L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR438W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.091 | 1.42E-7 | YNL160W | YGP1 | hom | Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p |
0.088 | 3.83E-7 | YBR028C | YPK3 | hom | An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner |
0.085 | 7.79E-7 | YLL006W-A_p | YLL006W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
0.082 | 2.14E-6 | YFR030W | MET10 | hom | Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide |
0.081 | 2.47E-6 | YDL091C | UBX3 | hom | Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10 |
0.080 | 3.31E-6 | YPR075C | OPY2 | hom | Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress |
0.080 | 3.67E-6 | YML104C | MDM1 | hom | Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) |
0.077 | 7.78E-6 | YNL268W | LYP1 | hom | Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids |
0.077 | 8.12E-6 | YDR108W | TRS85 | hom | Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role |
0.073 | 2.02E-5 | YOL086W-A | MHF1 | hom | Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1 |
0.073 | 2.04E-5 | YKL031W_d | YKL031W_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species |
0.073 | 2.31E-5 | YOR215C | AIM41 | hom | Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss |
0.072 | 3.38E-5 | YDR301W | CFT1 | het | RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF |
0.069 | 5.63E-5 | YFR038W | IRC5 | hom | Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci |
0.069 | 5.83E-5 | YNL306W | MRPS18 | het | Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins |