YLR428C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR428C / YLR428C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.63|P-value:1.73E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.41|P-value:3.30E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.18|P-value:1.53E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.49|P-value:2.51E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.54|P-value:3.78E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.28|P-value:6.25E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.66|P-value:2.10E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:4.72|P-value:1.55E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.00|P-value:3.98E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.22|P-value:7.57E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.16|P-value:9.27E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.34|P-value:4.96E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.81|P-value:1.04E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:4.33|P-value:9.70E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:-4.44|P-value:4.93E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.49|P-value:2.48E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.88|P-value:6.48E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.42|P-value:3.74E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.68|P-value:1.43E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.22|P-value:7.58E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.00|P-value:3.99E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.23|P-value:7.31E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.34|P-value:5.08E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.27|P-value:1.26E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.59|P-value:2.96E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.40|P-value:4.11E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.43|P-value:3.64E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.88|P-value:6.39E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.90|P-value:6.09E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.23|P-value:7.24E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.13|P-value:8.94E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.53|P-value:2.48E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.33|P-value:5.14E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.15|P-value:8.32E-4 ID:SGTC_1863|Compound:st057641|FD-Score:5.80|P-value:5.14E-9 ID:SGTC_1865|Compound:st057639|FD-Score:4.23|P-value:1.49E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.23|P-value:7.26E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.34|P-value:5.02E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.42|P-value:3.80E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.59|P-value:2.00E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.28|P-value:6.08E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.34|P-value:4.97E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.26|P-value:6.61E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.24|P-value:6.02E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.21|P-value:7.74E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.33|P-value:5.11E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.30|P-value:5.67E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.60|P-value:2.84E-6 ID:SGTC_2826|Compound:7992541|FD-Score:6.02|P-value:1.33E-9 ID:SGTC_2844|Compound:9010103|FD-Score:-3.98|P-value:3.70E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.22|P-value:7.54E-4 ID:SGTC_2973|Compound:9094665|FD-Score:6.83|P-value:7.17E-12 ID:SGTC_2982|Compound:9019404|FD-Score:6.34|P-value:1.89E-10 ID:SGTC_2988|Compound:9073640|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.57|P-value:1.84E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.63|P-value:1.73E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.69|P-value:1.36E-4 ID:SGTC_3082|Compound:9117008|FD-Score:4.47|P-value:5.11E-6 ID:SGTC_3182|Compound:9108849|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_3207|Compound:9114163|FD-Score:5.12|P-value:2.16E-7 ID:SGTC_3212|Compound:9128307|FD-Score:-6.26|P-value:2.35E-10 ID:SGTC_3295|Compound:9122362|FD-Score:-3.59|P-value:1.71E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.18|P-value:8.71E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.63|P-value:1.73E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.41|P-value:3.30E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-4.18|P-value:1.53E-5 ID:SGTC_75|Compound:0159-0059|FD-Score:-3.49|P-value:2.51E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.54|P-value:3.78E-6 ID:SGTC_198|Compound:3454-2873|FD-Score:3.28|P-value:6.25E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:4.66|P-value:2.10E-6 ID:SGTC_274|Compound:sirtinol|FD-Score:4.72|P-value:1.55E-6 ID:SGTC_387|Compound:norethindrone acetate|FD-Score:4.00|P-value:3.98E-5 ID:SGTC_417|Compound:st075190|FD-Score:3.22|P-value:7.57E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:3.16|P-value:9.27E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.34|P-value:4.96E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:4.81|P-value:1.04E-6 ID:SGTC_760|Compound:0568-0725|FD-Score:4.33|P-value:9.70E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:-4.44|P-value:4.93E-6 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.49|P-value:2.48E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:3.88|P-value:6.48E-5 ID:SGTC_839|Compound:0122-0028|FD-Score:3.42|P-value:3.74E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.68|P-value:1.43E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:3.22|P-value:7.58E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:4.00|P-value:3.99E-5 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.23|P-value:7.31E-4 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.34|P-value:5.08E-4 ID:SGTC_1085|Compound:doxorubicin|FD-Score:4.27|P-value:1.26E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:4.59|P-value:2.96E-6 ID:SGTC_1195|Compound:1502-0147|FD-Score:3.40|P-value:4.11E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.43|P-value:3.64E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.88|P-value:6.39E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.90|P-value:6.09E-5 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.23|P-value:7.24E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:-3.13|P-value:8.94E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:3.53|P-value:2.48E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.33|P-value:5.14E-4 ID:SGTC_1841|Compound:st054148|FD-Score:-3.15|P-value:8.32E-4 ID:SGTC_1863|Compound:st057641|FD-Score:5.80|P-value:5.14E-9 ID:SGTC_1865|Compound:st057639|FD-Score:4.23|P-value:1.49E-5 ID:SGTC_1866|Compound:st057638|FD-Score:3.23|P-value:7.26E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.34|P-value:5.02E-4 ID:SGTC_1900|Compound:st060200|FD-Score:3.42|P-value:3.80E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.59|P-value:2.00E-4 ID:SGTC_2034|Compound:5197015|FD-Score:3.28|P-value:6.08E-4 ID:SGTC_2067|Compound:5224629|FD-Score:3.34|P-value:4.97E-4 ID:SGTC_2224|Compound:6650123|FD-Score:3.26|P-value:6.61E-4 ID:SGTC_2307|Compound:7538926|FD-Score:-3.24|P-value:6.02E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.21|P-value:7.74E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.33|P-value:5.11E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.30|P-value:5.67E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.60|P-value:2.84E-6 ID:SGTC_2826|Compound:7992541|FD-Score:6.02|P-value:1.33E-9 ID:SGTC_2844|Compound:9010103|FD-Score:-3.98|P-value:3.70E-5 ID:SGTC_2940|Compound:9060638|FD-Score:3.22|P-value:7.54E-4 ID:SGTC_2973|Compound:9094665|FD-Score:6.83|P-value:7.17E-12 ID:SGTC_2982|Compound:9019404|FD-Score:6.34|P-value:1.89E-10 ID:SGTC_2988|Compound:9073640|FD-Score:3.59|P-value:2.01E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.57|P-value:1.84E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.63|P-value:1.73E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.69|P-value:1.36E-4 ID:SGTC_3082|Compound:9117008|FD-Score:4.47|P-value:5.11E-6 ID:SGTC_3182|Compound:9108849|FD-Score:3.54|P-value:2.47E-4 ID:SGTC_3207|Compound:9114163|FD-Score:5.12|P-value:2.16E-7 ID:SGTC_3212|Compound:9128307|FD-Score:-6.26|P-value:2.35E-10 ID:SGTC_3295|Compound:9122362|FD-Score:-3.59|P-value:1.71E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.18|P-value:8.71E-4

Top fitness defect scores for YLR428C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2973 9094665 6.83 18.0 µM 7.17E-12 NEO1 2 4.14E-12
2 SGTC_2982 9019404 6.34 26.0 µM 1.89E-10 6 1.16E-10
3 SGTC_2826 7992541 6.02 19.5 µM 1.33E-9 3 8.50E-10
4 SGTC_1863 st057641 5.80 20.1 µM 5.14E-9 2 3.39E-9
5 SGTC_3207 9114163 5.12 49.5 µM 2.16E-7 11 1.54E-7
6 SGTC_754 3474-0146 4.81 171.0 µM 1.04E-6 copper-dependent oxidative stress 9 7.65E-7
7 SGTC_274 sirtinol 4.72 40.1 µM 1.55E-6 11 1.15E-6
8 SGTC_272 doxorubicin 4.66 8.1 µM 2.10E-6 anthracycline transcription coupled DNA repair 11 1.56E-6
9 SGTC_2825 7998094 4.60 58.4 µM 2.84E-6 fatty acid desaturase (OLE1) 19 2.13E-6
10 SGTC_1187 1391-0724 4.59 117.0 µM 2.96E-6 amide catabolism 9 2.22E-6
11 SGTC_160 3453-0671 4.54 289.7 µM 3.78E-6 28 2.85E-6
12 SGTC_3082 9117008 4.47 49.5 µM 5.11E-6 9 3.88E-6
13 SGTC_760 0568-0725 4.33 82.9 µM 9.70E-6 6 7.47E-6
14 SGTC_1085 doxorubicin 4.27 7.7 µM 1.26E-5 anthracycline transcription coupled DNA repair 12 9.74E-6
15 SGTC_1865 st057639 4.23 52.2 µM 1.49E-5 7 1.16E-5
16 SGTC_387 norethindrone acetate 4.00 66.7 µM 3.98E-5 15 3.15E-5
17 SGTC_1033 k072-0102 4.00 21.3 µM 3.99E-5 60S ribosome export 19 3.17E-5
18 SGTC_1388 3346-4487 3.90 254.0 µM 6.09E-5 27 4.88E-5
19 SGTC_1286 0929-0070 3.88 131.0 µM 6.39E-5 19 5.12E-5
20 SGTC_799 1310-0557 3.88 151.0 µM 6.48E-5 superoxide 25 5.19E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 5.86E-13 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.105 1.19E-9 YML023C NSE5 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
0.090 1.84E-7 YLR444C_d YLR444C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 5.68E-7 YGR216C GPI1 het Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
0.084 1.25E-6 YBL077W_d YBL077W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
0.082 1.87E-6 YLL013C PUF3 hom Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
0.082 1.96E-6 YMR244W_p YMR244W_p hom Putative protein of unknown function
0.078 6.18E-6 YMR188C MRPS17 hom Mitochondrial ribosomal protein of the small subunit
0.078 6.79E-6 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.071 3.93E-5 YCR002C CDC10 hom Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress
0.071 4.13E-5 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
0.071 4.18E-5 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.071 4.21E-5 YIL035C CKA1 hom Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching
0.070 4.85E-5 YGR003W CUL3 hom Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3
0.070 5.59E-5 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication