YLR435W / TSR2

Protein with a potential role in pre-rRNA processing

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR435W / TSR2

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.27|P-value:3.82E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.59|P-value:6.97E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.40|P-value:1.52E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.35|P-value:2.76E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.13|P-value:4.41E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.39|P-value:2.43E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.37|P-value:1.71E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.41|P-value:2.60E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.44|P-value:1.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.08|P-value:1.23E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.06|P-value:8.36E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.63|P-value:2.66E-9 ID:SGTC_831|Compound:k061-1017|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.55|P-value:1.27E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:3.14|P-value:6.08E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.23|P-value:6.07E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.25|P-value:4.07E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.33|P-value:2.03E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.62|P-value:9.35E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.24|P-value:4.18E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:5.01|P-value:1.04E-7 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.99|P-value:1.89E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.13|P-value:6.46E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.39|P-value:2.43E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.15|P-value:5.96E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-4.57|P-value:6.58E-7 ID:SGTC_1781|Compound:st038725|FD-Score:4.36|P-value:3.29E-6 ID:SGTC_1901|Compound:st060216|FD-Score:3.31|P-value:3.20E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.42|P-value:1.40E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.25|P-value:2.77E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.31|P-value:3.21E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.46|P-value:1.81E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.07|P-value:5.45E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.91|P-value:2.64E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.99|P-value:1.19E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.73|P-value:5.96E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-3.06|P-value:5.71E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.49|P-value:1.59E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.19|P-value:5.20E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.51|P-value:1.57E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.35|P-value:2.06E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.06|P-value:1.39E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.30|P-value:3.34E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.29|P-value:2.39E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.13|P-value:6.10E-6 ID:SGTC_2854|Compound:9024559|FD-Score:4.29|P-value:4.50E-6 ID:SGTC_2856|Compound:9022925|FD-Score:3.23|P-value:4.46E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.15|P-value:5.96E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.39|P-value:2.34E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.09|P-value:7.34E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.27|P-value:3.82E-4 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.59|P-value:6.97E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.40|P-value:1.52E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:3.35|P-value:2.76E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.13|P-value:4.41E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.39|P-value:2.43E-4 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.37|P-value:1.71E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.41|P-value:2.60E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.56|P-value:1.21E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.44|P-value:1.31E-4 ID:SGTC_588|Compound:3970-1144|FD-Score:4.08|P-value:1.23E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.44|P-value:1.92E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.06|P-value:8.36E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:5.63|P-value:2.66E-9 ID:SGTC_831|Compound:k061-1017|FD-Score:4.00|P-value:1.79E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:4.55|P-value:1.27E-6 ID:SGTC_930|Compound:2810-3379|FD-Score:3.14|P-value:6.08E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:4.23|P-value:6.07E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.25|P-value:4.07E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:-3.33|P-value:2.03E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.62|P-value:9.35E-5 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.24|P-value:4.18E-4 ID:SGTC_1285|Compound:0929-0069|FD-Score:5.01|P-value:1.04E-7 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.99|P-value:1.89E-5 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.13|P-value:6.46E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.39|P-value:2.43E-4 ID:SGTC_1730|Compound:st033808|FD-Score:3.52|P-value:1.41E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.15|P-value:5.96E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-4.57|P-value:6.58E-7 ID:SGTC_1781|Compound:st038725|FD-Score:4.36|P-value:3.29E-6 ID:SGTC_1901|Compound:st060216|FD-Score:3.31|P-value:3.20E-4 ID:SGTC_1921|Compound:5740136|FD-Score:-3.42|P-value:1.40E-4 ID:SGTC_1930|Compound:st074634|FD-Score:-3.25|P-value:2.77E-4 ID:SGTC_1958|Compound:st076513|FD-Score:3.31|P-value:3.21E-4 ID:SGTC_1982|Compound:st072467|FD-Score:3.46|P-value:1.81E-4 ID:SGTC_2254|Compound:7938975|FD-Score:-3.07|P-value:5.45E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.43|P-value:2.02E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.91|P-value:2.64E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.99|P-value:1.19E-5 ID:SGTC_2412|Compound:st077135|FD-Score:3.73|P-value:5.96E-5 ID:SGTC_2413|Compound:inermin|FD-Score:-3.06|P-value:5.71E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.49|P-value:1.59E-4 ID:SGTC_2447|Compound:5741742|FD-Score:3.19|P-value:5.20E-4 ID:SGTC_2460|Compound:5552655|FD-Score:4.51|P-value:1.57E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-4.35|P-value:2.06E-6 ID:SGTC_2593|Compound:nobiletin|FD-Score:4.06|P-value:1.39E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.30|P-value:3.34E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.29|P-value:2.39E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.13|P-value:6.10E-6 ID:SGTC_2854|Compound:9024559|FD-Score:4.29|P-value:4.50E-6 ID:SGTC_2856|Compound:9022925|FD-Score:3.23|P-value:4.46E-4 ID:SGTC_2996|Compound:9066192|FD-Score:3.15|P-value:5.96E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.39|P-value:2.34E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.09|P-value:7.34E-4

Top fitness defect scores for YLR435W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_764 1951-2361 5.63 146.0 µM 2.66E-9 9 9.07E-9
2 SGTC_1285 0929-0069 5.01 65.5 µM 1.04E-7 4 2.67E-7
3 SGTC_882 0843-0131 4.55 351.0 µM 1.27E-6 9 2.71E-6
4 SGTC_2460 5552655 4.51 174.2 µM 1.57E-6 amide catabolism 19 3.31E-6
5 SGTC_445 e6 berbamine 4.41 66.0 µM 2.60E-6 NEO1-PIK1 85 5.28E-6
6 SGTC_1781 st038725 4.36 66.3 µM 3.29E-6 NEO1 86 6.55E-6
7 SGTC_2854 9024559 4.29 71.4 µM 4.50E-6 12 8.76E-6
8 SGTC_1014 4130-3005 4.23 69.3 µM 6.07E-6 10 1.16E-5
9 SGTC_588 3970-1144 4.08 52.9 µM 1.23E-5 25 2.23E-5
10 SGTC_2593 nobiletin 4.06 86.2 µM 1.39E-5 22 2.49E-5
11 SGTC_831 k061-1017 4.00 217.0 µM 1.79E-5 translation 60 3.15E-5
12 SGTC_1297 1068-0111 3.99 14.1 µM 1.89E-5 10 3.32E-5
13 SGTC_2296 7971656 3.91 126.5 µM 2.64E-5 44 4.52E-5
14 SGTC_2412 st077135 3.73 33.4 µM 5.96E-5 29 9.64E-5
15 SGTC_1176 0848-0131 3.62 83.3 µM 9.35E-5 Golgi 29 1.46E-4
16 SGTC_449 xestospongin c 3.56 11.2 µM 1.21E-4 NEO1-PIK1 89 1.86E-4
17 SGTC_450 aminopyrene 3.56 156.0 nM 1.21E-4 44 1.86E-4
18 SGTC_1730 st033808 3.52 45.1 µM 1.41E-4 53 2.15E-4
19 SGTC_2420 aureobasidin a 3.49 50.0 nM 1.59E-4 61 2.39E-4
20 SGTC_1982 st072467 3.46 71.9 µM 1.81E-4 54 2.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 5.96E-12 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.117 1.06E-11 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.117 1.17E-11 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.111 1.05E-10 YOL121C RPS19A hom Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication
0.111 1.25E-10 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.102 3.38E-9 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.100 5.59E-9 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.100 6.63E-9 YGL088W_d YGL088W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
0.099 8.88E-9 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.098 1.32E-8 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.097 1.83E-8 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.095 3.99E-8 YML063W RPS1B hom Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication
0.090 1.56E-7 YOR078W BUD21 hom Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
0.090 2.00E-7 YBR189W RPS9B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication
0.089 2.22E-7 YJL075C_d APQ13_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate