HIPHOP chemogenomics database

YLR439W / MRPL4

Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR439W / MRPL4

Click on Significant Values for Screen Details

Top fitness defect scores for YLR439W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1742	st038235	12.00	28.9 µM	5.54E-26	mitochondrial stress	6	1.17E-33
2	SGTC_310	1273-0058	8.67	1.1 µM	2.36E-14	mitochondrial stress	70	2.14E-18
3	SGTC_236	1509-0011	8.14	5.3 µM	7.49E-13		245	2.00E-16
4	SGTC_70	0141-0289	7.67	43.3 µM	1.30E-11	mitochondrial stress	43	8.48E-15
5	SGTC_173	1273-0061	6.06	2.7 µM	7.35E-8	mitochondrial stress	106	6.98E-10
6	SGTC_1247	0448-0043	5.66	5.8 µM	4.58E-7	ERG2	13	7.67E-9
7	SGTC_2232	chlorophetanol	5.49	41.5 µM	9.57E-7	TRP & mitochondrial translation	56	2.01E-8
8	SGTC_63	0099-0242	5.39	26.7 µM	1.47E-6	mitochondrial stress	42	3.51E-8
9	SGTC_2091	4-phenylthiadiazole	5.24	200.0 µM	2.79E-6		4	8.15E-8
10	SGTC_118	0083-0097	5.07	135.3 µM	5.54E-6	translation	50	1.99E-7
11	SGTC_28	pentachloropyridine N-oxide	4.93	1.6 µM	9.72E-6	TSC3-RPN4	31	4.16E-7
12	SGTC_341	1486-1430	4.78	230.0 µM	1.72E-5		10	8.80E-7
13	SGTC_119	0121-0043	4.77	24.8 µM	1.78E-5	mitochondrial stress	66	9.19E-7
14	SGTC_1189	1431-2119	4.55	7.3 µM	3.98E-5		12	2.62E-6
15	SGTC_1998	st075797	4.47	76.8 µM	5.40E-5	mitochondrial response to ROS	9	3.90E-6
16	SGTC_275	trichlorophene	4.36	5.7 µM	7.96E-5	mitochondrial stress	207	6.48E-6
17	SGTC_1240	0356-0016	4.33	42.1 µM	8.94E-5	mitochondrial response to ROS	29	7.54E-6
18	SGTC_2144	5628481	4.23	200.0 µM	1.25E-4	ERG2	17	1.17E-5
19	SGTC_10	0279-0212	4.23	42.6 µM	1.26E-4	TRP & mitochondrial translation	107	1.18E-5
20	SGTC_1371	2421-0008	4.23	32.7 µM	1.27E-4	mitochondrial processes	26	1.19E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.465	1.33E-179	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.443	2.76E-161	YJL063C	MRPL8	hom	Mitochondrial ribosomal protein of the large subunit
0.431	3.69E-152	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.425	1.18E-147	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.424	8.14E-147	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.418	1.28E-141	YLR260W	LCB5	hom	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.417	5.19E-141	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.408	3.52E-135	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.408	4.75E-134	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.404	3.08E-132	YLR149C	YLR149C	hom	Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress
0.404	6.55E-132	YKL170W	MRPL38	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.401	1.81E-129	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.400	2.36E-129	YNR037C	RSM19	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein
0.398	6.23E-128	YMR257C	PET111	hom	Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.398	9.06E-128	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth