YLR440C / SEC39

Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR440C / SEC39

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-8.30|P-value:4.85E-21 ID:SGTC_88|Compound:0180-0332|FD-Score:-3.41|P-value:5.92E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:6.00|P-value:8.38E-12 ID:SGTC_154|Compound:3389-1638|FD-Score:4.68|P-value:7.56E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.02|P-value:2.90E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.16|P-value:1.96E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.42|P-value:6.29E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.02|P-value:3.30E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.00|P-value:3.68E-6 ID:SGTC_276|Compound:colchicine|FD-Score:-3.48|P-value:4.46E-5 ID:SGTC_296|Compound:1222-0039|FD-Score:3.12|P-value:2.34E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.64|P-value:2.27E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.22|P-value:1.09E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.39|P-value:7.30E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.79|P-value:1.09E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.80|P-value:3.74E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:3.00|P-value:3.94E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.21|P-value:1.61E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.68|P-value:7.86E-11 ID:SGTC_917|Compound:harmaline|FD-Score:3.35|P-value:8.56E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.40|P-value:6.84E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.07|P-value:2.88E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.18|P-value:1.85E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:2.92|P-value:5.38E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.24|P-value:1.39E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-2.75|P-value:9.77E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.62|P-value:2.51E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.02|P-value:3.36E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.48|P-value:4.91E-5 ID:SGTC_1530|Compound:rhein|FD-Score:-3.18|P-value:1.70E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.59|P-value:1.30E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.01|P-value:3.49E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.82|P-value:7.97E-4 ID:SGTC_1927|Compound:st060202|FD-Score:4.00|P-value:3.61E-6 ID:SGTC_2242|Compound:6630449|FD-Score:-3.95|P-value:4.33E-6 ID:SGTC_2244|Compound:6635614|FD-Score:-2.92|P-value:4.91E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.33|P-value:9.43E-5 ID:SGTC_2310|Compound:7668677|FD-Score:6.43|P-value:2.63E-13 ID:SGTC_2331|Compound:7980721|FD-Score:3.73|P-value:1.44E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-2.78|P-value:8.49E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.98|P-value:1.13E-8 ID:SGTC_2339|Compound:9000433|FD-Score:3.85|P-value:7.82E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.67|P-value:8.25E-8 ID:SGTC_2436|Compound:5633522|FD-Score:3.88|P-value:6.96E-6 ID:SGTC_2483|Compound:5729050|FD-Score:-2.87|P-value:5.99E-4 ID:SGTC_2488|Compound:5268135|FD-Score:2.77|P-value:9.54E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-2.74|P-value:9.84E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-2.80|P-value:7.92E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.07|P-value:2.54E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:2.91|P-value:5.55E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.72|P-value:1.52E-5 ID:SGTC_2798|Compound:7813637|FD-Score:4.07|P-value:2.56E-6 ID:SGTC_2854|Compound:9024559|FD-Score:2.83|P-value:7.67E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.12|P-value:2.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.37|P-value:4.69E-7 ID:SGTC_3352|Compound:9151559|FD-Score:-3.25|P-value:1.22E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-8.30|P-value:4.85E-21 ID:SGTC_88|Compound:0180-0332|FD-Score:-3.41|P-value:5.92E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:6.00|P-value:8.38E-12 ID:SGTC_154|Compound:3389-1638|FD-Score:4.68|P-value:7.56E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.02|P-value:2.90E-6 ID:SGTC_230|Compound:MPP+|FD-Score:3.16|P-value:1.96E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:3.42|P-value:6.29E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:-3.02|P-value:3.30E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.00|P-value:3.68E-6 ID:SGTC_276|Compound:colchicine|FD-Score:-3.48|P-value:4.46E-5 ID:SGTC_296|Compound:1222-0039|FD-Score:3.12|P-value:2.34E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:3.64|P-value:2.27E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.16|P-value:1.81E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:4.22|P-value:1.09E-6 ID:SGTC_480|Compound:am 92016|FD-Score:3.39|P-value:7.30E-5 ID:SGTC_481|Compound:bay k-8644|FD-Score:3.79|P-value:1.09E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.80|P-value:3.74E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:3.00|P-value:3.94E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.21|P-value:1.61E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.68|P-value:7.86E-11 ID:SGTC_917|Compound:harmaline|FD-Score:3.35|P-value:8.56E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.40|P-value:6.84E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.07|P-value:2.88E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.18|P-value:1.85E-4 ID:SGTC_1218|Compound:1348-1416|FD-Score:2.92|P-value:5.38E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.24|P-value:1.39E-4 ID:SGTC_1385|Compound:3091-4834|FD-Score:-2.75|P-value:9.77E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:3.62|P-value:2.51E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.02|P-value:3.36E-6 ID:SGTC_1519|Compound:esterone|FD-Score:3.48|P-value:4.91E-5 ID:SGTC_1530|Compound:rhein|FD-Score:-3.18|P-value:1.70E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:4.59|P-value:1.30E-7 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.01|P-value:3.49E-4 ID:SGTC_1854|Compound:st056233|FD-Score:2.82|P-value:7.97E-4 ID:SGTC_1927|Compound:st060202|FD-Score:4.00|P-value:3.61E-6 ID:SGTC_2242|Compound:6630449|FD-Score:-3.95|P-value:4.33E-6 ID:SGTC_2244|Compound:6635614|FD-Score:-2.92|P-value:4.91E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.33|P-value:9.43E-5 ID:SGTC_2310|Compound:7668677|FD-Score:6.43|P-value:2.63E-13 ID:SGTC_2331|Compound:7980721|FD-Score:3.73|P-value:1.44E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-2.78|P-value:8.49E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.98|P-value:1.13E-8 ID:SGTC_2339|Compound:9000433|FD-Score:3.85|P-value:7.82E-6 ID:SGTC_2415|Compound:st077333|FD-Score:4.67|P-value:8.25E-8 ID:SGTC_2436|Compound:5633522|FD-Score:3.88|P-value:6.96E-6 ID:SGTC_2483|Compound:5729050|FD-Score:-2.87|P-value:5.99E-4 ID:SGTC_2488|Compound:5268135|FD-Score:2.77|P-value:9.54E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:-2.74|P-value:9.84E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-2.80|P-value:7.92E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.07|P-value:2.54E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:2.91|P-value:5.55E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.72|P-value:1.52E-5 ID:SGTC_2798|Compound:7813637|FD-Score:4.07|P-value:2.56E-6 ID:SGTC_2854|Compound:9024559|FD-Score:2.83|P-value:7.67E-4 ID:SGTC_2958|Compound:9077254|FD-Score:-3.12|P-value:2.18E-4 ID:SGTC_2997|Compound:9067075|FD-Score:4.37|P-value:4.69E-7 ID:SGTC_3352|Compound:9151559|FD-Score:-3.25|P-value:1.22E-4

Top fitness defect scores for YLR440C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2310 7668677 6.43 200.0 µM 2.63E-13 2 6.28E-11 1.78
2 SGTC_151 3013-0144 6.00 2.3 µM 8.38E-12 iron homeostasis 2 9.89E-10 0.30
3 SGTC_2335 9018011 4.98 154.2 µM 1.13E-8 4 3.10E-7 0.57
4 SGTC_491 tetrandrine 4.80 80.3 µM 3.74E-8 2 8.09E-7 0.54
5 SGTC_154 3389-1638 4.68 511.1 µM 7.56E-8 1 1.42E-6 0.34
6 SGTC_2415 st077333 4.67 57.7 µM 8.25E-8 9 1.52E-6 0.01
7 SGTC_1570 verbenone 4.59 133.0 µM 1.30E-7 2 2.19E-6 0.50
8 SGTC_2997 9067075 4.37 71.4 µM 4.69E-7 unfolded protein response 18 6.11E-6 0.10
9 SGTC_464 bw-b 70c 4.22 158.0 µM 1.09E-6 6 1.20E-5 0.09
10 SGTC_2772 vinpocetine 4.07 57.1 µM 2.54E-6 5 2.37E-5 0.00
11 SGTC_2798 7813637 4.07 45.5 µM 2.56E-6 12 2.38E-5 0.22
12 SGTC_1495 4469-0029 4.02 237.0 µM 3.36E-6 6 2.96E-5 0.34
13 SGTC_1927 st060202 4.00 13.8 µM 3.61E-6 6 3.14E-5 0.06
14 SGTC_268 camptothecin 4.00 39.6 µM 3.68E-6 DNA damage response 44 3.19E-5 0.03
15 SGTC_2436 5633522 3.88 8.1 µM 6.96E-6 12 5.31E-5 0.04
16 SGTC_2339 9000433 3.85 200.0 µM 7.82E-6 4 5.83E-5 0.01
17 SGTC_481 bay k-8644 3.79 50.0 µM 1.09E-5 5 7.62E-5 0.12
18 SGTC_2331 7980721 3.73 200.0 µM 1.44E-5 16 9.53E-5 0.14
19 SGTC_2794 7785382 3.72 27.3 µM 1.52E-5 15 9.93E-5 0.03
20 SGTC_303 1348-1668 3.64 34.2 µM 2.27E-5 5 1.37E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.251 2.32E-49 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.193 1.51E-29 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.193 2.37E-29 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.187 8.54E-28 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.185 2.45E-27 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.178 3.29E-25 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.174 2.84E-24 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.171 1.55E-23 YLR040C_p YLR040C_p hom Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential
0.167 1.75E-22 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.166 3.97E-22 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.165 9.06E-22 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.153 5.86E-19 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.146 2.10E-17 YOR014W RTS1 hom B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A
0.144 6.54E-17 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.143 9.30E-17 YKL034W TUL1 hom Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1