YLR432W / IMD3

Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR432W / IMD3

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-3.64|P-value:3.17E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:5.14|P-value:1.31E-6 ID:SGTC_549|Compound:1661-1316|FD-Score:4.33|P-value:3.90E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.46|P-value:2.31E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.95|P-value:2.95E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.87|P-value:2.12E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.35|P-value:8.26E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.44|P-value:2.52E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.53|P-value:1.74E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.50|P-value:7.16E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.47|P-value:7.83E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.20|P-value:6.25E-5 ID:SGTC_1638|Compound:st008370|FD-Score:6.28|P-value:4.23E-9 ID:SGTC_1685|Compound:st024049|FD-Score:3.45|P-value:8.40E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.72|P-value:3.50E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.01|P-value:1.26E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.58|P-value:1.41E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.42|P-value:2.70E-5 ID:SGTC_2047|Compound:4141938|FD-Score:4.13|P-value:8.29E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.85|P-value:2.25E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.46|P-value:8.12E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.41|P-value:9.58E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-3.53|P-value:4.54E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.68|P-value:2.74E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.27|P-value:4.86E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.73|P-value:3.42E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.69|P-value:3.92E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.64|P-value:3.17E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:5.14|P-value:1.31E-6 ID:SGTC_549|Compound:1661-1316|FD-Score:4.33|P-value:3.90E-5 ID:SGTC_635|Compound:k038-0028|FD-Score:4.46|P-value:2.31E-5 ID:SGTC_704|Compound:1310-0270|FD-Score:4.95|P-value:2.95E-6 ID:SGTC_718|Compound:1130-0073|FD-Score:3.87|P-value:2.12E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:-3.35|P-value:8.26E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:4.44|P-value:2.52E-5 ID:SGTC_860|Compound:0443-0016|FD-Score:4.53|P-value:1.74E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:3.50|P-value:7.16E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.47|P-value:7.83E-4 ID:SGTC_1605|Compound:st000082|FD-Score:4.20|P-value:6.25E-5 ID:SGTC_1638|Compound:st008370|FD-Score:6.28|P-value:4.23E-9 ID:SGTC_1685|Compound:st024049|FD-Score:3.45|P-value:8.40E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.72|P-value:3.50E-4 ID:SGTC_1767|Compound:st044992|FD-Score:4.01|P-value:1.26E-4 ID:SGTC_1849|Compound:st056239|FD-Score:4.58|P-value:1.41E-5 ID:SGTC_1930|Compound:st074634|FD-Score:4.42|P-value:2.70E-5 ID:SGTC_2047|Compound:4141938|FD-Score:4.13|P-value:8.29E-5 ID:SGTC_2051|Compound:5263410|FD-Score:3.85|P-value:2.25E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.46|P-value:8.12E-4 ID:SGTC_2238|Compound:6671620|FD-Score:3.41|P-value:9.58E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-3.53|P-value:4.54E-4 ID:SGTC_2281|Compound:7943571|FD-Score:-3.68|P-value:2.74E-4 ID:SGTC_2291|Compound:7917025|FD-Score:4.27|P-value:4.86E-5 ID:SGTC_2330|Compound:7979373|FD-Score:3.73|P-value:3.42E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.69|P-value:3.92E-4

Top fitness defect scores for YLR432W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1638 st008370 6.28 60.6 µM 4.23E-9 ergosterol biosynthesis 9 1.66E-10
2 SGTC_404 fumagillin 5.14 50.0 µM 1.31E-6 4 1.41E-7
3 SGTC_704 1310-0270 4.95 142.0 µM 2.95E-6 15 3.64E-7
4 SGTC_1849 st056239 4.58 19.2 µM 1.41E-5 RPP1 & pyrimidine depletion 12 2.29E-6
5 SGTC_860 0443-0016 4.53 25.1 µM 1.74E-5 18 2.92E-6
6 SGTC_635 k038-0028 4.46 24.7 µM 2.31E-5 ubiquinone biosynthesis & proteasome 38 4.09E-6
7 SGTC_748 0136-0228 4.44 77.9 µM 2.52E-5 redox potentiating 63 4.52E-6
8 SGTC_1930 st074634 4.42 34.3 µM 2.70E-5 RNA pol III & RNase P/MRP 24 4.91E-6
9 SGTC_549 1661-1316 4.33 519.0 µM 3.90E-5 10 7.56E-6
10 SGTC_2291 7917025 4.27 104.3 µM 4.86E-5 iron homeostasis 39 9.80E-6
11 SGTC_1605 st000082 4.20 49.1 µM 6.25E-5 60S ribosome export 12 1.31E-5
12 SGTC_2047 4141938 4.13 200.0 µM 8.29E-5 7 1.83E-5
13 SGTC_1767 st044992 4.01 70.3 µM 1.26E-4 20 2.99E-5
14 SGTC_718 1130-0073 3.87 349.0 µM 2.12E-4 22 5.53E-5
15 SGTC_2051 5263410 3.85 176.0 µM 2.25E-4 17 5.94E-5
16 SGTC_2330 7979373 3.73 200.0 µM 3.42E-4 60S ribosome export 41 9.67E-5
17 SGTC_1724 st037281 3.72 8.3 µM 3.50E-4 50 9.95E-5
18 SGTC_2781 5567276 3.69 71.4 µM 3.92E-4 59 1.14E-4
19 SGTC_944 3370-0224 3.50 231.0 µM 7.16E-4 41 2.30E-4
20 SGTC_1408 3909-7976 3.47 48.8 µM 7.83E-4 Golgi 40 2.56E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.52E-12 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.098 1.14E-8 YBL060W YEL1 hom Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip
0.093 6.50E-8 YKL142W MRP8 hom Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis
0.091 1.32E-7 YFL041W-A_p YFL041W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.086 5.30E-7 YJL038C LOH1 hom Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1
0.085 7.26E-7 YOR233W KIN4 hom Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication
0.082 1.96E-6 YOR248W_d YOR248W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.081 2.87E-6 YFR038W IRC5 hom Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci
0.080 3.24E-6 YPL020C ULP1 het Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
0.079 4.91E-6 YIL037C PRM2 hom Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion
0.078 6.01E-6 YNR035C ARC35 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
0.076 1.02E-5 YGL186C TPN1 hom Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
0.076 1.17E-5 YLR244C MAP1 hom Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
0.071 3.58E-5 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.071 3.91E-5 YNL117W MLS1 hom Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic