YLR409C / UTP21

Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR409C / UTP21

Click on Significant Values for Screen Details ID:SGTC_182|Compound:3448-4371|FD-Score:-3.22|P-value:9.31E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.85|P-value:1.29E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.27|P-value:7.95E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.54|P-value:3.23E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.84|P-value:1.59E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.51|P-value:3.51E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.70|P-value:3.81E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.37|P-value:6.94E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.71|P-value:2.15E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.43|P-value:5.72E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.83|P-value:1.39E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.27|P-value:9.63E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.66|P-value:2.58E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.13|P-value:4.34E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.45|P-value:1.16E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.44|P-value:4.49E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.63|P-value:2.85E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.32|P-value:8.20E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.74|P-value:1.56E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.32|P-value:8.04E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.47|P-value:4.03E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-4.85|P-value:1.54E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:-3.22|P-value:9.31E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:3.85|P-value:1.29E-4 ID:SGTC_610|Compound:4215-0184|FD-Score:-3.27|P-value:7.95E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.54|P-value:3.23E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:-4.84|P-value:1.59E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.51|P-value:3.51E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:4.70|P-value:3.81E-6 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.37|P-value:6.94E-4 ID:SGTC_1518|Compound:st038567|FD-Score:3.71|P-value:2.15E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.43|P-value:5.72E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.77|P-value:1.70E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.83|P-value:1.39E-4 ID:SGTC_2168|Compound:5727979|FD-Score:3.82|P-value:1.43E-4 ID:SGTC_2268|Compound:7933382|FD-Score:3.27|P-value:9.63E-4 ID:SGTC_2276|Compound:7947513|FD-Score:3.66|P-value:2.58E-4 ID:SGTC_2279|Compound:7948423|FD-Score:4.13|P-value:4.34E-5 ID:SGTC_2381|Compound:9035592|FD-Score:4.45|P-value:1.16E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.44|P-value:4.49E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.63|P-value:2.85E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.32|P-value:8.20E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.74|P-value:1.56E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.32|P-value:8.04E-4 ID:SGTC_3311|Compound:9131146|FD-Score:-3.47|P-value:4.03E-4 ID:SGTC_3315|Compound:9136395|FD-Score:-4.85|P-value:1.54E-6

Top fitness defect scores for YLR409C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1149 3909-7961 4.70 23.3 µM 3.81E-6 2 1.27E-6 0.25
2 SGTC_2381 9035592 4.45 200.0 µM 1.16E-5 5 4.32E-6 0.32
3 SGTC_2279 7948423 4.13 32.9 µM 4.34E-5 6 1.82E-5 0.14
4 SGTC_547 1120-0019 3.85 610.0 nM 1.29E-4 azole & statin 8 5.98E-5 0.25
5 SGTC_2026 5148700 3.83 152.0 µM 1.39E-4 7 6.49E-5 0.31
6 SGTC_2168 5727979 3.82 200.0 µM 1.43E-4 6 6.73E-5 0.30
7 SGTC_1156 4092-0367 3.82 4.9 µM 1.43E-4 5 6.73E-5 0.26
8 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 3.77 19.1 µM 1.70E-4 5 8.12E-5 0.33
9 SGTC_1518 st038567 3.71 90.8 µM 2.15E-4 4 1.05E-4 0.01
10 SGTC_2276 7947513 3.66 42.1 µM 2.58E-4 6 1.28E-4 0.24
11 SGTC_2623 humulene 3.63 100.0 µM 2.85E-4 3 1.43E-4 0.15
12 SGTC_1575 cyproterone acetate 3.43 48.0 µM 5.72E-4 11 3.06E-4 0.01
13 SGTC_1178 0988-0033 3.37 191.0 µM 6.94E-4 11 3.78E-4 0.23
14 SGTC_3211 9128781 3.32 49.5 µM 8.04E-4 16 4.43E-4 0.17
15 SGTC_2815 7968870 3.32 71.4 µM 8.20E-4 11 4.54E-4 0.26
16 SGTC_2268 7933382 3.27 153.8 µM 9.63E-4 10 5.41E-4 0.04
17 SGTC_1186 1319-0216 3.22 26.0 µM 0.00113 8 6.44E-4 0.01
18 SGTC_2471 5466956 3.21 24.8 µM 0.00118 mitochondrial processes 26 6.74E-4 0.03
19 SGTC_2787 5284540 3.18 71.4 µM 0.00128 16 7.38E-4 0.03
20 SGTC_653 0203-0016 3.15 55.2 µM 0.00140 9 8.11E-4 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.34E-10 YMR062C ARG7 hom Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
0.094 5.25E-8 YPL210C SRP72 het Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
0.089 2.11E-7 YDR525W-A SNA2 hom Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.089 2.79E-7 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.081 2.78E-6 YNL270C ALP1 hom Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
0.075 1.45E-5 YKL196C YKT6 het Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.074 1.96E-5 YLR063W_p YLR063W_p hom Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
0.074 2.02E-5 YJR148W BAT2 hom Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase
0.073 2.28E-5 YLR145W RMP1 het Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
0.071 3.48E-5 YNL304W YPT11 hom Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
0.069 7.09E-5 YMR246W FAA4 hom Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles; involved in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon DNA replication stress; FAA4 has a paralog, FAA1, that arose from the whole genome duplication
0.067 9.29E-5 YIL130W ASG1 hom Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance
0.067 9.46E-5 YOR285W RDL1 hom Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress
0.067 1.04E-4 YPL201C YIG1 hom Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
0.067 1.07E-4 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W