 ID:SGTC_3163|Compound:9099914|FD-Score:-2.96|P-value:5.37E-4 ID:SGTC_3184|Compound:9108758|FD-Score:-3.19|P-value:2.16E-4 ID:SGTC_3317|Compound:9138495|FD-Score:-4.14|P-value:2.44E-6

Top fitness defect scores for YLR389C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1061 3448-9325 6.86 110.0 µM 1.96E-14 2 3.37E-12
2 SGTC_1489 4065-0444 5.29 182.0 µM 2.86E-9 7 6.26E-8
3 SGTC_1475 4092-1048 4.29 11.7 µM 1.13E-6 plasma membrane duress 23 8.88E-6
4 SGTC_916 4466-0038 4.23 42.0 nM 1.60E-6 cell wall 56 1.18E-5
5 SGTC_2797 7859098 4.21 81.8 µM 1.72E-6 25 1.25E-5
6 SGTC_538 2922-0838 4.17 53.3 µM 2.13E-6 Golgi 28 1.50E-5
7 SGTC_2255 7941087 4.16 197.4 µM 2.34E-6 27 1.62E-5
8 SGTC_2519 cryptotanshinone 4.06 88.0 µM 3.89E-6 heme biosynthesis & mitochondrial translocase 11 2.47E-5
9 SGTC_2770 toltrazuril 3.97 17.5 µM 6.17E-6 25 3.63E-5
10 SGTC_2160 5660466 3.95 132.9 µM 6.59E-6 60S ribosome export 14 3.83E-5
11 SGTC_939 1165-0479 3.78 45.3 µM 1.59E-5 33 7.95E-5
12 SGTC_261 5-fluorouridine 3.77 15.4 µM 1.64E-5 exosome 16 8.15E-5
13 SGTC_788 1182-0090 3.64 188.0 µM 3.02E-5 endomembrane recycling 91 1.36E-4
14 SGTC_1720 st037298 3.61 9.5 µM 3.44E-5 44 1.51E-4
15 SGTC_2524 avocatin b 3.60 10.6 µM 3.59E-5 32 1.57E-4
16 SGTC_2786 7743617 3.51 45.5 µM 5.57E-5 44 2.26E-4
17 SGTC_270 tamoxifen 3.50 5.5 µM 5.78E-5 NEO1 52 2.33E-4
18 SGTC_68 0986-0284 3.36 82.8 µM 1.06E-4 101 3.84E-4
19 SGTC_1356 1502-0781 3.36 85.8 µM 1.08E-4 fatty acid desaturase (OLE1) 32 3.91E-4
20 SGTC_535 2293-4129 3.35 48.2 µM 1.12E-4 NEO1 96 4.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 2.88E-12 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.106 8.32E-10 YJL152W_d YJL152W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 1.66E-8 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.092 9.28E-8 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.090 1.55E-7 YKL214C YRA2 hom Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus
0.090 2.00E-7 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.086 6.14E-7 YIL058W_d YIL058W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.085 9.16E-7 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.084 9.50E-7 YIL119C RPI1 hom Transcription factor with allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF
0.083 1.62E-6 YNR075W COS10 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.081 2.39E-6 YJL136W-A_p YJL136W-A_p hom Putative protein of unknown function; identified by SAGE
0.081 2.38E-6 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.081 2.98E-6 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.076 9.59E-6 YDR476C_p YDR476C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
0.075 1.51E-5 YLR212C TUB4 het Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress