YLR419W_p

Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR419W / YLR419W

Click on Significant Values for Screen Details ID:SGTC_98|Compound:0074-0023|FD-Score:-4.09|P-value:9.87E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.61|P-value:9.34E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.22|P-value:3.95E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.89|P-value:2.07E-7 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.35|P-value:3.45E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.79|P-value:4.38E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.03|P-value:8.84E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.05|P-value:1.41E-5 ID:SGTC_296|Compound:1222-0039|FD-Score:5.51|P-value:5.96E-9 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.43|P-value:1.70E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.17|P-value:5.35E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.49|P-value:1.53E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.14|P-value:5.23E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.80|P-value:4.27E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.30|P-value:2.86E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.58|P-value:9.31E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.29|P-value:3.37E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.08|P-value:6.59E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.39|P-value:2.33E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:-3.16|P-value:4.88E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.30|P-value:4.41E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:4.31|P-value:4.15E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.03|P-value:1.55E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.42|P-value:1.77E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.92|P-value:2.46E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-6.57|P-value:4.01E-12 ID:SGTC_1759|Compound:st043059|FD-Score:-3.72|P-value:5.31E-5 ID:SGTC_1799|Compound:st045822|FD-Score:4.02|P-value:1.64E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.37|P-value:2.17E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.09|P-value:7.04E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.29|P-value:2.99E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.00|P-value:9.75E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.11|P-value:6.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.13|P-value:9.81E-6 ID:SGTC_2080|Compound:5212524|FD-Score:3.78|P-value:4.64E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-3.25|P-value:3.46E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.85|P-value:3.39E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.40|P-value:2.19E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-4.04|P-value:1.24E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-4.13|P-value:8.22E-6 ID:SGTC_2468|Compound:5987765|FD-Score:4.50|P-value:1.59E-6 ID:SGTC_2523|Compound:spermine|FD-Score:3.14|P-value:5.94E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.27|P-value:3.66E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.59|P-value:8.45E-7 ID:SGTC_2975|Compound:9084847|FD-Score:-4.17|P-value:7.06E-6 ID:SGTC_98|Compound:0074-0023|FD-Score:-4.09|P-value:9.87E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.61|P-value:9.34E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.22|P-value:3.95E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.89|P-value:2.07E-7 ID:SGTC_225|Compound:nsc-122657|FD-Score:4.35|P-value:3.45E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.79|P-value:4.38E-5 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.03|P-value:8.84E-4 ID:SGTC_264|Compound:promethazine|FD-Score:4.05|P-value:1.41E-5 ID:SGTC_296|Compound:1222-0039|FD-Score:5.51|P-value:5.96E-9 ID:SGTC_377|Compound:3970-0964|FD-Score:-3.43|P-value:1.70E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.37|P-value:2.50E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.52|P-value:1.39E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.17|P-value:5.35E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:3.49|P-value:1.53E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-3.14|P-value:5.23E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.80|P-value:4.27E-5 ID:SGTC_665|Compound:3914-0008|FD-Score:-3.30|P-value:2.86E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:-3.58|P-value:9.31E-5 ID:SGTC_801|Compound:0866-0028|FD-Score:3.29|P-value:3.37E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:-3.08|P-value:6.59E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:-4.39|P-value:2.33E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:-3.16|P-value:4.88E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.30|P-value:4.41E-6 ID:SGTC_1322|Compound:1348-1070|FD-Score:4.31|P-value:4.15E-6 ID:SGTC_1334|Compound:1486-0610|FD-Score:4.03|P-value:1.55E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.42|P-value:1.77E-4 ID:SGTC_1753|Compound:st043925|FD-Score:3.92|P-value:2.46E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-6.57|P-value:4.01E-12 ID:SGTC_1759|Compound:st043059|FD-Score:-3.72|P-value:5.31E-5 ID:SGTC_1799|Compound:st045822|FD-Score:4.02|P-value:1.64E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.37|P-value:2.17E-4 ID:SGTC_1866|Compound:st057638|FD-Score:3.09|P-value:7.04E-4 ID:SGTC_1909|Compound:st060837|FD-Score:-3.29|P-value:2.99E-4 ID:SGTC_1924|Compound:st058459|FD-Score:3.00|P-value:9.75E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.11|P-value:6.50E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.13|P-value:9.81E-6 ID:SGTC_2080|Compound:5212524|FD-Score:3.78|P-value:4.64E-5 ID:SGTC_2087|Compound:5276107|FD-Score:-3.25|P-value:3.46E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.85|P-value:3.39E-5 ID:SGTC_2309|Compound:7664088|FD-Score:3.40|P-value:2.19E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-4.04|P-value:1.24E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-4.13|P-value:8.22E-6 ID:SGTC_2468|Compound:5987765|FD-Score:4.50|P-value:1.59E-6 ID:SGTC_2523|Compound:spermine|FD-Score:3.14|P-value:5.94E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.27|P-value:3.66E-4 ID:SGTC_2971|Compound:9092186|FD-Score:-4.59|P-value:8.45E-7 ID:SGTC_2975|Compound:9084847|FD-Score:-4.17|P-value:7.06E-6

Top fitness defect scores for YLR419W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_296 1222-0039 5.51 74.9 µM 5.96E-9 4 1.85E-8
2 SGTC_219 mitoxanthrone 4.89 164.4 µM 2.07E-7 DNA intercalators 28 5.04E-7
3 SGTC_2468 5987765 4.50 72.9 µM 1.59E-6 7 3.36E-6
4 SGTC_225 nsc-122657 4.35 1.0 µM 3.45E-6 8 6.94E-6
5 SGTC_1322 1348-1070 4.31 12.0 µM 4.15E-6 3 8.25E-6
6 SGTC_1203 3992-3522 4.30 103.0 µM 4.41E-6 21 8.73E-6
7 SGTC_1935 st074532 4.13 41.6 µM 9.81E-6 24 1.84E-5
8 SGTC_264 promethazine 4.05 12.5 mM 1.41E-5 DNA intercalators 48 2.58E-5
9 SGTC_1334 1486-0610 4.03 236.0 µM 1.55E-5 60S ribosome export 16 2.82E-5
10 SGTC_1799 st045822 4.02 46.1 µM 1.64E-5 13 2.97E-5
11 SGTC_1753 st043925 3.92 64.0 µM 2.46E-5 9 4.34E-5
12 SGTC_2130 NSC 7 3.85 2.5 µM 3.39E-5 copper-dependent oxidative stress 27 5.85E-5
13 SGTC_566 0958-0068 3.80 16.5 µM 4.27E-5 RSC & ERG11 19 7.27E-5
14 SGTC_230 MPP+ 3.79 141.7 µM 4.38E-5 19 7.44E-5
15 SGTC_2080 5212524 3.78 12.4 µM 4.64E-5 copper-dependent oxidative stress 16 7.85E-5
16 SGTC_143 4032-1194 3.61 15.7 µM 9.34E-5 81 1.51E-4
17 SGTC_405 ebelactone b 3.52 50.0 µM 1.39E-4 28 2.19E-4
18 SGTC_412 gemfibrozil 3.49 100.0 µM 1.53E-4 DNA intercalators 16 2.39E-4
19 SGTC_2309 7664088 3.40 163.9 µM 2.19E-4 69 3.35E-4
20 SGTC_386 1509-0011 3.37 3.1 µM 2.50E-4 173 3.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 7.04E-27 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.172 9.13E-24 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.168 1.30E-22 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.133 1.07E-14 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.128 1.09E-13 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.124 6.52E-13 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.117 1.18E-11 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.112 8.57E-11 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.109 2.05E-10 YMR181C_p YMR181C_p hom Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication
0.109 3.02E-10 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.101 4.94E-9 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.101 5.00E-9 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.098 1.35E-8 YLR271W_p YLR271W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.098 1.32E-8 YJL196C ELO1 hom Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, FEN1, that arose from the whole genome duplication
0.097 1.78E-8 YBR253W SRB6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation