YLR412C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR412C-A / YLR412C-A

Click on Significant Values for Screen Details ID:SGTC_197|Compound:4544-0043|FD-Score:3.33|P-value:3.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.80|P-value:5.47E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.88|P-value:3.59E-7 ID:SGTC_604|Compound:1000-0114|FD-Score:5.91|P-value:1.00E-9 ID:SGTC_615|Compound:k087-0205|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:4.09|P-value:1.68E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.69|P-value:9.36E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.06|P-value:9.76E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.52|P-value:1.83E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.19|P-value:5.56E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.23|P-value:5.26E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.35|P-value:5.03E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.97|P-value:2.35E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.58|P-value:1.25E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.91|P-value:3.69E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.54|P-value:2.10E-6 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.09|P-value:8.75E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.46|P-value:2.97E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.05|P-value:9.03E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.33|P-value:3.72E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.22|P-value:5.04E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.11|P-value:1.51E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.71|P-value:8.70E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.02|P-value:2.29E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:5.87|P-value:1.23E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:5.81|P-value:1.80E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.35|P-value:3.38E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.82|P-value:4.93E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.88|P-value:4.23E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.26|P-value:4.82E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:4.45|P-value:3.15E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:-3.20|P-value:5.46E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.13|P-value:6.97E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.33|P-value:3.73E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.79|P-value:6.05E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.62|P-value:1.21E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.51|P-value:1.87E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.46|P-value:2.01E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.09|P-value:8.69E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:3.33|P-value:3.68E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.34|P-value:3.56E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.80|P-value:5.47E-7 ID:SGTC_420|Compound:mitomycin C|FD-Score:4.88|P-value:3.59E-7 ID:SGTC_604|Compound:1000-0114|FD-Score:5.91|P-value:1.00E-9 ID:SGTC_615|Compound:k087-0205|FD-Score:3.11|P-value:8.26E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:4.09|P-value:1.68E-5 ID:SGTC_870|Compound:0573-2213|FD-Score:3.69|P-value:9.36E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.06|P-value:9.76E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.52|P-value:1.83E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.19|P-value:5.56E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.23|P-value:5.26E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:4.35|P-value:5.03E-6 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.97|P-value:2.35E-7 ID:SGTC_1126|Compound:isoteolin|FD-Score:-3.58|P-value:1.25E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.91|P-value:3.69E-5 ID:SGTC_1204|Compound:4049-0315|FD-Score:4.54|P-value:2.10E-6 ID:SGTC_1211|Compound:1056-0033|FD-Score:3.09|P-value:8.75E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.46|P-value:2.97E-6 ID:SGTC_1402|Compound:3909-7673|FD-Score:-3.05|P-value:9.03E-4 ID:SGTC_1554|Compound:st069299|FD-Score:3.33|P-value:3.72E-4 ID:SGTC_1835|Compound:st008666|FD-Score:-3.22|P-value:5.04E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.11|P-value:1.51E-5 ID:SGTC_2007|Compound:4011539|FD-Score:4.71|P-value:8.70E-7 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.02|P-value:2.29E-5 ID:SGTC_2544|Compound:sphondin|FD-Score:5.87|P-value:1.23E-9 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:5.81|P-value:1.80E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:3.35|P-value:3.38E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:4.82|P-value:4.93E-7 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.88|P-value:4.23E-5 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.26|P-value:4.82E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:4.45|P-value:3.15E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:-3.20|P-value:5.46E-4 ID:SGTC_2833|Compound:9001315|FD-Score:3.49|P-value:2.03E-4 ID:SGTC_2853|Compound:9015042|FD-Score:-3.13|P-value:6.97E-4 ID:SGTC_2984|Compound:9022109|FD-Score:3.33|P-value:3.73E-4 ID:SGTC_2989|Compound:9073649|FD-Score:3.79|P-value:6.05E-5 ID:SGTC_3146|Compound:9095609|FD-Score:3.64|P-value:1.11E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.62|P-value:1.21E-4 ID:SGTC_3189|Compound:9110682|FD-Score:3.51|P-value:1.87E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.46|P-value:2.01E-4 ID:SGTC_3225|Compound:9130819|FD-Score:3.09|P-value:8.69E-4

Top fitness defect scores for YLR412C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_604 1000-0114 5.91 314.0 µM 1.00E-9 1 1.73E-9
2 SGTC_2544 sphondin 5.87 68.5 µM 1.23E-9 RNA pol III & RNase P/MRP 8 2.12E-9
3 SGTC_2553 4-methylesculetin 5.81 85.1 µM 1.80E-9 4 3.05E-9
4 SGTC_1122 capsaicin 4.97 818.6 nM 2.35E-7 13 3.43E-7
5 SGTC_420 mitomycin C 4.88 81.9 mM 3.59E-7 7 5.17E-7
6 SGTC_2557 derrustone 4.82 83.8 µM 4.93E-7 13 7.03E-7
7 SGTC_411 enrofloxacin 4.80 100.0 µM 5.47E-7 DNA damage response 2 7.78E-7
8 SGTC_2007 4011539 4.71 71.8 µM 8.70E-7 cell wall signaling 38 1.22E-6
9 SGTC_1204 4049-0315 4.54 18.3 µM 2.10E-6 13 2.86E-6
10 SGTC_1360 1598-0022 4.46 39.8 µM 2.97E-6 ERG2 21 4.02E-6
11 SGTC_2657 nystatin 4.45 74.4 µM 3.15E-6 7 4.25E-6
12 SGTC_1121 fusaric acid 4.35 630.5 nM 5.03E-6 22 6.68E-6
13 SGTC_1928 4'-methoxychalcone 4.11 40.3 µM 1.51E-5 9 1.94E-5
14 SGTC_845 0330-0138 4.09 4.5 µM 1.68E-5 14 2.16E-5
15 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.02 100.0 µM 2.29E-5 19 2.91E-5
16 SGTC_1194 1488-0194 3.91 225.0 µM 3.69E-5 32 4.62E-5
17 SGTC_2562 3',7'-dimethoxyflavone 3.88 64.9 µM 4.23E-5 34 5.28E-5
18 SGTC_2989 9073649 3.79 71.4 µM 6.05E-5 46 7.48E-5
19 SGTC_870 0573-2213 3.69 57.6 µM 9.36E-5 ERG2 26 1.14E-4
20 SGTC_3146 9095609 3.64 49.5 µM 1.11E-4 23 1.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.104 1.32E-9 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.100 5.76E-9 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.099 9.27E-9 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.099 9.82E-9 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.094 5.39E-8 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.093 8.04E-8 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.092 9.02E-8 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.092 9.37E-8 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.091 1.17E-7 YGR174C CBP4 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex
0.090 1.85E-7 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.088 2.85E-7 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.088 3.23E-7 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.088 3.24E-7 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.088 3.76E-7 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.088 3.76E-7 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress