YLR423C / ATG17

Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR423C / ATG17

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:3.94|P-value:6.71E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.81|P-value:1.10E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.20|P-value:9.89E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.34|P-value:6.06E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:4.10|P-value:3.44E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.86|P-value:7.49E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:3.78|P-value:1.25E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.68|P-value:2.17E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:3.24|P-value:8.44E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.27|P-value:1.73E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.46|P-value:3.34E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.79|P-value:9.74E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:3.25|P-value:8.38E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.32|P-value:1.38E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.56|P-value:2.80E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.42|P-value:4.55E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.57|P-value:2.22E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-4.15|P-value:2.29E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:4.12|P-value:3.20E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.99|P-value:2.89E-9 ID:SGTC_918|Compound:glabranin|FD-Score:3.48|P-value:3.74E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.44|P-value:3.52E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.34|P-value:9.88E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.62|P-value:2.29E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.17|P-value:2.58E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.41|P-value:9.54E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.78|P-value:1.75E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.07|P-value:1.85E-9 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.77|P-value:1.84E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.72|P-value:1.57E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.65|P-value:1.65E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:6.28|P-value:5.12E-10 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.74|P-value:1.44E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.63|P-value:2.19E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.67|P-value:2.95E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.70|P-value:2.55E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_1650|Compound:st011916|FD-Score:5.90|P-value:4.79E-9 ID:SGTC_1660|Compound:st012960|FD-Score:4.74|P-value:2.11E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.47|P-value:3.92E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.22|P-value:9.10E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.39|P-value:5.11E-4 ID:SGTC_1763|Compound:st044482|FD-Score:5.95|P-value:3.64E-9 ID:SGTC_1801|Compound:st050089|FD-Score:4.39|P-value:1.03E-5 ID:SGTC_1849|Compound:st056239|FD-Score:5.13|P-value:3.10E-7 ID:SGTC_1851|Compound:st056236|FD-Score:3.74|P-value:1.43E-4 ID:SGTC_1920|Compound:st075728|FD-Score:5.54|P-value:3.61E-8 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.14|P-value:2.33E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.69|P-value:2.63E-6 ID:SGTC_2261|Compound:9010538|FD-Score:4.01|P-value:5.11E-5 ID:SGTC_2269|Compound:7935389|FD-Score:4.08|P-value:3.79E-5 ID:SGTC_2270|Compound:7924575|FD-Score:5.74|P-value:1.19E-8 ID:SGTC_2297|Compound:7971671|FD-Score:3.90|P-value:7.94E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.42|P-value:4.57E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.42|P-value:4.63E-4 ID:SGTC_2350|Compound:9023895|FD-Score:5.42|P-value:7.16E-8 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.41|P-value:4.01E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-3.51|P-value:2.80E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.26|P-value:7.95E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.01|P-value:5.07E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.30|P-value:6.92E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.47|P-value:3.82E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.60|P-value:2.43E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.28|P-value:7.49E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.67|P-value:2.95E-6 ID:SGTC_2709|Compound:st078560|FD-Score:4.87|P-value:1.13E-6 ID:SGTC_2714|Compound:st079313|FD-Score:4.48|P-value:6.89E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.32|P-value:6.41E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.22|P-value:9.02E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.39|P-value:5.12E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.30|P-value:6.90E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.91|P-value:9.38E-7 ID:SGTC_2919|Compound:7978188|FD-Score:-3.66|P-value:1.60E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.66|P-value:1.98E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.91|P-value:6.16E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.27|P-value:7.59E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.80|P-value:1.54E-6 ID:SGTC_3280|Compound:9140961|FD-Score:3.85|P-value:9.45E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:3.94|P-value:6.71E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:3.81|P-value:1.10E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.20|P-value:9.89E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.34|P-value:6.06E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:4.10|P-value:3.44E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.86|P-value:7.49E-5 ID:SGTC_303|Compound:1348-1668|FD-Score:3.78|P-value:1.25E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.68|P-value:2.17E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:3.24|P-value:8.44E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:4.27|P-value:1.73E-5 ID:SGTC_501|Compound:nsc-95397|FD-Score:-3.46|P-value:3.34E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.79|P-value:9.74E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:3.25|P-value:8.38E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.32|P-value:1.38E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:3.56|P-value:2.80E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.42|P-value:4.55E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.57|P-value:2.22E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:-4.15|P-value:2.29E-5 ID:SGTC_872|Compound:0588-0139|FD-Score:4.12|P-value:3.20E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:5.99|P-value:2.89E-9 ID:SGTC_918|Compound:glabranin|FD-Score:3.48|P-value:3.74E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.44|P-value:3.52E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.34|P-value:9.88E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.62|P-value:2.29E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:4.17|P-value:2.58E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:4.41|P-value:9.54E-6 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.78|P-value:1.75E-6 ID:SGTC_1293|Compound:1000-1278|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:6.07|P-value:1.85E-9 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.77|P-value:1.84E-6 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.72|P-value:1.57E-4 ID:SGTC_1365|Compound:1672-3266|FD-Score:-3.65|P-value:1.65E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:6.28|P-value:5.12E-10 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.74|P-value:1.44E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.63|P-value:2.19E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.67|P-value:2.95E-6 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:4.70|P-value:2.55E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_1650|Compound:st011916|FD-Score:5.90|P-value:4.79E-9 ID:SGTC_1660|Compound:st012960|FD-Score:4.74|P-value:2.11E-6 ID:SGTC_1687|Compound:st020778|FD-Score:3.47|P-value:3.92E-4 ID:SGTC_1708|Compound:st033234|FD-Score:3.22|P-value:9.10E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.39|P-value:5.11E-4 ID:SGTC_1763|Compound:st044482|FD-Score:5.95|P-value:3.64E-9 ID:SGTC_1801|Compound:st050089|FD-Score:4.39|P-value:1.03E-5 ID:SGTC_1849|Compound:st056239|FD-Score:5.13|P-value:3.10E-7 ID:SGTC_1851|Compound:st056236|FD-Score:3.74|P-value:1.43E-4 ID:SGTC_1920|Compound:st075728|FD-Score:5.54|P-value:3.61E-8 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-4.14|P-value:2.33E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.76|P-value:1.34E-4 ID:SGTC_2259|Compound:7964009|FD-Score:4.69|P-value:2.63E-6 ID:SGTC_2261|Compound:9010538|FD-Score:4.01|P-value:5.11E-5 ID:SGTC_2269|Compound:7935389|FD-Score:4.08|P-value:3.79E-5 ID:SGTC_2270|Compound:7924575|FD-Score:5.74|P-value:1.19E-8 ID:SGTC_2297|Compound:7971671|FD-Score:3.90|P-value:7.94E-5 ID:SGTC_2314|Compound:7727897|FD-Score:3.42|P-value:4.57E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.42|P-value:4.63E-4 ID:SGTC_2350|Compound:9023895|FD-Score:5.42|P-value:7.16E-8 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.41|P-value:4.01E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-3.51|P-value:2.80E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.26|P-value:7.95E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.01|P-value:5.07E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.30|P-value:6.92E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.47|P-value:3.82E-4 ID:SGTC_2649|Compound:anisomycin|FD-Score:3.60|P-value:2.43E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.28|P-value:7.49E-4 ID:SGTC_2703|Compound:st077852|FD-Score:4.67|P-value:2.95E-6 ID:SGTC_2709|Compound:st078560|FD-Score:4.87|P-value:1.13E-6 ID:SGTC_2714|Compound:st079313|FD-Score:4.48|P-value:6.89E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.32|P-value:6.41E-4 ID:SGTC_2784|Compound:7567673|FD-Score:3.22|P-value:9.02E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.39|P-value:5.12E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.30|P-value:6.90E-4 ID:SGTC_2911|Compound:7942208|FD-Score:4.91|P-value:9.38E-7 ID:SGTC_2919|Compound:7978188|FD-Score:-3.66|P-value:1.60E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.66|P-value:1.98E-4 ID:SGTC_2948|Compound:9070189|FD-Score:-3.91|P-value:6.16E-5 ID:SGTC_2963|Compound:9082507|FD-Score:3.27|P-value:7.59E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.88|P-value:8.39E-5 ID:SGTC_3233|Compound:9132340|FD-Score:4.80|P-value:1.54E-6 ID:SGTC_3280|Compound:9140961|FD-Score:3.85|P-value:9.45E-5

Top fitness defect scores for YLR423C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1366 1683-0113 6.28 21.9 µM 5.12E-10 1 1.70E-10
2 SGTC_1304 1165-0502 6.07 251.0 µM 1.85E-9 30 6.54E-10
3 SGTC_908 3448-7491 5.99 47.7 µM 2.89E-9 mitochondrial stress 49 1.05E-9
4 SGTC_1763 st044482 5.95 94.5 µM 3.64E-9 copper-dependent oxidative stress 5 1.34E-9
5 SGTC_1650 st011916 5.90 45.8 µM 4.79E-9 2 1.78E-9
6 SGTC_2270 7924575 5.74 90.9 µM 1.19E-8 RPP1 & pyrimidine depletion 2 4.64E-9
7 SGTC_1920 st075728 5.54 45.7 µM 3.61E-8 1 1.49E-8
8 SGTC_2350 9023895 5.42 38.9 µM 7.16E-8 ergosterol biosynthesis 15 3.06E-8
9 SGTC_1849 st056239 5.13 19.2 µM 3.10E-7 RPP1 & pyrimidine depletion 7 1.43E-7
10 SGTC_2911 7942208 4.91 15.6 µM 9.38E-7 mitochondrial response to ROS 6 4.59E-7
11 SGTC_2709 st078560 4.87 56.0 µM 1.13E-6 2 5.61E-7
12 SGTC_3233 9132340 4.80 49.5 µM 1.54E-6 5 7.74E-7
13 SGTC_1239 0337-0584 4.78 35.4 µM 1.75E-6 unfolded protein response 30 8.88E-7
14 SGTC_1324 1418-0026 4.77 34.4 µM 1.84E-6 4 9.32E-7
15 SGTC_1660 st012960 4.74 28.1 µM 2.11E-6 iron homeostasis 19 1.08E-6
16 SGTC_1576 erythromycin ethylsuccinate 4.70 23.2 µM 2.55E-6 12 1.31E-6
17 SGTC_2259 7964009 4.69 200.0 µM 2.63E-6 superoxide 20 1.36E-6
18 SGTC_2703 st077852 4.67 53.4 µM 2.95E-6 8 1.54E-6
19 SGTC_1503 4585-0012 4.67 61.3 µM 2.95E-6 4 1.54E-6
20 SGTC_2714 st079313 4.48 56.9 µM 6.89E-6 5 3.75E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.89E-11 YMR271C URA10 hom Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication
0.105 1.24E-9 YBL079W NUP170 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
0.098 1.39E-8 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.088 2.84E-7 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.086 5.25E-7 YPL026C SKS1 hom Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
0.086 6.50E-7 YFL001W DEG1 hom tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability
0.084 1.12E-6 YJR074W MOG1 hom Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p
0.080 3.08E-6 YKR093W PTR2 hom Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
0.080 3.61E-6 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.078 7.20E-6 YLR315W NKP2 hom Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2
0.077 7.19E-6 YGR063C SPT4 hom Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair; Spt4p also localizes to kinetochores and heterochromatin and affects chromosome dynamics and silencing; required for transcription through lengthy trinucleotide repeats in ORFs or non-protein coding regions
0.076 1.06E-5 YFL032W_d YFL032W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
0.075 1.22E-5 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.074 1.69E-5 YPR074C TKL1 hom Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
0.074 1.77E-5 YGR085C RPL11B hom Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication