YLR393W / ATP10

Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR393W / ATP10

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.27|P-value:5.53E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.20|P-value:2.65E-45 ID:SGTC_310|Compound:1273-0058|FD-Score:4.31|P-value:9.15E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.95|P-value:5.31E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:4.91|P-value:5.38E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.18|P-value:1.60E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.11|P-value:9.57E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.29|P-value:6.32E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.56|P-value:1.98E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.40|P-value:3.54E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.35|P-value:7.50E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.44|P-value:3.72E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.30|P-value:9.29E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.68|P-value:1.22E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.61|P-value:1.79E-8 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.87|P-value:5.82E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.37|P-value:4.74E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.47|P-value:2.68E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.26|P-value:5.79E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.10|P-value:2.24E-5 ID:SGTC_1567|Compound:st069303|FD-Score:-3.85|P-value:8.11E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.46|P-value:3.51E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.89|P-value:6.86E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-4.25|P-value:1.49E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.66|P-value:1.91E-11 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.41|P-value:7.45E-6 ID:SGTC_2177|Compound:5811945|FD-Score:4.49|P-value:4.02E-6 ID:SGTC_2399|Compound:5884133|FD-Score:-3.20|P-value:8.72E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-4.29|P-value:1.29E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.05|P-value:3.60E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.45|P-value:3.62E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.17|P-value:9.67E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.38|P-value:4.59E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.30|P-value:6.05E-4 ID:SGTC_2877|Compound:9040724|FD-Score:4.03|P-value:3.08E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.70|P-value:1.44E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-4.57|P-value:3.52E-6 ID:SGTC_3083|Compound:9117465|FD-Score:4.07|P-value:2.52E-5 ID:SGTC_3130|Compound:9127414|FD-Score:-3.56|P-value:2.46E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.92|P-value:4.75E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.60|P-value:3.20E-6 ID:SGTC_118|Compound:0083-0097|FD-Score:3.32|P-value:4.67E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.27|P-value:5.53E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:14.20|P-value:2.65E-45 ID:SGTC_310|Compound:1273-0058|FD-Score:4.31|P-value:9.15E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.95|P-value:5.31E-5 ID:SGTC_549|Compound:1661-1316|FD-Score:4.91|P-value:5.38E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.18|P-value:1.60E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.69|P-value:1.21E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.11|P-value:9.57E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.29|P-value:6.32E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:3.56|P-value:1.98E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.40|P-value:3.54E-4 ID:SGTC_873|Compound:0591-4978|FD-Score:4.35|P-value:7.50E-6 ID:SGTC_923|Compound:1900-2434|FD-Score:-3.44|P-value:3.72E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.30|P-value:9.29E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:3.26|P-value:5.88E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.68|P-value:1.22E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.61|P-value:1.79E-8 ID:SGTC_1182|Compound:1222-0449|FD-Score:3.87|P-value:5.82E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.37|P-value:4.74E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.47|P-value:2.68E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.26|P-value:5.79E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.10|P-value:2.24E-5 ID:SGTC_1567|Compound:st069303|FD-Score:-3.85|P-value:8.11E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:-3.46|P-value:3.51E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.89|P-value:6.86E-5 ID:SGTC_2127|Compound:5253358|FD-Score:-4.25|P-value:1.49E-5 ID:SGTC_2165|Compound:5727197|FD-Score:6.66|P-value:1.91E-11 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-4.41|P-value:7.45E-6 ID:SGTC_2177|Compound:5811945|FD-Score:4.49|P-value:4.02E-6 ID:SGTC_2399|Compound:5884133|FD-Score:-3.20|P-value:8.72E-4 ID:SGTC_2423|Compound:st077119|FD-Score:-4.29|P-value:1.29E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.05|P-value:3.60E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-3.45|P-value:3.62E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.17|P-value:9.67E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.38|P-value:4.59E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.30|P-value:6.05E-4 ID:SGTC_2877|Compound:9040724|FD-Score:4.03|P-value:3.08E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-3.70|P-value:1.44E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-4.57|P-value:3.52E-6 ID:SGTC_3083|Compound:9117465|FD-Score:4.07|P-value:2.52E-5 ID:SGTC_3130|Compound:9127414|FD-Score:-3.56|P-value:2.46E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.92|P-value:4.75E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-4.60|P-value:3.20E-6

Top fitness defect scores for YLR393W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 14.20 5.3 µM 2.65E-45 113 3.61E-46
2 SGTC_2165 5727197 6.66 32.1 µM 1.91E-11 6 1.35E-11
3 SGTC_549 1661-1316 4.91 519.0 µM 5.38E-7 4 4.62E-7
4 SGTC_2177 5811945 4.49 192.0 µM 4.02E-6 18 3.58E-6
5 SGTC_873 0591-4978 4.35 488.0 µM 7.50E-6 12 6.75E-6
6 SGTC_310 1273-0058 4.31 1.1 µM 9.15E-6 mitochondrial stress 223 8.26E-6
7 SGTC_931 2812-0076 4.30 566.0 µM 9.29E-6 15 8.39E-6
8 SGTC_563 tetrahydrosecaminediol 4.18 614.0 µM 1.60E-5 amide catabolism 14 1.46E-5
9 SGTC_1391 3442-0225 4.10 151.0 µM 2.24E-5 13 2.05E-5
10 SGTC_3083 9117465 4.07 49.5 µM 2.52E-5 18 2.32E-5
11 SGTC_2877 9040724 4.03 71.4 µM 3.08E-5 8 2.84E-5
12 SGTC_3135 9127742 3.92 49.5 µM 4.75E-5 23 4.40E-5
13 SGTC_1182 1222-0449 3.87 220.0 µM 5.82E-5 20 5.42E-5
14 SGTC_656 4090-1979 3.69 187.0 µM 1.21E-4 26 1.14E-4
15 SGTC_1100 amiodarone 3.68 5.1 µM 1.22E-4 21 1.15E-4
16 SGTC_827 3253-0474 3.56 693.0 µM 1.98E-4 30 1.87E-4
17 SGTC_1248 0469-0687 3.47 58.6 µM 2.68E-4 48 2.56E-4
18 SGTC_832 4083-0019 3.40 164.0 µM 3.54E-4 translation 141 3.39E-4
19 SGTC_118 0083-0097 3.32 135.3 µM 4.67E-4 translation 217 4.49E-4
20 SGTC_188 3229-0966 3.27 278.5 µM 5.53E-4 61 5.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.380 8.62E-116 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.380 2.03E-115 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.379 7.34E-115 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.360 2.74E-103 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.355 3.81E-100 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.355 5.18E-100 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.355 7.32E-100 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.353 3.09E-99 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.348 4.52E-96 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.348 6.33E-96 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.344 1.45E-93 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.342 5.74E-93 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.342 1.80E-92 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.329 1.12E-85 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
0.327 2.45E-84 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes