YLR412W / BER1

Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR412W / BER1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:7.48|P-value:7.21E-15 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.39|P-value:3.35E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:12.60|P-value:1.33E-38 ID:SGTC_77|Compound:0828-0286|FD-Score:3.75|P-value:5.61E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.70|P-value:7.08E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.26|P-value:4.02E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:8.04|P-value:6.85E-17 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.97|P-value:2.29E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.46|P-value:1.86E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.56|P-value:6.76E-19 ID:SGTC_365|Compound:0121-0052|FD-Score:3.05|P-value:8.58E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.54|P-value:1.54E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:4.95|P-value:1.82E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.89|P-value:3.13E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.96|P-value:1.73E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.65|P-value:4.13E-12 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.17|P-value:5.84E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-4.30|P-value:5.11E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:-5.66|P-value:3.14E-9 ID:SGTC_829|Compound:1635-0120|FD-Score:3.03|P-value:9.08E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.35|P-value:2.85E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.18|P-value:5.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.07|P-value:8.11E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-5.04|P-value:1.14E-7 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.36|P-value:2.83E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.47|P-value:1.88E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.32|P-value:3.23E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.15|P-value:5.95E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.31|P-value:3.39E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.18|P-value:5.43E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.52|P-value:1.79E-6 ID:SGTC_2266|Compound:7929956|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.46|P-value:1.85E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.80|P-value:4.90E-5 ID:SGTC_2441|Compound:5730946|FD-Score:4.43|P-value:2.54E-6 ID:SGTC_2485|Compound:5633444|FD-Score:4.51|P-value:1.72E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.85|P-value:3.75E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.23|P-value:4.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.10|P-value:1.73E-10 ID:SGTC_2793|Compound:7325131|FD-Score:3.39|P-value:2.40E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.36|P-value:2.80E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.45|P-value:2.03E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.16|P-value:9.45E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.39|P-value:2.44E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.54|P-value:1.38E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.83|P-value:4.32E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.02|P-value:1.77E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.01|P-value:9.59E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:7.48|P-value:7.21E-15 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.39|P-value:3.35E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:12.60|P-value:1.33E-38 ID:SGTC_77|Compound:0828-0286|FD-Score:3.75|P-value:5.61E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:3.70|P-value:7.08E-5 ID:SGTC_92|Compound:0063-0024|FD-Score:3.26|P-value:4.02E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:8.04|P-value:6.85E-17 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.97|P-value:2.29E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.46|P-value:1.86E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.48|P-value:1.73E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:8.56|P-value:6.76E-19 ID:SGTC_365|Compound:0121-0052|FD-Score:3.05|P-value:8.58E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:4.54|P-value:1.54E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:4.95|P-value:1.82E-7 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.89|P-value:3.13E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:4.96|P-value:1.73E-7 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.65|P-value:4.13E-12 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.17|P-value:5.84E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:-4.30|P-value:5.11E-6 ID:SGTC_729|Compound:4092-0585|FD-Score:-5.66|P-value:3.14E-9 ID:SGTC_829|Compound:1635-0120|FD-Score:3.03|P-value:9.08E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:3.35|P-value:2.85E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.30|P-value:3.39E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.18|P-value:5.40E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.15|P-value:6.17E-4 ID:SGTC_1260|Compound:0700-1617|FD-Score:-3.07|P-value:8.11E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-5.04|P-value:1.14E-7 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.36|P-value:2.83E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.47|P-value:1.88E-4 ID:SGTC_1616|Compound:st002734|FD-Score:3.32|P-value:3.23E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.15|P-value:5.95E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:-3.31|P-value:3.39E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.18|P-value:5.43E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.52|P-value:1.79E-6 ID:SGTC_2266|Compound:7929956|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.46|P-value:1.85E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.80|P-value:4.90E-5 ID:SGTC_2441|Compound:5730946|FD-Score:4.43|P-value:2.54E-6 ID:SGTC_2485|Compound:5633444|FD-Score:4.51|P-value:1.72E-6 ID:SGTC_2487|Compound:5918373|FD-Score:3.85|P-value:3.75E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.23|P-value:4.38E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.10|P-value:1.73E-10 ID:SGTC_2793|Compound:7325131|FD-Score:3.39|P-value:2.40E-4 ID:SGTC_2796|Compound:7949634|FD-Score:-3.36|P-value:2.80E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.45|P-value:2.03E-4 ID:SGTC_2974|Compound:9094440|FD-Score:4.16|P-value:9.45E-6 ID:SGTC_2975|Compound:9084847|FD-Score:3.43|P-value:2.12E-4 ID:SGTC_2977|Compound:9011197|FD-Score:3.39|P-value:2.44E-4 ID:SGTC_2985|Compound:9022375|FD-Score:-3.54|P-value:1.38E-4 ID:SGTC_2987|Compound:9018338|FD-Score:-3.83|P-value:4.32E-5 ID:SGTC_2991|Compound:9074669|FD-Score:4.02|P-value:1.77E-5 ID:SGTC_3212|Compound:9128307|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_3295|Compound:9122362|FD-Score:3.01|P-value:9.59E-4

Top fitness defect scores for YLR412W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 12.60 9.0 µM 1.33E-38 cell wall 44 1.18E-36
2 SGTC_310 1273-0058 8.56 1.1 µM 6.76E-19 mitochondrial stress 73 5.55E-18
3 SGTC_98 0074-0023 8.04 107.7 µM 6.85E-17 Golgi 5 4.42E-16
4 SGTC_6 0844-0013 7.48 19.8 µM 7.21E-15 2 3.64E-14
5 SGTC_682 0kpi-0099 6.65 17.0 µM 4.13E-12 19 1.50E-11
6 SGTC_2582 agaric acid 6.10 100.0 µM 1.73E-10 redox potentiating 154 5.16E-10
7 SGTC_660 4031-1742 4.96 102.0 µM 1.73E-7 redox potentiating 23 3.60E-7
8 SGTC_372 0155-0182 4.95 15.9 µM 1.82E-7 mitochondrial response to ROS 16 3.78E-7
9 SGTC_369 0957-0393 4.54 4.5 µM 1.54E-6 cell wall signaling 11 2.87E-6
10 SGTC_2485 5633444 4.51 17.8 µM 1.72E-6 redox potentiating 29 3.18E-6
11 SGTC_2441 5730946 4.43 39.1 µM 2.54E-6 10 4.61E-6
12 SGTC_2974 9094440 4.16 9.7 µM 9.45E-6 ergosterol biosynthesis 40 1.60E-5
13 SGTC_2991 9074669 4.02 71.4 µM 1.77E-5 azole & statin 59 2.90E-5
14 SGTC_457 grayanotoxin iii 3.89 135.0 µM 3.13E-5 71 4.99E-5
15 SGTC_2487 5918373 3.85 44.0 µM 3.75E-5 19 5.92E-5
16 SGTC_77 0828-0286 3.75 12.5 µM 5.61E-5 TSC3-RPN4 45 8.68E-5
17 SGTC_89 0302-0250 3.70 142.1 µM 7.08E-5 27 1.08E-4
18 SGTC_165 k038-0023 3.48 64.4 µM 1.73E-4 ubiquinone biosynthesis & proteasome 109 2.53E-4
19 SGTC_2357 9067248 3.46 200.0 µM 1.85E-4 36 2.69E-4
20 SGTC_138 0850-0259 3.46 40.9 µM 1.86E-4 cell wall 226 2.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 8.79E-78 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.285 8.53E-64 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.282 2.41E-62 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.282 3.53E-62 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.269 1.16E-56 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.264 1.09E-54 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.262 1.04E-53 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.260 7.49E-53 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.259 1.59E-52 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.251 2.15E-49 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.235 1.81E-43 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.230 1.11E-41 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.230 1.44E-41 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.229 3.73E-41 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.223 5.58E-39 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase