YLR438C-A / LSM3

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR438C-A / LSM3

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.12|P-value:1.54E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.29|P-value:4.16E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.51|P-value:1.99E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.93|P-value:3.53E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:6.08|P-value:3.98E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:3.80|P-value:6.05E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:5.22|P-value:6.60E-8 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.40|P-value:2.79E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.62|P-value:1.50E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:4.03|P-value:2.34E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.71|P-value:3.87E-9 ID:SGTC_368|Compound:fentichlor|FD-Score:4.79|P-value:6.39E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.36|P-value:3.48E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.48|P-value:2.19E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.68|P-value:1.14E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.06|P-value:9.53E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:7.05|P-value:4.86E-13 ID:SGTC_593|Compound:1203-0218|FD-Score:3.09|P-value:8.91E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.59|P-value:7.73E-9 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.42|P-value:3.77E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.30|P-value:4.08E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.17|P-value:1.26E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:5.02|P-value:1.98E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:4.24|P-value:9.22E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.18|P-value:1.15E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.12|P-value:8.18E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.29|P-value:4.42E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.94|P-value:9.48E-10 ID:SGTC_998|Compound:3996-0085|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.35|P-value:3.42E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.44|P-value:2.52E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.51|P-value:1.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.81|P-value:5.64E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.27|P-value:4.48E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.29|P-value:4.18E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.91|P-value:3.84E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.62|P-value:1.26E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.84|P-value:5.18E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.72|P-value:8.38E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.12|P-value:8.03E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.54|P-value:1.04E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.84|P-value:5.25E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.38|P-value:4.68E-6 ID:SGTC_1829|Compound:berberine|FD-Score:4.85|P-value:4.73E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-9.73|P-value:3.37E-23 ID:SGTC_2060|Compound:5238662|FD-Score:4.01|P-value:2.48E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.64|P-value:1.37E-6 ID:SGTC_2100|Compound:5377183|FD-Score:4.70|P-value:1.02E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.91|P-value:3.84E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.18|P-value:6.57E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.12|P-value:7.84E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.16|P-value:6.65E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.44|P-value:3.58E-11 ID:SGTC_2260|Compound:7964312|FD-Score:3.85|P-value:4.93E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.18|P-value:6.51E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.97|P-value:3.02E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.05|P-value:2.14E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:-3.08|P-value:8.83E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.37|P-value:5.89E-11 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.22|P-value:5.69E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:8.40|P-value:1.02E-17 ID:SGTC_2585|Compound:alliin|FD-Score:3.41|P-value:2.80E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.34|P-value:3.67E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.37|P-value:4.91E-6 ID:SGTC_2817|Compound:7995342|FD-Score:-5.17|P-value:7.89E-8 ID:SGTC_2823|Compound:7987624|FD-Score:5.49|P-value:1.45E-8 ID:SGTC_2860|Compound:9025725|FD-Score:3.88|P-value:4.45E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.11|P-value:7.94E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.41|P-value:2.75E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.39|P-value:3.04E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.14|P-value:7.14E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.69|P-value:9.01E-5 ID:SGTC_2912|Compound:7964298|FD-Score:-4.78|P-value:6.33E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-12.00|P-value:2.38E-34 ID:SGTC_2973|Compound:9094665|FD-Score:-3.15|P-value:7.08E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.47|P-value:1.57E-8 ID:SGTC_3056|Compound:9094900|FD-Score:3.52|P-value:1.88E-4 ID:SGTC_3086|Compound:9117350|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.34|P-value:3.53E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.72|P-value:8.00E-5 ID:SGTC_3107|Compound:9121808|FD-Score:3.87|P-value:4.58E-5 ID:SGTC_3114|Compound:9122766|FD-Score:-3.67|P-value:9.88E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.82|P-value:5.63E-5 ID:SGTC_3247|Compound:9135149|FD-Score:-3.17|P-value:6.59E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.75|P-value:7.57E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.11|P-value:8.39E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.39|P-value:3.07E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.12|P-value:1.54E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.29|P-value:4.16E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.51|P-value:1.99E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.93|P-value:3.53E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:6.08|P-value:3.98E-10 ID:SGTC_119|Compound:0121-0043|FD-Score:3.80|P-value:6.05E-5 ID:SGTC_124|Compound:0136-0217|FD-Score:5.22|P-value:6.60E-8 ID:SGTC_257|Compound:daunorubicin|FD-Score:-3.40|P-value:2.79E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:4.62|P-value:1.50E-6 ID:SGTC_280|Compound:3448-3607|FD-Score:4.03|P-value:2.34E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.71|P-value:3.87E-9 ID:SGTC_368|Compound:fentichlor|FD-Score:4.79|P-value:6.39E-7 ID:SGTC_371|Compound:0195-0006|FD-Score:3.39|P-value:3.09E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.36|P-value:3.48E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.48|P-value:2.19E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.68|P-value:1.14E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:-3.06|P-value:9.53E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:7.05|P-value:4.86E-13 ID:SGTC_593|Compound:1203-0218|FD-Score:3.09|P-value:8.91E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:5.59|P-value:7.73E-9 ID:SGTC_609|Compound:0986-0026|FD-Score:-4.42|P-value:3.77E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:-3.30|P-value:4.08E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.17|P-value:1.26E-5 ID:SGTC_765|Compound:1319-0117|FD-Score:5.02|P-value:1.98E-7 ID:SGTC_795|Compound:0685-0265|FD-Score:4.24|P-value:9.22E-6 ID:SGTC_829|Compound:1635-0120|FD-Score:-4.18|P-value:1.15E-5 ID:SGTC_833|Compound:3852-0053|FD-Score:3.12|P-value:8.18E-4 ID:SGTC_866|Compound:0495-0101|FD-Score:3.29|P-value:4.42E-4 ID:SGTC_969|Compound:1313-0238|FD-Score:5.94|P-value:9.48E-10 ID:SGTC_998|Compound:3996-0085|FD-Score:3.60|P-value:1.37E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.35|P-value:3.42E-4 ID:SGTC_1081|Compound:sertraline|FD-Score:3.44|P-value:2.52E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-3.51|P-value:1.87E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.81|P-value:5.64E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:-3.27|P-value:4.48E-4 ID:SGTC_1211|Compound:1056-0033|FD-Score:-3.29|P-value:4.18E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:3.91|P-value:3.84E-5 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.68|P-value:1.01E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.62|P-value:1.26E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.84|P-value:5.18E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.72|P-value:8.38E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.12|P-value:8.03E-4 ID:SGTC_1786|Compound:berberine|FD-Score:5.54|P-value:1.04E-8 ID:SGTC_1800|Compound:st050079|FD-Score:3.84|P-value:5.25E-5 ID:SGTC_1818|Compound:st052136|FD-Score:4.38|P-value:4.68E-6 ID:SGTC_1829|Compound:berberine|FD-Score:4.85|P-value:4.73E-7 ID:SGTC_2054|Compound:5233173|FD-Score:-9.73|P-value:3.37E-23 ID:SGTC_2060|Compound:5238662|FD-Score:4.01|P-value:2.48E-5 ID:SGTC_2065|Compound:5221596|FD-Score:4.64|P-value:1.37E-6 ID:SGTC_2100|Compound:5377183|FD-Score:4.70|P-value:1.02E-6 ID:SGTC_2110|Compound:5483698|FD-Score:3.91|P-value:3.84E-5 ID:SGTC_2117|Compound:5521686|FD-Score:3.18|P-value:6.57E-4 ID:SGTC_2238|Compound:6671620|FD-Score:-3.12|P-value:7.84E-4 ID:SGTC_2243|Compound:6634756|FD-Score:-3.16|P-value:6.65E-4 ID:SGTC_2257|Compound:7960413|FD-Score:6.44|P-value:3.58E-11 ID:SGTC_2260|Compound:7964312|FD-Score:3.85|P-value:4.93E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.18|P-value:6.51E-4 ID:SGTC_2424|Compound:5537928|FD-Score:3.97|P-value:3.02E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.05|P-value:2.14E-5 ID:SGTC_2492|Compound:derrusnin|FD-Score:-3.08|P-value:8.83E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.65|P-value:1.14E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.37|P-value:5.89E-11 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.22|P-value:5.69E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:8.40|P-value:1.02E-17 ID:SGTC_2585|Compound:alliin|FD-Score:3.41|P-value:2.80E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.15|P-value:7.39E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.34|P-value:3.67E-4 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.13|P-value:7.96E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:4.37|P-value:4.91E-6 ID:SGTC_2817|Compound:7995342|FD-Score:-5.17|P-value:7.89E-8 ID:SGTC_2823|Compound:7987624|FD-Score:5.49|P-value:1.45E-8 ID:SGTC_2860|Compound:9025725|FD-Score:3.88|P-value:4.45E-5 ID:SGTC_2866|Compound:9034245|FD-Score:-3.11|P-value:7.94E-4 ID:SGTC_2875|Compound:9039966|FD-Score:-3.41|P-value:2.75E-4 ID:SGTC_2905|Compound:7799065|FD-Score:3.39|P-value:3.04E-4 ID:SGTC_2908|Compound:7930301|FD-Score:-3.14|P-value:7.14E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.69|P-value:9.01E-5 ID:SGTC_2912|Compound:7964298|FD-Score:-4.78|P-value:6.33E-7 ID:SGTC_2965|Compound:9082772|FD-Score:-12.00|P-value:2.38E-34 ID:SGTC_2973|Compound:9094665|FD-Score:-3.15|P-value:7.08E-4 ID:SGTC_2988|Compound:9073640|FD-Score:5.47|P-value:1.57E-8 ID:SGTC_3056|Compound:9094900|FD-Score:3.52|P-value:1.88E-4 ID:SGTC_3086|Compound:9117350|FD-Score:3.21|P-value:5.83E-4 ID:SGTC_3102|Compound:9121669|FD-Score:-3.34|P-value:3.53E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.72|P-value:8.00E-5 ID:SGTC_3107|Compound:9121808|FD-Score:3.87|P-value:4.58E-5 ID:SGTC_3114|Compound:9122766|FD-Score:-3.67|P-value:9.88E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.82|P-value:5.63E-5 ID:SGTC_3247|Compound:9135149|FD-Score:-3.17|P-value:6.59E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.75|P-value:7.57E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.11|P-value:8.39E-4 ID:SGTC_3353|Compound:9151644|FD-Score:3.39|P-value:3.07E-4

Top fitness defect scores for YLR438C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2584 androsterone 8.40 48.7 µM 1.02E-17 cell wall 4 2.31E-17 0.91
2 SGTC_584 0986-0246 7.05 15.4 µM 4.86E-13 heme requiring 5 8.65E-13 0.31
3 SGTC_2257 7960413 6.44 200.0 µM 3.58E-11 NEO1-PIK1 7 5.78E-11 0.18
4 SGTC_2582 agaric acid 6.37 100.0 µM 5.89E-11 redox potentiating 14 9.40E-11 0.21
5 SGTC_97 0535-0701 6.08 19.1 µM 3.98E-10 60S ribosome export 5 6.09E-10 0.62
6 SGTC_969 1313-0238 5.94 134.0 µM 9.48E-10 mitochondrial processes 5 1.42E-9 0.22
7 SGTC_366 0181-0206 5.71 4.3 µM 3.87E-9 Golgi 4 5.62E-9 0.43
8 SGTC_607 4491-0986 5.59 66.8 µM 7.73E-9 heme requiring 4 1.11E-8 1.12
9 SGTC_1786 berberine 5.54 21.6 µM 1.04E-8 60S ribosome export 7 1.48E-8 0.10
10 SGTC_2823 7987624 5.49 58.4 µM 1.45E-8 4 2.05E-8 0.07
11 SGTC_2988 9073640 5.47 71.4 µM 1.57E-8 5 2.22E-8 0.69
12 SGTC_124 0136-0217 5.22 7.1 µM 6.60E-8 mitochondrial stress 12 9.00E-8 0.14
13 SGTC_765 1319-0117 5.02 244.0 µM 1.98E-7 60S ribosome export 5 2.64E-7 1.15
14 SGTC_1829 berberine 4.85 14.4 µM 4.73E-7 60S ribosome export 7 6.18E-7 0.07
15 SGTC_368 fentichlor 4.79 4.6 µM 6.39E-7 4 8.29E-7 0.39
16 SGTC_2100 5377183 4.70 190.0 µM 1.02E-6 60S ribosome export 6 1.31E-6 0.52
17 SGTC_568 1193-0097 4.68 7.5 µM 1.14E-6 ERAD & cell cycle 21 1.46E-6 0.25
18 SGTC_2065 5221596 4.64 34.3 µM 1.37E-6 2 1.75E-6 0.10
19 SGTC_266 formosanin C 4.62 406.0 nM 1.50E-6 sphingolipid biosynthesis & PDR1 16 1.90E-6 0.02
20 SGTC_1818 st052136 4.38 56.3 µM 4.68E-6 NEO1-PIK1 12 5.81E-6 0.05

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 1.08E-76 YER112W LSM4 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress
0.179 1.63E-25 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.173 5.82E-24 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.164 1.00E-21 YJL167W ERG20 het Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
0.137 1.37E-15 YMR308C PSE1 het Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
0.135 5.18E-15 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.135 4.99E-15 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.125 3.72E-13 YDR232W HEM1 het 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
0.125 4.39E-13 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.123 8.17E-13 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.120 3.02E-12 YGL099W LSG1 het Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
0.119 4.74E-12 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.118 7.16E-12 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.112 7.15E-11 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.107 4.73E-10 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p