YLR404W / FLD1

Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR404W / FLD1

Click on Significant Values for Screen Details ID:SGTC_299|Compound:1273-0059|FD-Score:5.16|P-value:1.88E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:4.01|P-value:3.87E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:6.36|P-value:1.91E-10 ID:SGTC_338|Compound:4055-0136|FD-Score:5.75|P-value:7.15E-9 ID:SGTC_369|Compound:0957-0393|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:12.40|P-value:1.23E-34 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.54|P-value:2.50E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.24|P-value:6.92E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.62|P-value:2.65E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.59|P-value:2.04E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.49|P-value:2.92E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.26|P-value:1.08E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:3.89|P-value:6.33E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.89|P-value:6.45E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.16|P-value:9.15E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.09|P-value:2.74E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.59|P-value:2.04E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.66|P-value:7.33E-18 ID:SGTC_1610|Compound:st001799|FD-Score:-5.86|P-value:4.08E-9 ID:SGTC_1611|Compound:st001856|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.37|P-value:4.44E-4 ID:SGTC_1624|Compound:st003710|FD-Score:7.58|P-value:4.06E-14 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.27|P-value:1.27E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.20|P-value:4.96E-10 ID:SGTC_1800|Compound:st050079|FD-Score:4.80|P-value:1.13E-6 ID:SGTC_1803|Compound:st050068|FD-Score:7.33|P-value:2.53E-13 ID:SGTC_1826|Compound:st055655|FD-Score:3.37|P-value:4.51E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.17|P-value:9.10E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.31|P-value:5.51E-4 ID:SGTC_1997|Compound:st073024|FD-Score:5.05|P-value:3.30E-7 ID:SGTC_2021|Compound:4019055|FD-Score:4.52|P-value:4.21E-6 ID:SGTC_2034|Compound:5197015|FD-Score:4.40|P-value:7.33E-6 ID:SGTC_2082|Compound:5219693|FD-Score:3.95|P-value:5.02E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.86|P-value:7.17E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.67|P-value:1.48E-4 ID:SGTC_2143|Compound:5623677|FD-Score:4.22|P-value:1.62E-5 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-5.02|P-value:3.87E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.64|P-value:1.67E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.28|P-value:1.24E-5 ID:SGTC_2830|Compound:7992007|FD-Score:4.10|P-value:2.65E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-3.26|P-value:6.62E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.78|P-value:9.70E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.51|P-value:2.73E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.05|P-value:3.36E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-3.92|P-value:5.80E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-3.27|P-value:6.54E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:5.16|P-value:1.88E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:4.01|P-value:3.87E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:6.36|P-value:1.91E-10 ID:SGTC_338|Compound:4055-0136|FD-Score:5.75|P-value:7.15E-9 ID:SGTC_369|Compound:0957-0393|FD-Score:3.77|P-value:1.01E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:12.40|P-value:1.23E-34 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.54|P-value:2.50E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:3.24|P-value:6.92E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.62|P-value:2.65E-6 ID:SGTC_658|Compound:3253-0951|FD-Score:3.59|P-value:2.04E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.49|P-value:2.92E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:5.26|P-value:1.08E-7 ID:SGTC_818|Compound:4072-2707|FD-Score:3.89|P-value:6.33E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:-3.89|P-value:6.45E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:3.16|P-value:9.15E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.09|P-value:2.74E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.59|P-value:2.04E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.62|P-value:1.83E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.53|P-value:2.55E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:8.66|P-value:7.33E-18 ID:SGTC_1610|Compound:st001799|FD-Score:-5.86|P-value:4.08E-9 ID:SGTC_1611|Compound:st001856|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_1615|Compound:st002656|FD-Score:3.37|P-value:4.44E-4 ID:SGTC_1624|Compound:st003710|FD-Score:7.58|P-value:4.06E-14 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.27|P-value:1.27E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.20|P-value:4.96E-10 ID:SGTC_1800|Compound:st050079|FD-Score:4.80|P-value:1.13E-6 ID:SGTC_1803|Compound:st050068|FD-Score:7.33|P-value:2.53E-13 ID:SGTC_1826|Compound:st055655|FD-Score:3.37|P-value:4.51E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.17|P-value:9.10E-4 ID:SGTC_1884|Compound:5633444|FD-Score:3.31|P-value:5.51E-4 ID:SGTC_1997|Compound:st073024|FD-Score:5.05|P-value:3.30E-7 ID:SGTC_2021|Compound:4019055|FD-Score:4.52|P-value:4.21E-6 ID:SGTC_2034|Compound:5197015|FD-Score:4.40|P-value:7.33E-6 ID:SGTC_2082|Compound:5219693|FD-Score:3.95|P-value:5.02E-5 ID:SGTC_2122|Compound:5258151|FD-Score:3.86|P-value:7.17E-5 ID:SGTC_2133|Compound:5320837|FD-Score:3.67|P-value:1.48E-4 ID:SGTC_2143|Compound:5623677|FD-Score:4.22|P-value:1.62E-5 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.45|P-value:3.42E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-5.02|P-value:3.87E-7 ID:SGTC_2753|Compound:fluvastatin|FD-Score:-3.64|P-value:1.67E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:-4.28|P-value:1.24E-5 ID:SGTC_2830|Compound:7992007|FD-Score:4.10|P-value:2.65E-5 ID:SGTC_2840|Compound:9008771|FD-Score:-3.26|P-value:6.62E-4 ID:SGTC_2896|Compound:9052656|FD-Score:3.78|P-value:9.70E-5 ID:SGTC_3000|Compound:9075062|FD-Score:3.51|P-value:2.73E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-4.05|P-value:3.36E-5 ID:SGTC_3236|Compound:9132701|FD-Score:-3.92|P-value:5.80E-5 ID:SGTC_3270|Compound:9137563|FD-Score:-3.27|P-value:6.54E-4

Top fitness defect scores for YLR404W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_528 3492-0019 12.40 172.0 µM 1.23E-34 calcium & mitochondrial duress 28 1.23E-35
2 SGTC_1597 7-benzyloxygramine 8.66 47.5 µM 7.33E-18 calcium & mitochondrial duress 22 2.38E-18
3 SGTC_1624 st003710 7.58 6.2 µM 4.06E-14 calcium & mitochondrial duress 8 1.71E-14
4 SGTC_1803 st050068 7.33 52.4 µM 2.53E-13 NEO1-PIK1 50 1.13E-13
5 SGTC_310 1273-0058 6.36 1.1 µM 1.91E-10 mitochondrial stress 135 1.04E-10
6 SGTC_1754 st042065 6.20 16.1 µM 4.96E-10 NEO1-PIK1 94 2.78E-10
7 SGTC_338 4055-0136 5.75 114.0 µM 7.15E-9 1 4.34E-9
8 SGTC_788 1182-0090 5.26 188.0 µM 1.08E-7 endomembrane recycling 48 7.13E-8
9 SGTC_299 1273-0059 5.16 1.4 µM 1.88E-7 11 1.26E-7
10 SGTC_1997 st073024 5.05 93.8 µM 3.30E-7 2 2.25E-7
11 SGTC_1800 st050079 4.80 29.1 µM 1.13E-6 NEO1-PIK1 84 8.00E-7
12 SGTC_649 1123-0311 4.62 367.0 µM 2.65E-6 endomembrane recycling 45 1.92E-6
13 SGTC_2021 4019055 4.52 173.0 µM 4.21E-6 endomembrane recycling 93 3.09E-6
14 SGTC_2034 5197015 4.40 53.1 µM 7.33E-6 SWF1 & branched chain AA biosynthesis 15 5.47E-6
15 SGTC_1679 4130-1276 4.27 6.7 µM 1.27E-5 Golgi 52 9.59E-6
16 SGTC_2143 5623677 4.22 140.5 µM 1.62E-5 3 1.24E-5
17 SGTC_2830 7992007 4.10 71.4 µM 2.65E-5 18 2.05E-5
18 SGTC_1130 3454-2858 4.09 15.9 µM 2.74E-5 NEO1 82 2.12E-5
19 SGTC_308 4092-1169 4.01 104.0 µM 3.87E-5 plasma membrane duress 50 3.03E-5
20 SGTC_2082 5219693 3.95 150.0 µM 5.02E-5 RNA processing & uracil transport 28 3.96E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.362 2.79E-104 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.278 1.95E-60 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.268 2.13E-56 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.264 1.74E-54 YOR086C TCB1 hom Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains three calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact
0.242 5.83E-46 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.241 1.54E-45 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.238 2.80E-44 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.235 1.90E-43 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.228 5.80E-41 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.228 7.68E-41 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.219 8.15E-38 YIL105C SLM1 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication
0.213 8.07E-36 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 4.46E-35 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.210 8.04E-35 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
0.206 1.84E-33 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication