YLR413W_p

Putative protein of unknown function; YLR413W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR413W / YLR413W

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:3.11|P-value:8.06E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.48|P-value:2.06E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.32|P-value:3.82E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.68|P-value:9.62E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.44|P-value:2.41E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.59|P-value:1.70E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.78|P-value:6.52E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.69|P-value:1.25E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.05|P-value:2.06E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.48|P-value:2.06E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.31|P-value:3.98E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.44|P-value:3.57E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.15|P-value:8.92E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.09|P-value:8.50E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.07|P-value:9.20E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.57|P-value:1.85E-6 ID:SGTC_1836|Compound:st055642|FD-Score:3.16|P-value:6.66E-4 ID:SGTC_2013|Compound:4024628|FD-Score:5.78|P-value:2.63E-9 ID:SGTC_2016|Compound:5121758|FD-Score:-5.00|P-value:3.22E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.86|P-value:4.52E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.27|P-value:4.57E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.09|P-value:8.41E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.07|P-value:9.23E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.55|P-value:1.59E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.21|P-value:5.68E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.49|P-value:1.97E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.10|P-value:8.25E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.31|P-value:5.18E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.16|P-value:9.22E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.07|P-value:9.07E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.98|P-value:3.64E-7 ID:SGTC_2819|Compound:7996655|FD-Score:-3.95|P-value:4.39E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.31|P-value:5.05E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.50|P-value:1.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.18|P-value:6.29E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-4.35|P-value:7.42E-6 ID:SGTC_3047|Compound:9092122|FD-Score:4.16|P-value:1.25E-5 ID:SGTC_3177|Compound:9107506|FD-Score:3.35|P-value:3.43E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.48|P-value:2.05E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.11|P-value:8.06E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:3.48|P-value:2.06E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.32|P-value:3.82E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.68|P-value:9.62E-5 ID:SGTC_859|Compound:0439-0102|FD-Score:3.44|P-value:2.41E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:4.59|P-value:1.70E-6 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.78|P-value:6.52E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.69|P-value:1.25E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.58|P-value:1.41E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:4.05|P-value:2.06E-5 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.48|P-value:2.06E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.31|P-value:3.98E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:4.44|P-value:3.57E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.15|P-value:8.92E-4 ID:SGTC_1617|Compound:st002906|FD-Score:3.09|P-value:8.50E-4 ID:SGTC_1654|Compound:st012436|FD-Score:3.31|P-value:3.84E-4 ID:SGTC_1658|Compound:st012944|FD-Score:3.07|P-value:9.20E-4 ID:SGTC_1723|Compound:st034307|FD-Score:3.40|P-value:2.84E-4 ID:SGTC_1791|Compound:st048313|FD-Score:4.57|P-value:1.85E-6 ID:SGTC_1836|Compound:st055642|FD-Score:3.16|P-value:6.66E-4 ID:SGTC_2013|Compound:4024628|FD-Score:5.78|P-value:2.63E-9 ID:SGTC_2016|Compound:5121758|FD-Score:-5.00|P-value:3.22E-7 ID:SGTC_2021|Compound:4019055|FD-Score:3.86|P-value:4.52E-5 ID:SGTC_2060|Compound:5238662|FD-Score:3.27|P-value:4.57E-4 ID:SGTC_2061|Compound:5245884|FD-Score:3.09|P-value:8.41E-4 ID:SGTC_2069|Compound:5228469|FD-Score:3.07|P-value:9.23E-4 ID:SGTC_2102|Compound:5377816|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.55|P-value:1.59E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.21|P-value:5.68E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:3.49|P-value:1.97E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:3.10|P-value:8.25E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-3.31|P-value:5.18E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:5.16|P-value:9.22E-8 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.07|P-value:9.07E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-4.98|P-value:3.64E-7 ID:SGTC_2819|Compound:7996655|FD-Score:-3.95|P-value:4.39E-5 ID:SGTC_2821|Compound:7996764|FD-Score:-3.31|P-value:5.05E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.50|P-value:1.91E-4 ID:SGTC_2928|Compound:9011484|FD-Score:3.18|P-value:6.29E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-4.35|P-value:7.42E-6 ID:SGTC_3047|Compound:9092122|FD-Score:4.16|P-value:1.25E-5 ID:SGTC_3177|Compound:9107506|FD-Score:3.35|P-value:3.43E-4 ID:SGTC_3207|Compound:9114163|FD-Score:3.48|P-value:2.05E-4

Top fitness defect scores for YLR413W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2013 4024628 5.78 200.0 µM 2.63E-9 18 3.70E-9
2 SGTC_2583 asiatic acid 5.16 100.0 µM 9.22E-8 19 1.24E-7
3 SGTC_1039 k821-0043 4.59 94.0 µM 1.70E-6 Golgi 14 2.20E-6
4 SGTC_1791 st048313 4.57 56.1 µM 1.85E-6 6 2.39E-6
5 SGTC_1430 4049-0248 4.44 69.1 µM 3.57E-6 10 4.57E-6
6 SGTC_3047 9092122 4.16 49.5 µM 1.25E-5 15 1.57E-5
7 SGTC_1285 0929-0069 4.05 65.5 µM 2.06E-5 11 2.57E-5
8 SGTC_2021 4019055 3.86 173.0 µM 4.52E-5 endomembrane recycling 128 5.57E-5
9 SGTC_1103 duloxetine 3.78 36.1 µM 6.52E-5 36 8.00E-5
10 SGTC_631 k072-0230 3.68 41.5 µM 9.62E-5 60S ribosome export 23 1.17E-4
11 SGTC_2130 NSC 7 3.63 2.5 µM 1.17E-4 copper-dependent oxidative stress 39 1.42E-4
12 SGTC_1261 0712-0010 3.58 12.7 µM 1.41E-4 RNA processing & uracil transport 34 1.71E-4
13 SGTC_2128 5255449 3.55 168.5 µM 1.59E-4 50 1.92E-4
14 SGTC_2920 7982904 3.50 15.8 µM 1.91E-4 34 2.30E-4
15 SGTC_2548 3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin 3.49 19.9 µM 1.97E-4 redox potentiating 16 2.38E-4
16 SGTC_3207 9114163 3.48 49.5 µM 2.05E-4 51 2.47E-4
17 SGTC_95 0471-0001 3.48 561.1 µM 2.06E-4 41 2.48E-4
18 SGTC_1373 2887-0003 3.48 58.5 µM 2.06E-4 Golgi 34 2.49E-4
19 SGTC_859 0439-0102 3.44 54.6 µM 2.41E-4 redox potentiating 25 2.89E-4
20 SGTC_1723 st034307 3.40 2.5 µM 2.84E-4 mitochondrial processes 47 3.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.203 1.21E-32 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.114 3.48E-11 YFL003C MSH4 hom Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein
0.113 6.08E-11 YGL042C_d YGL042C_d hom Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
0.112 8.76E-11 YFR015C GSY1 hom Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.105 1.08E-9 YLR086W SMC4 het Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate
0.101 4.09E-9 YBR276C PPS1 hom Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
0.098 1.12E-8 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.095 3.89E-8 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.093 7.63E-8 YMR066W SOV1 hom Mitochondrial protein of unknown function
0.091 1.40E-7 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.089 2.33E-7 YGL061C DUO1 het Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.089 2.32E-7 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.089 2.33E-7 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.089 2.49E-7 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.088 3.39E-7 YDR430C CYM1 hom Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology