YLR417W / VPS36

Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR417W / VPS36

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.34|P-value:2.70E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.05|P-value:6.18E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-16.20|P-value:4.94E-39 ID:SGTC_59|Compound:0330-0160|FD-Score:-5.98|P-value:7.31E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:7.51|P-value:9.28E-10 ID:SGTC_86|Compound:0417-1630|FD-Score:6.12|P-value:5.06E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:17.00|P-value:1.12E-42 ID:SGTC_117|Compound:lucigenin|FD-Score:17.00|P-value:1.34E-42 ID:SGTC_123|Compound:0083-0120|FD-Score:8.58|P-value:3.32E-12 ID:SGTC_156|Compound:3474-0145|FD-Score:6.12|P-value:4.93E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:5.02|P-value:3.03E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-6.45|P-value:1.03E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.92|P-value:1.11E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.90|P-value:8.22E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:12.00|P-value:4.89E-22 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.30|P-value:9.86E-20 ID:SGTC_227|Compound:fluconazole|FD-Score:9.04|P-value:2.31E-13 ID:SGTC_232|Compound:clozapine|FD-Score:5.79|P-value:1.87E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.99|P-value:7.30E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.38|P-value:2.06E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.14|P-value:4.74E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:13.10|P-value:6.56E-26 ID:SGTC_304|Compound:1310-0298|FD-Score:-10.20|P-value:1.05E-16 ID:SGTC_309|Compound:k408-0051|FD-Score:-7.10|P-value:5.50E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.63|P-value:1.95E-12 ID:SGTC_313|Compound:3474-0040|FD-Score:6.18|P-value:3.84E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.57|P-value:1.14E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.20|P-value:4.05E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.78|P-value:6.81E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.43|P-value:1.14E-7 ID:SGTC_459|Compound:nigericin|FD-Score:5.95|P-value:9.81E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.57|P-value:3.55E-6 ID:SGTC_470|Compound:aa-861|FD-Score:5.67|P-value:2.98E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:4.15|P-value:4.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:15.70|P-value:1.48E-36 ID:SGTC_514|Compound:4466-0038|FD-Score:6.90|P-value:1.74E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:4.80|P-value:6.29E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:9.07|P-value:1.98E-13 ID:SGTC_526|Compound:4469-0568|FD-Score:4.57|P-value:1.31E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.85|P-value:2.12E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:5.77|P-value:1.97E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.24|P-value:3.14E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.05|P-value:2.79E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.00|P-value:7.05E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.94|P-value:4.00E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.08|P-value:4.92E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.56|P-value:4.48E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:6.56|P-value:7.84E-8 ID:SGTC_748|Compound:0136-0228|FD-Score:10.90|P-value:1.47E-18 ID:SGTC_768|Compound:0384-0033|FD-Score:4.64|P-value:1.07E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.83|P-value:5.00E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:4.43|P-value:2.04E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.61|P-value:1.17E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:4.71|P-value:8.53E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.42|P-value:2.09E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.11|P-value:5.24E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.88|P-value:9.93E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.95|P-value:8.15E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.77|P-value:7.01E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:12.70|P-value:1.75E-24 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.29|P-value:1.18E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.10|P-value:5.31E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:6.51|P-value:9.76E-8 ID:SGTC_1174|Compound:0739-0097|FD-Score:8.49|P-value:5.59E-12 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.48|P-value:5.93E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.96|P-value:9.52E-7 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.47|P-value:1.80E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.20|P-value:4.03E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-4.00|P-value:6.17E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.92|P-value:8.78E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:14.30|P-value:7.69E-31 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.28|P-value:3.23E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.04|P-value:2.46E-5 ID:SGTC_1665|Compound:st014639|FD-Score:4.32|P-value:2.81E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.95|P-value:7.16E-4 ID:SGTC_1687|Compound:st020778|FD-Score:10.40|P-value:3.45E-17 ID:SGTC_1718|Compound:roemerine|FD-Score:4.43|P-value:2.06E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-4.93|P-value:3.57E-5 ID:SGTC_1754|Compound:st042065|FD-Score:7.95|P-value:1.02E-10 ID:SGTC_1760|Compound:st045453|FD-Score:7.67|P-value:4.37E-10 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.14|P-value:4.84E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.09|P-value:5.57E-7 ID:SGTC_1801|Compound:st050089|FD-Score:6.04|P-value:6.80E-7 ID:SGTC_1803|Compound:st050068|FD-Score:13.00|P-value:1.09E-25 ID:SGTC_1804|Compound:st050076|FD-Score:5.36|P-value:9.30E-6 ID:SGTC_1809|Compound:st050081|FD-Score:5.36|P-value:9.12E-6 ID:SGTC_1884|Compound:5633444|FD-Score:10.40|P-value:5.53E-17 ID:SGTC_1962|Compound:st076595|FD-Score:5.91|P-value:1.17E-6 ID:SGTC_1991|Compound:st073000|FD-Score:4.83|P-value:5.73E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.41|P-value:2.18E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.49|P-value:1.68E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.32|P-value:2.84E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.97|P-value:9.10E-7 ID:SGTC_2210|Compound:7115885|FD-Score:5.25|P-value:1.39E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.24|P-value:3.15E-4 ID:SGTC_2257|Compound:7960413|FD-Score:5.22|P-value:1.51E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.56|P-value:1.37E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.32|P-value:2.85E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.34|P-value:2.64E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.83|P-value:1.61E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.51|P-value:1.62E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:17.90|P-value:6.36E-47 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.09|P-value:1.76E-13 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:10.70|P-value:5.08E-18 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.37|P-value:8.80E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:15.00|P-value:1.51E-33 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.52|P-value:1.56E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:5.08|P-value:2.50E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.17|P-value:3.82E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.18|P-value:4.21E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.02|P-value:6.78E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.54|P-value:1.46E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.05|P-value:8.70E-9 ID:SGTC_2835|Compound:9006588|FD-Score:5.16|P-value:1.87E-5 ID:SGTC_2867|Compound:9039098|FD-Score:6.24|P-value:3.12E-7 ID:SGTC_2881|Compound:9058953|FD-Score:8.41|P-value:8.65E-12 ID:SGTC_2884|Compound:9058502|FD-Score:5.83|P-value:1.59E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.14|P-value:1.71E-5 ID:SGTC_2925|Compound:9010536|FD-Score:5.56|P-value:4.42E-6 ID:SGTC_2930|Compound:9013230|FD-Score:7.84|P-value:1.76E-10 ID:SGTC_2949|Compound:9072542|FD-Score:4.73|P-value:8.08E-5 ID:SGTC_3033|Compound:9090887|FD-Score:5.17|P-value:1.81E-5 ID:SGTC_3037|Compound:9091026|FD-Score:6.49|P-value:1.05E-7 ID:SGTC_3041|Compound:9091929|FD-Score:6.43|P-value:1.38E-7 ID:SGTC_3110|Compound:9122132|FD-Score:6.03|P-value:7.12E-7 ID:SGTC_3112|Compound:9123419|FD-Score:4.33|P-value:2.74E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.45|P-value:6.69E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-3.87|P-value:8.92E-4 ID:SGTC_3308|Compound:9128332|FD-Score:7.41|P-value:1.54E-9 ID:SGTC_15|Compound:0266-0086|FD-Score:4.34|P-value:2.70E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.05|P-value:6.18E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-16.20|P-value:4.94E-39 ID:SGTC_59|Compound:0330-0160|FD-Score:-5.98|P-value:7.31E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:7.51|P-value:9.28E-10 ID:SGTC_86|Compound:0417-1630|FD-Score:6.12|P-value:5.06E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:17.00|P-value:1.12E-42 ID:SGTC_117|Compound:lucigenin|FD-Score:17.00|P-value:1.34E-42 ID:SGTC_123|Compound:0083-0120|FD-Score:8.58|P-value:3.32E-12 ID:SGTC_156|Compound:3474-0145|FD-Score:6.12|P-value:4.93E-7 ID:SGTC_159|Compound:3970-0959|FD-Score:5.02|P-value:3.03E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-6.45|P-value:1.03E-7 ID:SGTC_168|Compound:3970-0862|FD-Score:5.92|P-value:1.11E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:-3.90|P-value:8.22E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:12.00|P-value:4.89E-22 ID:SGTC_221|Compound:trifluoperazine|FD-Score:11.30|P-value:9.86E-20 ID:SGTC_227|Compound:fluconazole|FD-Score:9.04|P-value:2.31E-13 ID:SGTC_232|Compound:clozapine|FD-Score:5.79|P-value:1.87E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.99|P-value:7.30E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.38|P-value:2.06E-4 ID:SGTC_300|Compound:r073-0011|FD-Score:4.14|P-value:4.74E-4 ID:SGTC_301|Compound:4119-0100|FD-Score:13.10|P-value:6.56E-26 ID:SGTC_304|Compound:1310-0298|FD-Score:-10.20|P-value:1.05E-16 ID:SGTC_309|Compound:k408-0051|FD-Score:-7.10|P-value:5.50E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:-8.63|P-value:1.95E-12 ID:SGTC_313|Compound:3474-0040|FD-Score:6.18|P-value:3.84E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.57|P-value:1.14E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:4.20|P-value:4.05E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.78|P-value:6.81E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.43|P-value:1.14E-7 ID:SGTC_459|Compound:nigericin|FD-Score:5.95|P-value:9.81E-7 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.57|P-value:3.55E-6 ID:SGTC_470|Compound:aa-861|FD-Score:5.67|P-value:2.98E-6 ID:SGTC_505|Compound:gw-5074|FD-Score:4.15|P-value:4.64E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:15.70|P-value:1.48E-36 ID:SGTC_514|Compound:4466-0038|FD-Score:6.90|P-value:1.74E-8 ID:SGTC_524|Compound:r073-0010|FD-Score:4.80|P-value:6.29E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:9.07|P-value:1.98E-13 ID:SGTC_526|Compound:4469-0568|FD-Score:4.57|P-value:1.31E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:6.85|P-value:2.12E-8 ID:SGTC_576|Compound:1073-0113|FD-Score:5.77|P-value:1.97E-6 ID:SGTC_601|Compound:0986-0029|FD-Score:-4.24|P-value:3.14E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:5.05|P-value:2.79E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.00|P-value:7.05E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.94|P-value:4.00E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.08|P-value:4.92E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:5.56|P-value:4.48E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:6.56|P-value:7.84E-8 ID:SGTC_748|Compound:0136-0228|FD-Score:10.90|P-value:1.47E-18 ID:SGTC_768|Compound:0384-0033|FD-Score:4.64|P-value:1.07E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.83|P-value:5.00E-5 ID:SGTC_788|Compound:1182-0090|FD-Score:4.43|P-value:2.04E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:4.61|P-value:1.17E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:4.71|P-value:8.53E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:4.42|P-value:2.09E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.11|P-value:5.24E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:3.88|P-value:9.93E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:3.95|P-value:8.15E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:4.77|P-value:7.01E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:12.70|P-value:1.75E-24 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.29|P-value:1.18E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.10|P-value:5.31E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:6.51|P-value:9.76E-8 ID:SGTC_1174|Compound:0739-0097|FD-Score:8.49|P-value:5.59E-12 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.48|P-value:5.93E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.96|P-value:9.52E-7 ID:SGTC_1387|Compound:3342-1166|FD-Score:4.47|P-value:1.80E-4 ID:SGTC_1409|Compound:3909-8004|FD-Score:4.20|P-value:4.03E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:-4.00|P-value:6.17E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.92|P-value:8.78E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:14.30|P-value:7.69E-31 ID:SGTC_1596|Compound:piperlongumine|FD-Score:4.28|P-value:3.23E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.04|P-value:2.46E-5 ID:SGTC_1665|Compound:st014639|FD-Score:4.32|P-value:2.81E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.95|P-value:7.16E-4 ID:SGTC_1687|Compound:st020778|FD-Score:10.40|P-value:3.45E-17 ID:SGTC_1718|Compound:roemerine|FD-Score:4.43|P-value:2.06E-4 ID:SGTC_1720|Compound:st037298|FD-Score:-4.93|P-value:3.57E-5 ID:SGTC_1754|Compound:st042065|FD-Score:7.95|P-value:1.02E-10 ID:SGTC_1760|Compound:st045453|FD-Score:7.67|P-value:4.37E-10 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.14|P-value:4.84E-4 ID:SGTC_1800|Compound:st050079|FD-Score:6.09|P-value:5.57E-7 ID:SGTC_1801|Compound:st050089|FD-Score:6.04|P-value:6.80E-7 ID:SGTC_1803|Compound:st050068|FD-Score:13.00|P-value:1.09E-25 ID:SGTC_1804|Compound:st050076|FD-Score:5.36|P-value:9.30E-6 ID:SGTC_1809|Compound:st050081|FD-Score:5.36|P-value:9.12E-6 ID:SGTC_1884|Compound:5633444|FD-Score:10.40|P-value:5.53E-17 ID:SGTC_1962|Compound:st076595|FD-Score:5.91|P-value:1.17E-6 ID:SGTC_1991|Compound:st073000|FD-Score:4.83|P-value:5.73E-5 ID:SGTC_2016|Compound:5121758|FD-Score:4.41|P-value:2.18E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.49|P-value:1.68E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.32|P-value:2.84E-4 ID:SGTC_2200|Compound:6600604|FD-Score:5.97|P-value:9.10E-7 ID:SGTC_2210|Compound:7115885|FD-Score:5.25|P-value:1.39E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.24|P-value:3.15E-4 ID:SGTC_2257|Compound:7960413|FD-Score:5.22|P-value:1.51E-5 ID:SGTC_2307|Compound:7538926|FD-Score:4.56|P-value:1.37E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.32|P-value:2.85E-4 ID:SGTC_2389|Compound:9091542|FD-Score:4.34|P-value:2.64E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.83|P-value:1.61E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.51|P-value:1.62E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:17.90|P-value:6.36E-47 ID:SGTC_2582|Compound:agaric acid|FD-Score:9.09|P-value:1.76E-13 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:10.70|P-value:5.08E-18 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.37|P-value:8.80E-6 ID:SGTC_2619|Compound:obliquin|FD-Score:15.00|P-value:1.51E-33 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.52|P-value:1.56E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:5.08|P-value:2.50E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.17|P-value:3.82E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.18|P-value:4.21E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.02|P-value:6.78E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.54|P-value:1.46E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:7.05|P-value:8.70E-9 ID:SGTC_2835|Compound:9006588|FD-Score:5.16|P-value:1.87E-5 ID:SGTC_2867|Compound:9039098|FD-Score:6.24|P-value:3.12E-7 ID:SGTC_2881|Compound:9058953|FD-Score:8.41|P-value:8.65E-12 ID:SGTC_2884|Compound:9058502|FD-Score:5.83|P-value:1.59E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-5.14|P-value:1.71E-5 ID:SGTC_2925|Compound:9010536|FD-Score:5.56|P-value:4.42E-6 ID:SGTC_2930|Compound:9013230|FD-Score:7.84|P-value:1.76E-10 ID:SGTC_2949|Compound:9072542|FD-Score:4.73|P-value:8.08E-5 ID:SGTC_3033|Compound:9090887|FD-Score:5.17|P-value:1.81E-5 ID:SGTC_3037|Compound:9091026|FD-Score:6.49|P-value:1.05E-7 ID:SGTC_3041|Compound:9091929|FD-Score:6.43|P-value:1.38E-7 ID:SGTC_3110|Compound:9122132|FD-Score:6.03|P-value:7.12E-7 ID:SGTC_3112|Compound:9123419|FD-Score:4.33|P-value:2.74E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.45|P-value:6.69E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-3.87|P-value:8.92E-4 ID:SGTC_3308|Compound:9128332|FD-Score:7.41|P-value:1.54E-9

Top fitness defect scores for YLR417W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2567 aureobasidin a 17.90 60.0 nM 6.36E-47 2 6.48E-72
2 SGTC_102 gallobenzophenone 17.00 83.6 µM 1.12E-42 redox potentiating 2 2.55E-65
3 SGTC_117 lucigenin 17.00 22.1 µM 1.34E-42 redox potentiating 1 3.37E-65
4 SGTC_513 4245-1575 15.70 41.7 µM 1.48E-36 unfolded protein response 5 8.08E-56
5 SGTC_2619 obliquin 15.00 87.9 µM 1.51E-33 cell wall 10 3.81E-51
6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 14.30 54.9 µM 7.69E-31 redox potentiating 7 6.06E-47
7 SGTC_301 4119-0100 13.10 24.5 µM 6.56E-26 NEO1 7 2.72E-39
8 SGTC_1803 st050068 13.00 52.4 µM 1.09E-25 NEO1-PIK1 6 5.99E-39
9 SGTC_1044 1222-0021 12.70 1.8 µM 1.75E-24 heme biosynthesis & mitochondrial translocase 3 4.45E-37
10 SGTC_206 4546-0025 12.00 72.0 µM 4.89E-22 NEO1 9 2.76E-33
11 SGTC_221 trifluoperazine 11.30 10.3 µM 9.86E-20 NEO1-PIK1 46 1.03E-29
12 SGTC_748 0136-0228 10.90 77.9 µM 1.47E-18 redox potentiating 8 6.84E-28
13 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 10.70 70.0 µM 5.08E-18 redox potentiating 7 4.67E-27
14 SGTC_1687 st020778 10.40 55.4 µM 3.45E-17 45 9.08E-26
15 SGTC_1884 5633444 10.40 25.0 µM 5.53E-17 redox potentiating 12 1.88E-25
16 SGTC_2582 agaric acid 9.09 100.0 µM 1.76E-13 redox potentiating 83 5.01E-20
17 SGTC_525 k781-2675 9.07 26.7 µM 1.98E-13 redox potentiating 8 6.00E-20
18 SGTC_227 fluconazole 9.04 33.5 µM 2.31E-13 azole & statin 19 7.63E-20
19 SGTC_123 0083-0120 8.58 66.7 µM 3.32E-12 9 4.73E-18
20 SGTC_1174 0739-0097 8.49 51.1 µM 5.59E-12 redox potentiating 3 1.06E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.640 0 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.605 0 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.585 2.33E-307 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.544 1.32E-257 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.538 2.04E-251 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.508 1.41E-219 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.401 1.18E-129 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress
0.399 2.52E-128 YDR323C PEP7 hom Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance
0.392 1.62E-123 YOR036W PEP12 hom Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin
0.374 1.59E-111 YHL027W RIM101 hom Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to a alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
0.371 5.85E-110 YDR495C VPS3 hom Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase
0.370 4.28E-109 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.360 3.54E-103 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.348 7.35E-96 YGL045W RIM8 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
0.346 1.03E-94 YOR089C VPS21 hom Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication