Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR439W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.465 | 1.33E-179 | YGL064C | MRH4 | hom | Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function |
0.443 | 2.76E-161 | YJL063C | MRPL8 | hom | Mitochondrial ribosomal protein of the large subunit |
0.431 | 3.69E-152 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.425 | 1.18E-147 | YDR462W | MRPL28 | hom | Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress |
0.424 | 8.14E-147 | YER050C | RSM18 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein |
0.418 | 1.28E-141 | YLR260W | LCB5 | hom | Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules |
0.417 | 5.19E-141 | YLR069C | MEF1 | hom | Mitochondrial elongation factor involved in translational elongation |
0.408 | 3.52E-135 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |
0.408 | 4.75E-134 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.404 | 3.08E-132 | YLR149C | YLR149C | hom | Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress |
0.404 | 6.55E-132 | YKL170W | MRPL38 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |
0.401 | 1.81E-129 | YDR194C | MSS116 | hom | DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing |
0.400 | 2.36E-129 | YNR037C | RSM19 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein |
0.398 | 6.23E-128 | YMR257C | PET111 | hom | Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane |
0.398 | 9.06E-128 | YPL040C | ISM1 | hom | Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth |