HIPHOP chemogenomics database

YLR406C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR406C-A / YLR406C-A

Click on Significant Values for Screen Details

Top fitness defect scores for YLR406C-A deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_776	4476-4378	6.90	112.0 µM	7.31E-12	ERG2	4	2.66E-12
2	SGTC_2635	hydroquinidine	5.99	100.0 µM	2.30E-9		3	1.08E-9
3	SGTC_2610	ononetin	5.82	44.2 µM	6.06E-9		8	2.96E-9
4	SGTC_1331	1472-0049	5.03	76.2 µM	4.25E-7		3	2.49E-7
5	SGTC_400	oxethazaine	4.96	37.5 µM	5.93E-7	calcium & mitochondrial duress	10	3.52E-7
6	SGTC_787	4152-0075	4.84	138.0 µM	1.07E-6		8	6.52E-7
7	SGTC_169	k015-0017	4.83	16.0 µM	1.10E-6		11	6.72E-7
8	SGTC_78	0336-0123	4.78	156.8 µM	1.42E-6		13	8.76E-7
9	SGTC_2606	farnesol	4.77	9.8 µM	1.49E-6		10	9.18E-7
10	SGTC_2757	clomiphene	4.29	4.2 µM	1.32E-5	fatty acid desaturase (OLE1)	28	8.98E-6
11	SGTC_2987	9018338	3.97	71.4 µM	5.05E-5	RPP1 & pyrimidine depletion	17	3.62E-5
12	SGTC_2604	4'-hydroxychalcone	3.96	11.3 µM	5.22E-5		37	3.74E-5
13	SGTC_1922	5578187	3.80	25.0 µM	9.64E-5	TRP & mitochondrial translation	39	7.09E-5
14	SGTC_2394	5221648	3.80	200.0 µM	9.81E-5		28	7.23E-5
15	SGTC_153	4077-0274	3.65	519.7 µM	1.75E-4		21	1.32E-4
16	SGTC_1178	0988-0033	3.64	191.0 µM	1.81E-4		38	1.37E-4
17	SGTC_2623	humulene	3.62	100.0 µM	1.92E-4		29	1.46E-4
18	SGTC_566	0958-0068	3.51	16.5 µM	2.87E-4	RSC & ERG11	29	2.21E-4
19	SGTC_1068	loratadine	3.45	26.9 µM	3.65E-4		45	2.84E-4
20	SGTC_3228	9131799	3.39	49.5 µM	4.48E-4	amide catabolism	18	3.51E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.145	3.84E-17	YAL066W_d	YAL066W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.139	5.78E-16	YHR148W	IMP3	het	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
0.139	7.09E-16	YGL152C_d	YGL152C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W
0.126	2.62E-13	YMR034C_p	YMR034C_p	hom	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.113	4.69E-11	YPL249C	GYP5	hom	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.111	1.17E-10	YGL257C	MNT2	hom	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
0.111	1.35E-10	YDL239C	ADY3	hom	Protein required for spore wall formation; thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication
0.103	1.99E-9	YGL149W_d	YGL149W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
0.100	5.92E-9	YKL164C	PIR1	hom	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication
0.091	1.24E-7	YGR286C	BIO2	hom	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
0.089	2.36E-7	YGR097W	ASK10	hom	Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.089	2.80E-7	YLR237W	THI7	hom	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.088	3.10E-7	YGL156W	AMS1	hom	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.086	7.04E-7	YPR137W	RRP9	het	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.081	2.50E-6	YOL115W	PAP2	hom	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p