YLR431C / ATG23

Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR431C / ATG23

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:3.54|P-value:3.83E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.53|P-value:3.66E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.63|P-value:2.78E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.74|P-value:1.70E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.60|P-value:3.13E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.96|P-value:7.68E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.86|P-value:1.21E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.82|P-value:1.38E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.48|P-value:4.74E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.48|P-value:9.91E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:3.60|P-value:3.05E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.44|P-value:5.43E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.48|P-value:4.65E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.23|P-value:2.86E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.41|P-value:5.56E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.36|P-value:7.00E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.28|P-value:9.22E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.09|P-value:5.05E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.73|P-value:1.94E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.05|P-value:5.90E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.04|P-value:5.96E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.50|P-value:4.43E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.69|P-value:4.01E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.34|P-value:7.46E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.73|P-value:1.92E-4 ID:SGTC_1665|Compound:st014639|FD-Score:5.66|P-value:3.50E-8 ID:SGTC_1744|Compound:st037937|FD-Score:-3.29|P-value:8.17E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.01|P-value:6.71E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.48|P-value:4.66E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.92|P-value:9.50E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.49|P-value:4.25E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.84|P-value:1.30E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.30|P-value:8.49E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.77|P-value:1.66E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.72|P-value:3.52E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.68|P-value:2.34E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.30|P-value:8.44E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.74|P-value:1.89E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.64|P-value:2.71E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.29|P-value:8.82E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_2957|Compound:9076800|FD-Score:5.35|P-value:1.73E-7 ID:SGTC_3068|Compound:9116768|FD-Score:3.27|P-value:9.50E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.08|P-value:5.09E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.24|P-value:9.79E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.61|P-value:5.77E-6 ID:SGTC_52|Compound:0329-0193|FD-Score:3.54|P-value:3.83E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.53|P-value:3.66E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.63|P-value:2.78E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:-3.74|P-value:1.70E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.60|P-value:3.13E-4 ID:SGTC_603|Compound:3794-0023|FD-Score:-3.96|P-value:7.68E-5 ID:SGTC_659|Compound:k018-0002|FD-Score:3.86|P-value:1.21E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.82|P-value:1.38E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:3.48|P-value:4.74E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:4.48|P-value:9.91E-6 ID:SGTC_904|Compound:1141-0088|FD-Score:3.60|P-value:3.05E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:3.44|P-value:5.43E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.48|P-value:4.65E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.23|P-value:2.86E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:-3.41|P-value:5.56E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.36|P-value:7.00E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.28|P-value:9.22E-4 ID:SGTC_1141|Compound:3253-0389|FD-Score:4.09|P-value:5.05E-5 ID:SGTC_1156|Compound:4092-0367|FD-Score:3.73|P-value:1.94E-4 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.05|P-value:5.90E-5 ID:SGTC_1196|Compound:1588-0294|FD-Score:4.04|P-value:5.96E-5 ID:SGTC_1421|Compound:4029-0249|FD-Score:3.50|P-value:4.43E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.69|P-value:4.01E-6 ID:SGTC_1629|Compound:st005085|FD-Score:3.34|P-value:7.46E-4 ID:SGTC_1655|Compound:st012546|FD-Score:3.73|P-value:1.92E-4 ID:SGTC_1665|Compound:st014639|FD-Score:5.66|P-value:3.50E-8 ID:SGTC_1744|Compound:st037937|FD-Score:-3.29|P-value:8.17E-4 ID:SGTC_1821|Compound:st053465|FD-Score:3.84|P-value:1.28E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.01|P-value:6.71E-5 ID:SGTC_2053|Compound:5265679|FD-Score:3.48|P-value:4.66E-4 ID:SGTC_2093|Compound:5331342|FD-Score:3.92|P-value:9.50E-5 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.49|P-value:4.25E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.84|P-value:1.30E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.30|P-value:8.49E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.77|P-value:1.66E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:4.72|P-value:3.52E-6 ID:SGTC_2563|Compound:tomatine|FD-Score:3.68|P-value:2.34E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:3.30|P-value:8.44E-4 ID:SGTC_2745|Compound:rifampicin|FD-Score:3.74|P-value:1.89E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.64|P-value:2.71E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.29|P-value:8.82E-4 ID:SGTC_2937|Compound:9044753|FD-Score:3.83|P-value:1.35E-4 ID:SGTC_2957|Compound:9076800|FD-Score:5.35|P-value:1.73E-7 ID:SGTC_3068|Compound:9116768|FD-Score:3.27|P-value:9.50E-4 ID:SGTC_3104|Compound:9120930|FD-Score:4.08|P-value:5.09E-5 ID:SGTC_3282|Compound:9108498|FD-Score:-3.24|P-value:9.79E-4 ID:SGTC_3319|Compound:9138450|FD-Score:4.61|P-value:5.77E-6

Top fitness defect scores for YLR431C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1665 st014639 5.66 11.4 µM 3.50E-8 NEO1 8 7.48E-9
2 SGTC_2957 9076800 5.35 11.5 µM 1.73E-7 8 4.33E-8
3 SGTC_2522 biochanin a 4.72 4.9 µM 3.52E-6 RNA pol III & RNase P/MRP 4 1.18E-6
4 SGTC_1446 4239-0190 4.69 62.0 µM 4.01E-6 21 1.36E-6
5 SGTC_3319 9138450 4.61 16.8 µM 5.77E-6 6 2.03E-6
6 SGTC_804 1595-0054 4.48 20.9 µM 9.91E-6 sphingolipid biosynthesis & PDR1 25 3.67E-6
7 SGTC_946 3434-1334 4.23 87.4 µM 2.86E-5 24 1.18E-5
8 SGTC_1141 3253-0389 4.09 52.6 µM 5.05E-5 6 2.19E-5
9 SGTC_3104 9120930 4.08 49.5 µM 5.09E-5 9 2.21E-5
10 SGTC_1172 0370-0043 4.05 85.0 µM 5.90E-5 21 2.60E-5
11 SGTC_1196 1588-0294 4.04 184.0 µM 5.96E-5 10 2.63E-5
12 SGTC_1824 st053723 4.01 68.6 µM 6.71E-5 31 2.99E-5
13 SGTC_2093 5331342 3.92 194.4 µM 9.50E-5 27 4.38E-5
14 SGTC_659 k018-0002 3.86 107.0 µM 1.21E-4 19 5.70E-5
15 SGTC_1821 st053465 3.84 65.6 µM 1.28E-4 6 6.05E-5
16 SGTC_2340 7987427 3.84 183.4 µM 1.30E-4 37 6.16E-5
17 SGTC_2937 9044753 3.83 11.3 µM 1.35E-4 60S ribosome export 38 6.44E-5
18 SGTC_755 1995-0008 3.82 37.3 µM 1.38E-4 24 6.60E-5
19 SGTC_2520 obtusaquinone 3.77 4.7 µM 1.66E-4 23 8.10E-5
20 SGTC_2745 rifampicin 3.74 24.3 µM 1.89E-4 3 9.30E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.086 6.61E-7 YML087C AIM33 hom Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication
0.085 7.85E-7 YHR152W SPO12 hom Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.081 2.47E-6 YBR038W CHS2 het Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis
0.076 1.08E-5 YPL016W SWI1 het Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer
0.075 1.20E-5 YGL120C PRP43 het RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
0.075 1.50E-5 YDR299W BFR2 het Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock
0.072 2.84E-5 YOR296W_p YOR296W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene
0.069 6.64E-5 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.069 7.11E-5 YOR106W VAM3 hom Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region
0.068 8.40E-5 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.067 9.94E-5 YAL040C CLN3 hom G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
0.067 1.04E-4 YDR182W CDC1 het Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution
0.067 1.13E-4 YLL002W RTT109 hom Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p
0.065 1.58E-4 YDR535C_d YDR535C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
0.063 2.38E-4 YPL249C-A RPL36B hom Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication