YLR407W_p

Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR407W / YLR407W

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:-3.41|P-value:3.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.38|P-value:7.56E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:9.09|P-value:4.76E-20 ID:SGTC_133|Compound:0724-0033|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.29|P-value:4.71E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.24|P-value:5.54E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.18|P-value:7.46E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.17|P-value:7.75E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.23|P-value:8.62E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.63|P-value:1.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.27|P-value:9.94E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.76|P-value:9.57E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.98|P-value:3.24E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.75|P-value:8.37E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.13|P-value:8.33E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.74|P-value:1.06E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:3.16|P-value:7.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.89|P-value:4.48E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-7.89|P-value:1.25E-15 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.02|P-value:2.33E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.12|P-value:2.25E-16 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.77|P-value:7.73E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.82|P-value:6.68E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.52|P-value:1.99E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.19|P-value:7.33E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.58|P-value:1.77E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.50|P-value:2.35E-4 ID:SGTC_1658|Compound:st012944|FD-Score:6.71|P-value:9.84E-12 ID:SGTC_1742|Compound:st038235|FD-Score:5.48|P-value:2.12E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-4.49|P-value:3.25E-6 ID:SGTC_1750|Compound:st081859|FD-Score:8.35|P-value:3.37E-17 ID:SGTC_1818|Compound:st052136|FD-Score:-3.31|P-value:4.36E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.67|P-value:1.21E-4 ID:SGTC_1913|Compound:st060213|FD-Score:7.72|P-value:5.73E-15 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:5.56|P-value:1.38E-8 ID:SGTC_2016|Compound:5121758|FD-Score:-3.33|P-value:4.13E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.19|P-value:1.42E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.13|P-value:8.29E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.35|P-value:3.85E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.12|P-value:9.19E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.41|P-value:3.36E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.39|P-value:3.52E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.47|P-value:3.97E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.13|P-value:8.20E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.28|P-value:5.22E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.64|P-value:1.40E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.45|P-value:2.61E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_2386|Compound:9075165|FD-Score:5.36|P-value:4.23E-8 ID:SGTC_2389|Compound:9091542|FD-Score:-3.81|P-value:6.51E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-3.25|P-value:5.50E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:5.08|P-value:1.90E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.33|P-value:5.05E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.68|P-value:1.15E-11 ID:SGTC_2934|Compound:9036370|FD-Score:3.31|P-value:4.77E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.12|P-value:9.27E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.57|P-value:1.80E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.99|P-value:3.36E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.58|P-value:1.78E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.14|P-value:8.51E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:-3.41|P-value:3.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:7.38|P-value:7.56E-14 ID:SGTC_103|Compound:0844-0104|FD-Score:9.09|P-value:4.76E-20 ID:SGTC_133|Compound:0724-0033|FD-Score:3.76|P-value:8.80E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.29|P-value:4.71E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.24|P-value:5.54E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.18|P-value:7.46E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.17|P-value:7.75E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:5.23|P-value:8.62E-8 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.63|P-value:1.32E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.27|P-value:9.94E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:4.76|P-value:9.57E-7 ID:SGTC_730|Compound:1436-0052|FD-Score:-3.98|P-value:3.24E-5 ID:SGTC_731|Compound:3966-0296|FD-Score:-3.75|P-value:8.37E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.13|P-value:8.33E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:4.74|P-value:1.06E-6 ID:SGTC_1070|Compound:indatraline|FD-Score:3.16|P-value:7.92E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.89|P-value:4.48E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-7.89|P-value:1.25E-15 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.02|P-value:2.33E-7 ID:SGTC_1161|Compound:k007-0610|FD-Score:8.12|P-value:2.25E-16 ID:SGTC_1310|Compound:1188-0297|FD-Score:-3.77|P-value:7.73E-5 ID:SGTC_1379|Compound:2144-0755|FD-Score:3.82|P-value:6.68E-5 ID:SGTC_1425|Compound:4048-4433|FD-Score:-3.52|P-value:1.99E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.19|P-value:7.33E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:3.58|P-value:1.77E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.50|P-value:2.35E-4 ID:SGTC_1658|Compound:st012944|FD-Score:6.71|P-value:9.84E-12 ID:SGTC_1742|Compound:st038235|FD-Score:5.48|P-value:2.12E-8 ID:SGTC_1745|Compound:st081495|FD-Score:-4.49|P-value:3.25E-6 ID:SGTC_1750|Compound:st081859|FD-Score:8.35|P-value:3.37E-17 ID:SGTC_1818|Compound:st052136|FD-Score:-3.31|P-value:4.36E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.67|P-value:1.21E-4 ID:SGTC_1913|Compound:st060213|FD-Score:7.72|P-value:5.73E-15 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:5.56|P-value:1.38E-8 ID:SGTC_2016|Compound:5121758|FD-Score:-3.33|P-value:4.13E-4 ID:SGTC_2217|Compound:6934799|FD-Score:4.19|P-value:1.42E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.13|P-value:8.29E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.35|P-value:3.85E-4 ID:SGTC_2292|Compound:7671323|FD-Score:3.12|P-value:9.19E-4 ID:SGTC_2310|Compound:7668677|FD-Score:3.41|P-value:3.36E-4 ID:SGTC_2314|Compound:7727897|FD-Score:3.39|P-value:3.52E-4 ID:SGTC_2338|Compound:7999974|FD-Score:4.47|P-value:3.97E-6 ID:SGTC_2340|Compound:7987427|FD-Score:-3.13|P-value:8.20E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.28|P-value:5.22E-4 ID:SGTC_2372|Compound:9071633|FD-Score:3.64|P-value:1.40E-4 ID:SGTC_2377|Compound:9073351|FD-Score:-3.45|P-value:2.61E-4 ID:SGTC_2380|Compound:9035439|FD-Score:3.60|P-value:1.60E-4 ID:SGTC_2386|Compound:9075165|FD-Score:5.36|P-value:4.23E-8 ID:SGTC_2389|Compound:9091542|FD-Score:-3.81|P-value:6.51E-5 ID:SGTC_2452|Compound:5863136|FD-Score:-3.25|P-value:5.50E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:5.08|P-value:1.90E-7 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.33|P-value:5.05E-8 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.69|P-value:1.15E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:6.68|P-value:1.15E-11 ID:SGTC_2934|Compound:9036370|FD-Score:3.31|P-value:4.77E-4 ID:SGTC_2935|Compound:9038016|FD-Score:3.12|P-value:9.27E-4 ID:SGTC_3024|Compound:9090631|FD-Score:3.57|P-value:1.80E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.99|P-value:3.36E-5 ID:SGTC_3215|Compound:9129942|FD-Score:3.58|P-value:1.78E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.14|P-value:8.51E-4

Top fitness defect scores for YLR407W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 9.09 51.8 µM 4.76E-20 ERAD & cell cycle 36 5.01E-20
2 SGTC_1750 st081859 8.35 2.4 µM 3.37E-17 endomembrane recycling 62 3.49E-17
3 SGTC_1161 k007-0610 8.12 110.0 µM 2.25E-16 ERAD & cell cycle 24 2.32E-16
4 SGTC_1913 st060213 7.72 96.1 µM 5.73E-15 3 5.87E-15
5 SGTC_58 0957-0393 7.38 9.0 µM 7.56E-14 cell wall 149 7.70E-14
6 SGTC_1658 st012944 6.71 20.0 µM 9.84E-12 iron homeostasis 20 9.92E-12
7 SGTC_2618 avocadyne 6.68 43.4 µM 1.15E-11 15 1.16E-11
8 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 5.56 70.1 µM 1.38E-8 4 1.38E-8
9 SGTC_1742 st038235 5.48 28.9 µM 2.12E-8 mitochondrial stress 61 2.11E-8
10 SGTC_2386 9075165 5.36 157.4 µM 4.23E-8 2 4.21E-8
11 SGTC_2581 avocatin a 5.33 64.0 µM 5.05E-8 sphingolipid biosynthesis & PDR1 30 5.01E-8
12 SGTC_309 k408-0051 5.23 1.5 µM 8.62E-8 21 8.55E-8
13 SGTC_2524 avocatin b 5.08 10.6 µM 1.90E-7 14 1.88E-7
14 SGTC_568 1193-0097 4.76 7.5 µM 9.57E-7 ERAD & cell cycle 98 9.47E-7
15 SGTC_955 1216-0110 4.74 33.0 µM 1.06E-6 sphingolipid biosynthesis & PDR1 46 1.05E-6
16 SGTC_2338 7999974 4.47 200.0 µM 3.97E-6 10 3.92E-6
17 SGTC_431 k089-0097 4.27 107.0 µM 9.94E-6 iron homeostasis 28 9.80E-6
18 SGTC_2217 6934799 4.19 96.1 µM 1.42E-5 TSC3-RPN4 6 1.40E-5
19 SGTC_3214 9129694 3.99 49.5 µM 3.36E-5 27 3.31E-5
20 SGTC_1379 2144-0755 3.82 36.5 µM 6.68E-5 29 6.57E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 3.07E-60 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.254 1.08E-50 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.248 2.15E-48 YOR061W CKA2 hom Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching
0.225 8.43E-40 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.207 8.46E-34 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.205 2.56E-33 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.202 2.48E-32 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.199 1.97E-31 YPR153W YPR153W hom Putative protein of unknown function
0.197 1.24E-30 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.194 8.92E-30 YMR116C ASC1 hom G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation
0.193 1.55E-29 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.190 1.13E-28 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.189 2.53E-28 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.188 7.86E-28 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.177 4.30E-25 YOR363C PIP2 hom Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication