YLR433C / CNA1

Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR433C / CNA1

Click on Significant Values for Screen Details ID:SGTC_95|Compound:0471-0001|FD-Score:2.87|P-value:7.16E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.91|P-value:6.24E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.95|P-value:6.15E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.19|P-value:2.00E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.23|P-value:1.67E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.21|P-value:1.84E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:7.27|P-value:4.36E-16 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.31|P-value:1.39E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.97|P-value:5.53E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.03|P-value:4.36E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:2.79|P-value:9.94E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:2.87|P-value:7.15E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.16|P-value:2.25E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.56|P-value:2.22E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.93|P-value:7.57E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:-2.90|P-value:7.13E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:2.81|P-value:9.00E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.18|P-value:2.12E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.90|P-value:8.69E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.09|P-value:8.93E-9 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.77|P-value:1.47E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.15|P-value:2.41E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.77|P-value:1.46E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-2.84|P-value:8.97E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.92|P-value:6.98E-6 ID:SGTC_1791|Compound:st048313|FD-Score:4.63|P-value:1.44E-7 ID:SGTC_1856|Compound:st057054|FD-Score:3.68|P-value:2.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.90|P-value:6.34E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.26|P-value:1.70E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.09|P-value:3.44E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:2.91|P-value:6.29E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.75|P-value:1.63E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.24|P-value:1.65E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.07|P-value:3.30E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.99|P-value:4.80E-6 ID:SGTC_2844|Compound:9010103|FD-Score:3.46|P-value:6.24E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.08|P-value:3.56E-4 ID:SGTC_2968|Compound:9090663|FD-Score:2.84|P-value:8.12E-4 ID:SGTC_3036|Compound:9090181|FD-Score:-3.03|P-value:4.33E-4 ID:SGTC_3089|Compound:9117425|FD-Score:2.86|P-value:7.65E-4 ID:SGTC_3131|Compound:9127911|FD-Score:5.77|P-value:8.63E-11 ID:SGTC_3136|Compound:9095672|FD-Score:2.82|P-value:8.70E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.53|P-value:4.62E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.10|P-value:2.79E-6 ID:SGTC_3251|Compound:9135047|FD-Score:4.25|P-value:1.24E-6 ID:SGTC_3310|Compound:9130229|FD-Score:-5.96|P-value:2.63E-11 ID:SGTC_95|Compound:0471-0001|FD-Score:2.87|P-value:7.16E-4 ID:SGTC_147|Compound:4466-0538|FD-Score:2.91|P-value:6.24E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:3.95|P-value:6.15E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:3.19|P-value:2.00E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:3.23|P-value:1.67E-4 ID:SGTC_524|Compound:r073-0010|FD-Score:3.21|P-value:1.84E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:7.27|P-value:4.36E-16 ID:SGTC_666|Compound:0272-0154|FD-Score:-3.31|P-value:1.39E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.97|P-value:5.53E-6 ID:SGTC_746|Compound:1095-0025|FD-Score:-3.03|P-value:4.36E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:2.79|P-value:9.94E-4 ID:SGTC_815|Compound:1582-0027|FD-Score:2.87|P-value:7.15E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:3.16|P-value:2.25E-4 ID:SGTC_872|Compound:0588-0139|FD-Score:4.56|P-value:2.22E-7 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.93|P-value:7.57E-6 ID:SGTC_1021|Compound:4476-0760|FD-Score:-2.90|P-value:7.13E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:2.81|P-value:9.00E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:2.91|P-value:6.13E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.18|P-value:2.12E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:-3.90|P-value:8.69E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:5.09|P-value:8.93E-9 ID:SGTC_1265|Compound:0819-1001|FD-Score:3.77|P-value:1.47E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.15|P-value:2.41E-4 ID:SGTC_1395|Compound:3486-0190|FD-Score:3.77|P-value:1.46E-5 ID:SGTC_1406|Compound:3909-7906|FD-Score:-2.84|P-value:8.97E-4 ID:SGTC_1433|Compound:4060-0023|FD-Score:3.92|P-value:6.98E-6 ID:SGTC_1791|Compound:st048313|FD-Score:4.63|P-value:1.44E-7 ID:SGTC_1856|Compound:st057054|FD-Score:3.68|P-value:2.30E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:2.90|P-value:6.34E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:-3.26|P-value:1.70E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.09|P-value:3.44E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:2.91|P-value:6.29E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.75|P-value:1.63E-5 ID:SGTC_2692|Compound:st077426|FD-Score:3.24|P-value:1.65E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.07|P-value:3.30E-4 ID:SGTC_2695|Compound:st077686|FD-Score:3.99|P-value:4.80E-6 ID:SGTC_2844|Compound:9010103|FD-Score:3.46|P-value:6.24E-5 ID:SGTC_2923|Compound:7992654|FD-Score:-3.08|P-value:3.56E-4 ID:SGTC_2968|Compound:9090663|FD-Score:2.84|P-value:8.12E-4 ID:SGTC_3036|Compound:9090181|FD-Score:-3.03|P-value:4.33E-4 ID:SGTC_3089|Compound:9117425|FD-Score:2.86|P-value:7.65E-4 ID:SGTC_3131|Compound:9127911|FD-Score:5.77|P-value:8.63E-11 ID:SGTC_3136|Compound:9095672|FD-Score:2.82|P-value:8.70E-4 ID:SGTC_3138|Compound:9097216|FD-Score:3.53|P-value:4.62E-5 ID:SGTC_3211|Compound:9128781|FD-Score:4.10|P-value:2.79E-6 ID:SGTC_3251|Compound:9135047|FD-Score:4.25|P-value:1.24E-6 ID:SGTC_3310|Compound:9130229|FD-Score:-5.96|P-value:2.63E-11

Top fitness defect scores for YLR433C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_661 1304-0007 7.27 33.6 µM 4.36E-16 2 1.80E-13
2 SGTC_3131 9127911 5.77 49.5 µM 8.63E-11 4 4.04E-9
3 SGTC_1260 0700-1617 5.09 7.8 µM 8.93E-9 calcium & mitochondrial duress 14 1.83E-7
4 SGTC_1791 st048313 4.63 56.1 µM 1.44E-7 5 1.81E-6
5 SGTC_872 0588-0139 4.56 234.0 µM 2.22E-7 19 2.58E-6
6 SGTC_3251 9135047 4.25 49.5 µM 1.24E-6 60S ribosome export 1 1.07E-5
7 SGTC_3211 9128781 4.10 49.5 µM 2.79E-6 51 2.08E-5
8 SGTC_2695 st077686 3.99 52.0 µM 4.80E-6 32 3.25E-5
9 SGTC_728 3030-5151 3.97 22.5 µM 5.53E-6 13 3.65E-5
10 SGTC_157 1348-1695 3.95 65.8 µM 6.15E-6 iron homeostasis 70 3.99E-5
11 SGTC_1433 4060-0023 3.92 7.6 µM 6.98E-6 tubulin folding & SWR complex 18 4.42E-5
12 SGTC_1395 3486-0190 3.77 4.3 µM 1.46E-5 18 8.12E-5
13 SGTC_1265 0819-1001 3.77 68.8 µM 1.47E-5 30 8.20E-5
14 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 3.75 100.0 µM 1.63E-5 40 8.92E-5
15 SGTC_1856 st057054 3.68 55.7 µM 2.30E-5 33 1.18E-4
16 SGTC_3138 9097216 3.53 49.5 µM 4.62E-5 23 2.11E-4
17 SGTC_2844 9010103 3.46 26.0 µM 6.24E-5 47 2.70E-4
18 SGTC_2692 st077426 3.24 47.7 µM 1.65E-4 49 6.02E-4
19 SGTC_177 1327-0068 3.23 8.4 µM 1.67E-4 75 6.11E-4
20 SGTC_524 r073-0010 3.21 27.8 µM 1.84E-4 88 6.61E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.78E-11 YMR191W SPG5 hom Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
0.114 4.31E-11 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.106 7.15E-10 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.101 4.51E-9 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.095 3.86E-8 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.091 1.32E-7 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.090 2.03E-7 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.086 6.36E-7 YPR135W CTF4 hom Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
0.085 8.37E-7 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.085 8.49E-7 YPR042C PUF2 hom Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins
0.085 9.39E-7 YPR003C_p YPR003C_p hom Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene
0.081 2.57E-6 YPR194C OPT2 hom Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles
0.080 3.37E-6 YGR122C-A_d YGR122C-A_d hom Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.080 3.52E-6 YFL050C ALR2 hom Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
0.079 5.19E-6 YLR121C YPS3 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor