YLR403W / SFP1

Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR403W / SFP1

Click on Significant Values for Screen Details ID:SGTC_17|Compound:0960-0276|FD-Score:6.06|P-value:5.78E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.22|P-value:7.33E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.04|P-value:1.99E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.20|P-value:6.09E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.12|P-value:1.35E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:5.84|P-value:2.17E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:4.77|P-value:7.87E-7 ID:SGTC_232|Compound:clozapine|FD-Score:3.67|P-value:1.09E-4 ID:SGTC_251|Compound:melphalan|FD-Score:8.12|P-value:1.96E-16 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.24|P-value:9.90E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.26|P-value:4.96E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:5.03|P-value:2.11E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.46|P-value:2.45E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.24|P-value:5.32E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.95|P-value:3.25E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.12|P-value:8.09E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.78|P-value:6.87E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:3.18|P-value:6.70E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.72|P-value:8.85E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:4.41|P-value:4.59E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.40|P-value:3.04E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.47|P-value:3.48E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.70|P-value:5.22E-9 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.23|P-value:5.64E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.28|P-value:5.56E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.29|P-value:1.37E-10 ID:SGTC_1179|Compound:1021-1431|FD-Score:5.02|P-value:2.18E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.88|P-value:1.30E-15 ID:SGTC_1197|Compound:1601-0112|FD-Score:7.62|P-value:1.03E-14 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.97|P-value:3.17E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.73|P-value:8.53E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.16|P-value:7.13E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.00|P-value:2.50E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.29|P-value:7.79E-6 ID:SGTC_1616|Compound:st002734|FD-Score:10.00|P-value:5.30E-24 ID:SGTC_1626|Compound:st003712|FD-Score:-3.61|P-value:1.73E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_1848|Compound:st056003|FD-Score:5.18|P-value:9.58E-8 ID:SGTC_1920|Compound:st075728|FD-Score:5.09|P-value:1.58E-7 ID:SGTC_1964|Compound:st076914|FD-Score:3.35|P-value:3.66E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_1981|Compound:st071826|FD-Score:-3.48|P-value:2.85E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.14|P-value:1.51E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.90|P-value:4.21E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.51|P-value:1.98E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.07|P-value:9.79E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.52|P-value:1.93E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.07|P-value:9.69E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.80|P-value:8.45E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.42|P-value:2.84E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.84|P-value:5.41E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.08|P-value:2.00E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.23|P-value:5.55E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.70|P-value:5.03E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.88|P-value:4.61E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.33|P-value:3.96E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.21|P-value:6.01E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.76|P-value:3.67E-9 ID:SGTC_2785|Compound:7756463|FD-Score:5.43|P-value:2.40E-8 ID:SGTC_2821|Compound:7996764|FD-Score:3.18|P-value:6.63E-4 ID:SGTC_2856|Compound:9022925|FD-Score:4.15|P-value:1.45E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.90|P-value:4.19E-5 ID:SGTC_3048|Compound:9093155|FD-Score:-4.14|P-value:2.04E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.27|P-value:6.16E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-4.18|P-value:1.72E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-5.47|P-value:2.73E-8 ID:SGTC_3202|Compound:9113761|FD-Score:-3.27|P-value:6.15E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.20|P-value:6.23E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.07|P-value:9.76E-4 ID:SGTC_17|Compound:0960-0276|FD-Score:6.06|P-value:5.78E-10 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.22|P-value:7.33E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.04|P-value:1.99E-7 ID:SGTC_121|Compound:0557-0495|FD-Score:3.20|P-value:6.09E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:5.12|P-value:1.35E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:5.84|P-value:2.17E-9 ID:SGTC_210|Compound:3551-0445|FD-Score:4.77|P-value:7.87E-7 ID:SGTC_232|Compound:clozapine|FD-Score:3.67|P-value:1.09E-4 ID:SGTC_251|Compound:melphalan|FD-Score:8.12|P-value:1.96E-16 ID:SGTC_475|Compound:α-linolenic acid|FD-Score:4.24|P-value:9.90E-6 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.55|P-value:1.74E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:3.26|P-value:4.96E-4 ID:SGTC_596|Compound:1155-0152|FD-Score:5.03|P-value:2.11E-7 ID:SGTC_625|Compound:k213-0058|FD-Score:3.46|P-value:2.45E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.24|P-value:5.32E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:4.95|P-value:3.25E-7 ID:SGTC_800|Compound:3448-7362|FD-Score:3.12|P-value:8.09E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:3.78|P-value:6.87E-5 ID:SGTC_835|Compound:0312-0010|FD-Score:3.18|P-value:6.70E-4 ID:SGTC_842|Compound:0271-0008|FD-Score:3.42|P-value:2.86E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.72|P-value:8.85E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:4.41|P-value:4.59E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.40|P-value:3.04E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:4.47|P-value:3.48E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.70|P-value:5.22E-9 ID:SGTC_1039|Compound:k821-0043|FD-Score:3.23|P-value:5.64E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:5.28|P-value:5.56E-8 ID:SGTC_1134|Compound:3477-0009|FD-Score:6.29|P-value:1.37E-10 ID:SGTC_1179|Compound:1021-1431|FD-Score:5.02|P-value:2.18E-7 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.88|P-value:1.30E-15 ID:SGTC_1197|Compound:1601-0112|FD-Score:7.62|P-value:1.03E-14 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.97|P-value:3.17E-5 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.73|P-value:8.53E-5 ID:SGTC_1329|Compound:1447-1697|FD-Score:3.16|P-value:7.13E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:5.00|P-value:2.50E-7 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.29|P-value:7.79E-6 ID:SGTC_1616|Compound:st002734|FD-Score:10.00|P-value:5.30E-24 ID:SGTC_1626|Compound:st003712|FD-Score:-3.61|P-value:1.73E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.58|P-value:1.54E-4 ID:SGTC_1847|Compound:st056231|FD-Score:3.30|P-value:4.30E-4 ID:SGTC_1848|Compound:st056003|FD-Score:5.18|P-value:9.58E-8 ID:SGTC_1920|Compound:st075728|FD-Score:5.09|P-value:1.58E-7 ID:SGTC_1964|Compound:st076914|FD-Score:3.35|P-value:3.66E-4 ID:SGTC_1975|Compound:st070967|FD-Score:4.18|P-value:1.28E-5 ID:SGTC_1981|Compound:st071826|FD-Score:-3.48|P-value:2.85E-4 ID:SGTC_1993|Compound:st073995|FD-Score:4.14|P-value:1.51E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.90|P-value:4.21E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.51|P-value:1.98E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.37|P-value:3.35E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.07|P-value:9.79E-4 ID:SGTC_2205|Compound:7238770|FD-Score:3.52|P-value:1.93E-4 ID:SGTC_2244|Compound:6635614|FD-Score:3.07|P-value:9.69E-4 ID:SGTC_2289|Compound:7946404|FD-Score:-3.80|P-value:8.45E-5 ID:SGTC_2362|Compound:9071156|FD-Score:3.42|P-value:2.84E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.84|P-value:5.41E-5 ID:SGTC_2467|Compound:5474540|FD-Score:3.54|P-value:1.76E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:4.08|P-value:2.00E-5 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.23|P-value:5.55E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:5.70|P-value:5.03E-9 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.88|P-value:4.61E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.33|P-value:3.96E-4 ID:SGTC_2720|Compound:fluspirilene|FD-Score:3.21|P-value:6.01E-4 ID:SGTC_2782|Compound:7736369|FD-Score:5.76|P-value:3.67E-9 ID:SGTC_2785|Compound:7756463|FD-Score:5.43|P-value:2.40E-8 ID:SGTC_2821|Compound:7996764|FD-Score:3.18|P-value:6.63E-4 ID:SGTC_2856|Compound:9022925|FD-Score:4.15|P-value:1.45E-5 ID:SGTC_2933|Compound:9026794|FD-Score:3.90|P-value:4.19E-5 ID:SGTC_3048|Compound:9093155|FD-Score:-4.14|P-value:2.04E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.27|P-value:6.16E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-4.18|P-value:1.72E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-5.47|P-value:2.73E-8 ID:SGTC_3202|Compound:9113761|FD-Score:-3.27|P-value:6.15E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.20|P-value:6.23E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.07|P-value:9.76E-4

Top fitness defect scores for YLR403W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1616 st002734 10.00 56.1 µM 5.30E-24 1 6.72E-24
2 SGTC_251 melphalan 8.12 456.5 µM 1.96E-16 DNA damage response 2 2.41E-16
3 SGTC_1188 1403-0014 7.88 4.6 µM 1.30E-15 mitochondrial stress 4 1.60E-15
4 SGTC_1197 1601-0112 7.62 267.0 µM 1.03E-14 1 1.26E-14
5 SGTC_1134 3477-0009 6.29 42.5 µM 1.37E-10 7 1.63E-10
6 SGTC_17 0960-0276 6.06 49.8 µM 5.78E-10 3 6.83E-10
7 SGTC_176 1486-1328 5.84 72.8 µM 2.17E-9 23 2.56E-9
8 SGTC_2782 7736369 5.76 71.4 µM 3.67E-9 9 4.32E-9
9 SGTC_2539 epi(13)torulosol 5.70 80.0 µM 5.03E-9 5 5.90E-9
10 SGTC_1035 k081-0041 5.70 55.2 µM 5.22E-9 Golgi 6 6.13E-9
11 SGTC_2785 7756463 5.43 72.7 µM 2.40E-8 5 2.80E-8
12 SGTC_1103 duloxetine 5.28 36.1 µM 5.56E-8 4 6.47E-8
13 SGTC_1848 st056003 5.18 16.4 µM 9.58E-8 3 1.11E-7
14 SGTC_166 k072-0058 5.12 166.4 µM 1.35E-7 DNA intercalators 15 1.56E-7
15 SGTC_1920 st075728 5.09 45.7 µM 1.58E-7 3 1.83E-7
16 SGTC_118 0083-0097 5.04 135.3 µM 1.99E-7 translation 56 2.30E-7
17 SGTC_596 1155-0152 5.03 116.0 µM 2.11E-7 TRP & mitochondrial translation 15 2.44E-7
18 SGTC_1179 1021-1431 5.02 9.3 µM 2.18E-7 18 2.52E-7
19 SGTC_1465 k213-0056 5.00 144.0 µM 2.50E-7 DNA intercalators 8 2.89E-7
20 SGTC_787 4152-0075 4.95 138.0 µM 3.25E-7 6 3.75E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.25E-11 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.112 6.52E-11 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.110 1.46E-10 YJR032W CPR7 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
0.109 2.62E-10 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.106 7.35E-10 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.104 1.68E-9 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.100 7.60E-9 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.098 1.46E-8 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.097 1.90E-8 YMR220W ERG8 het Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.097 1.94E-8 YIR007W_p YIR007W_p hom Putative glycosidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
0.093 6.05E-8 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.091 1.19E-7 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.091 1.37E-7 YPL113C_p YPL113C_p hom Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene
0.088 3.17E-7 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.088 3.18E-7 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication