YLR395C / COX8

Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR395C / COX8

Click on Significant Values for Screen Details ID:SGTC_260|Compound:nsc-65238|FD-Score:4.49|P-value:1.88E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.48|P-value:6.94E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.84|P-value:2.21E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.80|P-value:2.36E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.51|P-value:6.20E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.78|P-value:2.58E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.66|P-value:3.84E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.66|P-value:4.05E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.97|P-value:2.06E-8 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.51|P-value:6.34E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.62|P-value:1.08E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.39|P-value:9.06E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.49|P-value:6.95E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.72|P-value:3.09E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-4.75|P-value:6.99E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-3.47|P-value:7.62E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.99|P-value:2.25E-6 ID:SGTC_2364|Compound:9055074|FD-Score:5.30|P-value:5.49E-7 ID:SGTC_2367|Compound:9070478|FD-Score:3.46|P-value:7.29E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.38|P-value:9.41E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.49|P-value:1.86E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.55|P-value:5.53E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-19.40|P-value:5.48E-71 ID:SGTC_2694|Compound:st077685|FD-Score:3.68|P-value:3.55E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.77|P-value:2.85E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.96|P-value:1.38E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.70|P-value:3.35E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-4.92|P-value:3.31E-6 ID:SGTC_3072|Compound:9116419|FD-Score:3.38|P-value:9.39E-4 ID:SGTC_260|Compound:nsc-65238|FD-Score:4.49|P-value:1.88E-5 ID:SGTC_311|Compound:1315-0136|FD-Score:3.48|P-value:6.94E-4 ID:SGTC_337|Compound:1315-0038|FD-Score:-3.84|P-value:2.21E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:3.80|P-value:2.36E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.51|P-value:6.20E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:3.78|P-value:2.58E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:3.66|P-value:3.84E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.66|P-value:4.05E-4 ID:SGTC_1187|Compound:1391-0724|FD-Score:5.97|P-value:2.06E-8 ID:SGTC_1203|Compound:3992-3522|FD-Score:3.51|P-value:6.34E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:4.62|P-value:1.08E-5 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.39|P-value:9.06E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.49|P-value:6.95E-4 ID:SGTC_1368|Compound:1852-0141|FD-Score:3.72|P-value:3.09E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-4.75|P-value:6.99E-6 ID:SGTC_1952|Compound:st077036|FD-Score:-3.47|P-value:7.62E-4 ID:SGTC_2359|Compound:9039622|FD-Score:4.99|P-value:2.25E-6 ID:SGTC_2364|Compound:9055074|FD-Score:5.30|P-value:5.49E-7 ID:SGTC_2367|Compound:9070478|FD-Score:3.46|P-value:7.29E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.38|P-value:9.41E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.49|P-value:1.86E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.55|P-value:5.53E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-19.40|P-value:5.48E-71 ID:SGTC_2694|Compound:st077685|FD-Score:3.68|P-value:3.55E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-3.77|P-value:2.85E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.96|P-value:1.38E-4 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.70|P-value:3.35E-4 ID:SGTC_2915|Compound:7971052|FD-Score:-4.92|P-value:3.31E-6 ID:SGTC_3072|Compound:9116419|FD-Score:3.38|P-value:9.39E-4

Top fitness defect scores for YLR395C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1187 1391-0724 5.97 117.0 µM 2.06E-8 amide catabolism 4 1.17E-9
2 SGTC_2364 9055074 5.30 200.0 µM 5.49E-7 7 5.65E-8
3 SGTC_2359 9039622 4.99 200.0 µM 2.25E-6 endomembrane recycling 6 2.98E-7
4 SGTC_1265 0819-1001 4.62 68.8 µM 1.08E-5 10 1.89E-6
5 SGTC_2529 gangaleoidin 4.49 93.6 µM 1.86E-5 10 3.60E-6
6 SGTC_260 nsc-65238 4.49 4.0 µM 1.88E-5 endomembrane recycling 8 3.64E-6
7 SGTC_2833 9001315 3.96 45.5 µM 1.38E-4 amide catabolism 55 3.82E-5
8 SGTC_544 k015-0020 3.80 52.4 µM 2.36E-4 13 7.15E-5
9 SGTC_647 0140-0236 3.78 81.0 µM 2.58E-4 11 7.95E-5
10 SGTC_1368 1852-0141 3.72 284.0 µM 3.09E-4 ERG2 43 9.83E-5
11 SGTC_2901 5-(ethoxymethyl)quinolin-8-ol 3.70 39.7 µM 3.35E-4 4 1.08E-4
12 SGTC_2694 st077685 3.68 81.9 µM 3.55E-4 endomembrane recycling 38 1.15E-4
13 SGTC_792 4534-1957 3.66 155.0 µM 3.84E-4 48 1.27E-4
14 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 3.55 66.7 µM 5.53E-4 40 1.94E-4
15 SGTC_553 k007-0256 3.51 45.7 µM 6.20E-4 heme biosynthesis & mitochondrial translocase 34 2.22E-4
16 SGTC_1203 3992-3522 3.51 103.0 µM 6.34E-4 55 2.28E-4
17 SGTC_311 1315-0136 3.48 58.0 µM 6.94E-4 21 2.53E-4
18 SGTC_2367 9070478 3.46 135.4 µM 7.29E-4 cell wall 57 2.69E-4
19 SGTC_1282 0886-0010 3.39 32.4 µM 9.06E-4 endomembrane recycling 55 3.47E-4
20 SGTC_3072 9116419 3.38 49.5 µM 9.39E-4 ERG2 38 3.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.469 5.02E-183 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.369 5.14E-109 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.333 1.07E-87 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.319 3.68E-80 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.306 1.36E-73 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.293 3.11E-67 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.290 7.54E-66 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.275 2.72E-59 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.274 5.06E-59 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.267 1.17E-55 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.263 4.22E-54 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.260 6.32E-53 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.258 2.53E-52 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.235 2.93E-43 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
0.216 1.42E-36 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34