YLR430W / SEN1

Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR430W / SEN1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-3.98|P-value:1.91E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.96|P-value:2.02E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.54|P-value:3.76E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.76|P-value:3.90E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.34|P-value:9.26E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:4.53|P-value:2.59E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:3.99|P-value:1.82E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.72|P-value:4.46E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.23|P-value:8.00E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:5.38|P-value:7.83E-7 ID:SGTC_804|Compound:1595-0054|FD-Score:4.21|P-value:8.65E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-4.76|P-value:1.05E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.87|P-value:2.79E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.58|P-value:2.14E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.97|P-value:1.99E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.37|P-value:4.78E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.48|P-value:9.57E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.79|P-value:3.58E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.09|P-value:1.30E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.01|P-value:1.73E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.19|P-value:9.03E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.66|P-value:5.40E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.59|P-value:6.66E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:5.92|P-value:6.36E-8 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.83|P-value:3.15E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.92|P-value:6.19E-8 ID:SGTC_1618|Compound:st003135|FD-Score:6.50|P-value:3.32E-9 ID:SGTC_1727|Compound:st034309|FD-Score:3.48|P-value:9.41E-4 ID:SGTC_1778|Compound:st046819|FD-Score:5.34|P-value:9.18E-7 ID:SGTC_1786|Compound:berberine|FD-Score:5.44|P-value:5.94E-7 ID:SGTC_1897|Compound:st060201|FD-Score:4.20|P-value:8.92E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.75|P-value:4.06E-4 ID:SGTC_1970|Compound:st070122|FD-Score:7.50|P-value:1.06E-11 ID:SGTC_2002|Compound:4023503|FD-Score:4.37|P-value:4.79E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.89|P-value:2.56E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.24|P-value:1.27E-8 ID:SGTC_2117|Compound:5521686|FD-Score:4.14|P-value:1.08E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.80|P-value:3.43E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.40|P-value:4.29E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.63|P-value:5.98E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.39|P-value:4.42E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.88|P-value:2.71E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.02|P-value:1.67E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.15|P-value:1.05E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.38|P-value:4.61E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.97|P-value:1.93E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.73|P-value:4.31E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-3.64|P-value:5.74E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:6.89|P-value:3.76E-10 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.07|P-value:1.39E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.14|P-value:1.10E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.52|P-value:8.30E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-5.10|P-value:2.63E-6 ID:SGTC_2958|Compound:9077254|FD-Score:-5.92|P-value:6.26E-8 ID:SGTC_2962|Compound:9082311|FD-Score:6.09|P-value:2.73E-8 ID:SGTC_3149|Compound:9097855|FD-Score:4.09|P-value:1.32E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.77|P-value:3.84E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.48|P-value:9.42E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.29|P-value:6.49E-5 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.98|P-value:1.91E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:-3.96|P-value:2.02E-4 ID:SGTC_95|Compound:0471-0001|FD-Score:5.54|P-value:3.76E-7 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.76|P-value:3.90E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:5.34|P-value:9.26E-7 ID:SGTC_335|Compound:4077-0256|FD-Score:4.53|P-value:2.59E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:3.99|P-value:1.82E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.72|P-value:4.46E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.23|P-value:8.00E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:5.38|P-value:7.83E-7 ID:SGTC_804|Compound:1595-0054|FD-Score:4.21|P-value:8.65E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-4.76|P-value:1.05E-5 ID:SGTC_875|Compound:0709-0210|FD-Score:3.87|P-value:2.79E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.58|P-value:2.14E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.97|P-value:1.99E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.37|P-value:4.78E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:3.48|P-value:9.57E-4 ID:SGTC_1183|Compound:1254-0324|FD-Score:-3.79|P-value:3.58E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.09|P-value:1.30E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.01|P-value:1.73E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.19|P-value:9.03E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.66|P-value:5.40E-4 ID:SGTC_1449|Compound:4112-4002|FD-Score:-3.59|P-value:6.66E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:5.92|P-value:6.36E-8 ID:SGTC_1513|Compound:0337-0559|FD-Score:3.83|P-value:3.15E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.92|P-value:6.19E-8 ID:SGTC_1618|Compound:st003135|FD-Score:6.50|P-value:3.32E-9 ID:SGTC_1727|Compound:st034309|FD-Score:3.48|P-value:9.41E-4 ID:SGTC_1778|Compound:st046819|FD-Score:5.34|P-value:9.18E-7 ID:SGTC_1786|Compound:berberine|FD-Score:5.44|P-value:5.94E-7 ID:SGTC_1897|Compound:st060201|FD-Score:4.20|P-value:8.92E-5 ID:SGTC_1899|Compound:st063254|FD-Score:3.75|P-value:4.06E-4 ID:SGTC_1970|Compound:st070122|FD-Score:7.50|P-value:1.06E-11 ID:SGTC_2002|Compound:4023503|FD-Score:4.37|P-value:4.79E-5 ID:SGTC_2011|Compound:4012611|FD-Score:3.89|P-value:2.56E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-6.24|P-value:1.27E-8 ID:SGTC_2117|Compound:5521686|FD-Score:4.14|P-value:1.08E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.80|P-value:3.43E-4 ID:SGTC_2183|Compound:6420625|FD-Score:4.40|P-value:4.29E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.63|P-value:5.98E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.39|P-value:4.42E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.88|P-value:2.71E-4 ID:SGTC_2361|Compound:9034121|FD-Score:4.02|P-value:1.67E-4 ID:SGTC_2461|Compound:5755302|FD-Score:4.15|P-value:1.05E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.38|P-value:4.61E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-3.97|P-value:1.93E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.73|P-value:4.31E-4 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:-3.64|P-value:5.74E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:6.89|P-value:3.76E-10 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.07|P-value:1.39E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.14|P-value:1.10E-4 ID:SGTC_2947|Compound:9072639|FD-Score:3.52|P-value:8.30E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-5.10|P-value:2.63E-6 ID:SGTC_2958|Compound:9077254|FD-Score:-5.92|P-value:6.26E-8 ID:SGTC_2962|Compound:9082311|FD-Score:6.09|P-value:2.73E-8 ID:SGTC_3149|Compound:9097855|FD-Score:4.09|P-value:1.32E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.77|P-value:3.84E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.48|P-value:9.42E-4 ID:SGTC_3280|Compound:9140961|FD-Score:4.29|P-value:6.49E-5

Top fitness defect scores for YLR430W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1970 st070122 7.50 35.8 µM 1.06E-11 TSC3-RPN4 1 3.15E-14 0.95
2 SGTC_2561 acetosyringone 6.89 100.0 µM 3.76E-10 1 2.70E-12 1.20
3 SGTC_1618 st003135 6.50 44.5 µM 3.32E-9 1 4.09E-11 1.65
4 SGTC_2962 9082311 6.09 13.2 µM 2.73E-8 4 5.68E-10 0.72
5 SGTC_1604 st002052 5.92 72.4 µM 6.19E-8 TSC3-RPN4 3 1.58E-9 0.65
6 SGTC_1485 3909-9022 5.92 254.0 µM 6.36E-8 RPP1 & pyrimidine depletion 2 1.63E-9 2.35
7 SGTC_95 0471-0001 5.54 561.1 µM 3.76E-7 2 1.49E-8 1.03
8 SGTC_1786 berberine 5.44 21.6 µM 5.94E-7 60S ribosome export 8 2.64E-8 0.09
9 SGTC_733 4069-0007 5.38 56.1 µM 7.83E-7 ERAD & cell cycle 10 3.72E-8 0.03
10 SGTC_1778 st046819 5.34 58.9 µM 9.18E-7 1 4.54E-8 0.58
11 SGTC_268 camptothecin 5.34 39.6 µM 9.26E-7 DNA damage response 27 4.59E-8 0.15
12 SGTC_960 1222-0186 4.58 7.7 µM 2.14E-5 5 2.28E-6 0.08
13 SGTC_335 4077-0256 4.53 27.6 µM 2.59E-5 4 2.89E-6 0.55
14 SGTC_2183 6420625 4.40 130.5 µM 4.29E-5 mitochondrial processes 10 5.42E-6 0.05
15 SGTC_2481 5478948 4.38 45.2 µM 4.61E-5 PDR1 7 5.92E-6 0.70
16 SGTC_1052 3253-3998 4.37 198.0 µM 4.78E-5 4 6.20E-6 0.27
17 SGTC_2002 4023503 4.37 131.0 µM 4.79E-5 mitochondrial processes 6 6.22E-6 0.30
18 SGTC_3280 9140961 4.29 49.5 µM 6.49E-5 60S ribosome export 6 9.05E-6 0.57
19 SGTC_700 3453-2283 4.23 142.0 µM 8.00E-5 amide catabolism 5 1.17E-5 0.02
20 SGTC_804 1595-0054 4.21 20.9 µM 8.65E-5 sphingolipid biosynthesis & PDR1 3 1.29E-5 0.24

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.097 1.80E-8 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.090 1.81E-7 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.086 5.91E-7 YMR157C AIM36 hom Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
0.085 8.52E-7 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.079 4.53E-6 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.078 6.49E-6 YLR113W HOG1 hom Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress
0.076 1.11E-5 YLL004W ORC3 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.074 1.99E-5 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.073 2.20E-5 YJR022W LSM8 het Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
0.073 2.41E-5 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.071 3.69E-5 YKL165C MCD4 het Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
0.071 3.85E-5 YML013W UBX2 hom Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis
0.069 6.58E-5 YPL001W HAT1 hom Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair
0.069 6.87E-5 YHR009C_p TDA3_p hom Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1
0.068 8.81E-5 YKL061W_p BLI1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome