YLR426W_p / TDA5

Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR426W / TDA5

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.56|P-value:1.62E-13 ID:SGTC_72|Compound:0744-0168|FD-Score:5.02|P-value:1.09E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:4.20|P-value:1.99E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.81|P-value:2.39E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.83|P-value:4.00E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:4.73|P-value:3.23E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:8.17|P-value:1.88E-12 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.86|P-value:5.74E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.91|P-value:3.19E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-4.87|P-value:1.13E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.20|P-value:1.25E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.69|P-value:9.67E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.24|P-value:1.74E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.84|P-value:3.17E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:4.52|P-value:6.87E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:3.74|P-value:8.33E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.04|P-value:3.31E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.81|P-value:6.65E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.33|P-value:1.31E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.20|P-value:1.99E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.22|P-value:1.15E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.92|P-value:4.89E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.75|P-value:5.18E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.15|P-value:2.32E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.21|P-value:1.96E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:6.67|P-value:7.74E-9 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.45|P-value:8.58E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.95|P-value:2.84E-4 ID:SGTC_1651|Compound:st011928|FD-Score:6.03|P-value:1.59E-7 ID:SGTC_1652|Compound:st011932|FD-Score:4.23|P-value:1.81E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.03|P-value:3.45E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.23|P-value:1.78E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.83|P-value:6.32E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-5.85|P-value:1.87E-7 ID:SGTC_1744|Compound:st037937|FD-Score:7.22|P-value:4.44E-10 ID:SGTC_1745|Compound:st081495|FD-Score:12.00|P-value:7.94E-25 ID:SGTC_1776|Compound:st049249|FD-Score:3.88|P-value:5.37E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.39|P-value:1.06E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.08|P-value:8.65E-6 ID:SGTC_2017|Compound:5132927|FD-Score:4.03|P-value:3.48E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.45|P-value:8.67E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.05|P-value:3.25E-4 ID:SGTC_2111|Compound:5486399|FD-Score:5.97|P-value:2.07E-7 ID:SGTC_2145|Compound:5634607|FD-Score:4.07|P-value:3.02E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.04|P-value:1.02E-5 ID:SGTC_2274|Compound:7947094|FD-Score:5.57|P-value:1.21E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.42|P-value:9.71E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:7.41|P-value:1.50E-10 ID:SGTC_2602|Compound:kawain|FD-Score:-3.78|P-value:4.76E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.76|P-value:4.99E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.92|P-value:4.80E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-5.51|P-value:8.37E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:5.47|P-value:1.86E-6 ID:SGTC_2810|Compound:7959871|FD-Score:4.92|P-value:1.62E-5 ID:SGTC_2867|Compound:9039098|FD-Score:5.78|P-value:4.83E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.85|P-value:2.09E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.72|P-value:8.69E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.10|P-value:8.04E-6 ID:SGTC_3022|Compound:9087993|FD-Score:5.10|P-value:8.01E-6 ID:SGTC_3025|Compound:9087895|FD-Score:5.65|P-value:8.42E-7 ID:SGTC_3055|Compound:9094636|FD-Score:4.16|P-value:2.25E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.58|P-value:8.56E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.87|P-value:3.60E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-6.11|P-value:5.60E-8 ID:SGTC_3141|Compound:9094609|FD-Score:3.89|P-value:5.23E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.62|P-value:4.79E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.60|P-value:8.13E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.71|P-value:9.01E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.77|P-value:7.48E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.56|P-value:1.62E-13 ID:SGTC_72|Compound:0744-0168|FD-Score:5.02|P-value:1.09E-5 ID:SGTC_98|Compound:0074-0023|FD-Score:4.20|P-value:1.99E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.81|P-value:2.39E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.83|P-value:4.00E-7 ID:SGTC_160|Compound:3453-0671|FD-Score:4.73|P-value:3.23E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:8.17|P-value:1.88E-12 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.86|P-value:5.74E-4 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:-3.91|P-value:3.19E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:-4.87|P-value:1.13E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:-4.20|P-value:1.25E-4 ID:SGTC_509|Compound:pifithrin|FD-Score:3.69|P-value:9.67E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:4.24|P-value:1.74E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:6.84|P-value:3.17E-9 ID:SGTC_637|Compound:1181-0519|FD-Score:4.52|P-value:6.87E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:3.74|P-value:8.33E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:4.04|P-value:3.31E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.81|P-value:6.65E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.33|P-value:1.31E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:4.20|P-value:1.99E-4 ID:SGTC_1245|Compound:0418-0076|FD-Score:-4.22|P-value:1.15E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.92|P-value:4.89E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:-3.75|P-value:5.18E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.15|P-value:2.32E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.21|P-value:1.96E-4 ID:SGTC_1470|Compound:k295-0292|FD-Score:6.67|P-value:7.74E-9 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.45|P-value:8.58E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-3.95|P-value:2.84E-4 ID:SGTC_1651|Compound:st011928|FD-Score:6.03|P-value:1.59E-7 ID:SGTC_1652|Compound:st011932|FD-Score:4.23|P-value:1.81E-4 ID:SGTC_1657|Compound:st012939|FD-Score:4.03|P-value:3.45E-4 ID:SGTC_1717|Compound:st033143|FD-Score:4.23|P-value:1.78E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.83|P-value:6.32E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-5.85|P-value:1.87E-7 ID:SGTC_1744|Compound:st037937|FD-Score:7.22|P-value:4.44E-10 ID:SGTC_1745|Compound:st081495|FD-Score:12.00|P-value:7.94E-25 ID:SGTC_1776|Compound:st049249|FD-Score:3.88|P-value:5.37E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.39|P-value:1.06E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.08|P-value:8.65E-6 ID:SGTC_2017|Compound:5132927|FD-Score:4.03|P-value:3.48E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.45|P-value:8.67E-5 ID:SGTC_2092|Compound:5303694|FD-Score:4.05|P-value:3.25E-4 ID:SGTC_2111|Compound:5486399|FD-Score:5.97|P-value:2.07E-7 ID:SGTC_2145|Compound:5634607|FD-Score:4.07|P-value:3.02E-4 ID:SGTC_2266|Compound:7929956|FD-Score:5.04|P-value:1.02E-5 ID:SGTC_2274|Compound:7947094|FD-Score:5.57|P-value:1.21E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:4.42|P-value:9.71E-5 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:7.41|P-value:1.50E-10 ID:SGTC_2602|Compound:kawain|FD-Score:-3.78|P-value:4.76E-4 ID:SGTC_2625|Compound:euphol|FD-Score:-3.76|P-value:4.99E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.92|P-value:4.80E-4 ID:SGTC_2761|Compound:levamisole|FD-Score:-5.51|P-value:8.37E-7 ID:SGTC_2769|Compound:toremifene|FD-Score:5.47|P-value:1.86E-6 ID:SGTC_2810|Compound:7959871|FD-Score:4.92|P-value:1.62E-5 ID:SGTC_2867|Compound:9039098|FD-Score:5.78|P-value:4.83E-7 ID:SGTC_2924|Compound:9010168|FD-Score:4.85|P-value:2.09E-5 ID:SGTC_2981|Compound:9013952|FD-Score:3.72|P-value:8.69E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.10|P-value:8.04E-6 ID:SGTC_3022|Compound:9087993|FD-Score:5.10|P-value:8.01E-6 ID:SGTC_3025|Compound:9087895|FD-Score:5.65|P-value:8.42E-7 ID:SGTC_3055|Compound:9094636|FD-Score:4.16|P-value:2.25E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.58|P-value:8.56E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.87|P-value:3.60E-4 ID:SGTC_3137|Compound:9097352|FD-Score:-6.11|P-value:5.60E-8 ID:SGTC_3141|Compound:9094609|FD-Score:3.89|P-value:5.23E-4 ID:SGTC_3157|Compound:9099274|FD-Score:4.62|P-value:4.79E-5 ID:SGTC_3170|Compound:9103054|FD-Score:-3.60|P-value:8.13E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.71|P-value:9.01E-4 ID:SGTC_3266|Compound:9136860|FD-Score:3.77|P-value:7.48E-4

Top fitness defect scores for YLR426W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1745 st081495 12.00 74.0 µM 7.94E-25 RNA processing & uracil transport 4 2.07E-33
2 SGTC_58 0957-0393 8.56 9.0 µM 1.62E-13 cell wall 111 5.48E-18
3 SGTC_166 k072-0058 8.17 166.4 µM 1.88E-12 DNA intercalators 2 1.56E-16
4 SGTC_2553 4-methylesculetin 7.41 85.1 µM 1.50E-10 2 6.10E-14
5 SGTC_1744 st037937 7.22 38.9 µM 4.44E-10 1 2.68E-13
6 SGTC_635 k038-0028 6.84 24.7 µM 3.17E-9 ubiquinone biosynthesis & proteasome 10 3.90E-12
7 SGTC_1470 k295-0292 6.67 231.0 µM 7.74E-9 4 1.32E-11
8 SGTC_1651 st011928 6.03 86.1 µM 1.59E-7 RSC complex & mRNA processing 3 8.10E-10
9 SGTC_2111 5486399 5.97 200.0 µM 2.07E-7 6 1.16E-9
10 SGTC_138 0850-0259 5.83 40.9 µM 4.00E-7 cell wall 110 2.85E-9
11 SGTC_2867 9039098 5.78 71.4 µM 4.83E-7 iron homeostasis 7 3.69E-9
12 SGTC_3025 9087895 5.65 49.5 µM 8.42E-7 PDR1 16 7.86E-9
13 SGTC_2274 7947094 5.57 46.1 µM 1.21E-6 5 1.29E-8
14 SGTC_2769 toremifene 5.47 3.7 µM 1.86E-6 7 2.31E-8
15 SGTC_3022 9087993 5.10 49.5 µM 8.01E-6 3 1.69E-7
16 SGTC_3020 9089140 5.10 49.5 µM 8.04E-6 7 1.70E-7
17 SGTC_1965 Pectolinarigenin 5.08 58.4 µM 8.65E-6 RPP1 & pyrimidine depletion 7 1.87E-7
18 SGTC_2266 7929956 5.04 200.0 µM 1.02E-5 14 2.35E-7
19 SGTC_72 0744-0168 5.02 198.4 µM 1.09E-5 RPP1 & pyrimidine depletion 14 2.58E-7
20 SGTC_2810 7959871 4.92 45.5 µM 1.62E-5 copper-dependent oxidative stress 21 4.39E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.216 8.80E-37 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.163 2.14E-21 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.155 1.45E-19 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.149 3.57E-18 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.147 1.16E-17 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.140 3.67E-16 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.139 4.99E-16 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.138 1.01E-15 YFL056C AAD6 hom Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin
0.136 2.91E-15 YJL059W YHC3 hom Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis)
0.136 3.01E-15 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.135 3.62E-15 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.135 3.84E-15 YLR420W URA4 hom Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
0.132 1.89E-14 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.130 4.90E-14 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.128 1.09E-13 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants