YLR406C / RPL31B

Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR406C / RPL31B

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-4.02|P-value:2.27E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.68|P-value:7.09E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.43|P-value:6.09E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.57|P-value:9.18E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:7.02|P-value:5.41E-10 ID:SGTC_150|Compound:3970-0969|FD-Score:4.44|P-value:5.84E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:3.85E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.36|P-value:1.49E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:8.95|P-value:3.76E-15 ID:SGTC_611|Compound:3453-1652|FD-Score:5.14|P-value:4.12E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:3.82|P-value:4.61E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.70|P-value:6.76E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:5.70|P-value:3.70E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:4.58|P-value:3.53E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.55|P-value:9.74E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:5.03|P-value:6.30E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.41|P-value:6.50E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.98|P-value:2.73E-4 ID:SGTC_2019|Compound:4016004|FD-Score:5.17|P-value:3.60E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-7.07|P-value:3.62E-10 ID:SGTC_2136|Compound:5328288|FD-Score:12.40|P-value:2.77E-27 ID:SGTC_2147|Compound:5545932|FD-Score:4.74|P-value:1.95E-5 ID:SGTC_2267|Compound:7931562|FD-Score:4.70|P-value:2.28E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.62|P-value:7.84E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.92|P-value:3.35E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.58|P-value:3.52E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.00|P-value:2.59E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.88|P-value:3.51E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.03|P-value:2.19E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-7.44|P-value:4.43E-11 ID:SGTC_2700|Compound:st077718|FD-Score:4.43|P-value:6.02E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.63|P-value:7.66E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-4.02|P-value:2.27E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.68|P-value:7.09E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.43|P-value:6.09E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.57|P-value:9.18E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:7.02|P-value:5.41E-10 ID:SGTC_150|Compound:3970-0969|FD-Score:4.44|P-value:5.84E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.85|P-value:3.85E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-5.36|P-value:1.49E-6 ID:SGTC_517|Compound:1365-0151|FD-Score:8.95|P-value:3.76E-15 ID:SGTC_611|Compound:3453-1652|FD-Score:5.14|P-value:4.12E-6 ID:SGTC_782|Compound:0083-0095|FD-Score:3.82|P-value:4.61E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.70|P-value:6.76E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:5.70|P-value:3.70E-7 ID:SGTC_975|Compound:1335-0046|FD-Score:4.58|P-value:3.53E-5 ID:SGTC_1012|Compound:4112-3522|FD-Score:-3.55|P-value:9.74E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:5.03|P-value:6.30E-6 ID:SGTC_1479|Compound:0549-0158|FD-Score:4.41|P-value:6.50E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.98|P-value:2.73E-4 ID:SGTC_2019|Compound:4016004|FD-Score:5.17|P-value:3.60E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-7.07|P-value:3.62E-10 ID:SGTC_2136|Compound:5328288|FD-Score:12.40|P-value:2.77E-27 ID:SGTC_2147|Compound:5545932|FD-Score:4.74|P-value:1.95E-5 ID:SGTC_2267|Compound:7931562|FD-Score:4.70|P-value:2.28E-5 ID:SGTC_2366|Compound:9070441|FD-Score:-3.62|P-value:7.84E-4 ID:SGTC_2472|Compound:5377652|FD-Score:3.92|P-value:3.35E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:4.58|P-value:3.52E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.00|P-value:2.59E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.88|P-value:3.51E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:-4.03|P-value:2.19E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-7.44|P-value:4.43E-11 ID:SGTC_2700|Compound:st077718|FD-Score:4.43|P-value:6.02E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-3.63|P-value:7.66E-4

Top fitness defect scores for YLR406C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2136 5328288 12.40 199.3 µM 2.77E-27 1 1.84E-35
2 SGTC_517 1365-0151 8.95 113.0 µM 3.76E-15 2 1.82E-19
3 SGTC_147 4466-0538 7.02 29.2 µM 5.41E-10 ergosterol biosynthesis 2 1.12E-12
4 SGTC_965 1291-5240 5.70 308.0 µM 3.70E-7 8 5.95E-9
5 SGTC_2019 4016004 5.17 108.0 µM 3.60E-6 3 1.17E-7
6 SGTC_611 3453-1652 5.14 23.7 µM 4.12E-6 6 1.40E-7
7 SGTC_1064 honokiol 5.03 6.8 µM 6.30E-6 9 2.44E-7
8 SGTC_2147 5545932 4.74 89.7 µM 1.95E-5 ergosterol biosynthesis 7 1.07E-6
9 SGTC_2267 7931562 4.70 200.0 µM 2.28E-5 7 1.32E-6
10 SGTC_2566 crystal violet carbinol 4.58 226.0 nM 3.52E-5 25 2.32E-6
11 SGTC_975 1335-0046 4.58 28.5 µM 3.53E-5 RPP1 & pyrimidine depletion 17 2.33E-6
12 SGTC_150 3970-0969 4.44 77.2 µM 5.84E-5 47 4.50E-6
13 SGTC_2700 st077718 4.43 96.8 µM 6.02E-5 9 4.69E-6
14 SGTC_118 0083-0097 4.43 135.3 µM 6.09E-5 translation 90 4.75E-6
15 SGTC_1479 0549-0158 4.41 134.0 µM 6.50E-5 12 5.17E-6
16 SGTC_2575 plumbagin 4.00 510.0 nM 2.59E-4 superoxide 39 3.15E-5
17 SGTC_1504 k297-0033 3.98 30.0 µM 2.73E-4 11 3.37E-5
18 SGTC_2472 5377652 3.92 49.4 µM 3.35E-4 TRP & mitochondrial translation 58 4.40E-5
19 SGTC_782 0083-0095 3.82 30.5 µM 4.61E-4 32 6.68E-5
20 SGTC_954 1189-0853 3.70 2.9 µM 6.76E-4 endomembrane recycling 44 1.10E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.08E-12 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.110 1.48E-10 YMR117C SPC24 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
0.109 2.52E-10 YKL156W RPS27A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.096 2.93E-8 YHR136C SPL2 hom Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm
0.091 1.24E-7 YGL227W VID30 hom Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm
0.091 1.34E-7 YOR355W GDS1 hom Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.086 5.52E-7 YLR029C RPL15A het Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
0.085 7.75E-7 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.083 1.34E-6 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.082 1.85E-6 YOL039W RPP2A hom Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.082 1.97E-6 YOR073W SGO1 hom Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability
0.080 3.28E-6 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.080 3.35E-6 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.080 3.61E-6 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.079 4.53E-6 YOR234C RPL33B hom Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication