YLR418C / CDC73

Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR418C / CDC73

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:4.14|P-value:6.21E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:7.31|P-value:2.43E-9 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.55|P-value:3.45E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-7.26|P-value:2.34E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:4.74|P-value:9.96E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:8.55|P-value:2.82E-12 ID:SGTC_122|Compound:0236-0016|FD-Score:6.50|P-value:1.10E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:5.69|P-value:3.17E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:6.13|P-value:5.30E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:9.50|P-value:8.69E-15 ID:SGTC_188|Compound:3229-0966|FD-Score:4.40|P-value:2.89E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-4.02|P-value:1.98E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.30|P-value:1.38E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.93|P-value:2.63E-4 ID:SGTC_398|Compound:bronopol|FD-Score:10.40|P-value:1.60E-17 ID:SGTC_421|Compound:streptovitacin|FD-Score:-8.00|P-value:3.79E-12 ID:SGTC_431|Compound:k089-0097|FD-Score:-14.80|P-value:2.79E-36 ID:SGTC_439|Compound:amiodarone|FD-Score:4.49|P-value:2.17E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.14|P-value:3.90E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.52|P-value:3.84E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.99|P-value:2.19E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:5.48|P-value:7.07E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-6.39|P-value:1.77E-8 ID:SGTC_516|Compound:3992-2719|FD-Score:4.02|P-value:8.79E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.43|P-value:8.56E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.28|P-value:4.15E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.51|P-value:2.05E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.74|P-value:9.97E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.82|P-value:2.22E-9 ID:SGTC_580|Compound:1123-0028|FD-Score:4.00|P-value:9.31E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.44|P-value:2.56E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.74|P-value:9.73E-13 ID:SGTC_675|Compound:1309-0189|FD-Score:5.14|P-value:2.49E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.99|P-value:2.18E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.08|P-value:3.14E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.24|P-value:2.65E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.44|P-value:2.59E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:6.14|P-value:5.08E-7 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.33|P-value:7.10E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.60|P-value:7.05E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:5.91|P-value:1.35E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:4.46|P-value:2.42E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:7.92|P-value:9.87E-11 ID:SGTC_926|Compound:2268-1401|FD-Score:6.30|P-value:2.62E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.93|P-value:2.60E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:6.54|P-value:8.96E-8 ID:SGTC_959|Compound:1222-0044|FD-Score:-4.38|P-value:6.15E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:7.82|P-value:1.70E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:4.04|P-value:8.26E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.36|P-value:1.12E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.76|P-value:9.21E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:5.76|P-value:2.45E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.23|P-value:4.89E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.40|P-value:2.93E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.25|P-value:4.50E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:5.46|P-value:7.62E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.70|P-value:1.12E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.38|P-value:3.08E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:5.21|P-value:1.92E-5 ID:SGTC_1618|Compound:st003135|FD-Score:-3.98|P-value:2.25E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.44|P-value:2.59E-4 ID:SGTC_1745|Compound:st081495|FD-Score:13.20|P-value:2.31E-27 ID:SGTC_1750|Compound:st081859|FD-Score:7.48|P-value:1.03E-9 ID:SGTC_1772|Compound:st048439|FD-Score:4.24|P-value:4.67E-4 ID:SGTC_1778|Compound:st046819|FD-Score:4.61|P-value:1.48E-4 ID:SGTC_1814|Compound:st052110|FD-Score:5.08|P-value:3.04E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.09|P-value:6.35E-7 ID:SGTC_1917|Compound:st066507|FD-Score:4.00|P-value:9.25E-4 ID:SGTC_1981|Compound:st071826|FD-Score:5.28|P-value:1.52E-5 ID:SGTC_2012|Compound:4023501|FD-Score:7.59|P-value:5.84E-10 ID:SGTC_2082|Compound:5219693|FD-Score:4.49|P-value:2.17E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.81|P-value:7.69E-5 ID:SGTC_2221|Compound:6807166|FD-Score:4.52|P-value:2.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.99|P-value:9.56E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.11|P-value:6.92E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.40|P-value:2.86E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.19|P-value:2.09E-5 ID:SGTC_2351|Compound:9026858|FD-Score:5.12|P-value:2.71E-5 ID:SGTC_2377|Compound:9073351|FD-Score:4.66|P-value:1.27E-4 ID:SGTC_2385|Compound:9074692|FD-Score:6.13|P-value:5.39E-7 ID:SGTC_2389|Compound:9091542|FD-Score:-3.74|P-value:4.61E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.60|P-value:4.49E-6 ID:SGTC_2442|Compound:5158906|FD-Score:-5.13|P-value:3.95E-6 ID:SGTC_2443|Compound:5493264|FD-Score:4.63|P-value:1.42E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.59|P-value:1.61E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.23|P-value:1.79E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.30|P-value:3.90E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.22|P-value:5.00E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.52|P-value:1.99E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.08|P-value:7.52E-4 ID:SGTC_2865|Compound:9030313|FD-Score:5.90|P-value:1.40E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-6.59|P-value:7.06E-9 ID:SGTC_2942|Compound:9052777|FD-Score:4.67|P-value:1.22E-4 ID:SGTC_2945|Compound:9067681|FD-Score:4.57|P-value:1.72E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.55|P-value:1.79E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.91|P-value:2.75E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.67|P-value:5.62E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-5.17|P-value:3.48E-6 ID:SGTC_3137|Compound:9097352|FD-Score:-3.52|P-value:8.72E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.59|P-value:1.62E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.67|P-value:1.25E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-5.31|P-value:2.00E-6 ID:SGTC_3254|Compound:9136651|FD-Score:5.42|P-value:9.13E-6 ID:SGTC_3263|Compound:9137018|FD-Score:4.98|P-value:4.43E-5 ID:SGTC_3274|Compound:9138298|FD-Score:4.58|P-value:1.64E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:4.14|P-value:6.21E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:7.31|P-value:2.43E-9 ID:SGTC_97|Compound:0535-0701|FD-Score:-4.55|P-value:3.45E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-7.26|P-value:2.34E-10 ID:SGTC_115|Compound:0527-0192|FD-Score:4.74|P-value:9.96E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:8.55|P-value:2.82E-12 ID:SGTC_122|Compound:0236-0016|FD-Score:6.50|P-value:1.10E-7 ID:SGTC_165|Compound:k038-0023|FD-Score:5.69|P-value:3.17E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:6.13|P-value:5.30E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:9.50|P-value:8.69E-15 ID:SGTC_188|Compound:3229-0966|FD-Score:4.40|P-value:2.89E-4 ID:SGTC_288|Compound:1315-0019|FD-Score:-4.02|P-value:1.98E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.30|P-value:1.38E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.93|P-value:2.63E-4 ID:SGTC_398|Compound:bronopol|FD-Score:10.40|P-value:1.60E-17 ID:SGTC_421|Compound:streptovitacin|FD-Score:-8.00|P-value:3.79E-12 ID:SGTC_431|Compound:k089-0097|FD-Score:-14.80|P-value:2.79E-36 ID:SGTC_439|Compound:amiodarone|FD-Score:4.49|P-value:2.17E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-5.14|P-value:3.90E-6 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.52|P-value:3.84E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.99|P-value:2.19E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:5.48|P-value:7.07E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-6.39|P-value:1.77E-8 ID:SGTC_516|Compound:3992-2719|FD-Score:4.02|P-value:8.79E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:5.43|P-value:8.56E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:4.28|P-value:4.15E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.51|P-value:2.05E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.74|P-value:9.97E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.82|P-value:2.22E-9 ID:SGTC_580|Compound:1123-0028|FD-Score:4.00|P-value:9.31E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.44|P-value:2.56E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.74|P-value:9.73E-13 ID:SGTC_675|Compound:1309-0189|FD-Score:5.14|P-value:2.49E-5 ID:SGTC_685|Compound:1278-0033|FD-Score:-3.99|P-value:2.18E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:5.08|P-value:3.14E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.24|P-value:2.65E-6 ID:SGTC_742|Compound:0kpi-0133|FD-Score:4.44|P-value:2.59E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:6.14|P-value:5.08E-7 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.33|P-value:7.10E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:6.60|P-value:7.05E-8 ID:SGTC_832|Compound:4083-0019|FD-Score:5.91|P-value:1.35E-6 ID:SGTC_862|Compound:0452-0056|FD-Score:4.46|P-value:2.42E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:7.92|P-value:9.87E-11 ID:SGTC_926|Compound:2268-1401|FD-Score:6.30|P-value:2.62E-7 ID:SGTC_935|Compound:2996-0153|FD-Score:-3.93|P-value:2.60E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:6.54|P-value:8.96E-8 ID:SGTC_959|Compound:1222-0044|FD-Score:-4.38|P-value:6.15E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:7.82|P-value:1.70E-10 ID:SGTC_995|Compound:3931-2021|FD-Score:4.04|P-value:8.26E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:5.36|P-value:1.12E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.76|P-value:9.21E-5 ID:SGTC_1256|Compound:0570-0116|FD-Score:5.76|P-value:2.45E-6 ID:SGTC_1395|Compound:3486-0190|FD-Score:4.23|P-value:4.89E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.40|P-value:2.93E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:4.25|P-value:4.50E-4 ID:SGTC_1490|Compound:4089-0339|FD-Score:5.46|P-value:7.62E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.70|P-value:1.12E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.38|P-value:3.08E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:5.21|P-value:1.92E-5 ID:SGTC_1618|Compound:st003135|FD-Score:-3.98|P-value:2.25E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.44|P-value:2.59E-4 ID:SGTC_1745|Compound:st081495|FD-Score:13.20|P-value:2.31E-27 ID:SGTC_1750|Compound:st081859|FD-Score:7.48|P-value:1.03E-9 ID:SGTC_1772|Compound:st048439|FD-Score:4.24|P-value:4.67E-4 ID:SGTC_1778|Compound:st046819|FD-Score:4.61|P-value:1.48E-4 ID:SGTC_1814|Compound:st052110|FD-Score:5.08|P-value:3.04E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:6.09|P-value:6.35E-7 ID:SGTC_1917|Compound:st066507|FD-Score:4.00|P-value:9.25E-4 ID:SGTC_1981|Compound:st071826|FD-Score:5.28|P-value:1.52E-5 ID:SGTC_2012|Compound:4023501|FD-Score:7.59|P-value:5.84E-10 ID:SGTC_2082|Compound:5219693|FD-Score:4.49|P-value:2.17E-4 ID:SGTC_2111|Compound:5486399|FD-Score:4.81|P-value:7.69E-5 ID:SGTC_2221|Compound:6807166|FD-Score:4.52|P-value:2.02E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.99|P-value:9.56E-4 ID:SGTC_2273|Compound:7815444|FD-Score:4.11|P-value:6.92E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.40|P-value:2.86E-4 ID:SGTC_2342|Compound:7990637|FD-Score:5.19|P-value:2.09E-5 ID:SGTC_2351|Compound:9026858|FD-Score:5.12|P-value:2.71E-5 ID:SGTC_2377|Compound:9073351|FD-Score:4.66|P-value:1.27E-4 ID:SGTC_2385|Compound:9074692|FD-Score:6.13|P-value:5.39E-7 ID:SGTC_2389|Compound:9091542|FD-Score:-3.74|P-value:4.61E-4 ID:SGTC_2393|Compound:9031399|FD-Score:5.60|P-value:4.49E-6 ID:SGTC_2442|Compound:5158906|FD-Score:-5.13|P-value:3.95E-6 ID:SGTC_2443|Compound:5493264|FD-Score:4.63|P-value:1.42E-4 ID:SGTC_2484|Compound:5809818|FD-Score:4.59|P-value:1.61E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.23|P-value:1.79E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.30|P-value:3.90E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:4.22|P-value:5.00E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:4.52|P-value:1.99E-4 ID:SGTC_2858|Compound:9025781|FD-Score:4.08|P-value:7.52E-4 ID:SGTC_2865|Compound:9030313|FD-Score:5.90|P-value:1.40E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-6.59|P-value:7.06E-9 ID:SGTC_2942|Compound:9052777|FD-Score:4.67|P-value:1.22E-4 ID:SGTC_2945|Compound:9067681|FD-Score:4.57|P-value:1.72E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.55|P-value:1.79E-4 ID:SGTC_3108|Compound:9121785|FD-Score:-3.91|P-value:2.75E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-3.67|P-value:5.62E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-5.17|P-value:3.48E-6 ID:SGTC_3137|Compound:9097352|FD-Score:-3.52|P-value:8.72E-4 ID:SGTC_3143|Compound:9086658|FD-Score:4.59|P-value:1.62E-4 ID:SGTC_3187|Compound:9109394|FD-Score:4.67|P-value:1.25E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-5.31|P-value:2.00E-6 ID:SGTC_3254|Compound:9136651|FD-Score:5.42|P-value:9.13E-6 ID:SGTC_3263|Compound:9137018|FD-Score:4.98|P-value:4.43E-5 ID:SGTC_3274|Compound:9138298|FD-Score:4.58|P-value:1.64E-4

Top fitness defect scores for YLR418C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1745 st081495 13.20 74.0 µM 2.31E-27 RNA processing & uracil transport 2 2.69E-40
2 SGTC_398 bronopol 10.40 33.3 µM 1.60E-17 RNA processing & uracil transport 1 9.71E-26
3 SGTC_178 4092-0806 9.50 87.5 µM 8.69E-15 ergosterol depletion effects on membrane 11 1.10E-21
4 SGTC_673 1082-0474 8.74 110.0 µM 9.73E-13 RSC complex & mRNA processing 13 1.22E-18
5 SGTC_117 lucigenin 8.55 22.1 µM 2.82E-12 redox potentiating 15 5.92E-18
6 SGTC_923 1900-2434 7.92 73.3 µM 9.87E-11 RNA processing & uracil transport 6 1.17E-15
7 SGTC_964 1287-0107 7.82 19.4 µM 1.70E-10 cell wall 7 2.64E-15
8 SGTC_2012 4023501 7.59 200.0 µM 5.84E-10 3 1.65E-14
9 SGTC_1750 st081859 7.48 2.4 µM 1.03E-9 endomembrane recycling 80 3.85E-14
10 SGTC_86 0417-1630 7.31 471.9 µM 2.43E-9 ubiquinone biosynthesis & proteasome 67 1.38E-13
11 SGTC_825 1988-2224 6.60 89.6 µM 7.05E-8 cell wall signaling 8 2.11E-11
12 SGTC_954 1189-0853 6.54 2.9 µM 8.96E-8 endomembrane recycling 9 3.01E-11
13 SGTC_122 0236-0016 6.50 402.4 µM 1.10E-7 RNA processing & uracil transport 7 4.10E-11
14 SGTC_926 2268-1401 6.30 59.4 µM 2.62E-7 TSC3-RPN4 10 1.49E-10
15 SGTC_745 0469-0705 6.14 296.0 µM 5.08E-7 mitochondrial processes 3 4.03E-10
16 SGTC_171 k064-0041 6.13 9.7 µM 5.30E-7 heme requiring 5 4.29E-10
17 SGTC_2385 9074692 6.13 200.0 µM 5.39E-7 11 4.40E-10
18 SGTC_1873 rapamycin 6.09 2.0 nM 6.35E-7 34 5.63E-10
19 SGTC_832 4083-0019 5.91 164.0 µM 1.35E-6 translation 21 1.73E-9
20 SGTC_2865 9030313 5.90 52.0 µM 1.40E-6 4 1.83E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 3.35E-39 YGL244W RTF1 hom Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay
0.175 1.78E-24 YDR469W SDC1 hom Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30
0.168 9.76E-23 YDL074C BRE1 hom E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control
0.148 5.43E-18 YLL027W ISA1 hom Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins
0.145 3.91E-17 YLR015W BRE2 hom Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L
0.141 2.83E-16 YBR021W FUR4 hom Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation
0.139 7.26E-16 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.133 9.22E-15 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.131 3.02E-14 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.127 1.74E-13 YEL031W SPF1 hom P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
0.127 1.90E-13 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.123 9.81E-13 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.122 1.22E-12 YPL055C LGE1 hom Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
0.119 4.18E-12 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.119 4.72E-12 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins