YLR392C / ART10

Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR392C / ART10

Click on Significant Values for Screen Details ID:SGTC_179|Compound:1273-0063|FD-Score:4.16|P-value:1.04E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:3.74|P-value:9.81E-6 ID:SGTC_185|Compound:k048-0037|FD-Score:4.34|P-value:3.85E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:2.70|P-value:9.83E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.04|P-value:2.07E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:2.88|P-value:4.93E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:2.86|P-value:5.23E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:5.46|P-value:2.55E-10 ID:SGTC_945|Compound:3381-0768|FD-Score:3.50|P-value:3.17E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:5.69|P-value:4.97E-11 ID:SGTC_964|Compound:1287-0107|FD-Score:2.81|P-value:6.47E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.34|P-value:3.79E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.40|P-value:5.06E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.73|P-value:8.90E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:5.07|P-value:3.95E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.56|P-value:2.42E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.02|P-value:2.73E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.69|P-value:1.27E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.11|P-value:1.85E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.34|P-value:6.85E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:2.88|P-value:4.82E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.29|P-value:8.72E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.51|P-value:3.02E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.33|P-value:9.96E-5 ID:SGTC_1521|Compound:st012942|FD-Score:7.35|P-value:3.63E-17 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:2.93|P-value:4.02E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.27|P-value:9.28E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-4.45|P-value:3.03E-7 ID:SGTC_1752|Compound:st044819|FD-Score:2.85|P-value:5.56E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-2.79|P-value:9.15E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.31|P-value:7.65E-5 ID:SGTC_2090|Compound:5301565|FD-Score:-2.96|P-value:4.72E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.66|P-value:1.48E-5 ID:SGTC_2205|Compound:7238770|FD-Score:2.81|P-value:6.58E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.12|P-value:1.81E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.18|P-value:9.69E-7 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-2.87|P-value:6.76E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:2.92|P-value:4.12E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.92|P-value:1.06E-8 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.60|P-value:2.81E-5 ID:SGTC_2893|Compound:9048488|FD-Score:2.90|P-value:4.55E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.69|P-value:1.28E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.67|P-value:1.43E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.09|P-value:2.78E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:4.16|P-value:1.04E-6 ID:SGTC_180|Compound:1486-1293|FD-Score:3.74|P-value:9.81E-6 ID:SGTC_185|Compound:k048-0037|FD-Score:4.34|P-value:3.85E-7 ID:SGTC_196|Compound:k015-0023|FD-Score:2.70|P-value:9.83E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:4.04|P-value:2.07E-6 ID:SGTC_556|Compound:4058-0063|FD-Score:2.88|P-value:4.93E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:2.86|P-value:5.23E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:5.46|P-value:2.55E-10 ID:SGTC_945|Compound:3381-0768|FD-Score:3.50|P-value:3.17E-5 ID:SGTC_950|Compound:1165-0508|FD-Score:5.69|P-value:4.97E-11 ID:SGTC_964|Compound:1287-0107|FD-Score:2.81|P-value:6.47E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.34|P-value:3.79E-7 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.40|P-value:5.06E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:2.73|P-value:8.90E-4 ID:SGTC_1092|Compound:toremifene|FD-Score:5.07|P-value:3.95E-9 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.56|P-value:2.42E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.02|P-value:2.73E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.69|P-value:1.27E-5 ID:SGTC_1312|Compound:1218-2183|FD-Score:3.11|P-value:1.85E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.34|P-value:6.85E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:2.88|P-value:4.82E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:3.29|P-value:8.72E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.51|P-value:3.02E-5 ID:SGTC_1520|Compound:flindersine|FD-Score:-3.33|P-value:9.96E-5 ID:SGTC_1521|Compound:st012942|FD-Score:7.35|P-value:3.63E-17 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:2.93|P-value:4.02E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:3.27|P-value:9.28E-5 ID:SGTC_1672|Compound:st016598|FD-Score:-4.45|P-value:3.03E-7 ID:SGTC_1752|Compound:st044819|FD-Score:2.85|P-value:5.56E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-2.79|P-value:9.15E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.31|P-value:7.65E-5 ID:SGTC_2090|Compound:5301565|FD-Score:-2.96|P-value:4.72E-4 ID:SGTC_2184|Compound:6075246|FD-Score:3.66|P-value:1.48E-5 ID:SGTC_2205|Compound:7238770|FD-Score:2.81|P-value:6.58E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.12|P-value:1.81E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:4.18|P-value:9.69E-7 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:-2.87|P-value:6.76E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:2.92|P-value:4.12E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:4.92|P-value:1.06E-8 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.60|P-value:2.81E-5 ID:SGTC_2893|Compound:9048488|FD-Score:2.90|P-value:4.55E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.69|P-value:1.28E-5 ID:SGTC_3155|Compound:9099265|FD-Score:3.67|P-value:1.43E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-3.09|P-value:2.78E-4

Top fitness defect scores for YLR392C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1521 st012942 7.35 49.4 µM 3.63E-17 4 1.02E-13
2 SGTC_950 1165-0508 5.69 94.1 µM 4.97E-11 7 6.47E-9
3 SGTC_942 3253-1115 5.46 227.0 µM 2.55E-10 5 2.32E-8
4 SGTC_1092 toremifene 5.07 6.3 µM 3.95E-9 5 1.99E-7
5 SGTC_2638 epoxomicin 4.92 18.0 µM 1.06E-8 13 4.29E-7
6 SGTC_1039 k821-0043 4.34 94.0 µM 3.79E-7 Golgi 17 7.11E-6
7 SGTC_185 k048-0037 4.34 25.5 µM 3.85E-7 RSC & ERG11 6 7.19E-6
8 SGTC_2596 sinensetin 4.18 100.0 µM 9.69E-7 25 1.49E-5
9 SGTC_179 1273-0063 4.16 6.8 µM 1.04E-6 17 1.57E-5
10 SGTC_322 k048-0136 4.04 19.3 µM 2.07E-6 RSC & ERG11 12 2.70E-5
11 SGTC_180 1486-1293 3.74 102.8 µM 9.81E-6 44 9.14E-5
12 SGTC_1227 3909-8010 3.69 46.6 µM 1.27E-5 29 1.12E-4
13 SGTC_3142 9086498 3.69 49.5 µM 1.28E-5 iron homeostasis 45 1.12E-4
14 SGTC_3155 9099265 3.67 49.5 µM 1.43E-5 31 1.23E-4
15 SGTC_2184 6075246 3.66 200.0 µM 1.48E-5 36 1.26E-4
16 SGTC_1206 3978-0017 3.56 132.0 µM 2.42E-5 ERG2 51 1.86E-4
17 SGTC_1519 esterone 3.51 74.0 µM 3.02E-5 DNA intercalators 32 2.21E-4
18 SGTC_945 3381-0768 3.50 11.3 µM 3.17E-5 endomembrane recycling 45 2.30E-4
19 SGTC_1080 nisoldipine 3.40 24.4 µM 5.06E-5 TSC3-RPN4 44 3.32E-4
20 SGTC_1370 2001-0092 3.34 44.6 µM 6.85E-5 63 4.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.23E-15 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.119 3.80E-12 YER128W VFA1 hom Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology
0.102 2.79E-9 YJR109C CPA2 hom Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor
0.101 4.04E-9 YMR194C-A_d YMR194C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 7.25E-9 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.100 7.36E-9 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.099 9.84E-9 YER023W PRO3 het Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
0.093 7.28E-8 YBR269C_p FMP21_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.091 1.36E-7 YGL158W RCK1 hom Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication
0.091 1.38E-7 YKR012C_d YKR012C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
0.091 1.42E-7 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.090 1.68E-7 YDR399W HPT1 hom Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
0.087 3.99E-7 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.086 5.83E-7 YPL235W RVB2 het ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.080 3.14E-6 YDR169C-A_p YDR169C-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR