YLR437C / DIF1

Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR437C / DIF1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:-3.48|P-value:8.18E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:-2.92|P-value:7.84E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.53|P-value:6.44E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.24|P-value:2.05E-6 ID:SGTC_300|Compound:r073-0011|FD-Score:3.74|P-value:2.49E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.13|P-value:3.33E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.60|P-value:4.66E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.55|P-value:5.70E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.22|P-value:2.31E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.24|P-value:2.11E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.80|P-value:1.96E-5 ID:SGTC_459|Compound:nigericin|FD-Score:4.29|P-value:1.62E-6 ID:SGTC_500|Compound:h-89|FD-Score:3.54|P-value:6.15E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:4.02|P-value:6.27E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.91|P-value:8.14E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-2.87|P-value:9.64E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.77|P-value:2.14E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.03|P-value:4.98E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.90|P-value:7.44E-11 ID:SGTC_991|Compound:3996-0057|FD-Score:5.21|P-value:7.73E-9 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.76|P-value:2.23E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.91|P-value:7.83E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.26|P-value:1.92E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.71|P-value:2.85E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.51|P-value:7.16E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:5.75|P-value:2.16E-10 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.40|P-value:1.10E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.29|P-value:1.76E-4 ID:SGTC_1675|Compound:st018485|FD-Score:6.12|P-value:1.55E-11 ID:SGTC_1721|Compound:st082152|FD-Score:3.10|P-value:3.77E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.81|P-value:1.74E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.35|P-value:1.39E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.55|P-value:5.88E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.10|P-value:3.92E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.75|P-value:2.32E-5 ID:SGTC_1964|Compound:st076914|FD-Score:3.61|P-value:4.42E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.18|P-value:2.84E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.91|P-value:1.09E-5 ID:SGTC_2008|Compound:4012253|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.73|P-value:1.41E-7 ID:SGTC_2052|Compound:5265182|FD-Score:4.21|P-value:2.39E-6 ID:SGTC_2065|Compound:5221596|FD-Score:3.95|P-value:9.03E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.33|P-value:1.48E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.46|P-value:8.59E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:2.98|P-value:5.98E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.75|P-value:2.31E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-2.97|P-value:6.55E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.23|P-value:2.26E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.11|P-value:3.62E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.99|P-value:6.09E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.16|P-value:3.14E-6 ID:SGTC_2900|Compound:5328528|FD-Score:-4.00|P-value:7.51E-6 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.13|P-value:3.57E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.23|P-value:2.40E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.42|P-value:1.03E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.15|P-value:3.07E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.48|P-value:8.18E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:-2.92|P-value:7.84E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.53|P-value:6.44E-5 ID:SGTC_183|Compound:3914-0051|FD-Score:4.24|P-value:2.05E-6 ID:SGTC_300|Compound:r073-0011|FD-Score:3.74|P-value:2.49E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.13|P-value:3.33E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.60|P-value:4.66E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.55|P-value:5.70E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.22|P-value:2.31E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:4.24|P-value:2.11E-6 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.80|P-value:1.96E-5 ID:SGTC_459|Compound:nigericin|FD-Score:4.29|P-value:1.62E-6 ID:SGTC_500|Compound:h-89|FD-Score:3.54|P-value:6.15E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:4.02|P-value:6.27E-6 ID:SGTC_733|Compound:4069-0007|FD-Score:-2.91|P-value:8.14E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:-2.87|P-value:9.64E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.77|P-value:2.14E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:3.03|P-value:4.98E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.90|P-value:7.44E-11 ID:SGTC_991|Compound:3996-0057|FD-Score:5.21|P-value:7.73E-9 ID:SGTC_1030|Compound:k029-0042|FD-Score:3.76|P-value:2.23E-5 ID:SGTC_1043|Compound:0916-0009|FD-Score:2.91|P-value:7.83E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:4.26|P-value:1.92E-6 ID:SGTC_1150|Compound:3909-7983|FD-Score:3.71|P-value:2.85E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.51|P-value:7.16E-5 ID:SGTC_1402|Compound:3909-7673|FD-Score:5.75|P-value:2.16E-10 ID:SGTC_1407|Compound:3909-7909|FD-Score:3.40|P-value:1.10E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.29|P-value:1.76E-4 ID:SGTC_1675|Compound:st018485|FD-Score:6.12|P-value:1.55E-11 ID:SGTC_1721|Compound:st082152|FD-Score:3.10|P-value:3.77E-4 ID:SGTC_1771|Compound:st048882|FD-Score:3.81|P-value:1.74E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.35|P-value:1.39E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.55|P-value:5.88E-5 ID:SGTC_1921|Compound:5740136|FD-Score:-3.10|P-value:3.92E-4 ID:SGTC_1961|Compound:st076550|FD-Score:3.75|P-value:2.32E-5 ID:SGTC_1964|Compound:st076914|FD-Score:3.61|P-value:4.42E-5 ID:SGTC_1966|Compound:st070145|FD-Score:-3.18|P-value:2.84E-4 ID:SGTC_1971|Compound:st069429|FD-Score:3.91|P-value:1.09E-5 ID:SGTC_2008|Compound:4012253|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.73|P-value:1.41E-7 ID:SGTC_2052|Compound:5265182|FD-Score:4.21|P-value:2.39E-6 ID:SGTC_2065|Compound:5221596|FD-Score:3.95|P-value:9.03E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.33|P-value:1.48E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.46|P-value:8.59E-5 ID:SGTC_2170|Compound:morpholine|FD-Score:2.98|P-value:5.98E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.75|P-value:2.31E-5 ID:SGTC_2497|Compound:7-hydroxyflavone|FD-Score:-2.97|P-value:6.55E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.23|P-value:2.26E-4 ID:SGTC_2791|Compound:5663188|FD-Score:3.11|P-value:3.62E-4 ID:SGTC_2797|Compound:7859098|FD-Score:-2.99|P-value:6.09E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.16|P-value:3.14E-6 ID:SGTC_2900|Compound:5328528|FD-Score:-4.00|P-value:7.51E-6 ID:SGTC_2901|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.13|P-value:3.57E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.23|P-value:2.40E-4 ID:SGTC_2978|Compound:9011784|FD-Score:3.42|P-value:1.03E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.15|P-value:3.07E-4

Top fitness defect scores for YLR437C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1675 st018485 6.12 24.5 µM 1.55E-11 60S ribosome export 6 4.68E-10
2 SGTC_871 0574-0004 5.90 149.0 µM 7.44E-11 15 1.78E-9
3 SGTC_1402 3909-7673 5.75 35.9 µM 2.16E-10 5 4.42E-9
4 SGTC_991 3996-0057 5.21 64.7 µM 7.73E-9 5 9.38E-8
5 SGTC_2009 4012297 4.73 12.1 µM 1.41E-7 cell wall signaling 42 1.12E-6
6 SGTC_459 nigericin 4.29 15.3 µM 1.62E-6 55 9.04E-6
7 SGTC_1059 3448-6867 4.26 171.0 µM 1.92E-6 8 1.04E-5
8 SGTC_183 3914-0051 4.24 30.6 µM 2.05E-6 60S ribosome export 18 1.10E-5
9 SGTC_449 xestospongin c 4.24 11.2 µM 2.11E-6 NEO1-PIK1 55 1.13E-5
10 SGTC_2052 5265182 4.21 7.1 µM 2.39E-6 23 1.26E-5
11 SGTC_2849 9019321 4.16 13.0 µM 3.14E-6 25 1.59E-5
12 SGTC_632 0781-2353 4.02 4.7 µM 6.27E-6 Golgi 40 2.87E-5
13 SGTC_2065 5221596 3.95 34.3 µM 9.03E-6 16 3.92E-5
14 SGTC_1971 st069429 3.91 63.5 µM 1.09E-5 60S ribosome export 15 4.60E-5
15 SGTC_1771 st048882 3.81 4.2 µM 1.74E-5 RPP1 & pyrimidine depletion 24 6.89E-5
16 SGTC_866 0495-0101 3.77 262.0 µM 2.14E-5 60S ribosome export 20 8.22E-5
17 SGTC_1030 k029-0042 3.76 36.7 µM 2.23E-5 TSC3-RPN4 32 8.52E-5
18 SGTC_2344 7990960 3.75 77.0 µM 2.31E-5 29 8.77E-5
19 SGTC_1961 st076550 3.75 68.7 µM 2.32E-5 14 8.80E-5
20 SGTC_300 r073-0011 3.74 5.0 µM 2.49E-5 26 9.37E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.78E-10 YDL112W TRM3 hom 2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
0.102 3.59E-9 YER091C-A_d YER091C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.088 3.29E-7 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.082 1.86E-6 YKL037W AIM26 hom Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT
0.082 2.20E-6 YBR032W_d YBR032W_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
0.080 3.99E-6 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.079 4.47E-6 YGL130W CEG1 het Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
0.076 1.05E-5 YDR112W_d IRC2_d hom Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
0.075 1.20E-5 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.075 1.35E-5 YBR235W VHC1 hom Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
0.074 1.64E-5 YLR364W GRX8 hom Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic
0.073 2.14E-5 YKL073W LHS1 hom Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway
0.073 2.17E-5 YPR122W AXL1 hom Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
0.071 3.70E-5 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.071 4.00E-5 YGR013W SNU71 het Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart