YLR434C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR434C / YLR434C

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:6.54|P-value:3.68E-10 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.36|P-value:1.75E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:-4.36|P-value:1.76E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:3.37|P-value:7.78E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.34|P-value:8.66E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.26|P-value:9.57E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:4.62|P-value:6.96E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:3.29|P-value:9.97E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.80|P-value:1.80E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.52|P-value:4.74E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.24|P-value:3.36E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.70|P-value:2.19E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.78|P-value:1.93E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:5.75|P-value:3.09E-8 ID:SGTC_980|Compound:1473-0395|FD-Score:4.17|P-value:4.41E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:4.15|P-value:4.81E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.83|P-value:1.58E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.96|P-value:1.56E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.70|P-value:2.14E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.91|P-value:1.21E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.11|P-value:7.74E-7 ID:SGTC_1953|Compound:st076800|FD-Score:3.87|P-value:1.38E-4 ID:SGTC_2060|Compound:5238662|FD-Score:5.75|P-value:3.14E-8 ID:SGTC_2295|Compound:7971645|FD-Score:-3.32|P-value:8.01E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.51|P-value:4.89E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.65|P-value:2.60E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.18|P-value:4.18E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.71|P-value:2.43E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.68|P-value:2.74E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.60|P-value:3.12E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.56|P-value:3.49E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.62|P-value:3.42E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.91|P-value:1.21E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:6.54|P-value:3.68E-10 ID:SGTC_42|Compound:0133-0086|FD-Score:-4.36|P-value:1.75E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:-4.36|P-value:1.76E-5 ID:SGTC_197|Compound:4544-0043|FD-Score:3.37|P-value:7.78E-4 ID:SGTC_209|Compound:4077-0173|FD-Score:3.34|P-value:8.66E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.26|P-value:9.57E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:4.62|P-value:6.96E-6 ID:SGTC_653|Compound:0203-0016|FD-Score:3.29|P-value:9.97E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.80|P-value:1.80E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.52|P-value:4.74E-4 ID:SGTC_798|Compound:1287-0182|FD-Score:4.24|P-value:3.36E-5 ID:SGTC_939|Compound:1165-0479|FD-Score:-3.70|P-value:2.19E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.78|P-value:1.93E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:5.75|P-value:3.09E-8 ID:SGTC_980|Compound:1473-0395|FD-Score:4.17|P-value:4.41E-5 ID:SGTC_1064|Compound:honokiol|FD-Score:4.15|P-value:4.81E-5 ID:SGTC_1187|Compound:1391-0724|FD-Score:3.83|P-value:1.58E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:4.96|P-value:1.56E-6 ID:SGTC_1509|Compound:1326-1131|FD-Score:-3.70|P-value:2.14E-4 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.91|P-value:1.21E-4 ID:SGTC_1713|Compound:st033146|FD-Score:5.11|P-value:7.74E-7 ID:SGTC_1953|Compound:st076800|FD-Score:3.87|P-value:1.38E-4 ID:SGTC_2060|Compound:5238662|FD-Score:5.75|P-value:3.14E-8 ID:SGTC_2295|Compound:7971645|FD-Score:-3.32|P-value:8.01E-4 ID:SGTC_2321|Compound:7390090|FD-Score:3.51|P-value:4.89E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.65|P-value:2.60E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:4.18|P-value:4.18E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.71|P-value:2.43E-4 ID:SGTC_2968|Compound:9090663|FD-Score:3.68|P-value:2.74E-4 ID:SGTC_3195|Compound:9113082|FD-Score:-3.60|P-value:3.12E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-3.56|P-value:3.49E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.62|P-value:3.42E-4 ID:SGTC_3340|Compound:9146634|FD-Score:3.91|P-value:1.21E-4

Top fitness defect scores for YLR434C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_38 0929-0051 6.54 58.3 µM 3.68E-10 2 3.13E-11
2 SGTC_952 1185-0122 5.75 232.0 µM 3.09E-8 7 4.47E-9
3 SGTC_2060 5238662 5.75 140.0 µM 3.14E-8 9 4.55E-9
4 SGTC_1713 st033146 5.11 12.8 µM 7.74E-7 9 1.65E-7
5 SGTC_1276 0871-0068 4.96 94.2 µM 1.56E-6 6 3.61E-7
6 SGTC_552 k242-0005 4.62 476.0 µM 6.96E-6 8 1.93E-6
7 SGTC_798 1287-0182 4.24 476.0 µM 3.36E-5 15 1.12E-5
8 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 4.18 100.0 µM 4.18E-5 28 1.43E-5
9 SGTC_980 1473-0395 4.17 201.0 µM 4.41E-5 9 1.52E-5
10 SGTC_1064 honokiol 4.15 6.8 µM 4.81E-5 19 1.67E-5
11 SGTC_3340 9146634 3.91 11.1 µM 1.21E-4 15 4.70E-5
12 SGTC_1585 2',4'-dihydroxychalcone 3.91 10.4 µM 1.21E-4 33 4.71E-5
13 SGTC_1953 st076800 3.87 12.1 µM 1.38E-4 52 5.45E-5
14 SGTC_1187 1391-0724 3.83 117.0 µM 1.58E-4 amide catabolism 19 6.31E-5
15 SGTC_688 0527-0193 3.80 473.0 µM 1.80E-4 fatty acid desaturase (OLE1) 17 7.34E-5
16 SGTC_951 1171-0579 3.78 82.7 µM 1.93E-4 cell wall 90 7.92E-5
17 SGTC_2873 9040596 3.71 71.4 µM 2.43E-4 57 1.03E-4
18 SGTC_2968 9090663 3.68 33.4 µM 2.74E-4 41 1.17E-4
19 SGTC_3337 9144342 3.62 33.5 µM 3.42E-4 34 1.50E-4
20 SGTC_750 4073-0104 3.52 132.0 µM 4.74E-4 20 2.16E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.28E-8 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.083 1.63E-6 YPR138C MEP3 hom Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
0.081 2.80E-6 YAR014C BUD14 hom Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.31E-6 YNL059C ARP5 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.079 4.56E-6 YLR276C DBP9 het DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain
0.076 9.69E-6 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.075 1.43E-5 YCR073W-A SOL2 hom Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication
0.073 2.11E-5 YOR270C VPH1 hom Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress
0.073 2.25E-5 YDR003W-A_p YDR003W-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.072 3.21E-5 YBL071C_d YBL071C_d hom Dubious open reading frame, predicted protein contains a peroxisomal targeting signal
0.071 3.40E-5 YOR359W VTS1 hom Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity
0.069 7.04E-5 YER155C BEM2 hom Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
0.068 8.81E-5 YNL316C PHA2 hom Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
0.067 9.36E-5 YBR059C AKL1 hom Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
0.067 1.01E-4 YGR268C HUA1 hom Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly