YLR427W / MAG2

Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR427W / MAG2

Click on Significant Values for Screen Details ID:SGTC_709|Compound:3807-1509|FD-Score:3.59|P-value:4.33E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.29|P-value:3.41E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.95|P-value:1.21E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.53|P-value:4.77E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.29|P-value:3.31E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.72|P-value:5.37E-8 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.55|P-value:1.16E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.47|P-value:6.32E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.73|P-value:2.71E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.63|P-value:3.79E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.98|P-value:1.10E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.12|P-value:6.58E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.53|P-value:5.33E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.36|P-value:8.24E-4 ID:SGTC_2705|Compound:st078069|FD-Score:5.14|P-value:8.90E-7 ID:SGTC_2710|Compound:st078562|FD-Score:3.70|P-value:2.92E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.48|P-value:6.22E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.55|P-value:4.99E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.45|P-value:6.85E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-4.24|P-value:3.62E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-4.22|P-value:3.92E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-4.37|P-value:2.16E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.97|P-value:1.12E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.49|P-value:5.93E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.72|P-value:5.72E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-5.26|P-value:4.42E-7 ID:SGTC_709|Compound:3807-1509|FD-Score:3.59|P-value:4.33E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:4.29|P-value:3.41E-5 ID:SGTC_953|Compound:1188-0045|FD-Score:3.95|P-value:1.21E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.53|P-value:4.77E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:4.29|P-value:3.31E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.72|P-value:5.37E-8 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.55|P-value:1.16E-5 ID:SGTC_1978|Compound:st071761|FD-Score:3.47|P-value:6.32E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.73|P-value:2.71E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.63|P-value:3.79E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.98|P-value:1.10E-4 ID:SGTC_2267|Compound:7931562|FD-Score:4.12|P-value:6.58E-5 ID:SGTC_2274|Compound:7947094|FD-Score:3.53|P-value:5.33E-4 ID:SGTC_2379|Compound:9035213|FD-Score:-3.36|P-value:8.24E-4 ID:SGTC_2705|Compound:st078069|FD-Score:5.14|P-value:8.90E-7 ID:SGTC_2710|Compound:st078562|FD-Score:3.70|P-value:2.92E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:3.48|P-value:6.22E-4 ID:SGTC_2785|Compound:7756463|FD-Score:3.55|P-value:4.99E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.45|P-value:6.85E-4 ID:SGTC_2924|Compound:9010168|FD-Score:-4.24|P-value:3.62E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-4.22|P-value:3.92E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-4.37|P-value:2.16E-5 ID:SGTC_2964|Compound:9083345|FD-Score:3.97|P-value:1.12E-4 ID:SGTC_3100|Compound:9120536|FD-Score:3.49|P-value:5.93E-4 ID:SGTC_3208|Compound:9114115|FD-Score:4.72|P-value:5.72E-6 ID:SGTC_3211|Compound:9128781|FD-Score:-5.26|P-value:4.42E-7

Top fitness defect scores for YLR427W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1514 1189-1591 5.72 158.0 µM 5.37E-8 12 5.47E-9
2 SGTC_2705 st078069 5.14 42.8 µM 8.90E-7 2 1.38E-7
3 SGTC_3208 9114115 4.72 49.5 µM 5.72E-6 19 1.17E-6
4 SGTC_1582 3',3',6'-trihydroxyflavone 4.55 74.0 µM 1.16E-5 7 2.62E-6
5 SGTC_1391 3442-0225 4.29 151.0 µM 3.31E-5 8 8.75E-6
6 SGTC_711 k292-0785 4.29 179.0 µM 3.41E-5 DNA intercalators 15 9.05E-6
7 SGTC_2267 7931562 4.12 200.0 µM 6.58E-5 17 1.92E-5
8 SGTC_2170 morpholine 3.98 200.0 µM 1.10E-4 10 3.46E-5
9 SGTC_2964 9083345 3.97 53.4 µM 1.12E-4 17 3.54E-5
10 SGTC_953 1188-0045 3.95 9.7 µM 1.21E-4 60S ribosome export 28 3.88E-5
11 SGTC_2071 5230951 3.73 39.9 µM 2.71E-4 TSC3-RPN4 24 9.73E-5
12 SGTC_2710 st078562 3.70 53.7 µM 2.92E-4 25 1.06E-4
13 SGTC_2112 5488546 3.63 200.0 µM 3.79E-4 TSC3-RPN4 24 1.43E-4
14 SGTC_709 3807-1509 3.59 243.0 µM 4.33E-4 RSC complex & mRNA processing 24 1.67E-4
15 SGTC_2785 7756463 3.55 72.7 µM 4.99E-4 41 1.96E-4
16 SGTC_2274 7947094 3.53 46.1 µM 5.33E-4 51 2.12E-4
17 SGTC_3100 9120536 3.49 49.5 µM 5.93E-4 23 2.39E-4
18 SGTC_2756 carbadox 3.48 75.1 µM 6.22E-4 73 2.53E-4
19 SGTC_1978 st071761 3.47 42.0 µM 6.32E-4 TSC3-RPN4 23 2.57E-4
20 SGTC_2890 9046729 3.45 58.4 µM 6.85E-4 Golgi 33 2.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.73E-11 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.108 3.11E-10 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.099 1.05E-8 YMR075W RCO1 hom Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.094 5.60E-8 YMR172C-A_d YMR172C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.091 1.30E-7 YLR004C THI73 hom Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
0.091 1.46E-7 YOL137W BSC6 hom Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
0.090 1.54E-7 YCR023C YCR023C hom Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene
0.088 3.11E-7 YIL131C FKH1 hom Forkhead family transcription factor; has a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; binds to the recombination enhancer near HML, and regulates donor preference during mating-type switching by positioning HML near the MAT locus through FHA-domain mediated interactions with proteins near the DSB; FKH1 has a paralog, FKH2, that arose from the whole genome duplication
0.085 8.78E-7 YPL242C IQG1 het Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.083 1.46E-6 YML100W-A_p YML100W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.080 3.32E-6 YGL135W RPL1B hom Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal
0.080 3.87E-6 YMR084W_p YMR084W_p hom Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1
0.079 4.27E-6 YAL049C AIM2 hom Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor
0.079 4.53E-6 YER178W PDA1 hom E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
0.078 5.92E-6 YOR361C PRT1 het eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes