YLR408C_p / BLS1

Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR408C / BLS1

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:-3.05|P-value:6.39E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.01|P-value:8.58E-6 ID:SGTC_448|Compound:monastrol|FD-Score:3.24|P-value:2.54E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.14|P-value:4.58E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.46|P-value:9.02E-7 ID:SGTC_716|Compound:1683-5115|FD-Score:3.34|P-value:1.71E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.84|P-value:2.40E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.85|P-value:1.88E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.22|P-value:2.77E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:-4.85|P-value:1.43E-7 ID:SGTC_732|Compound:3970-1727|FD-Score:4.90|P-value:7.94E-8 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.34|P-value:2.05E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.90|P-value:8.15E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:4.48|P-value:8.25E-7 ID:SGTC_828|Compound:2074-0507|FD-Score:3.30|P-value:1.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.93|P-value:9.74E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.01|P-value:6.29E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.08|P-value:5.78E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-5.59|P-value:1.56E-9 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.74|P-value:3.10E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.23|P-value:3.20E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.90|P-value:1.46E-5 ID:SGTC_1712|Compound:st032288|FD-Score:7.78|P-value:4.77E-17 ID:SGTC_1909|Compound:st060837|FD-Score:-4.51|P-value:9.13E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:6.16|P-value:2.26E-11 ID:SGTC_1919|Compound:st067113|FD-Score:3.93|P-value:1.27E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.20|P-value:3.68E-4 ID:SGTC_2010|Compound:4012422|FD-Score:2.91|P-value:8.91E-4 ID:SGTC_2021|Compound:4019055|FD-Score:10.70|P-value:2.98E-30 ID:SGTC_2022|Compound:5136654|FD-Score:-3.67|P-value:5.09E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.72|P-value:3.41E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.19|P-value:3.06E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.30|P-value:2.71E-6 ID:SGTC_2246|Compound:7293507|FD-Score:4.94|P-value:6.17E-8 ID:SGTC_2276|Compound:7947513|FD-Score:-3.21|P-value:3.46E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.67|P-value:5.30E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.73|P-value:3.18E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.80|P-value:2.38E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-4.40|P-value:1.60E-6 ID:SGTC_2515|Compound:chrysin|FD-Score:3.87|P-value:1.68E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.65|P-value:6.15E-13 ID:SGTC_2694|Compound:st077685|FD-Score:-3.72|P-value:4.18E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.65|P-value:5.66E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:2.93|P-value:8.29E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.41|P-value:1.21E-6 ID:SGTC_2991|Compound:9074669|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.40|P-value:1.26E-6 ID:SGTC_3214|Compound:9129694|FD-Score:2.90|P-value:9.44E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.83|P-value:2.07E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:-3.05|P-value:6.39E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:4.01|P-value:8.58E-6 ID:SGTC_448|Compound:monastrol|FD-Score:3.24|P-value:2.54E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.14|P-value:4.58E-4 ID:SGTC_649|Compound:1123-0311|FD-Score:4.46|P-value:9.02E-7 ID:SGTC_716|Compound:1683-5115|FD-Score:3.34|P-value:1.71E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:-3.84|P-value:2.40E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:3.85|P-value:1.88E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.22|P-value:2.77E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:-4.85|P-value:1.43E-7 ID:SGTC_732|Compound:3970-1727|FD-Score:4.90|P-value:7.94E-8 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.34|P-value:2.05E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:4.90|P-value:8.15E-8 ID:SGTC_815|Compound:1582-0027|FD-Score:4.48|P-value:8.25E-7 ID:SGTC_828|Compound:2074-0507|FD-Score:3.30|P-value:1.98E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.93|P-value:9.74E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.01|P-value:6.29E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.08|P-value:5.78E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-5.59|P-value:1.56E-9 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.74|P-value:3.10E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-3.23|P-value:3.20E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.90|P-value:1.46E-5 ID:SGTC_1712|Compound:st032288|FD-Score:7.78|P-value:4.77E-17 ID:SGTC_1909|Compound:st060837|FD-Score:-4.51|P-value:9.13E-7 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:6.16|P-value:2.26E-11 ID:SGTC_1919|Compound:st067113|FD-Score:3.93|P-value:1.27E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.20|P-value:3.68E-4 ID:SGTC_2010|Compound:4012422|FD-Score:2.91|P-value:8.91E-4 ID:SGTC_2021|Compound:4019055|FD-Score:10.70|P-value:2.98E-30 ID:SGTC_2022|Compound:5136654|FD-Score:-3.67|P-value:5.09E-5 ID:SGTC_2108|Compound:5365811|FD-Score:3.72|P-value:3.41E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.19|P-value:3.06E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-4.30|P-value:2.71E-6 ID:SGTC_2246|Compound:7293507|FD-Score:4.94|P-value:6.17E-8 ID:SGTC_2276|Compound:7947513|FD-Score:-3.21|P-value:3.46E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-3.67|P-value:5.30E-5 ID:SGTC_2347|Compound:9049783|FD-Score:3.73|P-value:3.18E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.80|P-value:2.38E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-4.40|P-value:1.60E-6 ID:SGTC_2515|Compound:chrysin|FD-Score:3.87|P-value:1.68E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:6.65|P-value:6.15E-13 ID:SGTC_2694|Compound:st077685|FD-Score:-3.72|P-value:4.18E-5 ID:SGTC_2760|Compound:etidronate|FD-Score:-3.65|P-value:5.66E-5 ID:SGTC_2771|Compound:fluoxetine|FD-Score:2.93|P-value:8.29E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.41|P-value:1.21E-6 ID:SGTC_2991|Compound:9074669|FD-Score:3.19|P-value:3.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.40|P-value:1.26E-6 ID:SGTC_3214|Compound:9129694|FD-Score:2.90|P-value:9.44E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.83|P-value:2.07E-5

Top fitness defect scores for YLR408C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2021 4019055 10.70 173.0 µM 2.98E-30 endomembrane recycling 7 8.11E-27
2 SGTC_1712 st032288 7.78 53.4 µM 4.77E-17 calcium & mitochondrial duress 48 3.54E-15
3 SGTC_2688 kanamycin b 6.65 96.7 µM 6.15E-13 calcium & mitochondrial duress 122 1.48E-11
4 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 6.16 70.1 µM 2.26E-11 3 3.56E-10
5 SGTC_2246 7293507 4.94 91.6 µM 6.17E-8 18 3.82E-7
6 SGTC_732 3970-1727 4.90 52.7 µM 7.94E-8 3 4.77E-7
7 SGTC_788 1182-0090 4.90 188.0 µM 8.15E-8 endomembrane recycling 54 4.89E-7
8 SGTC_815 1582-0027 4.48 36.9 µM 8.25E-7 14 3.77E-6
9 SGTC_649 1123-0311 4.46 367.0 µM 9.02E-7 endomembrane recycling 51 4.08E-6
10 SGTC_2829 7992743 4.41 58.4 µM 1.21E-6 27 5.26E-6
11 SGTC_2997 9067075 4.40 71.4 µM 1.26E-6 unfolded protein response 43 5.45E-6
12 SGTC_308 4092-1169 4.01 104.0 µM 8.58E-6 plasma membrane duress 49 2.98E-5
13 SGTC_1919 st067113 3.93 52.3 µM 1.27E-5 TSC3-RPN4 28 4.19E-5
14 SGTC_1680 diphenhydramine 3.90 100.0 µM 1.46E-5 NEO1 27 4.76E-5
15 SGTC_2515 chrysin 3.87 20.8 µM 1.68E-5 RPP1 & pyrimidine depletion 9 5.37E-5
16 SGTC_722 3534-0461 3.85 190.0 µM 1.88E-5 PDR1 39 5.94E-5
17 SGTC_3225 9130819 3.83 49.5 µM 2.07E-5 amide catabolism 31 6.47E-5
18 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.80 200.0 µM 2.38E-5 16 7.32E-5
19 SGTC_1381 2324-0066 3.74 62.1 µM 3.10E-5 36 9.24E-5
20 SGTC_2347 9049783 3.73 174.8 µM 3.18E-5 39 9.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.304 6.82E-73 YDR467C_d YDR467C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.280 1.16E-61 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.231 7.44E-42 YNL086W_p SNN1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes
0.229 4.57E-41 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.224 2.32E-39 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.221 1.73E-38 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.214 5.53E-36 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.204 6.95E-33 YDL019C OSH2 hom Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
0.204 8.62E-33 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome
0.202 2.36E-32 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.202 3.56E-32 YDR466W PKH3 hom Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
0.194 1.00E-29 YCL021W-A_p YCL021W-A_p hom Putative protein of unknown function
0.183 1.50E-26 YMR230W-A_p YMR230W-A_p hom Putative protein of unknown function
0.181 5.01E-26 YJR083C ACF4 hom Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate
0.180 6.99E-26 YGL161C YIP5 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport