YLR425W / TUS1

Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR425W / TUS1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:5.79|P-value:6.87E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:3.53|P-value:7.99E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.67|P-value:1.29E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.51|P-value:2.37E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-4.03|P-value:4.46E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.81|P-value:3.15E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.77|P-value:3.63E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.24|P-value:1.97E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:4.96|P-value:3.51E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.05|P-value:1.78E-8 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.83|P-value:3.01E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.69|P-value:1.11E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.62|P-value:6.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.19|P-value:2.43E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.71|P-value:1.49E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.75|P-value:3.87E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.12|P-value:1.05E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.16|P-value:9.11E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:4.28|P-value:5.76E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:5.19|P-value:1.25E-6 ID:SGTC_646|Compound:4092-0839|FD-Score:4.74|P-value:9.26E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:4.03|P-value:1.47E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.49|P-value:9.30E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.67|P-value:5.07E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:5.13|P-value:1.68E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:4.75|P-value:8.67E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.49|P-value:9.16E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.78|P-value:3.57E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.61|P-value:6.34E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.32|P-value:7.02E-7 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.09|P-value:1.17E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.23|P-value:1.04E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.46|P-value:2.85E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.88|P-value:5.03E-6 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.42|P-value:3.34E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.96|P-value:1.88E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.54|P-value:2.09E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.62|P-value:6.07E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.85|P-value:2.82E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.94|P-value:3.87E-6 ID:SGTC_1719|Compound:st032227|FD-Score:4.68|P-value:1.16E-5 ID:SGTC_1724|Compound:st037281|FD-Score:4.08|P-value:1.22E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.30|P-value:6.07E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.80|P-value:3.35E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.51|P-value:8.59E-4 ID:SGTC_1963|Compound:st076565|FD-Score:4.27|P-value:6.14E-5 ID:SGTC_1966|Compound:st070145|FD-Score:5.08|P-value:2.06E-6 ID:SGTC_1970|Compound:st070122|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.00|P-value:1.66E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.23|P-value:7.66E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.71|P-value:4.45E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.75|P-value:3.86E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.33|P-value:4.79E-5 ID:SGTC_2370|Compound:9071495|FD-Score:4.59|P-value:1.72E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.28|P-value:5.84E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.45|P-value:2.95E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.49|P-value:3.06E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.54|P-value:2.07E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:4.28|P-value:5.85E-5 ID:SGTC_2678|Compound:equilin|FD-Score:4.19|P-value:8.16E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.74|P-value:4.01E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.79|P-value:3.37E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.65|P-value:5.40E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.78|P-value:3.57E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.82|P-value:1.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.41|P-value:9.56E-6 ID:SGTC_2899|Compound:9053889|FD-Score:4.39|P-value:3.87E-5 ID:SGTC_2932|Compound:9016711|FD-Score:4.30|P-value:5.38E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.19|P-value:8.64E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.34|P-value:4.53E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.66|P-value:1.29E-5 ID:SGTC_3012|Compound:9080433|FD-Score:4.27|P-value:5.93E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.81|P-value:3.22E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:5.79|P-value:6.87E-8 ID:SGTC_43|Compound:0570-0105|FD-Score:3.53|P-value:7.99E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:5.67|P-value:1.29E-7 ID:SGTC_70|Compound:0141-0289|FD-Score:4.51|P-value:2.37E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-4.03|P-value:4.46E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:3.81|P-value:3.15E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:3.77|P-value:3.63E-4 ID:SGTC_169|Compound:k015-0017|FD-Score:-4.24|P-value:1.97E-5 ID:SGTC_176|Compound:1486-1328|FD-Score:4.96|P-value:3.51E-6 ID:SGTC_182|Compound:3448-4371|FD-Score:6.05|P-value:1.78E-8 ID:SGTC_220|Compound:paclitaxel|FD-Score:3.83|P-value:3.01E-4 ID:SGTC_269|Compound:exalamide|FD-Score:4.69|P-value:1.11E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.62|P-value:6.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.19|P-value:2.43E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:-3.71|P-value:1.49E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:3.75|P-value:3.87E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:4.12|P-value:1.05E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:4.16|P-value:9.11E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:4.28|P-value:5.76E-5 ID:SGTC_644|Compound:1498-1197|FD-Score:5.19|P-value:1.25E-6 ID:SGTC_646|Compound:4092-0839|FD-Score:4.74|P-value:9.26E-6 ID:SGTC_667|Compound:1498-1044|FD-Score:4.03|P-value:1.47E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:3.49|P-value:9.30E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:3.67|P-value:5.07E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:5.13|P-value:1.68E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:4.75|P-value:8.67E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:3.49|P-value:9.16E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.78|P-value:3.57E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.61|P-value:6.34E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:5.32|P-value:7.02E-7 ID:SGTC_1159|Compound:4092-0538|FD-Score:4.09|P-value:1.17E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:5.23|P-value:1.04E-6 ID:SGTC_1365|Compound:1672-3266|FD-Score:4.46|P-value:2.85E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:4.88|P-value:5.03E-6 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:4.42|P-value:3.34E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.96|P-value:1.88E-4 ID:SGTC_1427|Compound:4048-4900|FD-Score:4.54|P-value:2.09E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.62|P-value:6.07E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.85|P-value:2.82E-4 ID:SGTC_1696|Compound:st025591|FD-Score:4.94|P-value:3.87E-6 ID:SGTC_1719|Compound:st032227|FD-Score:4.68|P-value:1.16E-5 ID:SGTC_1724|Compound:st037281|FD-Score:4.08|P-value:1.22E-4 ID:SGTC_1854|Compound:st056233|FD-Score:-3.30|P-value:6.07E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.80|P-value:3.35E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.51|P-value:8.59E-4 ID:SGTC_1963|Compound:st076565|FD-Score:4.27|P-value:6.14E-5 ID:SGTC_1966|Compound:st070145|FD-Score:5.08|P-value:2.06E-6 ID:SGTC_1970|Compound:st070122|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.00|P-value:1.66E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.23|P-value:7.66E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.71|P-value:4.45E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.75|P-value:3.86E-4 ID:SGTC_2347|Compound:9049783|FD-Score:4.33|P-value:4.79E-5 ID:SGTC_2370|Compound:9071495|FD-Score:4.59|P-value:1.72E-5 ID:SGTC_2477|Compound:5967686|FD-Score:4.28|P-value:5.84E-5 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:4.45|P-value:2.95E-5 ID:SGTC_2589|Compound:lobaric acid|FD-Score:5.49|P-value:3.06E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:4.54|P-value:2.07E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:4.28|P-value:5.85E-5 ID:SGTC_2678|Compound:equilin|FD-Score:4.19|P-value:8.16E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.74|P-value:4.01E-4 ID:SGTC_2715|Compound:st079500|FD-Score:3.79|P-value:3.37E-4 ID:SGTC_2800|Compound:7887935|FD-Score:3.65|P-value:5.40E-4 ID:SGTC_2816|Compound:7982706|FD-Score:3.78|P-value:3.57E-4 ID:SGTC_2822|Compound:7994718|FD-Score:-3.82|P-value:1.01E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-4.41|P-value:9.56E-6 ID:SGTC_2899|Compound:9053889|FD-Score:4.39|P-value:3.87E-5 ID:SGTC_2932|Compound:9016711|FD-Score:4.30|P-value:5.38E-5 ID:SGTC_2985|Compound:9022375|FD-Score:-3.19|P-value:8.64E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.34|P-value:4.53E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.66|P-value:1.29E-5 ID:SGTC_3012|Compound:9080433|FD-Score:4.27|P-value:5.93E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.81|P-value:3.22E-4

Top fitness defect scores for YLR425W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_182 3448-4371 6.05 550.5 µM 1.78E-8 10 7.14E-10
2 SGTC_35 0133-0054 5.79 64.1 µM 6.87E-8 4 3.46E-9
3 SGTC_65 0798-0905 5.67 35.0 µM 1.29E-7 calcium & mitochondrial duress 41 7.20E-9
4 SGTC_2589 lobaric acid 5.49 100.0 µM 3.06E-7 7 1.99E-8
5 SGTC_1157 4092-0394 5.32 27.6 µM 7.02E-7 9 5.25E-8
6 SGTC_1203 3992-3522 5.23 103.0 µM 1.04E-6 10 8.28E-8
7 SGTC_644 1498-1197 5.19 63.3 µM 1.25E-6 3 1.03E-7
8 SGTC_883 0850-0245 5.13 24.6 µM 1.68E-6 cell wall 11 1.46E-7
9 SGTC_1966 st070145 5.08 16.1 µM 2.06E-6 9 1.86E-7
10 SGTC_176 1486-1328 4.96 72.8 µM 3.51E-6 31 3.46E-7
11 SGTC_1696 st025591 4.94 34.8 µM 3.87E-6 SWF1 & branched chain AA biosynthesis 15 3.89E-7
12 SGTC_1408 3909-7976 4.88 48.8 µM 5.03E-6 Golgi 11 5.29E-7
13 SGTC_893 0958-0369 4.75 48.9 µM 8.67E-6 16 1.00E-6
14 SGTC_646 4092-0839 4.74 27.3 µM 9.26E-6 plasma membrane duress 11 1.08E-6
15 SGTC_269 exalamide 4.69 29.0 µM 1.11E-5 ergosterol biosynthesis 10 1.34E-6
16 SGTC_1719 st032227 4.68 49.2 µM 1.16E-5 13 1.41E-6
17 SGTC_3008 9078912 4.66 71.4 µM 1.29E-5 4 1.60E-6
18 SGTC_2370 9071495 4.59 200.0 µM 1.72E-5 mitochondrial processes 15 2.24E-6
19 SGTC_2666 tannic acid 4.54 100.0 µM 2.07E-5 iron homeostasis 26 2.79E-6
20 SGTC_1427 4048-4900 4.54 550.0 nM 2.09E-5 20 2.82E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.102 3.41E-9 YDL041W_d YDL041W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.088 3.84E-7 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.086 6.65E-7 YDR363W-A SEM1 hom Component of lid subcomplex of the 26S proteasome regulatory subunit; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1; protein abundance increases in response to DNA replication stress
0.086 6.78E-7 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.085 9.27E-7 YBR139W YBR139W hom Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner
0.083 1.42E-6 YMR069W NAT4 hom N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
0.082 1.87E-6 YER051W JHD1 hom JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe
0.079 4.35E-6 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.076 1.07E-5 YOR253W NAT5 hom Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
0.075 1.29E-5 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.073 2.18E-5 YHR021C RPS27B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication
0.071 3.90E-5 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.071 4.08E-5 YMR118C_p SHH3_p hom Putative mitochondrial inner membrane protein of unknown function; although similar to Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase
0.071 4.10E-5 YOR015W_d YOR015W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.070 4.98E-5 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively