YLR438W / CAR2

L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR438W / CAR2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.52|P-value:2.03E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.55|P-value:1.80E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.39|P-value:3.24E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.26|P-value:5.27E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.35|P-value:6.73E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.42|P-value:2.92E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.58|P-value:1.72E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.60|P-value:1.61E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.18|P-value:7.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.24|P-value:5.70E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:4.26|P-value:1.01E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.47|P-value:2.60E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.24|P-value:6.09E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.30|P-value:4.88E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:4.42|P-value:4.90E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.15|P-value:8.08E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.42|P-value:2.89E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.96|P-value:3.68E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.62|P-value:1.45E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.13|P-value:8.71E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.95|P-value:3.69E-7 ID:SGTC_1853|Compound:st056710|FD-Score:4.36|P-value:6.51E-6 ID:SGTC_2113|Compound:5491891|FD-Score:-3.11|P-value:8.75E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.63|P-value:1.42E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.10|P-value:9.62E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-4.80|P-value:6.93E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.07|P-value:9.96E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.78|P-value:7.12E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.19|P-value:1.37E-5 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.23|P-value:6.26E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:-3.18|P-value:6.93E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:4.45|P-value:4.15E-6 ID:SGTC_2712|Compound:st079126|FD-Score:3.45|P-value:2.82E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.45|P-value:2.57E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-5.69|P-value:5.40E-9 ID:SGTC_2824|Compound:7998404|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.10|P-value:9.65E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.80|P-value:7.15E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.12|P-value:9.22E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.40|P-value:3.13E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.87|P-value:5.37E-5 ID:SGTC_3080|Compound:9117754|FD-Score:5.16|P-value:1.18E-7 ID:SGTC_3085|Compound:9117376|FD-Score:-3.60|P-value:1.50E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.00|P-value:3.09E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.17|P-value:1.54E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-3.10|P-value:9.11E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.64|P-value:1.37E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.77|P-value:7.65E-5 ID:SGTC_3311|Compound:9131146|FD-Score:-3.08|P-value:9.83E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.38|P-value:3.69E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.49|P-value:2.25E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.52|P-value:2.03E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:-3.55|P-value:1.80E-4 ID:SGTC_326|Compound:k292-0812|FD-Score:-3.39|P-value:3.24E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:-3.26|P-value:5.27E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:4.35|P-value:6.73E-6 ID:SGTC_440|Compound:fluspirilene|FD-Score:-3.42|P-value:2.92E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.58|P-value:1.72E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:3.60|P-value:1.61E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:3.18|P-value:7.36E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.24|P-value:5.70E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:4.26|P-value:1.01E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:3.47|P-value:2.60E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.24|P-value:6.09E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.30|P-value:4.88E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:4.42|P-value:4.90E-6 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.15|P-value:8.08E-4 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.42|P-value:2.89E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:3.96|P-value:3.68E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.62|P-value:1.45E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.13|P-value:8.71E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.95|P-value:3.69E-7 ID:SGTC_1853|Compound:st056710|FD-Score:4.36|P-value:6.51E-6 ID:SGTC_2113|Compound:5491891|FD-Score:-3.11|P-value:8.75E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.63|P-value:1.42E-4 ID:SGTC_2356|Compound:9061756|FD-Score:3.10|P-value:9.62E-4 ID:SGTC_2361|Compound:9034121|FD-Score:-4.80|P-value:6.93E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:-3.07|P-value:9.96E-4 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.78|P-value:7.12E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:4.19|P-value:1.37E-5 ID:SGTC_2656|Compound:pseudo-anisatin|FD-Score:3.23|P-value:6.26E-4 ID:SGTC_2670|Compound:beta-carotene|FD-Score:-3.18|P-value:6.93E-4 ID:SGTC_2673|Compound:kobusone|FD-Score:4.45|P-value:4.15E-6 ID:SGTC_2712|Compound:st079126|FD-Score:3.45|P-value:2.82E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.45|P-value:2.57E-4 ID:SGTC_2789|Compound:5281112|FD-Score:-5.69|P-value:5.40E-9 ID:SGTC_2824|Compound:7998404|FD-Score:3.72|P-value:1.01E-4 ID:SGTC_2885|Compound:9057732|FD-Score:3.10|P-value:9.65E-4 ID:SGTC_2893|Compound:9048488|FD-Score:3.80|P-value:7.15E-5 ID:SGTC_2912|Compound:7964298|FD-Score:3.12|P-value:9.22E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.40|P-value:3.13E-4 ID:SGTC_2961|Compound:9083290|FD-Score:3.87|P-value:5.37E-5 ID:SGTC_3080|Compound:9117754|FD-Score:5.16|P-value:1.18E-7 ID:SGTC_3085|Compound:9117376|FD-Score:-3.60|P-value:1.50E-4 ID:SGTC_3100|Compound:9120536|FD-Score:4.00|P-value:3.09E-5 ID:SGTC_3108|Compound:9121785|FD-Score:4.17|P-value:1.54E-5 ID:SGTC_3127|Compound:9126946|FD-Score:-3.10|P-value:9.11E-4 ID:SGTC_3245|Compound:9134821|FD-Score:3.64|P-value:1.37E-4 ID:SGTC_3289|Compound:9119912|FD-Score:-3.77|P-value:7.65E-5 ID:SGTC_3311|Compound:9131146|FD-Score:-3.08|P-value:9.83E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.38|P-value:3.69E-4 ID:SGTC_3318|Compound:9139014|FD-Score:-3.49|P-value:2.25E-4

Top fitness defect scores for YLR438W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3080 9117754 5.16 49.5 µM 1.18E-7 6 1.20E-7
2 SGTC_1782 st039423 4.95 80.6 µM 3.69E-7 7 3.76E-7
3 SGTC_2673 kobusone 4.45 100.0 µM 4.15E-6 3 4.20E-6
4 SGTC_591 4299-0174 4.42 154.0 µM 4.90E-6 5 4.95E-6
5 SGTC_1853 st056710 4.36 91.2 µM 6.51E-6 amide catabolism 19 6.57E-6
6 SGTC_430 0958-0115 4.35 16.4 µM 6.73E-6 20 6.80E-6
7 SGTC_522 1273-0010 4.26 11.6 µM 1.01E-5 60S ribosome export 20 1.01E-5
8 SGTC_2604 4'-hydroxychalcone 4.19 11.3 µM 1.37E-5 31 1.38E-5
9 SGTC_3108 9121785 4.17 49.5 µM 1.54E-5 8 1.55E-5
10 SGTC_3100 9120536 4.00 49.5 µM 3.09E-5 14 3.11E-5
11 SGTC_1060 3448-7350 3.96 82.0 µM 3.68E-5 Golgi 34 3.69E-5
12 SGTC_2961 9083290 3.87 32.5 µM 5.37E-5 18 5.39E-5
13 SGTC_2893 9048488 3.80 26.0 µM 7.15E-5 fatty acid desaturase (OLE1) 24 7.17E-5
14 SGTC_2824 7998404 3.72 52.0 µM 1.01E-4 40 1.01E-4
15 SGTC_3245 9134821 3.64 49.5 µM 1.37E-4 30 1.37E-4
16 SGTC_2302 7771753 3.63 200.0 µM 1.42E-4 55 1.42E-4
17 SGTC_1191 1487-1166 3.62 10.6 µM 1.45E-4 azole & statin 42 1.45E-4
18 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 3.60 150.0 µM 1.61E-4 Golgi 51 1.61E-4
19 SGTC_451 chloral hydrate 3.58 100.0 µM 1.72E-4 69 1.72E-4
20 SGTC_556 4058-0063 3.47 51.5 µM 2.60E-4 40 2.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.091 1.42E-7 YNL160W YGP1 hom Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
0.088 3.83E-7 YBR028C YPK3 hom An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner
0.085 7.79E-7 YLL006W-A_p YLL006W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.082 2.14E-6 YFR030W MET10 hom Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide
0.081 2.47E-6 YDL091C UBX3 hom Subunit of the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; ortholog of fission yeast Ucp10
0.080 3.31E-6 YPR075C OPY2 hom Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress
0.080 3.67E-6 YML104C MDM1 hom Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)
0.077 7.78E-6 YNL268W LYP1 hom Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
0.077 8.12E-6 YDR108W TRS85 hom Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role
0.073 2.02E-5 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.073 2.04E-5 YKL031W_d YKL031W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
0.073 2.31E-5 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.072 3.38E-5 YDR301W CFT1 het RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
0.069 5.63E-5 YFR038W IRC5 hom Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci
0.069 5.83E-5 YNL306W MRPS18 het Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins