YLR406C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR406C-A / YLR406C-A

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-4.05|P-value:3.79E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.69|P-value:2.36E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:4.78|P-value:1.42E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.83|P-value:1.10E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.96|P-value:5.93E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.35|P-value:5.42E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.37|P-value:4.81E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.29|P-value:6.67E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:6.90|P-value:7.31E-12 ID:SGTC_787|Compound:4152-0075|FD-Score:4.84|P-value:1.07E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.38|P-value:9.35E-6 ID:SGTC_880|Compound:0833-0487|FD-Score:3.21|P-value:8.12E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.13|P-value:2.80E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.45|P-value:3.65E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.36|P-value:4.97E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:5.03|P-value:4.25E-7 ID:SGTC_1922|Compound:5578187|FD-Score:3.80|P-value:9.64E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.23|P-value:7.79E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-8.17|P-value:6.98E-16 ID:SGTC_2176|Compound:5809774|FD-Score:-4.29|P-value:1.41E-5 ID:SGTC_2186|Compound:6124449|FD-Score:-3.93|P-value:6.38E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.32|P-value:5.65E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.80|P-value:9.81E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-3.82|P-value:9.73E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.13|P-value:2.75E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.36|P-value:4.94E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.96|P-value:5.22E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:4.77|P-value:1.49E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.82|P-value:6.06E-9 ID:SGTC_2623|Compound:humulene|FD-Score:3.62|P-value:1.92E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.99|P-value:2.30E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.20|P-value:8.49E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.21|P-value:8.60E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.29|P-value:1.32E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.42|P-value:4.19E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.52|P-value:3.01E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.36|P-value:5.30E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.97|P-value:5.05E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-3.17|P-value:9.89E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.39|P-value:4.48E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.05|P-value:3.79E-5 ID:SGTC_74|Compound:000s-0487|FD-Score:-4.69|P-value:2.36E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:4.78|P-value:1.42E-6 ID:SGTC_153|Compound:4077-0274|FD-Score:3.65|P-value:1.75E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:4.83|P-value:1.10E-6 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.96|P-value:5.93E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.35|P-value:5.42E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.51|P-value:2.87E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:3.37|P-value:4.81E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:-3.29|P-value:6.67E-4 ID:SGTC_776|Compound:4476-4378|FD-Score:6.90|P-value:7.31E-12 ID:SGTC_787|Compound:4152-0075|FD-Score:4.84|P-value:1.07E-6 ID:SGTC_790|Compound:1575-0012|FD-Score:-4.38|P-value:9.35E-6 ID:SGTC_880|Compound:0833-0487|FD-Score:3.21|P-value:8.12E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.13|P-value:2.80E-5 ID:SGTC_1068|Compound:loratadine|FD-Score:3.45|P-value:3.65E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.64|P-value:1.81E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.36|P-value:4.97E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:5.03|P-value:4.25E-7 ID:SGTC_1922|Compound:5578187|FD-Score:3.80|P-value:9.64E-5 ID:SGTC_1999|Compound:st074831|FD-Score:3.23|P-value:7.79E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-8.17|P-value:6.98E-16 ID:SGTC_2176|Compound:5809774|FD-Score:-4.29|P-value:1.41E-5 ID:SGTC_2186|Compound:6124449|FD-Score:-3.93|P-value:6.38E-5 ID:SGTC_2294|Compound:7971431|FD-Score:3.32|P-value:5.65E-4 ID:SGTC_2394|Compound:5221648|FD-Score:3.80|P-value:9.81E-5 ID:SGTC_2447|Compound:5741742|FD-Score:-3.82|P-value:9.73E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-4.13|P-value:2.75E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:3.36|P-value:4.94E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.96|P-value:5.22E-5 ID:SGTC_2606|Compound:farnesol|FD-Score:4.77|P-value:1.49E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:5.82|P-value:6.06E-9 ID:SGTC_2623|Compound:humulene|FD-Score:3.62|P-value:1.92E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:5.99|P-value:2.30E-9 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:3.20|P-value:8.49E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.21|P-value:8.60E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.29|P-value:1.32E-5 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.42|P-value:4.19E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:-3.52|P-value:3.01E-4 ID:SGTC_2969|Compound:9091408|FD-Score:-3.36|P-value:5.30E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.97|P-value:5.05E-5 ID:SGTC_3052|Compound:9092717|FD-Score:-3.17|P-value:9.89E-4 ID:SGTC_3228|Compound:9131799|FD-Score:3.39|P-value:4.48E-4

Top fitness defect scores for YLR406C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_776 4476-4378 6.90 112.0 µM 7.31E-12 ERG2 4 2.66E-12
2 SGTC_2635 hydroquinidine 5.99 100.0 µM 2.30E-9 3 1.08E-9
3 SGTC_2610 ononetin 5.82 44.2 µM 6.06E-9 8 2.96E-9
4 SGTC_1331 1472-0049 5.03 76.2 µM 4.25E-7 3 2.49E-7
5 SGTC_400 oxethazaine 4.96 37.5 µM 5.93E-7 calcium & mitochondrial duress 10 3.52E-7
6 SGTC_787 4152-0075 4.84 138.0 µM 1.07E-6 8 6.52E-7
7 SGTC_169 k015-0017 4.83 16.0 µM 1.10E-6 11 6.72E-7
8 SGTC_78 0336-0123 4.78 156.8 µM 1.42E-6 13 8.76E-7
9 SGTC_2606 farnesol 4.77 9.8 µM 1.49E-6 10 9.18E-7
10 SGTC_2757 clomiphene 4.29 4.2 µM 1.32E-5 fatty acid desaturase (OLE1) 28 8.98E-6
11 SGTC_2987 9018338 3.97 71.4 µM 5.05E-5 RPP1 & pyrimidine depletion 17 3.62E-5
12 SGTC_2604 4'-hydroxychalcone 3.96 11.3 µM 5.22E-5 37 3.74E-5
13 SGTC_1922 5578187 3.80 25.0 µM 9.64E-5 TRP & mitochondrial translation 39 7.09E-5
14 SGTC_2394 5221648 3.80 200.0 µM 9.81E-5 28 7.23E-5
15 SGTC_153 4077-0274 3.65 519.7 µM 1.75E-4 21 1.32E-4
16 SGTC_1178 0988-0033 3.64 191.0 µM 1.81E-4 38 1.37E-4
17 SGTC_2623 humulene 3.62 100.0 µM 1.92E-4 29 1.46E-4
18 SGTC_566 0958-0068 3.51 16.5 µM 2.87E-4 RSC & ERG11 29 2.21E-4
19 SGTC_1068 loratadine 3.45 26.9 µM 3.65E-4 45 2.84E-4
20 SGTC_3228 9131799 3.39 49.5 µM 4.48E-4 amide catabolism 18 3.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.84E-17 YAL066W_d YAL066W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.139 5.78E-16 YHR148W IMP3 het Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.139 7.09E-16 YGL152C_d YGL152C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.126 2.62E-13 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.113 4.69E-11 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.111 1.17E-10 YGL257C MNT2 hom Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.111 1.35E-10 YDL239C ADY3 hom Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.103 1.99E-9 YGL149W_d YGL149W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.100 5.92E-9 YKL164C PIR1 hom O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.091 1.24E-7 YGR286C BIO2 hom Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
0.089 2.36E-7 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.089 2.80E-7 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.088 3.10E-7 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.086 7.04E-7 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.081 2.50E-6 YOL115W PAP2 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p